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Improvement of lipid profile after 6 months of self-initiated, multicomponent physical activity in a previously inactive 62-year-old patient: a case report
Full text linkBackground: Hypercholesterolemia has become one of the main, modifiable risk factors to develop atherosclerotic cardiovascular diseases.Diet modification and lipid‑lowering pharmacotherapy are standard of care, but some patients decline these options. Regular physical activity can improve lipid profile and blood pressure without any medications and diet .
Aim: To evaluate the effect of regular, multicomponent physical activity, without concurrent dietary change or pharmacotherapy on lipid profile, blood pressure and body mass in a previously inactive 62‑year‑old man.
Material and methods: A 62‑year‑old male patient with elevated total cholesterol (TC) and LDL‑cholesterol (LDL‑C) , previously sedentary, declined diet modification and lipid‑lowering medications. In April 2025 he initiated a multicomponent program: running ( 5 km, three times per week), swimming (twice per week), and resistance training (twice per Results: Over 6 months, TC decreased from 217 to 174 mg/dL (−19.8%; 5.61 to 4.50 mmol/L), LDL‑C from 147 to 116 mg/dL (−21.1%; 3.81 to 3.00 mmol/L), and HDL‑C increased from 49 to 54 mg/dL (+10.2%; 1.27 to 1.40 mmol/L). Non‑HDL cholesterol declined from 168 to 120 mg/dL (−28.6%; 4.35 to 3.10 mmol/L). Blood pressure decreased from 135/85 to 122/80 mmHg, and body mass from 85 to 83 kg (−2.4%).
Conclusions: In this previously inactive adult, 6 months of systematic, multicomponent physical activity without dietary or pharmacologic changes was associated with clinically meaningful improvements in LDL‑C, non‑HDL cholesterol, HDL‑C, blood pressure and body mass. The case supports multicomponent exercise as a practical, non‑pharmacologic intervention in primary prevention for patients declining standard lipid‑lowering strategies
Sensory Decline and Cardiovascular Risk in Older Adults: Psychosocial and Communication-Mediated Pathways – A narrative review
Full text linkBackground:Hearing loss affects roughly 65% of adults aged 70 and older, vision impairment 20–30%, and dual sensory loss becomes more common with age. Meta-analyses show that these forms of sensory decline are associated with higher risks of hypertension, stroke, coronary heart disease, and cardiovascular mortality, even after adjustment for traditional cardiovascular risk factors. Shared vascular pathology explains part of these associations, but psychosocial and communication pathways may also contribute.
Aim:To summarize evidence on psychosocial and communication-mediated mechanisms linking sensory decline to cardiovascular risk in older adults and to outline an integrated conceptual model.
Material and Methods:A narrative review was conducted using targeted searches of PubMed and Google Scholar. Meta-analyses, cohort studies, and relevant qualitative and mechanistic literature were included. Findings were synthesized qualitatively.
Results:Sensory impairment increases cognitive and communicative demands, which may heighten chronic stress and influence neuroendocrine and inflammatory pathways linked to cardiovascular disease. Reduced sensory input limits social participation and contributes to social isolation and loneliness, both established cardiovascular risk factors. In healthcare settings, communication barriers can impair symptom reporting, treatment adherence, and management of complex cardiovascular regimens. These pathways complement biological mechanisms and help explain persistent associations between sensory decline and cardiovascular outcomes.
Conclusions:Psychosocial and communication mechanisms appear to be modifiable contributors to cardiovascular vulnerability in older adults with sensory impairment. Potential strategies include routine sensory screening, communication-accessible care, and interventions addressing isolation and stress. Randomized trials are needed to determine whether sensory interventions can reduce cardiovascular events
Hypertrophic Cardiomyopathy in Athletes: A Paradigm Shift in Exercise Safety, the Role of Comorbid Factors, and the Impact of Anabolic Steroids - A Literature Review
Full text link Hypertrophic cardiomyopathy (HCM) in athletes is a complex condition requiring individualized risk assessment and interdisciplinary management. Advances in diagnostics, including advanced cardiac imaging and multiparametric risk stratification, allow differentiation between pathological hypertrophy and physiological adaptations in athletes. Current guidelines support carefully supervised participation in moderate and, in selected cases, high-intensity physical activity for low-risk patients. Targeted therapy, particularly the myosin inhibitor mavacamten, improves left ventricular outflow gradients, exercise tolerance, and quality of life, especially when combined with personalized training programs. Chronic use of anabolic-androgenic steroids can induce HCM-like cardiomyopathy, promote fibrosis, impair diastolic function, and increase arrhythmic risk, highlighting the need for thorough history-taking and advanced imaging. Comorbidities such as hypertension, obesity, and coronary artery disease exacerbate remodeling and arrhythmic risk, while complications like atrial fibrillation, HFpEF, and sudden cardiac death remain critical considerations. An integrated approach combining diagnostics, therapy, exercise guidance, and management of comorbidities allows safer and more flexible physical activity for athletes with HCM
Cenna monografia na temat historii Specjalnego Sądu Karnego w Katowicach
Full text linkThis article is a review of Adam Dziurok’s book on the activities of the special judiciary at the regional level in Poland, focusing on Upper Silesia in 1945–1946. The Special Criminal Court in Katowice became part of Poland’s post-war history, mainly due to the trials of those who collaborated with Germany during the Second World War.Artykuł recenzyjny dotyczy monografii Adama Dziuroka na temat działalności sądownictwa specjalnego w Polsce w wymiarze regionalnym na przykładzie Górnego Śląska w latach 1945–1946. Specjalny Sąd Karny w Katowicach wpisał się w powojenną historię Polski, głównie z uwagi na rozliczenia współpracy z Niemcami z okresu II wojny światowej
The Impact of Drinking Water Fluoride on the Risk of Hypothyroidism Development: A Review of the Latest Research
Full text linkIntroduction and purpose: Thyroid diseases are common endocrine disorders, with hypothyroidism being the most frequently diagnosed condition of the gland. Water fluoridation is an effective strategy for preventing dental caries, as confirmed by epidemiological studies. Despite the reported benefits, there are concerns about the risk of thyroid dysfunction with high fluoride exposure. The aim of this paper is to review the latest research on the impact of fluoride in drinking water on the risk of developing hypothyroidism.Materials and methods: A literature search was conducted using the medical databases PubMed and Google Scholar. Articles were retrieved in English, employing the keywords: “hipothyroidism”, “thyroid function”, “water fluoridation”, “fluoride”, “iodine”.State of Knowledge: Hypothyroidism affects approximately 4% of Europeans, with an annual incidence of 226 cases per 100,000 people. Drinking water is the main source of chronic fluoride exposure, and over 500 million people live in areas of endemic fluorosis. Numerous studies indicate a clear correlation between fluoride concentration in water and TSH levels, suggesting that excessive fluoride exposure increases the risk of hypothyroidism, which can have serious health implications, especially for pregnant women.Summary: Recent studies confirm the correlation between fluoride exposure and the development of hypothyroidism, emphasizing the need to monitor the impact of fluoride on health
The impact of obesity on clinical outcomes in acute pancreatitis: a systematic review
Full text linkBackground:
Obesity may influence the severity of acute pancreatitis (AP) by intensifying inflammatory and metabolic disturbances. However, evidence is inconsistent due to differences in patient characteristics and AP causes. Clarification is needed to determine if obesity reliably predicts severe AP and complications.
Aim:To evaluate the association between obesity, disease severity, complications, and clinical outcomes in AP.
Methods: We conducted a systematic review of observational studies following PRISMA guidelines. We searched databases for studies on adult AP patients assessing obesity or BMI in relation to disease severity, organ failure, local complications, ICU admission, or mortality. We excluded studies on visceral adiposity indices only, pediatric cohorts, non-original publications, and non-RCT/non-observational designs.
Results: Eleven studies met the inclusion criteria. Most reported that obesity is linked with increased AP severity and higher rates of systemic or local complications, such as organ failure, necrosis, and greater healthcare utilization. Large database studies confirmed increased complication rates in obese patients. However, findings regarding mortality were inconsistent: some studies noted higher mortality in overweight individuals, others showed no difference. Studies using BMI as a continuous variable found a consistent association between higher BMI and increased AP severity.
Conclusions: Obesity appears to be associated with more severe AP and selected complications, but its link to mortality remains unclear. BMI alone shows limited predictive value and should be interpreted alongside other clinical data. Further research is required to standardize the incorporation of obesity into early AP risk assessment
Zastawy jagiellońskie na Mazowszu do 1506 roku – zarys problematyki
Full text linkThe article concerns the pledging of royal property by three rulers from the Jagiellonian dynasty (Casimir IV Jagiellon, John I Albert and Alexander Jagiellon) in parts of Mazovia that were incorporated into the Kingdom of Poland in the 15th century. Emphasis is placed on attempting to take a broader view of the policy of pledging pursued by these rulers.Artykuł dotyczy zastawów dóbr monarszych dokonanych przez trzech władców z dynastii Jagiellonów (Kazimierza IV, Jana Olbrachta oraz Aleksandra Jagiellończyka) w częściach Mazowsza, które zostały włączone do Korony w XV w. Nacisk położony został na próbę szerszego spojrzenia na prowadzoną przez tych władców politykę zastawów
The role of the gut microbiota in childhood obesity
Full text linkThe gut microbiota has emerged as an important factor influencing metabolic health of people. Recent research indicates that children with obesity present distinct microbial compositions compared with their normal-weight peers, suggesting a potential role of intestinal microorganisms in the development adiposity. This paper discusses current findings on how dietary patterns, perinatal exposures and inherited microbial traits shape the gut microbiome in childhood. Particular attention is given to taxa associated with metabolic alterations, as well as to microbial metabolites that may influence energy balance and inflammation. Studies linking the gut microbiota to anthropometric measures and early markers of cardiovascular dysfunction highlight its potential value as a diagnostic tool. Understanding these complex host–microbe interactions may contribute to the development of targeted microbiota-based interventions and personalized therapeutic strategies aimed at preventing or treating childhood obesity
Education, Physical Activity, and Reproductive Health in Women: Understanding the Impact of the Vaginal Microbiome
Full text linkBackground. The vaginal microbiome is essential for women’s reproductive health, affecting fertility, implantation, pregnancy outcomes, and vulnerability to gynecological conditions. It is increasingly recognized within the broader context of women’s health literacy and lifestyle, including physical activity, which may influence microbial balance.
Aim. To summarize current evidence on the composition and clinical importance of the vaginal microbiome while integrating insights from public health, health education, and sports science.
Material and methods. A review of open access studies published between 2021 and 2025 identified 23 eligible articles. Additional literature on women’s health education and physical activity was included to highlight interdisciplinary links.
Results. Lactobacillus-dominant communities, especially those enriched with Lactobacillus crispatus, support mucosal stability and favorable reproductive outcomes. Dysbiosis, characterized by low Lactobacillus levels and high microbial diversity (CST IV), is linked to bacterial vaginosis, subfertility, implantation failure, and preterm birth. Education and lifestyle-focused interventions may help mitigate dysbiosis, while early evidence suggests physical activity supports systemic regulation relevant to microbial stability.
Conclusions. The vaginal microbiome significantly influences reproductive and overall health. Integrating microbiome knowledge into health education and lifestyle promotion may improve preventive strategies and clinical outcomes