JURNAL ILMU KEFARMASIAN INDONESIA
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Activity of hair tonic preparation combining Apium graveolens L extract, Tussilago farfara flower extract, Achillea millefolium extract, Cinchona succirubra bark extract on male New Zealand white rabbits
Full text linkNumerous hair care products are currently available in the market, including shampoo, conditioner, hair mask, hair serum, and hair tonic. Unlike shampoo, hair tonic remains in contact with the scalp for a longer duration, potentially enhancing its effectiveness. Apium graveolens L (EDS) and a combination of Tussilago Farfara flowers, Achillea Millefolium L leaves, and Cinchona Succirubra L stems, marketed as ATG, are known for their hair growth-promoting properties. This study aimed to evaluate the hair growth efficacy, stability, and safety of a hair tonic formulated from EDS and ATG extracts. The prepared extract solution was applied to the shaved backs of male New Zealand rabbits, aged 4 months and weighing 2.5-3 kg, and observations were recorded on days 7, 14, 21, and 28. Parameters measured included hair length and weight. The results indicated that the F1 formulation yielded an average hair length of 9.89 mm and weight of 49.38 mg; F2, 10.36 mm and 49.5 mg; F3, 11.98 mm and 49.5 mg; F4, 17.44 mm and 60.63 mg; F5, 17.27 mm and 52.75 mg; and F6, 19.06 mm and 56.5 mg. Conclusively, the F6 formulation demonstrated the most significant results, with an average hair length of 19.06 mm and weight of 56.5 mg. The hair tonic formulation was found to be non-irritating to the skin and remained stable throughout the study
Cytotoxic activity of isolate compounds from derendan (Lansium parasiticum (Osbeck) K.C. Sahni & Bennet) fruit peel
Full text linkDerendan (Lansium parasiticum (Osbeck) K.C. Sahni & Bennet) is a plant from the Meliaceae family that grows in the tropics, especially in Sumatra (Indonesia). It was reported that this plant has antimalarial, antimutagenic, and anticancer properties. This study aims to determine the cytotoxic activity of compounds isolated from the methanol extract of Lansium parasiticum bark. Extraction using maceration method with methanol solvent. Vacuum Liquid Chromatography (KVC) with 21 different eluent ratios (n-hexane : ethyl acetate and ethyl acetate ; methanol) was utilized for the fractionation. The result was 21 fractions. The washing technique was used to purify fraction 17. The obtained compound LPR17 with a melting point of 239-241ᵒC. Based on the UV spectrum, the wavelengths of the LPR17 compound were 277.0 nm and 205.0 nm. The FT-IR spectrum shows aliphatic OH, CH, C=O, C-H, and C-C functional groups. This compound reacts positively with the Liebermann-Burchard reagent. The compound obtained is a triterpenoid group. Cytotoxic test using BSLT method. LPR17 compounds provide very strong cytotoxic activity (LC50 = 67.15 g/mL)
Evaluation of anti-acne gel of Piper crocatum leaves ethanolic extract against Propionibacterium acnes
Full text linkThe red betel leaf (Piper crocatum) exhibited antibacterial properties by inhibiting Propionibacterium acnes, known for causing acne. The study aimed to develop an anti-acne gel formulation using Piper crocatum leaves ethanolic extract and to evaluate its antibacterial efficacy against Propionibacterium acnes. The extract was formulated into three gel formulas, with concentrations of 15%, 20%, and 25%, respectively. Antibacterial activity was evaluated using the agar well diffusion method, with Clindamycin gel as the positive control. The inhibition diameter were analyzed statistically using One Way ANOVA and Post Hoc LSD tests at a 95% confidence level. The result showed that the gel met the physical test requirements. The inhibition zone of the samples was observed with an inhibition diameter of 7.98 mm, 8.06 mm, and 8.16 mm for 15%, 20%, and 30% extract of gel, respectively, compared to the positive control 27.60 mm (p < 0,05). The research findings indicate that anti-acne gel of Piper crocatum leaves ethanolic extract exhibit moderate antibacterial activity in an in vitro setting. Statistically significant differences in inhibition diameters were observed between each gel sample and positive control
Antimicrobial activity and phytochemicals compound profile of ethanol extract Moringa leaf (Moringa oleifera) compounds by FTIR
Full text linkMoringa plants are known in various parts of the world as a type of vegetable plant that is rich in nutrients and has multiple properties, one of which is as an antimicrobial. This research was conducted to test the antimicrobial inhibition of Moringa leaf decoction and ethanol extract against the growth of Escherichia coli and Aspergillus niger. The antimicrobial test in this study used the Disc diffusion method using various concentrations, including 25%, 50%, 75%, and 100%. There were two test samples, Moringa leaf decoction and ethanol extract using the maceration method with 96% ethanol solvent. In addition to the test group, there was also a control group, namely a positive control using chloramphenicol and ketoconazole antibiotics, negative control using aquadest as a decoction solvent, and DMSO as an extraction solvent. The ethanol extract was identified by the FTIR method. The results showed that Moringa leaf decoction and Moringa leaf ethanol extract could be used as antibacterial. Inhibition zones on Escherichia coli bacteria produced at concentrations of 25%, 50%, and 75% had a weak zone of inhibition category for both decoction and ethanol extract of Moringa leaves. Meanwhile, at a concentration of 100%, the decoction has a weak zone of inhibition and 100% ethanol extract of Moringa leaves can inhibit 8.25 mm which is included in the medium category. The inhibition zones of the fungus Aspergillus niger produced at concentrations of 25%, 50%, 75%, and 100% had no inhibition on both the decoction and ethanol extract of Moringa leaves. From the analysis of functional groups using the FTIR method, it can be predicted that in the Moringa leaf extract with methanol as solvent there are groups of phenolic compounds or flavonoids
Analysis for quality of senggugu plant and herbal product (Rotheca Serrata (L.) with metabolomics approach
Full text linkSenggugu plant (Rotheca serrata (L.) has many benefits and has the potential as a raw material for herbal medicine, so an identify in the form of an FTIR fingerprint profile is needed. The purpose of this study was to ensure the quality of simplisia and herbal product of senggugu roots and leaves by metabolomics approach. Simplisia and herbal products powder of senggugu leaves and roots were extracted with 70% ethanol solvent using ultrasonic method. The dried extracts of simplisia and herbal products were analyzed by FTIR and TLC-Densitometry. Data obtained from FTIR and TLC-Densitometry analyzed with multivariate data analysis techniques, Principal Component Analysis (PCA) to obtain fingerprint profiles. The PCA results obtained a total Principal Component value of 98,7% and showed that leaf simplisia and herbal products of senggugu leaves can cluster well, while root simplisia and herbal products of senggugu roots were at a distance from the plot. The analysis with OPLS-DA showed the same fungtional groups, which are C=H, O-H, C=C. The results of antioxidant activity testing of 70% ethanol extracts of leaves, roots, and herbal products of senggugu obtained strong antioxidant activity ability with IC50 values of 80,08; 92,12; 80,53; and 94,03 ppm
The effect of technology implementation in providing drug information on consumer satisfaction in Jakarta, Indonesia
Full text linkThe provision of drug information (PDI) is a crucial factor influencing consumer behavior and ensuring appropriate drug use, thereby achieving therapeutic goals. With advancements in technology, digital platforms such as tele-counseling, WhatsApp, and social media are increasingly being used for PDI. However, challenges such as unclear communication, incomplete information, and delayed responses remain, which may affect consumer satisfaction. This study aims to assess consumer satisfaction with PDI through the implementation of a pharmacy application, using the End User Computing Satisfaction (EUCS) model, which evaluates information content, accuracy, format, ease of use, and timeliness. The research employed an associative, cross-sectional design and involved 250 consumers at Atma Jaya Pharmacy. Data were collected via a Likert-scale-based questionnaire, with responses analyzed to determine satisfaction levels in each EUCS dimension. Results showed that consumer satisfaction was consistently high across all dimensions, with the average satisfaction scores being 89.10% for information content, 90.19% for accuracy, 87.25% for format, 85.33% for ease of use, and 86.78% for timeliness. In conclusion, the use of technology in PDI significantly enhances consumer satisfaction, offering more accessible, accurate, and timely drug information. This study highlights the importance of optimizing technological tools in pharmaceutical services to improve user experience and satisfaction
Hand, foot, and mouth disease in children: forecasting of future research direction using bibliometric analysis
Full text linkSince 1997, hand, foot, and mouth disease (HFMD) has become a common health problem in Southeast Asia. Various types of research have been conducted and published to handle HFMD. However, until now, many children, especially in the Asia-Pacific region, including Indonesia, still have HFMD-causing enterovirus (EV) infection. By conducting a bibliometric analysis of the literature published over the last 27 years (1997–2024), the direction of HFMD research in children can be predicted, thus research areas that have the potential and still need to be developed for future better HFMD treatment can be known. The important HFMD research topics predicted to continue to develop were identified through keyword analysis, which was subsequently mapped using a network approach. Based on this study, it can be concluded that HFMD research is predicted to lead to the development of synbiotic supplements, which can reduce HFMD severity, especially in children, by utilizing a genome-wide association study (GWAS) and machine learning
Analisis Manajemen Penyimpanan Sediaan Vaksin COVID-19 di Instalasi Farmasi RSUD S. K. Lerik Kota Kupang
No full textThe COVID-19 pandemic poses a vast morbidity and mortality burden and disrupts communities and economies globally, including Indonesia. Vaccination is an essential prevention. Vaccine storage must be maintained to preserve its potency and safety. This study determined the suitability of the storage and COVID-19 vaccine preparations at the Pharmacy Installation of RSUD S. K. Lerik Kupang City, based on the 2020 Good Drug Distribution Method (Cara Distribusi Obat yang Baik or CDOB) standard and the 2021 Ministry of Health regarding Technical Instructions for Vaccination Implementation in Combating the Corona Virus Disease 2019 (COVID-19) Pandemic. This study used a qualitative, non-experimental observational method, data collection, structured interviews, and documentation. The storage management assessment for the COVID-19 vaccine is carried out using Zuhroh's checklist tool. The results show that the COVID-19 vaccine storage system at the RSUD S. K. Lerik needs development to follow CDOB 2020 and Kepmenkes 2021 rules fully. Indicators results that are below the standard: training and evaluation, the unavailability of a hygiene schedule, air ventilation, Vaccine Vial Monitor (VVM) images, expiration places, quarantine places, destruction of damaged vaccines, weekly and monthly recording maintenance, and also unavailability of replacement equipment during the implementation, repair, maintenance, and calibration of equipment
Ionic liquid-based ultrasound-assisted extraction: a novel insights of green extraction techniques for bioactive compounds from herbal plants
Full text linkThe ionic liquid-based ultrasound-assisted extraction (ILUAE) is a non-conventional environmentally friendly extraction method. ILUAE is considered as green chemistry since ILUAE utilize ionic liquids as solvents and ultrasound-assisted extraction to extract bioactive chemicals from herbal plants. The growing popularity of ILUAE as preferred extraction method in herbal medicine is not only due to its sustainable, eco-friendly characteristics but also its improvement in extraction efficiency while maintaining the quality of extracted products. Here, we discussed and reviewed ILUAE as preferred extraction method for herbal medicines. Through discussing ILUAE’s potential, advantage against traditional extraction technique, and summarized the successful extraction of bioactive components from various herbal plants using ILUAE, we hope to showcase the technology's efficiency, selectivity, and sustainability. Finally, we discussed current limitations and future challenge for ILUAE and potential ways to address these challenges
Red pomegranate (Punica granatum L.) peel extract mud mask formulation and tyrosinase-inhibition activity test
Full text linkThe peel of red pomegranates (Punica granatum L.) contains gallic acid and ellagic acid, which inhibit tyrosinase, an enzyme that aids melanin formation. This study aimed to determine how variations in the concentration of kaolin base affected the evaluation outcomes of mud mask formulations containing P. granatum fruit peel extract. P. granatum fruit peel extract was used in 3 formulas with variations in the kaolin base concentration of 19.5%, 22.5%, and 26.3%. The three formulations were subsequently evaluated through a series of procedures, which included organoleptic, homogeneity, spreadability, viscosity, pH measurements, and drying time. The enzyme-linked immunosorbent assay (ELISA) method was employed to determine the inhibitory activity of the tyrosinase enzyme. Formula 2 gives the best results with the characteristics of having a distinctive odor and thick brownish-green color, homogeneous preparation, spreadability of 20.5863 cm2, a viscosity of 16040 cPs; pH of 5.86, and drying time of 16.67 minutes. Inhibition of the tyrosinase enzyme by kojic acid, extracts, and preparations resulted in respective IC50 values of 31.64 μg/mL, 155.49 μg/mL, and 276.15 μg/mL. The results of the viscosity test, pH test, and mask drying time were significantly different as the concentration of the kaolin base varied (p<0.05)