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The Most Common Complications of Celiac Disease and the Impact of a Gluten-Free Diet on Their Course
Get PDFCeliac disease is a gluten-sensitive, immune-mediated enteropathy that occurs in people with a genetic predisposition and leads to inflammation in the small intestine. During its course, characteristic antibodies are produced, which together with histopathological examination of material taken from the intestine, are the main elements of the diagnostic process. Depending on the symptoms present and microscopic changes, we distinguish classical, non-classical, subclinical and potential forms. The most typical presentation, in the form of gastrointestinal symptoms includes diarrhea, abdominal pain and weight disturbances. Atypical symptom, which may involve multiple other systems, are also increasingly observed. The cornerstone of treatment is a lifelong gluten-free diet that excludes all products containing wheat, barley and rye. In most cases, it helps alleviate or resolve symptoms and regenerate the intestinal mucosa. The long diagnostic process, non-adherence to the diet and resistance to treatment pose a high risk of complications at various stages of the disease, so it is important for the patient to cooperate appropriately with the doctor and nutritionist. The purpose of this paper is to review the most common complications of celiac disease and evaluate the impact of an appropriate diet on their course. 
Balneotherapy in dermatology and rheumatology: a systematic review
Get PDFObjective: Article’s aim is to characterize what a balneology is, what it consists of. To picture actual usage of balneotherapy in different fields of medicine; its possibilities and restrictions.
Methods: A vast literature review was conducted using PubMed database. Reviewed articles included systematic reviews, randomized controlled trials, observational studies and meta-analyses. Keywords included “balneology”, “balneotherapy”, “peloid baths”, “water baths”, “balneotherapy dermatology”, “balneotherapy rheumatology”.
Conclusions: Although balneotherapy might be considered as antiquated and according to some physicians, not scientifically proven, is efficient in reducing symptoms of some dermatological and rheumatological conditions due to its anti-inflammatory, keratolytic, antimicrobial, analgesic and myorelaxant effects. Albeit its role as complement therapy, it can achieve very good results alleviating pain and reducing amount of painkillers used, extending periods of remission or quality of live and well-being improvement.  
The relationship between rheumatoid arthritis (RA) and psychiatric disorder
Get PDFRheumatoid arthritis (RA) is a chronic autoimmune disease that has a destructive effect on the joints, but also leads to many systemic complications, including mental disorders. This review will present the co-occurrence of mood disorders, such as depression, anxiety and cognitive disorders, in patients with RA and analyze the potential pathophysiological mechanisms. The impact of chronic inflammation and proinflammatory cytokines (IL-6, IL-1β, TNF-α) on the central nervous system and the hypothalamic-pituitary-adrenal axis (HPA) will be discussed. When rheumatoid arthritis (RA) is accompanied by mental health disorders, treatment methods used for RA may be less effective. This can make the condition harder to manage, increasing pain and reducing the quality of life. Additionally, the paper will present the impact of pain, fatigue and reduced physical fitness on the deterioration of the mental health of patients. In addition to the pharmacological treatment used for RA, which is also not neutral to patient’s health, additional therapeutic options such as psychological interventions will be discussed. Considering both somatic and psychological aspects, an interdisciplinary approach to the treatment of patients with RA is very important
The Effect of a Ketogenic Diet on Human Health and Diseases: A Literature Review
Get PDFIntroduction and Aim. The ketogenic diet (KD), rich in fats and low in carbohydrates, induces a state of ketosis and metabolic changes. Used for over a century in epilepsy treatment, it is also gaining popularity in the therapy of other conditions, including metabolic, cardiovascular, oncological, and neurodegenerative diseases. The aim of this work is to review the literature concerning its effects, applications, and potential adverse effects.
Methods. A review of PubMed and Google Scholar databases from the last five years was conducted, focusing on clinical studies, meta-analyses, and systematic reviews, using keywords: "ketogenic diet", "ketogenic diet and health”, "ketogenic diet mechanisms" and “ketogenic diet adverse effects”.
State of Knowledge. The KD promotes weight loss and improves glycemic control in patients with type 2 diabetes, and in type 1 diabetes, it may reduce insulin requirements; however, caution is necessary due to risks of hypoglycemia and ketoacidosis. The effects on lipid profiles are inconclusive. The diet can support cancer treatment by limiting glucose and insulin availability and exhibits neuroprotective effects in neurodegenerative diseases such as drug-resistant epilepsy, Alzheimer’s disease, and Parkinson’s disease. However, it may also be associated with side effects such as constipation, hypoglycemia, kidney stones, and lipid disturbances.
Summary. The KD has therapeutic potential but requires monitoring, especially with long-term use, due to possible adverse effects. Further research is needed to assess its long-term efficacy and safety, particularly in the treatment of neurodegenerative and oncological diseases, to fully evaluate its therapeutic potential
Gene therapy in cardiomyopathies - Review of the latest reports
Get PDFIntroduction and purpose
Gene therapy appears to be a promising treatment for patients with cardiomyopathy and innovative therapeutic option. The aim of this review is to present the latest gene therapy technologies, innovations, research in the treatment of cardiomyopathy and analysis of the ethical issues associated with the use of modern therapies.
Material and methods
This review is based on recent articles from the years 2020-2025 found in databases such PubMed, Elsevier.
Results
Gene editing through CRISPR-Cas technology allows for the modification of genetic material by making changes at precise locations what is highly useful in gene therapy. Gene Expression Regulation (RNAi) involves preventing the production of proteins by silencing a faulty gene. Antisense therapy (ASO) uses antisense oligonucleotides to exclude a particular exon and causes the translation process to stop. Gene replacement involves introducing a healthy copy of a mutated gene into the genome along with an appropriate vector.
Conclusions
Individual technologies in the treatment of cardiomyopathy show potential for treating patients in the future. It is also important to remember the ethical issues when using solutions based on gene therapy. Clinical trials in the future are necessary to further search for solutions for patients with cardiomyopathy
Polycystic Ovary Syndrome – A Clinical and Psychosocial Perspective
Get PDFPolycystic Ovary Syndrome (PCOS) is one of the most common endocrinopathies among women of reproductive age, characterized by a complex etiology and diverse clinical presentation. The aim of this paper is to present the current state of knowledge regarding the definition, diagnostic criteria, and differential diagnosis of PCOS, as well as to discuss treatment methods—both non-pharmacological and pharmacological. Particular attention is given to psychological aspects, which are often overlooked in clinical practice, despite their significant impact on the course of the disease and the quality of life of affected women. Women with PCOS more frequently experience depressive and anxiety disorders, along with low self-esteem, which can substantially hinder effective treatment and worsen prognosis. This paper emphasizes the need for a holistic approach to PCOS patients, taking into account not only somatic symptoms but also psychological and emotional needs, as a prerequisite for effective and long-term therapy
Yerba Mate: The Natural Boost Your Body Craves
Get PDFIntroduction: Yerba Mate (Ilex paraguariensis) is a traditional South American infusion known for its stimulant and antioxidant properties. Historically consumed for its energizing effects, it was also regarded as a medicinal remedy by indigenous cultures, used to treat fatigue, stress and digestive issues [1, 2]. In recent decades, Yerba Mate has gained global recognition and has garnered scientific interest due to its potential health benefits such as improving cardiovascular health, metabolic function and supporting physical performance [1–5]. Its rich content of polyphenols, xanthines and saponins may contribute to a range of protective and restorative effects on the human body [1, 8].
Purpose of the work: The aim of this study is to evaluate existing research on the effects of Yerba Mate consumption on human health and athletic performance, with a focus on its antioxidant activity, metabolic support and cardiovascular benefits.
Materials and methods: A comprehensive literature review was conducted using PubMed, Scopus, Google Scholar and Science Direct databases, encompassing clinical studies, randomized trials and relevant animal model research on the bioactive effects of Yerba Mate.
Results: This review indicates that Yerba Mate may support lipid metabolism, reduce oxidative stress and improve cardiovascular markers [3–5, 7, 8]. Furthermore, its caffeine content and phytochemical profile may serve as a natural alternative to synthetic stimulants used by athletes [1, 5, 13]. Nonetheless, more rigorous clinical trials are needed to fully establish its efficacy and safety profile in athletic and general populations
Interdisciplinary Educational and Physical Activity Interventions as Supportive Care Strategies for Women with Gynecological Cancers: A Comprehensive Review
Get PDFPurpose: This review synthesizes current evidence on supportive care strategies aimed at improving the quality of life (QoL) for women undergoing treatment for gynecological cancers. It addresses physical, psychological, and socio-demographic factors influencing outcomes and explores evidence-based interventions, including physical activity, mindfulness, trauma-informed care, and eHealth technologies.
Methods: A comprehensive literature review was conducted, examining studies focusing on supportive care interventions, psychological assessment tools, exercise programs, mindfulness techniques, and the influence of socio-demographic variables on health outcomes in women with gynecological cancers.
Results: The review highlights the significant burden of gynecological cancers on women's physical and psychological well-being. Effective supportive care strategies include tailored exercise programs, mindfulness-based interventions, trauma-informed care, and addressing sexual health concerns. Moreover, the importance of customized psychological support, interventions to promote adaptive coping skills, and eHealth approaches is highlighted. The review also identifies the influence of socio-demographic factors such as age, BMI, race/ethnicity, and socio-economic status on access to care and outcomes.
Conclusion: This review underscores the need for comprehensive, integrated, and personalized supportive care strategies to enhance the quality of life for women with gynecological cancers. Future research should prioritize large-scale randomized controlled trials, studies on specific populations, and the integration of artificial intelligence and interdisciplinary collaboration to optimize personalized treatment approaches
Anorexia nervosa: Trapped between Mind and Body: An Analysis of Causes, Symptoms, and a Holistic Approach to Therapy
Get PDFAnorexia nervosa is a serious eating disorder marked by an intense fear of gaining weight and a distorted body image, leading to extreme food restriction and dangerous weight loss. It most commonly affects adolescents and young adults, particularly women. The causes of anorexia are complex, involving a combination of genetic, psychological, and socio-cultural factors. Key symptoms include significant weight loss, obsessive thoughts about food, and excessive physical activity. Effective treatment requires a multidisciplinary approach, integrating medical stabilization, nutritional support, psychotherapy, and, when necessary, pharmacotherapy. Long-term care and relapse prevention are essential for sustained recovery. Raising public awareness and promoting healthy body image is vital in preventing anorexia and its complications. This article explores the causes, symptoms, and treatment options for anorexia nervosa, highlighting the importance of early intervention in improving outcomes
The application of ketamine in pain management for sports injuries and other medical conditions - literature review
Get PDFIntroduction: Ketamine is a well-established dissociative anesthetic. The discovery of its NMDA receptor antagonism revealed new potential applications in pain management. It has demonstrated promise as an analgesic for the treatment of chronic pain and has proven useful in managing acute pain, such as that resulting from sports injuries or in pediatric care settings. It is also a valuable alternative for patients who have not responded well to traditional pain medications.
Materials and methods: This article reviews promising role of ketamine in pain management, especially in chronic or cancer pain, incorporating data from Google Scholar, PubMed, using keywords such as „ketamine”,„chronic pain”, „acute pain”, „pain management”.
Summary: Current evidence supports the use of subanesthetic ketamine as an effective option for acute pain management across various clinical settings, with potential to reduce opioid dependence. Its unique antidepressant properties also make it beneficial for chronic pain patients, especially those with comorbid depression. In conditions like CRPS and sickle cell disease, low-dose ketamine has shown promising results in improving pain and function. However, its effectiveness in fibromyalgia appears limited, with short-term infusions offering only temporary relief. The pediatric population may particularly benefit from ketamine’s rapid, intranasal administration, though dosing and safety must be carefully considered. While early findings are encouraging, more research is needed to establish optimal protocols and to explore its role in managing sport-related injuries.
Conclusions: Ketamine finds various applications in pain therapy and is a promising medication due to its efficacy in both chronic and acute pain management. However, further research is necessary to precisely determine the therapeutic dosage ranges, the long-term effects of its use, and the risk of addiction associated with its administration