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Unlocking the therapeutic potential of tumor-derived EVs in ischemia-reperfusion: a breakthrough perspective from glioma and stroke
No full textAbstract Clinical studies have revealed a bidirectional relationship between glioma and ischemic stroke, with evidence of spatial overlap between the two conditions. This connection arises from significant similarities in their pathological processes, including the regulation of cellular metabolism, inflammation, coagulation, hypoxia, angiogenesis, and neural repair, all of which involve common biological factors. A significant shared feature of both diseases is the crucial role of extracellular vesicles (EVs) in mediating intercellular communication. Extracellular vesicles, with their characteristic bilayer structure, encapsulate proteins, lipids, and nucleic acids, shielding them from enzymatic degradation by ribonucleases, deoxyribonucleases, and proteases. This structural protection facilitates long-distance intercellular communication in multicellular organisms. In gliomas, EVs are pivotal in intracranial signaling and shaping the tumor microenvironment. Importantly, the cargos carried by glioma-derived EVs closely align with the biological factors involved in ischemic stroke, underscoring the substantial impact of glioma on stroke pathology, particularly through the crucial roles of EVs as key mediators in this interaction. This review explores the pathological interplay between glioma and ischemic stroke, addressing clinical manifestations and pathophysiological processes across the stages of hypoxia, stroke onset, progression, and recovery, with a particular focus on the crucial role of EVs and their cargos in these interactions
Nachwendekinder im Ost-Diskurs – Neue Stimmen für Sichtbarkeit, Aufarbeitung und Anerkennung
No full textCommon marmosets (Callithrix jacchus) excel in a one-trial spatial memory test, yet perform poorly in a classical memory task
No full textWhen quantifying animal cognition, memory represents one of the most tested domains and is key to understanding cognitive evolution. Memory tests thus play an important role in comparative cognitive research, yet slight variations in the experimental settings can substantially change the outcome, questioning whether different memory tests tap into different memory systems or whether they test memory at all. Here, we first assessed memory performance of 16 common marmosets (Callithrix jacchus) in two distinct paradigms varying in their format and delay. First, we examined marmoset memory in a 24-h delay memory test (24 h-DMT) in which they could freely explore an environment with three novel objects of which one contained food. We examined their retention the day after, and the procedure was iterated cumulatively with previous objects remaining in the enclosure until the marmosets had to choose the correct out of 30 objects. Second, we administered a classical delayed response test (DRT) in the same animals with three objects and a maximum delay of 30 s. In the DRT, marmoset performance was poor and not better than chance after 15 s already. However, individuals excelled in the 24 h-DMT, performing above chance level after 24 h even with tenfold the number of objects to choose from compared to the DRT. Moreover, individual performances in the two tests were not correlated, and typical age effects on memory could not be detected in both experiments. Together, these results suggest that the two tests explore different domains, and that the 24 h-DMT examines long-term memory. The outcome of the DRT is more difficult to assign to memory since individuals performed only moderately even in the 0-s delay condition. This puts into question whether this task design indeed tests memory or other cognitive processes
Age estimation for disorder characterization from pediatric polysomnograms
No full texthttp://dx.doi.org/10.13039/501100010570 Niedersächsisches Ministerium für Wissenschaft und Kulturhttp://dx.doi.org/10.13039/501100001663 Volkswagen Foundatio
Does gender really matter? How demographics and site characteristics influence behavior and attitudes of German small-scale private forest owners
No full textHow can a disaster trigger substantial policy? A power analysis of the 1998 floods and forest restoration in China
No full texthttp://dx.doi.org/10.13039/501100012325 National Office for Philosophy and Social Scienceshttp://dx.doi.org/10.13039/501100012456 Chinese National Funding of Social Science
Covariance-based decoding reveals a category-specific functional connectivity network for imagined visual objects
No full text501100009629 Fondazione Cassa Di Risparmio Di Trento E Roveret
