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MARCUS: molecular annotation and recognition for curating unravelled structures
No full textThe exponential growth of chemical literature necessitates the development of automated tools for extracting and curating molecular information from unstructured scientific publications into open-access chemical databases. Current optical chemical structure recognition (OCSR) and named entity recognition solutions operate in isolation, which limits their scalability for comprehensive literature curation. Here we present MARCUS (Molecular Annotation and Recognition for Curating Unravelled Structures), a tool designed for natural product literature curation that integrates COCONUT-aware schema mapping, CIP-based stereochemical validation, and human-in-the-loop structure refinement. This integrated web-based platform combines automated text annotation, multi-engine OCSR, and direct submission capabilities to the COCONUT database. MARCUS employs a fine-tuned GPT-4 model to extract chemical entities and utilises a Human-in-the-loop ensemble approach integrating DECIMER, MolNexTR, and MolScribe for structure recognition. The platform aims to streamline the data extraction workflow from PDF upload to database submission, significantly reducing curation time. MARCUS bridges the gap between unstructured chemical literature and machine-actionable databases, enabling FAIR data principles and facilitating AI-driven chemical discovery. Through open-source code, accessible models, and comprehensive documentation, the web application enhances accessibility and promotes community-driven development. This approach facilitates unrestricted use and encourages the collaborative advancement of automated chemical literature curation tools
„Verkauf“ der Staatsangehörigkeit durch Mitgliedstaat („goldene Pässe“) unionsrechtswidrig : [EuGH Urt. v. 29.4.2025 - C-181/23]
No full textDifferent Seas, Different Phishes: Large-Scale Analysis of Phishing Simulations Across Different Industries
No full textPhishing is an increasing threat to the security of end-users, networks, and organizations. Phishing simulations via email are a widespread tool used to measure user awareness, especially in workplace settings. However, current studies focusing on large-scale analysis of phishing simulations often have issues: The phishing simulations were conducted using a small sample size (mostly one or two organizations), or while many emails are sent, the analysis focuses only on specific companies. This study analyzes phishing simulations conducted over three years at 36 organizations with over 68 000 delivered emails. We compare different dimensions of the organizations where these simulations were conducted, such as the economic sector and departments. Furthermore, we evaluate various dimensions of phishing simulation campaigns, such as detection difficulty and the scenario under which the simulation occurs. Our findings indicate significant disparities in the results, such as the industry sector in which the company operates. Moreover, we find substantial differences between the success rates of varying scenarios used for phishing emails
High-temperature He+ Irradiation of Low-iron-bearing Olivine: Laboratory Simulations of Space Weathering on Mercury
No full textThe surface of Mercury is highly space weathered, and the products of space weathering are different than on the Moon. Here we simulate the interaction of solar wind ions with the surface of Mercury by implanting low-iron-bearing (∼3 wt% Fe) olivine slices with 4 keV He+ ions both under ambient conditions and at 450 °C during the irradiation. The sample irradiated under ambient conditions shows a ∼140 nm thick partially amorphous layer on top of the grain with high concentrations of bubbles and cavities. However, the sample irradiated at 450 °C has a 110–140 nm thick polycrystalline layer with 1–5 nm sized nanoparticles of metallic iron and no bubbles or cavities. Mg atoms are preferentially sputtered from the ion-damaged layer present on the sample irradiated under ambient conditions, but no difference in composition is seen between the crystalline olivine and the ion-damaged layer in the sample irradiated at 450 °C. In addition, a thin amorphous film deposited on a micro-electromechanical systems–based chip is heated up to 1200 °C in situ inside a transmission electron microscope for a few milliseconds, and it produced nanoparticles of size 5–30 nm. Our results show that solar wind irradiation of low-iron-bearing olivine in the equatorial regions of Mercury will produce nanoparticles of iron whose sizes will be larger than that on the surface of the Moon and that the size will further increase during impacts of dust particles. Solar-wind-implanted He can diffuse out of regolith grains and can be a source of He observed in the exosphere of Mercury
Teaching Bioinspired Design for Assistive Technologies Using Additive Manufacturing: A Collaborative Experience
No full textAbstract
Integrating bioinspired design and additive manufacturing into engineering education fosters innovation to meet the growing demand for accessible, personalized assistive technologies. This paper presents the outcomes of an international course, “3D Prosthetics and Orthotics”, offered to undergraduate students in the Biomimetic program at Westfälische Hochschule (Germany), in collaboration with the 3D Orthotics and Prosthetics Laboratory at the Federal University of São Paulo—UNIFESP (Brazil). The course combined theoretical and hands-on modules covering digital modeling (CAD), simulation (CAE), and fabrication (CAM), enabling students to develop bioinspired assistive devices through a Project-based learning approach. Working in interdisciplinary teams, students addressed real-world rehabilitation challenges by translating biological mechanisms into engineered solutions using additive manufacturing. Resulting prototypes included a hand prosthesis based on the Fin Ray effect, a modular finger prosthesis inspired by tendon–muscle antagonism, and a cervical orthosis designed based on stingray morphology. Each device was digitally modeled, mechanically analyzed, and physically fabricated using open-source and low-cost methods. This initiative illustrates how biomimetic mechanisms and design can be integrated into education to generate functional outcomes and socially impactful health technologies. Grounded in the Mao3D open-source methodology, this experience demonstrates the value of combining nature-inspired principles, digital fabrication, Design Thinking, and international collaboration to advance inclusive, low-cost innovations in assistive technology
Laser Powder Bed Fusion Additive Manufacturing of a CoCrFeNiCu High-Entropy Alloy: Processability, Microstructural Insights, and (In Situ) Mechanical Behavior
No full textHigh-entropy alloys are known for their promising mechanical properties, wear and corrosion resistance, which are maintained across a wide range of temperatures. In this study, a CoCrFeNiCu-based high-entropy alloy, distinguished from conventional CoCrFeNi systems by the addition of Cu, which is known to enhance toughness and wear resistance, was investigated to better understand the effects of compositional modification on processability and performance. The influence of key process parameters, specifically laser power and scan speed, on the processability of CoCrFeNiCu-based high-entropy alloys produced by laser powder bed fusion additive manufacturing was investigated, with a focus of low laser power, which is critical for minimizing defects and improving the resulting microstructure and mechanical performance. The printed sample density gradually increases with higher volumetric energy density, achieving densities exceeding 99.0%. However, at higher energy densities, the samples exhibit susceptibility to hot cracking, an issue that cannot be mitigated by adjusting the process parameters. Mechanical properties under optimized parameters were further evaluated using Charpy impact and (in situ) tensile tests. These evaluations were supplemented by in situ tensile experiments conducted within a scanning electron microscope to gain insights into the behavior of defects, such as hot cracks, during tensile testing. Despite the sensitivity to hot cracking, the samples exhibited a respectable ultimate tensile strength of 662 MPa, comparable to fine-grained steels like S500MC (070XLK). These findings underscore the potential of CoCrFeNiCu-based high-entropy alloys for advanced applications. However, they also highlight the necessity for developing strategies to ensure stable and reliable processing methods that can mitigate the susceptibility to hot cracking
Rethinking Support Policies: The Role of Belonging in Entrepreneurial Ecosystems
No full textThis article explores the importance of belongingness in migrant entrepreneurs' (MEs) engagement within entrepreneurial ecosystems (EEs), focusing on emotional and social dimensions often overlooked in favour of structural factors. Through two case studies in Germany's Ruhr area, the article demonstrates how a strong sense of belonging enhances resilience, trust and social capital, essential for business success. The experiences of two MEs, Ilyas and Elif, illustrate belongingness as a catalyst for connectedness and embeddedness, enabling access to networks and resources while countering discrimination. The study suggests that policy frameworks should acknowledge and support the emotional and relational aspects of MEs' integration in EEs. Emphasising informal support systems, community engagement and tailored interventions could help overcome structural barriers and foster more inclusive ecosystems. Future research should further examine these dynamics across diverse cultural and geographical contexts to offer a more comprehensive understanding of MEs' entrepreneurial trajectories
