European Institute of Knowledge and Innovation
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Environmental factors in the development of Alzheimer’s disease
Get PDFThis article delves into the profound significance of the early diagnosis of Alzheimer’s disease (AD), the leading cause of dementia worldwide. With no current cure for AD, early detection stands as a cornerstone in managing the disease. Early diagnosis not only enables symptomatic treatment to enhance the quality of life but also facilitates proactive planning, addressing health care and living arrangements for the future. Additionally, early diagnosis can promote participation in clinical trials, granting patients access to emerging treatments. An essential component to this early detection is a robust understanding of the disease\u27s causes. The paper examines the pathological indicators, such as beta-amyloid plaques and neurofibrillary tangles, while highlighting the multifaceted origins of AD encompassing genetics, environmental factors, inflammation, and potential links with other diseases. An in-depth discussion on the influence of the environment further illustrates the complex interplay between genetics and external factors. Toxic chemicals, lifestyle choices in western societies, and other environmental determinants are scrutinized for their potential role in AD onset. In summary, the piece underscores the importance of a holistic understanding of Alzheimer\u27s etiology, emphasizing that only through comprehensive knowledge can we aspire to identify, manage, and ultimately find a cure for this debilitating condition
When Eagle Stares into The Eye
Get PDFRetinal pigment epithelial detachment (PED) is the separation of the retinal pigment epithelium(RPE) from the Bruch’s membrane(BM). Eagle syndrome(ES) is characterized by an abnormally elongated styloid process with/without abnormal direction and/or ossification of the styloid ligament. Presence of both the above entities together is a rarest of rare sight. It may be a coincidence, or the diseases may have an association. Hence, further studies are warranted
Review the Role of Holistic Learning in Cultivating Global Citizenship Skills
Get PDFThis research paper provides a comprehensive review of the role of holistic learning in cultivating global citizenship skills. The paper explores the impact of holistic learning approaches on the development of intercultural competence, social justice awareness, environmental stewardship, and civic engagement among students. Through a thorough literature review, the paper examines the theoretical perspectives, practical applications, and empirical evidence supporting the integration of holistic learning in global citizenship education. The findings consistently demonstrate that holistic learning approaches, such as project-based learning, experiential learning, and integrated curriculum, offer unique benefits in fostering global citizenship skills. By providing students with real-world experiences, interdisciplinary perspectives, and hands-on activities, holistic learning engages students in active learning, critical thinking, and reflection. It promotes intercultural understanding, empathy, effective communication, social justice awareness, environmental stewardship, and a sense of civic responsibility. The paper compares and contrasts holistic learning approaches with other educational approaches, highlighting the distinctiveness and added value of holistic learning in providing a comprehensive and immersive educational experience for global citizenship education. In summary, this research paper contributes to the understanding of how holistic learning can effectively cultivate global citizenship skills, enabling individuals to become responsible and active global citizens in an interconnected world
Learning Local History and Culture Through Museum Visits
Get PDFThis study described how social studies preservice teachers learn local history and culture through museum visits. It employed a qualitative descriptive research design involving ten social studies preservice teachers selected through purposeful sampling. Data were collected through a written interview and analyzed using thematic analysis. Through museum visits, social studies preservice teachers learned the following: visual driven through images, relics and artifacts, and multimedia presentation; audio/oral driven through curator explanation and peer discussion; text driven through text description; and actual experience-driven through applying learning from exhibits, giving a point of view from the past, and wearing traditional attire. Preservice social studies teachers can learn about local history and culture by visiting museums. This study emphasizes the value of museums in preserving and promoting local heritage and culture, as well as how they can be a valuable resource for learning about local history and culture
Effects Of ADDIE Model As An Instructional System Design For Senior High School Students In Natural Science Through Alternative Delivery Learning
Get PDFThe nature of science learning is to teach students to be involved in the investigation. Investigations in science can help improve the performance and skills of students. The purpose of this study is to plan to design instructional strategies after crafting the Sustainability Action Plan in the school context. Specifically, it attempts to answer the following research objectives: (1) To determine the pretest and post-test scores of the experimental group after their exposure to the ADDIE model in teaching natural science, and (2) To determine the significant improvement in the students’ scores before and after exposure of the ADDIE model. Using a quasi-experimental design with non-probability sampling, the two experimental groups (n=30) per section taking up General Chemistry 2, and General Physics 2. The results revealed that the respondents obtained closer mean values of the pretest (M=10.80, M=9.03) but the mean value of the post-test for General Chemistry is greater than General Physics (M=23.00, M=12.27). Likewise, there is no significant difference in improvement between the means of General Physics (t =1.8959; p=0.0630) compared to General Chemistry which is significant (t = 13.6640; p=0.0001) when tested at α 0.05. The data suggest that students need a strong focus on the competencies taken from the modules on whatever modalities of learning are utilized. A parallel study is recommended to enhance the students’ problem-solving skills at the junior high school level to establish the effectiveness of ADDIE Model.
Assessment of Bone Marrow Failure Syndrome Management Outcome in Pediatrics – Saudi Perspective
Get PDFBone Marrow Failure Syndrome (BMFS) is a rare yet severe condition affecting pediatric populations, characterized by a reduced production of hematopoietic lineages leading to pancytopenia. This article explores the multifaceted nature of BMFS in children, its diverse etiologies, treatment modalities, and outcomes, with a particular focus on the Saudi Arabian context. BMFS encompasses both inherited and acquired forms, often presenting diagnostic challenges due to its heterogeneity. Inherited BMFS accounts for 30% of cases and includes rare conditions like Fanconi Anemia and Schwachman-Diamond Syndrome, where treatment approaches vary depending on severity. Acquired BMFS, constituting 70% of cases, may exhibit complete recovery or require prolonged treatment with immunosuppressants. Hematopoietic Stem Cell Transplantation (HSCT) remains a primary treatment option, with outcomes influenced by factors such as donor type and graft success. Saudi Arabia, despite its high-income status, has faced limited data availability on BMFS outcomes, but the number of HSCT procedures performed in the country is steadily increasing. Survival rates in HSCT patients vary based on factors such as donor match and the underlying cause of BMFS. Additionally, the risk of secondary malignancies is relatively high in BMFS patients, adding complexity to long-term management. While Saudi studies indicate survival rates comparable to international standards, challenges in the assessment of BMFS outcomes persist, given the condition\u27s rarity and diversity. This article underscores the importance of continued research and data collection to enhance our understanding and management of BMFS in the pediatric population, both in Saudi Arabia and globally
The electronic government implementation model in the Republic of Korea based on the theory of planned behavior TPB
Get PDFThis paper explains that the theory of planned behavior is a theoretical framework that explains the factors that affect the intention of the person which will affect his behavior. These factors are the attitude toward the behavior, the subjective norm, and the perceived behavioral control. Ajzen depended on Bandura’s self-efficacy theory which changed it to the perceived behavioral control. That tells more about the capability of the individual from the available resources and the possibilities of him to be able to proceed with a behavior. The research objective deals with the fact that Ajzen (1991) criticizes the technology acceptance model TAM theory applied in social science, he said that it does not provide the extendibility element in the research that needs to explain more about the usefulness elements. Therefore, other researchers advocated for the implantation of the TPB theory of planned behavior to be able to apply the extendibility element in the research of the electronic government field. In the domain of explaining human behavior the theory of planning behavior indicates a good direction in this field of explaining and understanding human behavior. Recently, technology has become a main factor in social science, here to discuss the government to citizens providing services G2C electronic government initiatives. Most of the research depends on the technology acceptance model TAM, and UTAT theories to explain the effect of the technology in the electronic government implementation. Most of the research about the Republic of Korea’ electronic government implements the technology acceptance model TAM theory and other theories. The results indicate that most foreigners are very familiar with the internet in their home countries more than they are with the electronic government in their home countries. Therefore, the Republic of Korean’ lifestyle made foreigners more familiar with the electronic government portal. The last general question is about whether to use the electronic government portal in Republic of Korea or not according to the yes or no answers are 78%, 22%
The Role of Feedback in Teacher Professional Development
Get PDFThis paper examines how professional development (PD) facilitators obtain feedback about the effectiveness of sessions they facilitate and to what extent feedback is an integral part of their planning. Three professional development facilitators with varying degrees of experience served as participants in this study. One-on-one semi-structured interviews were used to collect data, and the data were analyzed utilizing an interpretative phenomenological approach (IPA). The findings showed that the participants obtained feedback from teachers using different methods before, during, and after their professional development sessions. The facilitators used feedback to plan and check the effectiveness of their sessions, and feedback was an integral part of their professional development work.
Effectiveness of corticosteroids in the treatment of patients with Covid 19
Get PDFThe COVID-19 pandemic caused by the SARS-CoV-2 virus has emerged as one of the most significant health crises of the 21st century, with a devastating impact on global health. Understanding the disease pathogenesis and finding effective treatment strategies are crucial to mitigate its mortality rate. COVID-19 exhibits a biphasic illness, characterized by a viral response phase followed by a hyperinflammatory response phase, also known as the cytokine storm. This cytokine storm, rather than direct viral activity, has been identified as the major contributor to the high mortality associated with severe cases.
In this article, we explore the effectiveness of corticosteroids in managing the cytokine storm and reducing mortality in COVID-19. Corticosteroids have been extensively studied for their immunosuppressive properties and have shown potential in suppressing the hyperinflammatory response associated with the disease. The RECOVERY trial, a large-scale multicenter clinical trial conducted in the UK, demonstrated a significant reduction in mortality with the use of corticosteroids, particularly in critically ill patients requiring invasive mechanical ventilation.
However, the timing of corticosteroid therapy initiation is crucial, as early administration or use in milder cases may not yield the same benefits and could potentially increase mortality. Current evidence suggests that corticosteroids should be reserved for hospitalized patients with severe COVID-19, specifically those requiring oxygen therapy or invasive mechanical ventilation. In contrast, corticosteroid therapy has shown limited or even detrimental effects in non-severe cases
A Comprehensive Review of Acute Coronary Syndrome
Get PDFA significant sign of coronary artery disease is the acute coronary syndrome (ACS). Angina pectoris, ST-elevation myocardial infarction, and non-ST-elevation myocardial infarction (NSTEMI) are just a few of the conditions that are grouped together under the general term “ACS.” The main cause of death worldwide is cardiovascular disease, which puts ACS under a heavy financial strain. Reduced blood flow to the heart, primarily as a result of plaque rupture and thrombus development, is a pathogenesis of ACS. Numerous risk factors, both modifiable (such as smoking, hypertension, diabetes, hypercholesterolemia, obesity, and inactivity) and non-modifiable (like age, gender, and inheritance), can lead to the development of ACS. Electrocardiography (ECG), clinical evaluation, history-taking, and cardiac biomarkers are all used in the diagnosis process. For the best management, prompt diagnosis and risk classification are essential. Reperfusion therapy, anti-anginal therapy, and renin-angiotensin blocking are a few of the suggested procedures in treatment techniques that aim to minimise myocardial ischemia and restore coronary blood flow. Long-term management also strongly depends on modifying one’s lifestyle, including giving up smoking, eating a healthy diet, getting regular exercise, and obtaining rehabilitation. Acute cardiac failure, ventricular septum or papillary muscle rupture, arrhythmias, recurrent angina, and other consequences of ACS are also highlighted in the paper. The prognosis varies depending on variables, including persistent myocardial injury and the existence of ventricular arrhythmias; an unfavourable prognosis is frequently related to arrhythmias and is associated with poor left ventricular function. . This article offers a thorough review of ACS and gives readers important information about its pathophysiology, risk factors, diagnosis, therapy, and prognosis