27605 research outputs found
Sort by
A systematic review of health promoting effects of consumption of whey-based fermented products on adults
No full textIntroduction: Fermented whey-based products show significant potential as functional foods, owing to their rich nutritional profile and the generation of bioactive compounds during fermentation. This systematic narrative review evaluates the health effects of fermented-whey consumption based on evidence from human studies in adults. Methods: A systematic literature search was conducted using electronic databases including, PubMed, Scopus, and Cochrane Library for studies published between 1.1.1970 and 31.12.2024. All human clinical studies conducted with adults over 18 years old were included in this study. Inclusion criteria were randomized controlled trials and clinical studies involving adults consuming fermented whey products. Data extraction and quality assessment were performed using CADIMA software and standardized protocols. Studies identified by the search strategy and extracted data were screened independently by 2 reviewers using the CADIMA software. Risk of bias was assessed using the Risk of Bias 2 tool. Results: After screening 1852 titles and abstracts and assessing 20 articles for eligibility, a total of 12 human intervention studies met the inclusion criteria and were included in the systematic narrative review. Consumption of fermented whey products was associated with improvements in muscle mass, glycemic control, lipid profiles (notably triglycerides and LDL cholesterol), immune function (e.g., increased natural killer cell activity), and reductions in oxidative stress and inflammation. Some studies also reported benefits for gastrointestinal and urinary tract health. The health effects were attributed to increased bioavailability of branched-chain amino acids, bioactive peptides, and microbial metabolites such as exopolysaccharides and short-chain fatty acids. Most interventions were well tolerated, with no serious adverse effects reported. Conclusion: Fermented whey products demonstrate promising health benefits across multiple physiological systems. While current evidence supports their use as functional food ingredients, further large-scale, long-term clinical trials are needed to confirm efficacy and elucidate mechanisms of action. Fermented whey appears to be a safe and versatile option for enhancing adult nutrition and health.COST (European Cooperation in Science and Technology) [PIMENTO CA20128]The author(s) declare that financial support was received for the research and/or publication of this article. The work was supported by PIMENTO CA20128 by COST (European Cooperation in Science and Technology)
Importance of hereditary variants in ovarian cancer and endometrial cancer
No full textBackground: Ovarian and endometrial cancers are characterized by a complex interplay of genetic alterations that underlie their pathogenesis, progression and clinical behavior. Recent advances in genomic technologies have revolutionized our understanding of the genetic landscape of these gynecological malignancies, shedding light on the intricate molecular mechanisms driving tumorigenesis. The introduction of advanced sequencing methods and precision medicine has facilitated the investigation of targeted treatments tailored to specific genetic variations, opening up novel paths for personalized therapeutic interventions. Methods: Herein in our study, we analyzed fifty patients diagnosed with ovarian cancer and twenty patients diagnosed with endometrial cancer using the NextSeq-550-Illumina, Next-generation sequencing (NGS) system and Qiaseq Targeted (Qiagen) DNA panel. Results: Thirty-seven variants were detected in 50 ovarian cancer-diagnosed cases. In total forty-six variants were detected, eleven (23.9%) of them were pathogenic/likely pathogenic -one novel- and thirty-five (76.1%) of them were classified as variants of uncertain significance (VETS), so the diagnostic rate for ovarian cancer in our study is (18%). In endometrium cancer we detected variants in 12 cases, we detected 17 variants, six (35.2%) of which were pathogenic/likely pathogenic, and 11 (64.7%) VETS. For endometrium cancer, the diagnostic rate was (30%). Conclusions: Integrating genomic data with clinical and pathological parameters holds promise for refining risk stratification, prognostication and treatment selection, ultimately improving outcomes for patients. This study provides the landscape of genetic research in our laboratory in ovarian and endometrial cancer cases and also highlights the importance of hereditary variants in ovarian and endometrium cancers
Bio-hybrid whey protein-based gallic acid-loaded poly (vinyl alcohol) nanofibers by electrospinning
No full textElectrospinning is a promising technique for fabricating nanofibers with tailored functionalities by blending diverse biomaterials. In this study, poly (vinyl alcohol) (PVA) nanofibers incorporating whey protein isolate (WPI) and gallic acid (GA, 2.5 % w/w) were developed via electrospinning. Varying the PVA:WPI ratio allowed systematic evaluation of fiber morphology, wettability, thermal properties, antioxidant capacity, and antibacterial activity. The fibers exhibited smooth, bead-free morphologies, with average diameters decreasing from 205 to 129 nm as WPI content increased. Incorporation of GA significantly improved hydrophilicity and thermal stability. Antioxidant assays demonstrated up to 87 % DPPH radical scavenging, while antibacterial tests showed effective inhibition of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Among all formulations, PVAWPI-20-GA displayed the most favorable characteristics in terms of thermal resilience, antioxidant efficiency, and microbial reduction, indicating its strong potential for biomedical and active packaging applications.Trakya University Scientific Research Projects (TUBAP) [2024-169]Funding This work was financially supported by Trakya University Scientific Research Projects (TUBAP, Project No: 2024-169)
Analyzing Quinoa Seeds: LC-MS/MS and GC-MS/MS Approaches for Identifying a Nutrient-Rich Functional Food in Alzheimer's and Diabetes Care
No full textQuinoa is a versatile, nutrient-dense, gluten-free pseudocereal, increasingly recognized for its potential health benefits, particularly in managing diabetes mellitus and Alzheimer's disease-two conditions with growing links. Recent research on 14 quinoa genotypes explored fatty oil composition and bioactive potential of quinoa extracts. Linoleic acid was predominant fatty acid (46.60%-56.33%), whereas alanine was the most concentrated amino acid across all active extracts (192.4887-1578.0355 nmol/mL). French Vanilla hexane extract exhibited the strongest alpha-glucosidase inhibition (75.71%), with Santa Ana hexane extract showing the highest alpha-amylase inhibition (28.58%). Additionally, Titicaca hexane extract displayed notable acetylcholinesterase inhibition (22.22%), and Moqu Arochilla methanol extract had the most potent butyrylcholinesterase inhibition (47.20%). Antioxidant assays revealed that Salcedo and French Vanilla extracts had exceptional 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, with positive correlations found between total phenolic content and antioxidant activity (DPPH, beta-carotene, FRAP). These findings emphasize quinoa's potential as a functional food, offering significant benefits for disease management.Scientific and Technological Research Council of Turkey (TUBITAK) [TOVAG-214O232]This study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK Project No: TOVAG-214O232)
Online English Lessons in Western Thrace, Greece: Students and Parents’ Perspectives
No full textDuring the COVID-19 pandemic, schools have switched their education systems from the traditional classroom to an online learning environment to prevent the spreading of the virus. This study was designed to investigate the experiences of online English education of elementary students in the Western Thrace region of Greece during the coronavirus pandemic. It is further searched whether their demographic background influences their online English language education process, whether they are proficient users of technology, and whether they find it challenging to attend online classes. The quantitative data were collected through a scale from a hundred students and structured interview questions were used to collect the qualitative data from both students and parents. Based on the results, it was concluded that the participant students were sufficiently adept at using technology to take part in online courses. Nonetheless, the majority of them occasionally experienced some difficulties. Additionally, it was discovered that most students' opinions of online English instruction were favorable. Finally, the majority of parents who responded were pleased with the online English classes conducted throughout the pandemic
ON (k, n)-SEMISECOND SUBMODULES
No full textIn this paper we introduce a new class of submodules which is called (k, n)-semisecond submodules as a generalization of semisecond submodules. We give many characterizations and properties of this kind of submodules and investigate their relationships with (k, n)-closed ideals and (k, n)-semiprime submodules. We also characterize modules M in which every non-zero submodule of M is (k, n)-semisecond. © 2025 Elsevier B.V., All rights reserved
Turkish Version of the Montreal Children's Hospital Feeding Scale: Validity and Reliability Study in Children With Cerebral Palsy
No full textBackground: This study was conducted to translate The Montreal Children's Hospital Feeding Scale (MCH-FS) into Turkish and to evaluate the psychometric properties of the Turkish version (T-MCH-FS) in children with cerebral palsy (CP). Method: The study involved 160 children (70 children with CP and 90 typically developing children) aged 18 to 72 months. Karaduman Chewing Performance Scale (KCPS), Paediatric version of the Eating Assessment Tool-10 (PEDI-EAT-10) and Behavioral Pediatrics Feeding Assessment Scale (BPFAS) were used to examine the construct validity of the T-MCH-FS. Results: Internal consistency was sufficient with a Cronbach's alpha value of 0.820. There were correlations between the T-MCH-FS and the KCPS (r = 0.377, p < 0.001), the PEDI-EAT-10 (r = 0.655, p < 0.001) and the BPFAS scores for total frequency, child frequency, parent frequency, restriction and poor strategies (p < 0.001). Conclusions: The T-MCH-FS was found to be a reliable and valid instrument to evaluate feeding problems in children with CP and typically developing children.Turkiye Bilimsel ve Teknolojik Arastirma KurumuThis research was funded by Turkiye Bilimsel ve Teknolojik Arastirma Kurum
Retrospective evaluation of HIV/AIDS cases
No full textİnsan immün yetmezlik virüsü enfeksiyonu, tanı ve tedavideki gelişmelere rağmen halen önemli bir halk sağlığı sorunudur. Erken tanı hastalığın kontrolünü kolaylaştırırken, geç tanı tedavi başarısını ve prognozu olumsuz etkileyebilmektedir. Çalışmamızda, insan immün yetmezlik virüsü tanısı alan hastaların özellikleri retrospektif olarak değerlendirildi ve erken ile geç tanının etkileri incelendi. Trakya Üniversitesi Tıp Fakültesi Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği'nde, 01 Ağustos 2017 ile 01 Ağustos 2023 tarihleri arasında takip edilen, 18 yaşından büyük ve tedavi-naif 127 hasta çalışmaya dahil edildi. Hastalar, tanı anındaki CD4 T lenfosit sayılarına göre erken tanı (>350 hücre/mm³) ve geç tanı (?350 hücre/mm³) gruplarına ayrıldı. Geç tanı grubu ise CD4 T lenfosit sayısına göre 200-350 hücre/mm³ olanlar (grup 1) ve <200 hücre/mm³ olanlar (grup 2) olarak sınıflandırıldı. Hastaların %89'u erkek, medyan yaş ise 30 yıl olarak hesaplandı. Hastaların %52'si geç tanı aldı ve bu grubun daha ileri yaşta olduğu belirlendi. İleri insan immün yetmezlik virüsü hastalığı oranı %28,3'tü. Geç tanı grubunda ek kronik hastalık, fırsatçı enfeksiyon ve klinik belirtilerle tanı alma oranları daha yüksek bulundu. Bu grupta CD4 T lenfosit seviyeleri daha düşük, viral yük daha yüksek saptandı. Tedavinin altıncı ayında virolojik yanıt oranı, erken tanı grubunda daha iyi bulundu. Geç tanı grubunda immünolojik yanıt da sınırlı kaldı ve bu grupta hastaneye yatış, yoğun bakım ihtiyacı ile mortalite oranları daha yüksek bulundu. Çalışmamız Trakya bölgesindeki yüksek geç tanı oranlarının, insan immün yetmezlik virüsü ile mücadelede temel bir engel oluşturduğunu ortaya koydu. Bu kapsamda, geç başvurunun risk faktörleri belirlenmeli ve erken tanıyı artıracak tarama programları ülke genelinde yaygınlaştırılmalıdır.Human immunodeficiency virus infection remains a critical public health issue despite advance
Effects of diabetes education on the knowledge and awareness levels of classroom teachers about type 1 diabetes in Türkiye
No full textBackground: Teachers' knowledge and awareness of childhood type 1 diabetes remains limited. Aim: To evaluate the effect of diabetes education on classroom teachers' knowledge and awareness of type 1 diabetes. Methods: This quasi-experimental study with a pre-test and post-test included 87 classroom teachers (intervention = 42, control = 45) from six public primary schools in T & uuml;rkiye. Diabetes education materials developed by the International Diabetes Federation as part of the Kids and Diabetes in Schools project were translated into Turkish and used in the study. Data were collected using a Teacher Information Form, the Type 1 Diabetes Knowledge Test for Teachers, and the Type 1 Diabetes Awareness Scale for Teachers. Data were analysed using descriptive statistics, the Shapiro-Wilk test, the Chi-square test, the Mann-Whitney U test, the Wilcoxon signed-rank test, the Student's t-test. Results: Post-test mean ranks on the Type 1 Diabetes Knowledge Test for Teachers were significantly higher in the intervention group than those in the control group (p < .001). Similarly, post-test mean ranks on the total and sub-dimensions of the Type 1 Diabetes Awareness Scale for Teachers were significantly higher in the intervention group than in the control group (p < .001). Conclusion: Diabetes education significantly improved classroom teachers' knowledge and awareness of type 1 diabetes. All school personnel - especially teachers - should receive education on diabetes and its management, and the Kids and Diabetes in Schools project educational materials may be useful as part of training interventions.Scientific Research Projects Unit of Trakya University [TUBAP 2023/13]The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: this study was financially supported by the Scientific Research Projects Unit of Trakya University (Project number: TUBAP 2023/13)
Naringenin-Based Oximes and Hydrazones: Synthesis, Molecular Docking with Bovine Serum Albumin and Drug-Likeness, Admet Profiling Studies
No full textScientists are now increasingly interested in the flavonoid molecule naringenin due to the broad spectrum of biological roles it conducts. Oximes and hydrazones were created employing derivatives of the naringenin-active substances 7-piperidinethoxy and 7-morpholinethoxy to contribute to this research. The ability of the produced compounds to bind to BSA was determined by molecular docking and their potential as medications was assessed using various methods. Based on Lipinski's rule of five, none of the substances were hazardous or carcinogenic, and their blood-brain barrier crossing values were all within permissible limits