European Journal of Medical and Health Research
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Management Strategy of Brain Metastases in Lung Cancer
No full textBrain metastases represent the most frequent intracranial complication of bronchopulmonary cancers. We retrospectively analyzed 120 patients with lung cancer–related brain metastases treated at the Pierre and Marie Curie Center, Algiers, between 2011 and 2023, to describe their clinical and therapeutic characteristics. The cohort included 100 men and 20 women, with a mean age of 62 years. Brain metastases were present at diagnosis in 78% of cases, detected during staging in 13%, and occurred metachronously in 9%, with a mean delay of 18 months. Most patients presented with solitary brain lesions (79%). Adenocarcinoma was the predominant histological subtype (64%), followed by squamous cell carcinoma (20%) and small-cell lung cancer (10%). Surgical resection and radiotherapy were performed in 17% and 40% of patients, respectively. Median overall survival was 12.75 months. Brain metastases remain a frequent and poor prognostic event in lung cancer, and management should be individualized according to disease burden, performance status, number of brain lesions, and tumor biology, ideally within a multidisciplinary framework
Risk Factors for Pancreatic Cancer and Their Impact on Survival and Prognosis in Algerian Population
No full textPancreatic cancer, predominantly represented by pancreatic ductal adenocarcinoma (PDAC), is among the most severe malignancies and remains one of the most aggressive tumors worldwide. It ranks among the five leading causes of cancer-related mortality and exhibits the lowest survival rate of all cancers. Reported one-year and five-year survival rates are approximately 20% and less than 5%, respectively. Its incidence continues to rise, particularly among women and younger populations. Diagnosis is often delayed due to non-specific and poorly suggestive symptoms, which largely explains its unfavorable prognosis. Numerous modifiable and non-modifiable risk factors have been identified and play a decisive role in both disease incidence and clinical progression. This article aims to present the main risk factors for exocrine pancreatic cancer and to analyze their impact on patient survival and prognosis
Perceptions and Knowledge of Patients and Dentists towards Teledentistry in Indonesia and Other Countries During the COVID-19 Pandemic
No full textIntroduction: The COVID-19 pandemic has forced the health sector, including dentistry, to implement new methods of providing healthcare services. One such method is the use of teledentistry. This study aims to determine the perception and knowledge of dentists and patients regarding the use of teledentistry in various countries, including Indonesia, during the COVID-19 pandemic. Methods: This study used the rapid review method and focused on articles published between 2020 and 2023. Articles were identified through searches in electronic databases such as PubMed and Google Scholar, using relevant keywords. Articles were selected using the PRISMA method and through a screening process based on predetermined inclusion and exclusion criteria. Results: A total of 1554 articles were found, and 19 articles were selected as research samples. The results showed that the perception and knowledge of teledentistry was generally positive, both according to dentists and patients. Discussion: The majority of dentists had good experiences with teledentistry, although there were still doubts about teledentistry's ability to provide accurate diagnoses. Many patients were also satisfied with the experience of using teledentistry, despite technical obstacles such as difficulties in taking good intraoral images or internet connection problems. Conclusion: Knowledge and perceptions of teledentistry show considarable variation across countries. This study shows that dentists generally have good knowledge of teledentistry. Dentists' perception of teledentistry is also positive, although there are still doubts about teledentistry. Patients' knowledge of teledentistry increased during the pandemic. Patients also have a good perception of teledentistry, although some patients still experience technical issues. Overcoming these barriers is important in maximizing the use of teledentistry as part of dental health services
Venous Thromboembolic Disease: Epidemiological- Clinical, Therapeutic, and Evolutionary Aspects at the Reference Hospital of Maradi
No full textIntroduction: Venous thromboembolic disease (VTE), including deep vein thrombosis and pulmonary embolism, is a
major cause of morbidity and mortality worldwide. Its incidence, estimated at 1 to 2 cases per 1,000 inhabitants per year, increases significantly with age and the presence of comorbidities. Materials and Methods: This was a descriptive cross-sectional study with retrospective data collection over a period of 3 years and 3 months from January 1, 2022, to March 31, 2025, in the cardio-neurology department of the Maradi Reference Hospital. Data were collected on a pre-established survey form from patients' medical records and the hospitalization registry. The variables collected included sociodemographic data, VTE risk factors, clinical data, and evolutionary aspects. Data analysis was performed using Epi Info 7.2.5.0 software. Results: We collected 32 cases of VTE among 428 hospitalized patients, representing a hospital prevalence of 7.47%. The average age of patients was 50.59 ± 14.65, ranging from 23 to 80 years old. The predominant risk factors were prolonged bed rest in 53.13% of cases and acute infection in 40.63% of cases. The average length of hospital stay was 9.28 days, with extremes of 3 and 36 days. Pain and unilateral limb edema were the most common reasons for consultation, accounting for 65.62% and 62.50% of DVT cases, respectively. For PE, dyspnea and tachycardia were the most common clinical signs, followed by desaturation in 100% and 72.73% of cases, respectively. DOACs were the most commonly used drugs (84.37% of cases) and 72.73% of patients hospitalized for DVT had received elastic compression. The in-hospital outcome was favorable in 87.50% of cases. Conclusion: Venous thromboembolic disease is a reality in our clinical setting. Its management mainly involves direct oral anticoagulants
Doudenal Diverticulum Revealed by an Episode of Acute Pancreatitis: A Case Study
No full textDuodenal diverticulum is a common anatomical finding that is usually asymptomatic but may occasionally cause biliopancreatic complications, including acute pancreatitis. We report the case of a 48-year-old patient who was initialy operated for gallbladder sludge and underwent laparoscopic cholecystectomy. Postoperatively, she developed recurrent epigastric pain associated with elevated serum lipase levels. Computed tomography confirmed mild acute pancreatitis (Balthazar stage A). Magnetic resonance cholangiopancreatography and contrast-enhanced computed tomography after oral contrast ingestion revealed a small duodenal diverticulum in close contact with the second portion of the duodenum and the common bile duct, confirming the diagnosis. Conservative management resulted in a favorable outcome. This case emphasizes the importance of considering duodenal diverticulum as a rare etiology of acute pancreatitis when common causes are excluded
Assessing the Impact of Telemedicine on Continuity of Care in Rural Family Practice Settings
No full textDue to innovations in technology, telemedicine and rural family practice settings have regarded as important elements, giving unparalleled chances to increase accessibility, enhance the results of patients, and increase the use of healthcare resources. This research aims to comprehensively identify the implications of those technologies on outcomes of patient health, costs of healthcare, and quality of care. In this research, the qualitative research method is adopted, and the data are taken from secondary data sources. This research analyses seven studies on telemedicine and rural clinic settings, and different search terms and Boolean Operators are used to extract those papers, and the results are analysed through thematic analysis. The findings show that utilisation of services of telemedicine was minimising nosocomial contagions, supporting the remote areas of healthcare, handling tools of telemedicine, implementation of services of telemedicine on the ground and minimising stress. By strategically embedding telemedicine into routine workflows, rural family practices can increase engagement of patients, minimise missed appointments, and sustain robust long-term relationships between patient and provider
Ameliorative Effects of Aqueous Extract of Velvet Bean (Mucuna Pruriens) on Cadmium-induced Neurotoxicity in Frontal cortex of Male Adult Wistar Rats
No full textBackground: Cadmium (Cd) is a harmful environmental pollutant that induces neurotoxicity through oxidative stress and inflammation, particularly affecting the frontal cortex. Velvet Bean, a leguminous plant rich in antioxidants such as L-DOPA and flavonoids, offers a promising alternative for mitigating cadmium-induced neurotoxicity. This study aimed to evaluate the effects of aqueous extract of Velvet Bean on cadmium-induced neurotoxicity in the frontal cortex of adult male Wistar rats. Materials and Methods: Twenty-four rats were randomly assigned to four groups: normal control, cadmium only, cadmium + Velvet Bean extract, and Velvet Bean extract only. Cadmium chloride was administered intraperitoneally at a dose of 14 mg/kg body weight to induce neurotoxicity. Treatment began 72 hours post-induction and continued for four weeks, with Velvet Bean extract given orally at a dosage of 200 mg/kg bodyweight. Results: The cadmium-only group exhibited significant weight loss, decreased relative brain weight, and widespread histological degeneration, including necrotic pyramidal cells, reduced Nissl bodies, collagen deposition, and activated astrocytes, alongside elevated oxidative stress. In contrast, rats treated with Mucuna Pruriens extract showed significant improvements across all parameters compared to the cadmium-only group (P<0.05). The extract preserved neuronal structure, maintained body and brain weights, and restored antioxidant enzyme levels, leading to reduced neuroinflammation and fibrosis. Conclusion: Mucuna Pruriens shows neuroprotective and antioxidative properties, indicating its potential for treating cadmium- induced neurotoxicity and other neurodegenerative disorders
Dermatosurgical Rounds: Modified Rhomboid Flap for Reconstruction of a Skin Defect Following BCC Excision in the Nasal Area
No full textThe reconstructive ladder remains a foundational concept in dermatosurgery and reconstructive field, guiding clinicians toward the simplest effective technique for addressing a certain defect. However, in the context of modern innovations and increasingly personalized surgical planning, individualized modifications to established techniques may offer the most appropriate approach for each patient. We present a case of a patient with small-to-medium primary defect following excision of a skin cancer involving two nasal subunits - the dorsum nasi and right lateral sidewall. Based on the reconstructive ladder and the characteristics of the defect, a local transposition flap (rhomboid flap) was selected. During the intervention, a modification of the classical flap design was performed. At the one-month postoperative evaluation, the patient exhibited preserved nasal function and contour, along with an excellent cosmetic outcome
Diet-Microbiota Interactions in Metabolic Health: A Review of Personalized Nutritional Strategies for Gut Dysbiosis
No full textAs metabolic diseases, including obesity, type 2 diabetes, and metabolic syndrome, become increasingly common, attention has shifted to the gut microbiome as a vital link between nutrition and metabolic health. Imbalances in the gut microbiota, referred to as dysbiosis, are connected to metabolic impairments, primarily through inflammation-related mechanisms, insulin resistance, and altered energy homeostasis. The objective of this study is to examine the relationships among nutritional intake, the gut microbial ecosystem, and metabolic health, and to determine the potential of tailored nutrition plans to correct microbial imbalances. This research employs a qualitative literature review method, focusing on conceptual and thematic synthesis of peer-reviewed scientific literature published over the past 15 years. Data were collected systematically from reputable databases, including PubMed, Scopus, and ScienceDirect. Inclusion criteria focused on studies that explored dietary interventions, changes in microbiota composition, and metabolic outcomes. Thematic analysis was conducted to identify recurring patterns and mechanisms underlying diet-microbiota interactions. The findings demonstrate that high- fiber diets, particularly those enriched in fermentable substrates, promote the proliferation of gut bacteria that produce SCFAs, thereby enhancing insulin signaling and sensitivity. In contrast, Western-style diets reduce microbial diversity and increase inflammatory markers. Personalized nutrition, tailored to individual microbiota profiles, shows superior efficacy in restoring microbial balance and improving metabolic markers. In conclusion, personalized dietary interventions represent a promising strategy to correct gut dysbiosis and support metabolic health. Future research should integrate multi-omics approaches and long-term clinical trials to refine personalized models
Penile Skin Graft Urethroplasty: A Contemporary Evaluation of Surgical Outcomes and Tissue Characteristics
No full textIntroduction: The quest for an ideal substitute material for substitution urethroplasty is ongoing. While buccal mucosa graft (BMG) has gained prominence, penile skin graft (PSG) remains a valuable, historically significant option, particularly in settings with limited resources or specific contraindications to oral mucosa harvesting. This study aims to evaluate the outcomes and rationale for PSG in anterior urethral reconstruction. Methods: A retrospective analysis was conducted on 20 consecutive male patients who underwent single-stage anterior urethroplasty using a free penile skin graft between 2022 and 2025. Strictures were of various etiologies, including failed hypospadias repair (n=10), idiopathic (n=8), and post-TURP (n=2). The primary surgical technique was a dorsal onlay graft (n=18), with dorsal inlay used in two cases. Success was defined as the absence of obstructive symptoms and no need for subsequent intervention. Patients were followed for a minimum of 6 months. Results: The overall success rate was 90% (18/20 patients). The mean patient age was 35 years (range: 5-75). One patient developed a urethrocutaneous fistula, and one case was considered a failure requiring re-intervention. No significant graft loss, donor site morbidity, or new-onset chordee was reported. Conclusion: Penile skin graft urethroplasty is a reliable and effective single- stage procedure for anterior urethral strictures, demonstrating a high success rate comparable to other graft materials. Its unique histologic properties, surgical practicality, and avoidance of oral morbidity make it a vital component of the reconstructive urologist's armamentarium, especially in selected patients where BMG may be unsuitable or unavailable