Journal of Medical Genetics and Clinical Biology
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Clarithromycin and Amoxicillin Effect on Helicobacter Pylori-Infected Oxidative DNA Damage
Get PDFEpidemiological studies reveal that the risk of developing stomach cancer increase by Helicobacter pylori infection, and scientists assume that oxidative DNA damage caused by the bacteria is to blame. Oxidative DNA damage in Helicobacter pylori-infected cases was measured before and after two weeks of clarithromycin and amoxicillin (1 g/day) +amoxicillin (1 g/day) treatment using DNA chain fractures and form amidoprimidine DNA glycosylase (fpg)-sensitive regions. After treatment, it was found that the Comet method's measurement of the frequency of fpg-sensitive regions decreased (P0.001), while the frequency of DNA chain breaks remained unchanged. A favorable connection between age and prevalence off fpg-sensitive areas was found (r = 0.59, P 0.05). The results suggest that lowering oxidative DNA damage through treatment with clarithromycin + amoxicillin in helicobacter pylori-infected individuals may lessen the risk of helicobacter pylori-mediated stomach cancer formation
Etiopathogenesis Of Hypocobaltosis In Productive Сows
Get PDFThe article describes the cause, pathogenesis of hypocabolosis, symptoms and changes in the cicatricial fluid in this pathology in productive cows
MOLECULAR DETECTION OF UREASE AND HEMOLYSINE GENES IN PROTEUS MIRABILIS BACTERIA ISOLATED FROM URINE OF RHEUMATOID ARTHRITIS PATIENTS IN NAJAF PROVINCE
Get PDFP. mirabilis bacteria have a significant role in causing urinary tract infection which can be defined as the inflammatory response of urothelium to bacterial invasion, which is usually associated with bacteriuria and pyuria. According to the suggestion that Proteus microbes could possibly be involved in the etiopathogenesis. Proteus mirabilis was the commonest bacteria isolated in this study 15 (51% ) followed by E. coli in 6 ( 20.4 ), Klibsiella spp.5 (17%) and Staphylococcus saprophiticus 3 (10.3%). All isolates of P. mirabilis appeared highest rate of resistance (100%) in the case of Cefotaxime, Amoxicillin, Ampicillin. And moderately resistance to Netilmicin (71.4% ). All isolates presented high sensitivity (100%) to Meropenem, Levofloxacin, and Ciprofloxacin. All isolates15 (100%) appeared the presence of urease and hemolysine genes by using PCR techniqu
THE ROLE OF SENSITIVITY LEVELS IN THE PATHOGENESIS OF ALLERGIC RHINITIS AND BRONCHIAL ASTHMA OF THE GROUP UNDER STUDY
Get PDFThis article will provide feedback and feedback on the role of sensitivity levels in the pathogenesis of allergic rhinitis and bronchial asthma of the group under study. Allergic rhinitis and bronchial asthma are prevalent chronic inflammatory diseases that significantly impact the quality of life of millions of individuals worldwide. Both conditions are characterized by heightened immune responses to allergens, leading to inflammation of the respiratory tract. Recent research has shed light on the crucial role of Group 2 Innate Lymphoid Cells (ILC2s) in the pathogenesis of these diseases. Understanding the mechanisms by which ILC2s contribute to allergic rhinitis and bronchial asthma offers potential for novel therapeutic intervention
ASSESSMENT OF THE KNOWLEDGE AND ATTITUDE TOWARDS CIGARETTE SMOKING AMONG YOUTHS IN OGBIA TOWN; OGBIA LOCAL GOVERNMENT AREA OF BAYELSA STATE
Get PDFThis study investigated the assessment of the knowledge and attitude towards cigarette smoking among youths in Ogbia Town; Ogbia Local Government Area of Bayelsa State. The population of the study consisted of three hundred (300) Youths, and one hundred and fifty 150 (50%) were selected as the sample size for the study. The simple random sampling technique and systematic sampling techniques were adopted to select the sample for the study. Three research questions and objectives were used. The instrument used for data collection was a well-structured questionnaire; simple percentage was used to answer the research questions. The results showed that; 95.3% of the respondents knew the negative effect of cigarettes on health; 96.7% of the respondents said smoking should be strictly prohibited in public areas. 96.0% of the respondents indicated that Smoking is a disgusting behavior; 90.0% of the respondents indicated that smoking is hazardous to the health of others, while 19.3% of the respondents did not accept that smoking is a personal freedom. Again, 84.0% of the respondents indicated that peer groups influenced the cigarette smoking habits among youths. In light of the findings of the study, it was therefore recommended that; policies prohibiting the advertisement and use of tobacco in public places be properly enforced by the government, parents, and educational management; and finally that religious leaders should be good role models that will help youths in quitting cigarettes smokin
THE RELATIONSHIP BETWEEN FLAVONOIDS AND CANCER
Get PDFFlavonoids are the effective ingredients of the compounds found in grains, vegetables, fruits, seeds and some drinks that have medicinal, free radical reducing and anti-cancer functions. In plants, flavonoids play an important role in multiple functions including color formation, growth, and protection against damage and microorganisms. Articles have stated that the molecular functions of flavonoids may improve health and reduce disease symptoms, reduce antibiotic resistance and reduce inflammation in humans. One of the features of such research is the potential effect of flavonoids on cancer risk.Chemically, flavonoids have an overall 15-carbon skeletal structure consisting of two phenyl rings and one heterocyclic ring. This carbon structure can be abbreviated as C6-C3-C6. Flavonoids are the effective ingredients of the compounds found in grains, vegetables, fruits, seeds and some drinks that have medicinal, free radical reducing and anti-cancer functions. In plants, flavonoids play an important role in multiple functions including color formation, growth, and protection against damage and microorganisms. Articles have stated that the molecular functions of flavonoids may improve health and reduce disease symptoms, reduce antibiotic resistance and reduce inflammation in humans. One of the features of such research is the potential effect of flavonoids on cancer risk
THE EFFECT OF THE DRUG MIOSTA H® IN THE TREATMENT OF PURULENT AND NON-PURULENT INFLAMMATORY PROCESSES IN THE JOINTS OF THE LEGS IN HORSES
Get PDFIn this article, when treating horses with a purulent coffin joint, surgical treatment is performed, enrofloxacin 10% is injected into the muscle, platelet autoserum is injected around the joint, chondrolone is injected into the joint, and Miosta Н® is injected into the muscle, and the wound is treated with levomekol ointment. On the 18-19th day, horses normally experience early formation of scabs, lameness, swelling and a local decrease in leg and body temperature, and when treating horses with chronic non-purulent diseases of the joints of the feet, a sharp tickling ointment is used, massage and paraffin applications are applied around the joint and hydrocortisone 0.5% novocaine. It was also reported that with intramuscular injection of 5 ml of Miosta Н® for the first time and 10 days after intra-articular injection of 5 ml of chondrolone, lameness, swelling and local temperature decreased, and body temperature in horses normalized by day 14
ANTIBIOFILM SILVER NANOPARTICLES PRODUC BY ESCHERICHIA COLI
Get PDFcoli bacteria were obtained from the soil near the Euphrates River in the northern region of Basra City and cultured on nutrient agar media. The bacterial isolate was subjected to purification and thereafter seen under a microscope. The study revealed that E. coli bacteria has the capacity to synthesize silver nanoparticles when combined with a 1 mM AgNO3 solution. The synthesis of AgNPs was deduced by examining the change in color of the reaction mixture. The UV-vis spectroscopy results indicated that the silver nanoparticles exhibited absorbance at a specific wavelength of 428 nm. Additionally, the FT-IR analysis revealed the presence of active groups in the silver particles, which played a role in maintaining their stability. The SEM and TEM studies revealed that the AgNPs exhibited a spherical morphology, with diameters ranging from 47.66 to 11.68 nm. A cubic crystal structure of silver was confirmed using an X-ray diffraction examination, while an EDX test indicated that the final product was silver (Ag). The antimicrobial efficacy of silver nanoparticles (AgNPs) against bacteria isolated from diseased patients was evaluated using the Well diffusion agar technique. It was shown that nano-silver effectively inhibited the development of the bacteria.The study utilized 96 well Microtiter plates to assess the inhibitory effect of AgNPs on biofilm development in harmful bacteria
EVALUATION FOR MOTHERS' PRACTICES TOWARDS CARING FOR THEIR CHILDREN WITH EPILEPSY
Get PDFBackground: Epilepsy is classified as a neurological condition impacting the nervous system, characterized by spontaneous seizures that occur on a regular basis with varying occurrence and severity. The study aimed to assess the level of mother’s practices regarding epileptic among children in Babylon province.
Materials and methods: This descriptive and analytical cross-sectional study was conducted at Babil Teaching Hospital for Maternity and Children's EEG unit, emergency wards, and neurological consultation ward. A purposive sample of 100 mothers was selected. Closed-ended questions were asked to each woman in direct interviews. The study was conducted for period from November 2023 to February 2024 is the study period.
Results: The results found that 35.0% of mothers belonging to age group (29-34 years). The results found that the highest percentage was 71% of those with moderate practice, followed by 17% with poor practice, and 12% with good practice. Also, the results report that the mothers whom were sufficient family income, live in urban and have higher education level, were with the better practices score (P. value <0.05).
Conclusion: The study concluded that the majority of mothers in Babil Governorate have moderate practices of epilepsy. The results also revealed that sufficient family income, mothers living in urban areas, and higher education were associated with a good degree of practices. Educating the public about epilepsy through the mass media could go a long way in reducing the morbidity and mortality associated with this proble
BIOELECTRICAL PRODUCTION BY MICROBIAL NANOWIRES
Get PDFBacterial nanowires, which are electrically conductive appendages or threads that facilitate the transfer of electrons outside the bacterial cell, produced by a number of bacteria, have shown the potential to be useful in many fields, especially bioenergy and bioremediation. Bacteria have developed a group of nanowires in different forms, including Pilli, which are fine structures protruding from the surface of bacteria and used for adhesion, movement, and the formation of biofilms in some species that participate in extracellular respiration and use their filaments to transfer electrons. The world is currently witnessing an energy crisis due to the continuous increase in energy requirements around the world, so the trend today is to use microbial fuel cell (MFC) technology, which is an encouraging technology for generating electricity and a source of clean and environmentally friendly energy that uses microorganisms to convert the chemical energy of organic compounds into electricity using bacterial nanowires. Most MFC studies are being done for electricity generation, which is the primary application of the technology at the moment, and it is a fascinating technology that can use a variety of substrates, MFC cell with bacteria to achieve bioenergy production despite the fact that the energy levels in all these systems were relatively lo