Proceeding of Mulawarman Pharmaceuticals Conferences
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Kajian Penggunaan Obat Insomnia sebagai Penyakit Penyerta pada Salah Satu Rumah Sakit Khusus Daerah di Kalimantan Timur
No full textInsomnia is a sleep disorder such as dissatisfaction with sleep quality, difficulty in sleeping and maintaining sleep, causing physical and emotional symptoms that affect performance and also cognitivity. The existence of mental disorders such as depression, fatigue and anxiety which culminate in insomnia so that a person does not sleep soundly. The purpose of this study is to determine the characteristics, variations of the diseases that cause insomnia, drug use, and drug interactions that occur. The research method used an observational retrospective method by tracing medical record data at a special regional hospital in East Kalimantan with a total sampling technique during 2019. The results obtained for characteristic data that insomnia was greater for women (57%) at the age of 56-65 years (40%) with primary and junior high school education (30%) who do not work (77%) and who do not have a history of disease (93%) and insomnia due to anxiety (94%). For the variation of insomnia, based on the causes and history of the disease, whether there is anxiety disorder or anxiety. Treatment is done with 87% single therapy, namely using the drugs Alprazolam (8%), Clozapine (41%), Fluoxetine (4%), Risperidone (8%), Lorazepam (8%), Diazepam (11%), Zolpidem tartrate (4%), Amitripthyline (4%), Clonazepam (4%), and Clorpromazin (8%) while 13% uses 2 combination of drug therapy is using combination of Fluoxetine and Amitripthyline (25%), Clozapine and Sertraline (50%), and Maprotiline hydrochloride and Clobazam (25%). The potential interactions are entirely pharmacokinetic interactions of the metabolic phase with major severity of 75% and moderate severity of 25%
Pengaruh Induksi Tukak Lambung Menggunakan Aspirin terhadap Kerusakan Jaringan Mukosa Lambung Mencit
No full textGastric ulcer is a condition of damage to the gastric mucosa accompanied by an inflammatory process. Gastric mucosal damage can be induced by various factors, one of which is non-steroidal anti-inflammatory drugs (NSAIDs). The purpose of this study was to assess the appropriate dose and time as a cause of damage to the gastric mucosa of mice due to exposure to aspirin. Before being induced, mice were fasted for 24 hours, white mice DDY strains (Deutschland, Denkenand and Yoken) were divided into 3 groups namely normal groups, aspirin 14 mg / 20 g BW (1 day), aspirin 14 mg / 20 g BW (2 days) orally. The results showed that the aspirin induced group 14mg / 20g BW had the most significant weight loss of mice, and showed the most severe epithelial tissue damage to the gastric mucosa with mucosal integrity score based on Barthel Manja criteria, namely 1. It can be concluded that the right dose of aspirin as an induction of damage to the gastric mucosa of mice is a dose of 14mg / 20 g BW (2 days)
Terapi Kombinasi Air Perasan Daging Buah Mengkudu (Morinda citrifolia L.) dan Mentimun (Cucumis sativus L.) untuk Menurunkan Tekanan Darah pada Pasien Hipertensi
No full textNoni (Morinda citrifolia L.) and cucumber (Cucumis sativus L.) fruit are plants that have antihypertensive activity. The active ingredient scopoletin, anthosianin, xeronin in noni and high potassium in cucumber can lower blood pressure. This study aims to determine the characteristic description, hedonic quality test and the effect of giving a combination noni and cucumber squeezed water flesh of fruit on reduction in the systolic and diastolic blood pressure of hypertension patients in Muara Jawa District, East Kalimantan. The research method used was quasi experimental and research procedures measuring pre and post test being given treatment for 7 days. The highest percentage of respondents collected data obtained are aged 36-45 years as much as 45%, women70%, junior high school education 45%, family history 60%, frequent exercise habits 55% and normal BMI 45%. The highest percentage of sample hedonic quality test collected data obtained are the flavor test was sweet by 65%, the aroma test was sharp by 75% and the texture test was soft by 75%. The results of statistical tests using the paired sample t-test method showed a significant decrease in systolic blood pressure p = 0.000 < ? (0.05) of 12.3 mmHg and diastolic blood pressure p = 0.000 < ? (0.05) of 5.4 mmHg. Based on the results of the study, it can be concluded that giving a combination noni and cucumber squeezed water flesh of fruit can have reduced effect on systolic and diastolic blood pressure of hypertension patients
Studi Literatur: Tanaman yang Memiliki Aktivitas Peluruh Kalsium Batu Ginjal Secara In Vitro
No full textKidney stones are a disease that is often found in society due to various causes. This disease is characterized by hardened deposits in the kidneys, mostly containing calcium oxalate and calcium phosphate. The medical treatment used is most effective with surgery. But this can carry significant risks, unwanted side effects, and is relatively expensive. So that herbal medicine becomes an alternative. This study aims to determine which plants have the activity of calcium kidney stone breaking. The research method used is online data search using appropriate keywords, carried out online in indexed journal databases. Based on several studies, there are several plants that have in vitro activity so that they can provide an overview of certain herbal plants that have the potential to decay calcium kidney stones, namely Cocor Bebek (Bryophyllum Pinnatum Lam), Kelor Leaves (Moringa oleifera Lam.), combination of Soursop Leaves ( Annona muricata) and pegagan (Centella asiatica L.Urb) , Adam Hawa leaves (Rhoeo discolor Hance), starfruit leaves (Averrhoa bilimbii L.), Moonflower leaves (Tithonia diversifolia), and celery (Apium graveolens L.)The part of tamanan leaves studied has a good affinity for releasing kidney stones calcium
Potensi Antiinflamasi Tanaman Kaempferia
No full textKaempferia is one of the important in zingiberaceae family that can be found in Southeast Asia. Severalspecies of kaempferia are used in spices and traditional medicines such as anti-inflammatory. Tracingresults on the kaempferia genus showed that 6 species had anti-inflammatory activity. This antiinflammatoryin the kaempferia genus is caused by the presence of chalcone, flavonoids, and terpenoidscompounds
Zebrafish (Danio rerio) Sebagai Model Hewan Coba pada Pengujian Aktivitas Obat
No full textPerkembangan metode penelitian menggunakan hewan coba sering terkendala pada aspek 3R (reduce, replace, refinement). Untuk melakukan skrining aktivitas peneliti sering dihadapkan pada pilihan menggunakan hewan coba golongan rodent dalam jumlah banyak. Sedangkan pilihan menggunakan larva udang menawarkan pilihan jenis pengujian yang terbatas. Penelitian ini bertujuan mengkaji keunggulan dan kelemahan metode uji aktivitas menggunakan model zebrafish (Danio rerio). Penelitian dilakukan secara metaanalisis menggunakan berbagai literatur yang diakses dari Pubmed, Sciencedirect, dan Google Scholar. Metode pengujian menggunakan zebrafish menunjukkan keunggulan pada pengamatan perilaku setelah pemberian bahan uji, terutama yang berkaitan dengan sistem saraf. Sedangkan untuk pengujian aktivitas terhadap jantung, pengamatan perilaku fisik kurang menunjukkan perbedaan yang berarti, namun penelusuran aktivitas terhadap otot jantung dapat dilakukan dengan metode pewarnaan histopatologi. Pengamatan molekular tersebut mampu menunjukkan kemampuan kontraksi dan relaksasi otot jantung. Pengamatan pada fungsi pengaturan tekanan darah dan fungsi sistem pencernaan juga dapat terpantau jelas jika menggunakan model zebrafish transgenik. Model zebrafish hasil rekayasa ini dapat terlihat bening sehingga ritme kerja organ dalamnya terrekam menghasilkan data pengamatan yang valid. Sehingga, untuk penelitian skrining uji aktivitas suatu bahan, penggunaan zebrafish menjadi salah satu pilihan yang tepat
Pengaruh Pemberian Jus Buah Pepaya (Carica papaya L.) terhadap Penurunan Kadar Malondialdehid dan Asam Urat
No full textMalondialdehyde (MDA) is a biomarker of oxidative stress due to the presence of free radicals in the body. Papaya fruit contains vitamin C and ?-carotene which are useful as antioxidants. This study aims to determine the initial description of MDA levels in urine and uric acid in smoker and non-smoker respondents and to determine changes in urinary MDA and uric acid levels after administration of papaya fruit juice (Carica papaya L). The research method used was experimental with a pre-post test design. The results obtained at the initial MDA level of urine of smokers and non-smokers were an average of 2.504 nmol / mL and 1.821 nmol / mL and the results obtained after giving the juice on day 7 were 1.455 nmol / mL and 0.992 nmol / mL . Meanwhile, the initial uric acid levels of each respondent were 9.6 mg / dL and 8.4 mg / dL and the results obtained after giving the juice on day 7 were 7.8 mg / dL and 6.8 mg / dL. . So it can be concluded that the provision of papaya fruit juice can reduce the levels of MDA in urine and uric acid
Studi Literatur: Aktivitas Antidiabetes Bawang Dayak (Eleutherine americana) dan Serai (Cymbopogon citratus)
No full textDiabetes mellitus is a metabolic disease characterized by hyperglycemia. The Indonesian government is currently advising the public to consume traditional-based medicines because of their low side effects. One of the traditional medicines used is lemongrass and dayak onions. This study aims to determine the chemical compound content and antidiabetic activity of lemongrass and dayak onions. The research method used is the literature review method. Data searches were performed online on the PubMed, Science Direct, Google, Elsevier, and Google Scholar databases as well as other journal search websites. The scientific journals used are scientific journals published in the last 13 years. From 9 literature that has been studied, it shows that dayak onion tubers identify the presence of tannin compounds, saponins, flavonoids, alkaloids, steroids, terpenoids, glycosides, and anthraquinones while lemongrass contains tannin compounds, saponins, flavonoids, alkaloids, steroids, terpenoids, essential oils, phenolic, anthraquinones, carbohydrates, and glycosides. From 14 literature it is known that dayak onion tubers and lemongrass have antidiabetic activity. Compounds that have anti-diabetic activity properties include flavonoids, tannin and alkaloids contained in dayak onion and lemongrass, other than that essential oils contained in lemongrass
Studi Literatur: Aktivitas Imunomodulator Tanaman Jintan Hitam (Nigella sativa L.)
No full textAn immunomodulator is a substance or agent that can cause immunomodulatory activity by changing or affecting the immune system or producing an unwanted immune response through dynamic regulation of the target immune system. Black cumin (Nigella sativa L.) or better known to the public with Habbatus saudah already included in the Ranunculaceae plant family has properties to treat various diseases such as strengthening the immune system, asthma, bronchitis, diabetes, anti-histamine, anti-oxidant, anti-tumor. digestive tract and bacteria. This study aims to analyze the literature related to the immunomodulatory activity of black cumin plants. The research method used is a literature study. Data searches were carried out using online search engine instruments such as Google Scholar, Pubmed, Science Direct, Elsevier, NCBI without any time limit for cited journals. The results of research from 10 journals that have been analyzed show that black cumin (Nigella sativa L.) has acted as an immunomodulator
Uji Aktivitas Antidiare Madu dan Kombinasi Madu dengan Infusa Daun Jambu Biji (Psidium guajava L.) terhadap Mencit
No full textDiarrhea is a major cause of death in developing countries where changes in movement in the normal intestine are characterized by increased water content, volume, or frequency of bowel movements. This study aims to determine the antidiarrheal activity of honey and the combination of honey with guava leaf (Psidium guajava L.) infusion on mice. The method used is the protection method induced by Oleum Ricini. The results showed that honey 20 g / kgBB and a combination of honey 20g / kgBB with 30% Guava Leaf Infusion can provide antidiarrheal activity in mice.