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Investigation of metoprolol molecule interaction with Si-doped carbon nanotube using the density functional theory (DFT)
No full textKarbon nanotüpler (KNT) ilaç moleküllerinin taşınmasında ve algılanmasında hem deneysel hem de teorik olarak çok çalışılan ve nanoteknolojinin birçok alt alanında kullanılan nanomalzemelerdir. Bu çalışmada metoprolol (MTP) ilaç molekülünün Silisyum katkılı karbon nanotüp (Si-KNT) ile etkileşimi ilk kez yoğunluk fonksiyonel teorisi kullanılarak M062X metodu ve 6-31G(d) baz seti ile gaz ve su fazında incelendi. MTP ile Si-KNT'ün oluşturduğu kompleks yapıların moleküler parametreleri, yapısı, bağlanma, adsorbsiyon enerjileri ve elektronik özellikleri Yoğunluk fonksiyonel teorisi (DFT) kullanılarak hesaplandı. MTP ile Si-KNT arasındaki yük transferi analiz edildi ve etkileşimlerin doğası moleküllerdeki atomların quantum teorisi yaklaşımı (QTAIM) ile belirlendi. MTP ilacı üzerinde çözücü olarak su etkisi araştırıldı. Bu tezde çalışılan, hipertansiyon tedavisinde kullanılan beta-bloker, MTP ilaç molekülünün vakum ortamında Si-KNT'ler tarafından taşınabilir ve algılanabilir olduğu; atık sularda da bu ilacı tespit etmek için sensor olarak kullanılabileceği DFT hesaplamaları ile ortaya kondu.Carbon nanotubes (CNTs) are nanomaterials that have been ex
Late HIV Diagnosis in Thrace, Turkey: A Six-Year Experience from a Border Region
No full textDespite advances in diagnosis and treatment, human immunodeficiency virus (HIV) infection still continues to be a globally important public health problem. While early diagnosis facilitates the control of the disease, late diagnosis can affect treatment success and prognosis adversely. This retrospective study evaluated the clinical and demographic characteristics of 127 treatment-naive people living with HIV who were older than 18 years of age and who were followed between 2017 and 2023 in a center in Thrace, a transitional region between Europe and Turkey, and the effects of early and late diagnosis on the course of disease were examined. It was found that 89% of the patients were male, and median age was 30 years. Of the patients, 52% had been diagnosed late, and this group was found to be older. The rate of advanced HIV disease was 28.3%. The rates of additional chronic disease (42.4%), opportunistic infection, and diagnosis with clinical symptoms were higher in the late diagnosis group. CD4 T lymphocyte levels were lower, and viral load was found to be higher in this group. At the sixth month of treatment, the rate of virologic response was found to be better in the early diagnosis group. In the late diagnosis group, immunological response was also limited, and hospitalization (40.9%), need for intensive care (12.1%), and mortality (4.5%) rates were higher in this group. These findings demonstrate the prevalence of late diagnosis in the Thrace region and its significant effects on the clinical course of HIV infection. They also emphasize the importance of targeted screening and early diagnosis strategies in border regions
Evaluation of analgesia nociception index monitoring inintracranial surgical anesthesia
No full textBiz bu çalışmada intrakranial cerrahi geçiren ve intraoperatif dönemde entropi monitörizasyonuna veya entropi monitörizasyonu ile beraber ANİ monitörizasyonuna göre genel anestezi ve analjezi yönetimi uygulanan hastalarda, peroperatif opioid tüketimi, postoperatif ağrı ve anesteziden derlenme açısından karşılaştırmayı amaçladık. Çalışmamıza Trakya Üniversitesi Tıp Fakültesi Hastanesi'nde beyin ve sinir cerrahisi tarafından 01.01.2021 ile 01.01.2024 tarihleri arasında intrakranial cerrahi uygulanan 18-80 yaş arası ASA I-II risk grubunda 75 hasta dahil edildi. Hastalar intraopetarif kullanılan monitörizasyon uygulamalarına göre; Grup ANİ (n=38) ve Grup Kontrol (n=37) olarak ikiye ayrıldı. Operasyon masasına alınan tüm hastalara entropi monitorizasyonu uygulandı. Grup ANİ 'de ağrı yönetimi için ANİ monitörizasyonu uygulandı. Hastaların bazal, indüksiyon, entübasyon, pin uygulanması, cilt insizyonu, kraniyotomi, dura açılması, kanama kontrolü, pin çıkartılması, cilt kapatılması ve postoperatif, intraoperatif dönemde ilk 20 dk'da 5 dk aralıklarla 60.dk'ya kadar 10dk aralıklarla 180.dk'ya kadar 30dk aralıklarla; ortalama kan basıncı, kalp atım hızı, SpO2, endtidal CO2, ANİ, RE, SE değerleri, cerrahinin tipi, cerrahi ve anestezi süresi, intraoperatif gereksinime göre verilen eritrosit su?spansiyonu, taze donmuş plazma miktarları, hastalara intraoperatif dönemde kullanılan anestezik ilaçlar; propofol, rokuronyum, fentanil dozu kaydedildi. Tu?ketilen toplam remifentanil miktarı infu?zyon pompasından kaydedildi. Postoperatif derlenme ünitesinde GKS, Ramsey Sedasyon Skalası, MAS>9 olma süresi değerlendirilerek kayıt edildi. Ağrı değerlendirilmesi Vizüel Analog Skala (VAS) ile yapıldı. VAS değerleri 1, 2, 4, 6, 12, 24. saatler de bakılarak her iki grupta da VAS skorları 4'ten fazla olduğunda hastalara intravenöz olarak sırası ile parasetamol, tramadol ve aldolan basamak tedavisi şeklinde verildi. Hastaların postoperatif ilk analjezi kullanılma zamanı, postoperatif ilk 24 saatte kullanılan analjezikler ve miktarları, postoperatif gelişen komlikasyonlar kaydedildi. Çalışma verileri değerlendirilirken kategorik değişkenler için frekans dağılımı (sayı, yüzde), sayısal değişkenler için tamamlayıcı istatistikler (ortalama, standart sapma) verilmiştir. İki gruba sahip kategorik değişkenler arasındaki farkın incelenmesinde bağımsız örneklem t testinden, iki sayısal değişken arasındaki ilişkinin incelenmesinde pearson korelasyon analizinden, iki kategorik değişken arasındaki ilişkinin incelenmesinde ki-kare testinden yararlanılmıştır. P9 olma süresi kontrol grubunda istatistiksel olarak anlamlı derecede daha yüksek bulundu. Postoperatif 1. saatteki VAS değerlerinin ANİ grubunda kontrol grubuna göre daha düşük olduğu bulundu. Biz de çalışmamızda ANİ monitörizasyonun kullanımıyla intraoperatif opioid tüketim miktarının azaldığını, buna bağlı olarak postoperatif ağrı skorlarının daha düşük ve postoperatif derlenmenin daha yüksek olduğunu saptamakla beraber Entropi monitörizasyonunun ağrıyı değerlendirmede tek başına yeterli olmadığını ANİ ile birlikte kullanımının hasta güvenliği için uygun olduğunu bulduk. Anahtar kelimeler: Analjezi Nosisepsiyon İndeks, İntrakranial Cerrahi, EntropiIn this study, we aimed to compare perioperative opioi
Molecular dynamics simulation study of the mechanical and protein adsorption properties of polyurethane systems
No full textÇalışmanın amacı, hidrofilik-hidrofobik ve hidrofilik sarkan zincirlere sahip poliüretan (PU) sistemlerin mekanik-termal özellikleri ve protein etkileşimlerini moleküler dinamik (MD) simülasyon yöntemini kullanarak araştırmaktır. PU kaplamaların farklı bileşenlerinin termal ve mekanik özelliklerini nasıl etkilediğini ve bu sistemlerin biyoteknolojik uygulamalarına katkıda bulunma potansiyelini araştırmaktadır. Çalışma, hidrofilik ve amfifilik PU sistemlerinin mekanik ve termal özelliklerinde belirgin farklılıklar gösterdiğini ortaya koymuştur. Aynı zamanda, PU kaplamaların deniz organizmalarının yapışkan proteinleri ile etkileşimlerini incelemek için protein-polimer etkileşim enerjileri hesaplanmış ve PU kaplamaların bu tür etkileşimlere duyarlılığı araştırılmıştır. Bu bulgular biyoteknolojik ve antifouling kaplama tasarımlarının geliştirilmesine katkıda bulunmaktadır. Ayrıca çalışma, çok ölçekli modelleme tekniklerinin moleküler düzeydeki faaliyetlere dayalı olarak makro ölçekteki özellikleri ne kadar iyi tahmin edebildiğini göstermektedir. Bulgular, çeşitli çevresel ortamlarda daha iyi performans gösteren ve gelişmiş biyo-direnç ve dayanıklılığa sahip yeni nesil PU kaplamaların mantıksal gelişimi için yararlı öneriler sunmaktadır.The aim of this study is to in
The Relationship Between Compliance with the Principles of Transparency and Best Practice and Journal Sustainability in Scientific Publishing
No full textThe sustainability of journals in Turkiye has emerged as a crucial and timely issue. This study aims to address this issue by analyzing journal sustainability using transparency principles. We delve into the relationship between principles oftransparency and best practice and journal sustainability, aiming to shed light on the importance of compliance with these principles in scientific publishing. In this study, all 45 peer-reviewed journals in Turkiye in economics and administrative sciences on the DergiPark platform were selected as the study sample to minimize confounding factors. The compliance of journal sustainability indicators of these journals in the 2015-2020 period, such as publication status (active-continuing publishing or ceased publishing), annual published volumes, annual manuscript submission numbers, annual number of published articles, rejection rates, combined volume or issue, was compared with 16 principles of transparency and best practice items. As a result of the analysis, it was revealed that the compliance of the journals with the transparency principles especially the ethical principles should be increased. It has been concluded that the high rejection rate, the publication of more issues per year, the use of the DergiPark submission system, and indexing coverage increase the sustainability of the journals
Effects of Different Treatment Modalities on Lung Injury in Experimental Pulmonary Contusion Model
No full textIntroduction: The study experimentally evaluated the efficacies of different agents in treating pulmonary contusion. Methods: In our study, 42 Wistar albino rats were divided into six groups of seven animals each. A model of lung contusion with blunt chest trauma was performed in five groups, except for the control group. One group with pulmonary contusion was considered an untreated group, and saline was administered. For other groups, prednisolone, tranexamic acid, N-acetylcysteine, and vitamin E were applied to determine their efficacy in treatment. The rats were sacrificed 24 h after trauma, and their injured lungs were collected for histopathological examination and blood samples for blood gas analysis. Histopathologically, bronchial damage, alveolar hemorrhage, emphysema, and leukocyte infiltration were assessed using the scoring system. Results: In our study, statistically significant differences were detected between the rat groups in terms of intraalveolar hemorrhage, leukocyte infiltration, and bronchial damage. In post hoc analysis, intraalveolar hemorrhage was significantly higher in the untreated group compared to the control group (P = 0.012). A near-significant difference was observed between the untreated group and the N-acetylcysteine group (P = 0.061). Regarding leukocyte infiltration, the tranexamic acid group showed significantly higher values compared to both the prednisolone and control groups (P = 0.007; P = 0.016, respectively). For bronchial damage, the levels observed in the vitamin E and tranexamic acid groups were significantly higher than those in the control group (P = 0.08 and P = 0.037, respectively). Conclusions: Many agents are used to treat pulmonary contusion, but no gold standard treatment exists. Prednisolone and N-acetylcysteine play significant roles in treatment. These two drugs contributed to the regression of the findings in pulmonary contusion treatment. 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies
Technologically supported educational arrangements in developing disaster awareness in early childhood education
No full textIn recent years, the frequency of natural disasters has increased, affecting all people, especially the most vulnerable groups. Among these vulnerable and defenseless groups, preschool children are particularly affected by natural disasters, including death and injuries, in a lasting way. Natural disasters have short-and long-term effects on preschool children. Educators and caregivers play an important role in reducing the impact of natural disasters on preschool children. These individuals can provide children with information about natural disasters, teach them coping skills, and support them. Additionally, it is important to develop disaster preparedness and response plans in schools. These plans should be designed to ensure the safety of children and help maintain their emotional well-being. Digital technology, which is becoming increasingly widespread today, can be used to protect children from the effects of disasters. It can be used for "information and education about natural disasters" before disasters and for "coping skills training," "support and communication," "assisting with normalization," and "continuation of remote learning processes" during possible disaster situations to support children's well-being. © 2025 Elsevier B.V., All rights reserved
Investigation of the pollution effect on reducing energy production in solar panels and self-cleaning with hydrophilic nano-coatings without using water
No full textThere is a growing interest in solar electricity generation in many countries worldwide. This current trend is the installation of photovoltaic (PV) panels on the roofs of independent units rather than solar power plants. However, the conversion efficiency of PV panels in solar electricity generation is declining due to the accumulation of dust and surface contamination. Furthermore, the process of cleaning PV panels placed on the roofs of residential and commercial buildings is a challenging and potentially hazardous task. In this study, the SELFCLEAN PV hydrophilic nano-coating was applied to a single PV panel on a solar energy conversion system at Trakya University Faculty of Engineering, with consideration given to the roof slopes of buildings in the Edirne Province. During the summer season, when solar radiation was at its highest levels, data were collected continuously over 4 months. As a result of this practice, it was observed that energy production increased by 8.14% in June, 7.73% in July, 6.34% in August, and 5.34% in September in comparison to the standard PV panel. Furthermore, not having to clean PV panels for over 4 months offers labor and cost advantages, while water use is not required in this process, which significantly contributes to sustainability. © 2025 Elsevier B.V., All rights reserved
Nadir Bir Olgu: Histopatoloji ve 18F-FDG PET/BT’de Erkek Primer Peritoneal Seröz Karsinomu
No full textPrimary peritoneal serous carcinoma (PPSC) is a rare malignancy that mostly affects women. In males, there are only few reports in the literature. 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) is useful for evaluating the origin of the tumor, its extent, and distant metastasis. Moreover, 18F-FDG PET/CT was helpful in distinguishing between PPSC and peritoneal carcinomatosis. We present a case of PPSC on 18F-FDG PET/CT in a male with histopathological correlation
Using Explainable Artificial Intelligence to Predict Internet Addiction in Turkish University Students
No full textThe rising incidence of internet addiction (IA) among university students has raised concerns about its impact on academic performance, mental health, and social relationships. This study aims to model internet addiction in 1,180 university students using Explainable Artificial Intelligence (XAI) methods, including SHapley Additive Explanations (SHAP). Unlike traditional statistical approaches, such as linear regression, and opaque AI models like deep neural networks, XAI offers interpretable outputs that help reveal underlying factors contributing to IA. Student demographics, internet use patterns, and psychological variables were analyzed by machine learning algorithms, and SHAP was used to interpret the models. The findings reveal key predictors of IA, such as fear of missing out (FoMO), social anxiety, and social-emotional loneliness. By using XAI, the study shows how specific traits and behaviors elevate IA risk and offers actionable insights for educators and policymakers. It also supports early detection and intervention strategies in educational and psychological contexts