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Response to electroconvulsive therapy is associated with a more diverse oral microbiome– a prospective longitudinal cohort pilot study
No full textAbstract Recently it has been shown that psychiatric disorders are associated with changes in the host microbiome. Little is known about the association of electroconvulsive therapy (ECT) and microbiome alterations. In our pilot-study, 15 patients with severe or treatment resistant depression were prospectively recruited and oral swabs were collected pre- and post-ECT. Compared to a control group, ECT did not lead to a significant microbial shift in longitudinal samples ( p = 0.65). However, alpha diversity measurements significantly differed between responders and non-responders before ECT (observed species p = 0.014, Shannon p = 0.03) and after ECT (observed species p = 0.015, Shannon p = 0.13)
Multidimensionality of tree communities structure host-parasitoid networks and their phylogenetic composition
No full textEnvironmental factors can influence ecological networks, but these effects are poorly understood in the realm of the phylogeny of host-parasitoid interactions. Especially, we lack a comprehensive understanding of the ways that biotic factors, including plant species richness, overall community phylogenetic and functional composition of consumers, and abiotic factors such as microclimate, determine host-parasitoid network structure and host-parasitoid community dynamics. To address this, we leveraged a 5-year dataset of trap-nesting bees and wasps and their parasitoids collected in a highly controlled, large-scale subtropical tree biodiversity experiment. We tested for effects of tree species richness, tree phylogenetic, and functional diversity, and species and phylogenetic composition on species and phylogenetic diversity of both host and parasitoid communities and the composition of their interaction networks. We show that multiple components of tree diversity and canopy cover impacted both, species and phylogenetic composition of hosts and parasitoids. Generally, phylogenetic associations between hosts and parasitoids reflected nonrandomly structured interactions between phylogenetic trees of hosts and parasitoids. Further, host-parasitoid network structure was influenced by tree species richness, tree phylogenetic diversity, and canopy cover. Our study indicates that the composition of higher trophic levels and corresponding interaction networks are determined by plant diversity and canopy cover, especially via trophic links in species-rich ecosystems.The National Key Development program of ChinaThe National Natural Science Foundation, China http://dx.doi.org/10.13039/501100001809The National Science Fund for Excellent Young ScholarsThe Strategic Priority Research Program of the Chinese Academy of SciencesThe National Natural Science Foundation, China http://dx.doi.org/10.13039/501100001809The Alexander von Humboldt research fellowshipsThe Key Program of the National Natural Science Foundation of ChinaThe Key Laboratory of the Zoological Systematics and Evolution of the Chinese Academy of ScienceThe National Science Fund for Distinguished Young Scholar
Relevance of proteomics and metabolomics approaches to overview the tumorigenesis and better management of cancer
No full textAssessment of frailty in patients with heart failure: A new Heart Failure Frailty Score developed by Delphi consensus
No full textAbstract Aims The Heart Failure Frailty Score (HFFS) is a novel, multidimensional tool to assess frailty in patients with heart failure (HF). It has been developed to overcome limitations of existing frailty assessment tools while being practical for clinical use. The HFFS reflects the concept of frailty as a multidimensional, dynamic and potentially reversible state, which increases vulnerability to stressors and risk of poor outcomes in patients with HF. Methods and results The HFFS was developed through a Delphi consensus process involving 54 international experts. This approach involved iterative rounds of questionnaires and interviews, where a panel of experts provided their opinions on specific questions prepared by the Steering Committee. The experts were invited to vote and share their views anonymously, using a 5‐point Likert scale over iterative rounds. An 80% threshold was set for agreement or disagreement for each statement. Twenty‐two variables from four domains (clinical, functional, psycho‐cognitive and social) have been selected for inclusion in the HFFS after the third round of the Delphi process. A shorter version (S‐HFFS), including 10 variables, has also been developed for daily clinical use. Conclusions The HFFS is a new multidimensional tool for the identification of frailty in patients with HF. It should also enables healthcare providers to identify potential ‘red flags’ for frailty in order to develop personalized care plans. The next step will be to validate the new score in patients with HF
Personality Functioning in Inpatients With Eating Disorders: Association With Symptom Severity and Treatment Outcome
No full textABSTRACT Objective Impairment in personality functioning (PF) has been linked to a number of mental disorders, including eating disorders (EDs). However, the precise relationship between PF and symptom severity, as well as the potential impact on outcome, remains unclear. The study aimed to analyse the association of PF and its change with severity of ED symptomatology as well as outcome of hospital treatment. Method The sample consisted of 397 patients with EDs, treated in 19 university hospitals for Psychosomatic Medicine and Psychotherapy in Germany between 1/2019 and 12/2020. PF was measured with the Structure Questionnaire of the Operationalised Psychodynamic Diagnosis (OPD‐SQ, short version), eating psychopathology with the ED examination questionnaire (EDE‐Q). Outcome was defined as a change in the EDE‐Q total score. We used Latent Change Score Modelling to analyse changes in ED pathology during treatment and a 1‐year follow‐up period. Results A higher level of impairment in PF at admission correlated with more eating psychopathology and a less favourable outcome. Additionally, greater improvement in PF correlated with greater improvements in ED symptomatology at discharge. Conclusion Impairment in PF needs to be part of diagnostic assessments and should be considered an important treatment target for psychotherapeutic interventions. Trial Registration The MEPP study was registered in the German Clinical Trials Register (DRKS, www.drks.de; ID: DRKS00016412
Corrigendum to “mFOLFOX6 versus mFOLFOX6 + aflibercept as neoadjuvant treatment in MRI-defined T3-rectal cancer: a randomized phase-II-trial of the German Rectal Cancer Study Group (CAO/ARO/AIO 0214) and the ABCSG (R-06)”
No full textClinGen recuration of hearing loss associated-genes demonstrates significant changes in gene-disease validity over time
No full texthttp://dx.doi.org/10.13039/100000051 National Human Genome Research Institut
Preservation of archaeal core lipids in siliceous hot spring deposits: An experimental study
No full textChronic exposure to a synthetic cannabinoid improves cognition and increases locomotor activity in Tg4-42 Alzheimer's disease mice
No full textAlzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and behavior impairments. Despite recent approvals of anti-amyloid antibodies, there remains a need for disease modifying and easily accessible therapies. Emerging evidence suggests that targeting the endocannabinoid system may hold promise for AD therapy as it plays a crucial role in different physiological processes, including learning, memory and anxiety, as well as inflammatory and immune responses.Open-Access-Publikationsfonds 202
Impact of face masks on empathy and communication in head and neck cancer patients: a case-control study
No full textOpen-Access-Publikationsfonds 202