Journal of Medical Genetics and Clinical Biology
Not a member yet
406 research outputs found
Sort by
STUDY OF ANTIBODIES TO OPPORTUNISTIC ENTEROBACTERIA IN THE BLOOD OF ADULTS
Get PDFBackground: Opportunistic enterobacteria (OE), including various Gram-negative bacteria, are known to cause infections, particularly in immunocompromised individuals. Specific Background: Despite their clinical relevance, there is limited data on the prevalence of antibodies against these bacteria in the general adult population. Knowledge Gap: The extent to which antibodies to opportunistic enterobacteria are present in serum samples from healthy adults has not been thoroughly investigated. Aims: This study aimed to evaluate the presence and frequency of antibodies to seven types of Gram-negative opportunistic enterobacteria in adult serum samples using enzyme-linked immunosorbent assay (ELISA). Results: The analysis revealed a significant prevalence of antibodies against the bacteria E. coli, Proteus vulgaris, Citrobacter freundii, Klebsiella pneumoniae, Enterobacter aerogenes, Enterobacter cloacae, and Pseudomonas aeruginosa among the subjects. Novelty: This research provides new insights into the widespread presence of antibodies to OE in a healthy adult population, highlighting previously underexplored immunological responses. Implications: These findings could enhance diagnostic approaches and inform treatment strategies for infections caused by opportunistic enterobacteria, potentially leading to improved management of such infections in clinical settings
DIABETES MELLITUS AND COVID-19. CARDIOVASCULAR COMPLICATIONS AND COURSE OF TYPE 2 DIABETES MELLITUS AFTER CORONAVIRUS INFECTION
Get PDFThe COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has had profound effects on global health and economics since its emergence in late 2019. Over 770 million confirmed cases of COVID-19 have been reported worldwide, with millions of deaths attributed to the virus. Studies have shown that individuals with T2DM are at a higher risk of severe illness and mortality if they contract COVID-19. The presence of diabetes, especially when poorly controlled, can exacerbate the inflammatory response to the virus. Patients with T2DM often have comorbidities such as cardiovascular disease, hypertension, and obesity, which further increase the risk of severe COVID-19 complication
PSYCHOSOCIAL FACTORS ASSOCIATED WITH MAJOR THALASSEMIA
Get PDFThalassemia is a hereditary condition that results in the creation of defective haemoglobin molecules. Patients are diagnosed with thalassemia major after exhibiting severe clinical symptoms and profound anaemia. This study aims to investigate the major thalassemia and psychosocial aspects of it, which is a critical issue, in order to serve as a road map for better treating these patients and contribute to the literature. This study used narrative review as its method. Between 2018 and 2023, a literature review was undertaken by searching materials published in databases such as Web of Science, PubMed, Scopus, and the Google Scholar search engine. Additionally, the WHO website was searched. Thalassemia major harms the heart, liver, lungs, and endocrine organs due to anaemia and iron buildup. Furthermore, the patient could experience. Mental and social issues arise as a result of the disease's congenital aetiology and lifelong duration. Thalassemia patients face significant emotional challenges as well as therapeutic burden. There are numerous research on the prevalence and physical implications of thalassemia. However, there are insufficient papers and studies documenting the psychosocial impacts of thalassemia on patients and what may be done to mitigate these effects. As a result, this research focuses on the process of thalassemia and the psychosocial problems it causes in order to contribute to the literature and provide a road map for better managing these individual
LABORATORY CHARACTERISTICS OF PATIENTS WITH LIVER CIRRHOSIS OF VIRUS ETIOLOGY COMPLICATED WITH SPONTANEOUS BACTERIAL PERITONITIS
Get PDFBackground: Systemic inflammation plays a crucial role in the pathophysiology of various diseases, particularly in patients with liver cirrhosis. Specific Background: The Neutrophil-to-Albumin Percentage Ratio (NPAR) has emerged as a novel biomarker for assessing systemic inflammation. Low serum albumin levels combined with elevated neutrophil counts have been associated with an increased risk of infections, including spontaneous bacterial peritonitis (SBP), a serious complication in cirrhotic patients. Knowledge Gap: Despite the recognized risks and mortality associated with SBP, the specific role of NPAR in predicting outcomes in patients with cirrhotic ascites remains underexplored. Aims: This study aims to evaluate the predictive value of NPAR in identifying patients at high risk for developing SBP and to assess its association with in-hospital mortality rates. Results: Our findings indicate that elevated NPAR is significantly correlated with the incidence of SBP and is associated with higher in-hospital mortality, reinforcing the potential of this biomarker in clinical practice. Novelty: This research provides new insights into the utility of NPAR as a predictive tool for SBP in cirrhotic patients, potentially guiding clinicians in early diagnosis and intervention. Implications: By highlighting the importance of NPAR, this study advocates for its incorporation into routine clinical assessments to improve patient outcomes, emphasizing that timely diagnosis and appropriate treatment of SBP can significantly reduce mortality rates
DESCRIPTION OF THE SPECIESBRADYBAENA PLECTOTROPIS LIVING IN THE VICINITY OF THE NARYN RIVER
Get PDFObjective: This study aimed to investigate the terrestrial malacofauna in the Naryn River region, with a specific focus on Bradybaena plectotropis in Grigorievskoe Gorge, Kyrgyzstan, to enhance understanding of its ecological roles and biological features. Methods: Field surveys and anatomical analyses were conducted in August 2024, covering diverse biotopes across Grigorievskoe Gorge and Boom Gorge. Forty specimens were collected, documented, and examined for morphological and reproductive characteristics to determine ecological preferences and habitat distribution. Results: The study identified Bradybaena plectotropis as a dominant species in the region, demonstrating significant morphological adaptations and ecological versatility. Its roles in soil formation, organic matter decomposition, and trophic chains underscore its ecological importance. Additionally, its presence across varied biotopes highlights its adaptability and widespread distribution. Novelty: This research provides the first comprehensive faunistic and anatomical study of Bradybaena plectotropis in the Naryn River region, offering valuable insights into its taxonomy, ecological roles, and conservation relevance in Kyrgyzstan's mountainous ecosystem
THE PREVALENCE OF URINARY TRACT INFECTIONS AND THE AGENTS RESPONSIBLE FOR THEM IN PREGNANT WOMEN IN THE PROVINCE OF KARBALA
Get PDFObjective: This study aimed to determine the prevalence of urinary tract infections (UTIs) and identify the uropathogens present in pregnant women. Methods: A total of 417 midstream urine samples were collected and examined between December 2021 and August 2022. The diagnosis of UTI was established when a urinary tract pathogen exhibited growth of at least 10510^5105 CFU/ml in culture. Isolated microorganisms were identified using biochemical assays. Results: The findings revealed that 49.4% of the pregnant women had a UTI. Among the isolated organisms, E. coli was the most prevalent (56.79%), followed by Proteus sp. (5.8%), Pseudomonas sp. (6.3%), and Klebsiella sp. (19.9%). Novelty: This study provides updated insights into the prevalence and microbial profile of UTIs among pregnant women, highlighting the dominance of E. coli as the leading uropathogen during pregnancy
Estimate of Some Immune-Biomarkers in Children with Entamoeba Histolytica Infection
Get PDFThe current work was aimed to evaluate of some immune-biomarkers in children with Entamoeba histolytica infection. General stool examination was done to patients for detection of E. histolytica infection. A total 150 patients of less than 13 years, whom attended the parasitology section at period February to June 2023. The chosen patients were suffered from abdominal pain and diarrhea. The results showed that gender is not related to infection with E. histolytica, as there were no significant (P≤0.05) differences between the proportions of males and females. The IgG concentration of infected children (24.05±3.94 ng/L) indicated a significant (P≤0.05) rise compared to the healthy children (11.72±2.55 ng/L). IgA concentration of infected children (159.42±18.62 ng/L) indicated a significant (P≤0.05) rise compared to the healthy children (38.93±7.01 ng/L). IgM concentration of infected children (4.84±0.45 ng/L) indicated a significant (P≤0.05) rise compared to the healthy children (2.17±0.35 ng/L). The IL-4 concentration of infected children (29.47±4.04 pg/ml) indicated a significant (P≤0.05) rise compared to the healthy children (16.54±3.94 pg/ml). IL-6 concentration of infected children (183.25±21.37 pg/ml) indicated a significant (P≤0.05) rise compared to the healthy children (26.12±4.51 pg/ml). The TLR2 levels of infected children (24.05±3.94 ng/L) indicated a significant (P≤0.05) rise compared to the healthy children (11.72±2.55 ng/L). therefore, its concluded that E. histolytica lead to a high immune response that leads to an increase in levels of immune parameters in infected childre
THE ROLE OF PRIVATE CLINICS IN PUBLIC HEALTH CARE
Get PDFIn the course of reforms carried out in the years of independence in the field of health care, special attention was paid to the development of private sector activities along with state medical institutions. Strengthening all-round support for the development of the private sector in the health sector, creating the necessary conditions for private medical institutions to provide high-tech quality medical services to the population, expanding foreign investments, and attracting highly qualified specialists to the private medical sector, as well as medical tourism and to develop the export of medical services
MINI REVIEW ABOUT RISKS OF RADIATION IN MEDICINE
Get PDFRadiation is currently widely used and routinely applied in medicine. Diagnostic radiology, nuclear medicine, and radiation treatment have grown from their primitive beginnings 100 years ago to modern methods that are regarded as critical tools across all fields and specializations of medicine today. Ionizing radiation's inherent qualities give numerous benefits, but they can also be harmful. Its usage in medical practice requires an informed decision on the risk-benefit ratio. This choice requires knowledge of radiation in general as well as medical skill in specific. This review investigated the risks associated with radiation, their connection to medicine, and the advancements in diagnostic and therapeutic technologies. Radioactive substances and radiation are used in medicine, research, and diagnosis. The forms of radiation and their varied impacts on medicine, particularly in the treatment and diagnosis of disorders like cancer, were disclosed by our review's conclusions. It has been demonstrated that mistakes in radiation dosage can result in health issues, hence managing radiation must be done carefully both during research and in practic
THE SIGNIFICANCE OF ECHINOCOCCOSIS IN VETERINARY MEDICINE AND HUMAN LIFE
Get PDFThis article provides information on the history, prevalence, veterinary and human significance of echinococcosis, as well as preventive measures