JURNAL ILMU KEFARMASIAN INDONESIA
Not a member yet
670 research outputs found
Sort by
Physical-chemical stability test on spray gel with active compound ethyl p-methoxycinnamate (Kaempferia galanga Linn.) and menthol, using combination gelling agent na cmc and copovidone
Full text linkThe major component of galangal rhizome (Kaempferia galanga Linn) is ethyl p-methoxycinnamate (EPMS), which amounts to 80.05%. Significant anti-inflammatory activity is exhibited by EPMS from galangal rhizome through the inhibition of carrageenan-induced mouse edema and the inhibition of IL-6 production. EPMC is recognized for various pharmacological effects, particularly its potential as a wound healing agent due to its anti-inflammatory properties. The choice of spray was made because it meets the characteristics of anti-inflammatory preparations in the wound healing process. The preparation must be moist, easily adjusted to the shape of the wound (flexible), sterile, and evenly distributed, covering the tissue, and can be easily removed from the tissue, including the wound. A spray gel dosage form was formulated with varying concentrations of the gelling agent Na CMC, F1 (0.5%), F2 (1.0%), and F3 (1.5%). Physical stability was evaluated at room temperature storage on days 0, 7, 14, and 21. Organoleptics, homogeneity, viscosity, pH, spray pattern, adhesive spread ability, centrifugation test, and cycling test were evaluated. Chemical stability evaluation was carried out using UV-Vis spectrophotometry to assess the EPMS levels in the preparation. The results of the physical evaluation showed that all formulas were stable in terms of organoleptics, homogeneity, and pH, which was in the range of 6.6–7.1; the weight per spray was uniform and relatively stable in centrifugation and cycling tests. The use of a combination of sodium carboxymethylcellulose and copovidone can produce a spray gel preparation of a good aromatic ginger (Kaempferia galanga Linn) crystal with a 1%
Literature review: treatment design to overcome anticancer drug resistance
Full text linkOne of the main causes of death in the world today is cancer. Chemotherapy is one treatment that cancer patients may utilize. Anticancer medication resistance, which might forecast a rise in treatment failure rates among cancer patients, poses a challenge to the current use of anticancer treatments. Numerous investigators have studied potential approaches to combat anti-cancer medication resistance. The purpose of this literature review is to provide information on treatment planning that can be applied to counteract anti-cancer medication resistance. Cancer is one of the leading causes of death in the modern world. One therapeutic option available to cancer patients is chemotherapy. The current usage of anticancer medicines is challenged by anticancer medication resistance, which may predict an increase in treatment failure rates among cancer patients. Many researchers have looked into possible strategies to fight drug resistance to anti-cancer medications. This review of the literature aims to give information on treatment planning that can be used to combat drug resistance to anti-cancer medications
Acute toxicity of arumanis mango leaves (Mangifera indica L.) extract against zebrafish (Danio rerio) embryos
Full text linkArumanis is one of the cultivars of Indonesian mangoes used as a horticultural commodity. Young leaves arumanis can be used for traditional herbal medicine. Pharmacological activity of young leaf arumanis extract are known to be antidiabetic, anticancer, antibacterial, anti-inflammatory, and analgesic effects. However, it is necessary to carry out toxicity testing before young leaf arumanis extract is used in traditional herbal medicine. This study aimed to determine the LC50 value of young leaf arumanis extract and identify the hatching time of embryos, heart rate of larvae, swimming movement of larvae, and malformations in both embryos and larvae. Forty five embryos of zebrafish were exposed to several concentrations of young leaf arumanis extract at 24 h post-fertilization until 96 h post-fertilization. Percentage of embryonic death calculated using probit analysis model LC50. Hatching rate, swimming movements, and heart rate were analyzed using the IBM SPSS software version 26. The LC50 values of the young leaf arumanis extract were 42.65μg/mL at 96 hpf and also 42.65μg/mL at 72 hpf. The embryotoxic effects at high concentrations of the extract are hatching delay and decreasing heart rate. The extract also caused abnormalities in embryo morphology, including pericardial edema and tail bending
Biotechnology-based therapy for stroke treatment: review
No full textVarious therapeutic agents have been used to treat stroke. However, currently there is extensive exploration of new potential therapies for stroke involving novel signaling pathways and development of therapeutic agents through biotechnological approaches. This article examines the recent advances in stroke therapy using biotechnology-based drugs. We conducted a comprehensive search using specific keywords relating to Ischemic Stroke, ATMP, Peptide, Antibody, Stem Cells, and connected topics in the databases of Medline, Scopus, Web of Science, and Pubmed. The main focus of the selection criteria was on English-language literature that explored the relationship between Ischemic Stroke, ATMP, Peptide, Antibody, Stem Cells, and related factors. This article exhibits that numerous studies are being conducted and have demonstrated the use of biotechnology-based therapeutic agents for stroke, including tissue plasminogen activators, therapeutic peptides, microRNA, monoclonal antibodies, as well as stem cells. These therapeutic agents have not only been tested on test animals but have also been commenced to be tested in clinical studies or have obtained marketing approval for use in ischemic stroke patients. In conclusion, despite the limited number of approved drugs, advancements in biotechnology are poised to make them common adjunct treatments for stroke patients, not just for managing the disease but also for its cure and regenerative effects in survivors
Hydrating serum made of potassium azeloyl diglycinate with CMC-Na variations as a gelling agent on physical-chemical and safety tests
Full text linkPotassium azeloyl diglycinate is an ingredient for moisturizing the skin. In this research, potassium-azeloyl-diglycinate was formulated into a gel-based hydrating serum. A good serum gel can be identified by its physicochemical properties and stability, which are determined by the composition of the ingredients used, one of which is CMC-Na, which is used as a gelling agent. The aim of this research was to test the effect of CMC-Na concentrations (1%, 1.25%, and 1.5%) on the physicochemical stability of serum and to find a formulation with the best stability by testing the water content and safety. The evaluation results show that increasing the concentration of CMC-Na has an impact on increasing viscosity, pH, and adhesion, thereby providing a different gel consistency in each formula and reducing its spreadability. The best formulation is Formula-2, which is then tested for water content on respondents. The research results show that this formula has the ability to hydrate the skin, as seen from an increase in oil content of 8.39% and an increase in water content of 8.86%. Initial acute dermal toxicity test results show that the serum is safe to use on the skin and does not cause side effects or toxicity reactions
Effect of solvent polarity on secondary metabolite content and α-glucosidase enzyme IC50 of Dendrophthoe pentandra (L). Miq leaves extract
Full text linkCherry mistletoe (Dendrophthoe pentandra (L). Miq) have an inhibitory effect on the α-glucosidase enzyme, but research related to solvent optimization to find active compound is unclear. Secondary metabolites that can be identified depend on the level of solvent polarity. This study aims to determine the effect of solvent polarity on the secondary metabolite content and the α-glucosidase enzyme by using the polar and nonpolar fractions of the ethyl acetate extract of cherry mistletoe leaves. Cherry mistletoe leaves were extracted using ethyl acetate and were followed by a liquid-liquid fractionation. The polar fraction used ethanol and ethyl acetate as solvents, whereas the nonpolar fraction used n-hexane and ethyl acetate as solvents. Secondary metabolites present in polar fractions were alkaloids, flavonoids, steroids, tannins, and terpenoids, whereas those present in nonpolar fractions were flavonoids and steroids. The IC50 value of the polar fraction (54.8 ppm) was lower than that of the nonpolar fraction (192.0 ppm). The polar fraction of the ethyl acetate extract of cherry mistletoe leaves could inhibit the α-glucosidase enzyme and, therefore, is classified as active. On the other hand, the nonpolar fraction of the ethyl acetate extract of cherry mistletoe leaves could not inhibit the α-glucosidase enzyme and, therefore, is classified as inactive in general
Association of side effects to medication adherence of antiepileptic drug use in epileptic patients
Full text linkEpilepsy is a chronic neurological disorder with symptoms characterized by seizures, arising spontaneously with brief episodes with the main symptom of decreased or loss of consciousness. This study aims to examine the effect of side effects of medication adherence to antiepileptic drug use in epilepsy patients. This research is an observational study that was analyzed using quantitative descriptive methods in Neurology patients at the Airlangga University Hospital from March until May 2022. Side effects were measured using the LAEP (Liverpool Adverse Effects Profile) questionnaire and adherence was measured using a pill count. Results showed that the influence of side effects on medication adherence (pill count method) to antiepileptic drugs using linear regression, it is known that the P-value is 0.501. There is no significant relationship between the category of side effects and medication adherence to antiepileptic drugs. Another factor that influences compliance with medication use is the appearance of seizures. Based on the results of this study, it is known that the greater the frequency of seizures, the more likely patients are to be non-compliant (P-value 0.006). To increase adherence, it is necessary to pay attention to other factors such as knowledge, economy, and type of therapy in epilepsy patients so that therapeutic outcomes can be achieved
Cost effectiveness analysis of ceftriaxone with cefoperazon in thypoid patients at X Mataram Hospital
Full text linkTyphoid is the third most common cause of hospitalisation in Indonesia, affecting 100,000 people every year. Typhoid fever, with an average case fatality rate of 2.45% at X Mataram Hospital, was among the top 10 most common inpatient illnesses in 2019 and 2020. Antibiotics are effective in reducing typhoid infection, lowering body temperature, shortening the length of hospitalisation, and reducing mortality. The aim study to determine the cost-effectiveness of using ceftriaxone and cefoperazone antibiotics for typhoid patients at X Mataram Hospital. Method a compares two groups of antibiotics and evaluates direct costs and clinical outcomes clinic (length of stay and time free of fever). This research is using ACER's cost-effectiveness analysis. The study included 63 samples with an average direct cost of Rp 3,645,106 for cefoperazon and Rp 3,168,106 for ceftriaxone. According to the ACER analysis results, hospitalisation with ceftriaxone is more cost-effective a lower cost of Rp 704,023 and based on fever-free time, cefoperazone is more cost-effective at Rp. 1,024,094. No correlation between antibiotic effectiveness and fever-free time, no correlation between antibiotic effectiveness and length of hospitalisation (p-value >0.05)
Impact of education on anemia in pregnant women attending Bandung community health centers: knowledge, therapy adherence, hemoglobin, and iron intake
Full text linkAnemia in pregnant women poses risks to maternal and infant health. Iron supplementation therapy (IST) adherence and adequate dietary iron intake are crucial for maintaining normal hemoglobin (Hb) levels. This study investigates the impact of education on iron deficiency anemia (IDA) knowledge, IST adherence, iron intake, and Hb levels in pregnant women. A pre-post test study was conducted at Padasuka and Pagarsih Community Health Centers in Bandung. Questionnaires measuring IDA knowledge, Brief Medication Questionnaire (BMQ) for IST adherence, and Food Frequency Questionnaire (FFQ) for iron intake were utilized. This study included a total of 88 pregnant women. The majority of the participants were aged 26-35 years (55.7%), had normal BMI values (45.4%), and exhibited normal blood pressure (60.2%). Additionally, 89.8% had no history of anemia, 90.9% had no other medical history, 92% reported having a good appetite, and 97.7% did not smoke. Education significantly improved IDA knowledge (p = 0.011), IST adherence (p = 0.006), iron intake (p = 0.001), and Hb levels (p = 0.011). Strong positive correlations were found between knowledge of IDA in pregnant women and adherence to IST (r = 0.957; p<0.001), knowledge and Fe intake (r = 0.972; p<0.001), knowledge and Hb levels (r = 0.988; p<0.001), adherence to IST and Fe intake (r = 0.933; p<0.001), adherence to IST and Hb levels (r = 0.948; p<0.001), as well as Fe intake and Hb levels (r = 0.978; p<0.001). Enhanced knowledge, IST adherence, and iron intake may mitigate anemia risks in pregnant women
Optimization of sodium starch glycolate and maltodextrin in chlorpheniramine maleate Fast Disintegrating Tablet (FDT) by factorial design
Full text linkChlorpheniramine maleate (CTM) is an antihistamine that is widely available on the market in tablet form. It needs to be formulated in the form of Fast Disintegrating Tablets (FDT) to produce a faster therapeutic effect to treat allergy symptoms, which are often irritating. The FDT contains a super disintegrant to regulate the disintegration speed of tablet and a binder to provide the ability to bind between powders. This research was conducted to obtain the effect of Sodium Starch Glycolate (SSG) as a super disintegrant and maltodextrin as a binder, and their interaction in the chlorpheniramine maleate tablet formulation. This research was categorized as true experimental designs with FDT quality parameters such as organoleptic, hardness, friability, disintegration time, wetting time, water absorption ratio, and content uniformity. The optimization method used is factorial design. Data analysis was performed using Analysis of Variance (ANOVA). Based on the data, it conclude that Sodium Starch glycolate (SSG) affects increasing hardness, increasing friability, extending disintegration time, extending wetting time, and reducing the water absorption ratio. Maltodextrin, has the effect of increasing hardness, reducing friability, extending disintegration time, extending wetting time, and reducing the water absorption ratio. The interaction of SSG and maltodextrin has the effect of reducing hardness, increasing friability, shortening disintegration time, shortening wetting time, and increasing the water absorption ratio