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Physical activity as part of therapy of spondyloarthropathy - review
Full text linkSpondyloarthropathy is a group of chronic inflammatory diseases involving the sacroiliac joints and spine. Due to the prevalence of spinal pain, its diagnosis is often delayed for up to several years. If left untreated, it leads to a significant deterioration of the patient's quality of life, disability, and eventually premature death. At present, there are drugs with which the disease activity can be effectively controlled, although some of them are not widely used due to their high cost. Despite the development of modern technology and the increasing spectrum of available therapies, rehabilitation and exercise still remain one of the basic elements of treatment. This article discusses and evaluates various forms of physical activity in terms of their effects on disease activity, joint and non-joint complaints, inflammatory markers and patient well-being. The most important conclusion of the analysis is that physical activity is safe for patients and it is never too late to start
Urolithiasis: Comprehensive Review of Etiology, Diagnosis and Treatment
Full text linkUrolithiasis, commonly referred to as kidney stone disease, is a prevalent and recurrent urological condition with significant global health and economic implications. The formation of urinary calculi results from a multifactorial interplay between genetic predisposition, metabolic abnormalities, dietary habits, and environmental factors. The incidence of urolithiasis has been rising worldwide, particularly in developed countries, contributing to an increasing burden on healthcare systems.
This review provides a comprehensive analysis of the etiology and risk factors associated with kidney stone formation, including dietary and non-dietary contributors such as high animal protein intake, calcium and oxalate metabolism, obesity, diabetes, and climate influences. Advances in diagnostic modalities, particularly the role of non-contrast computed tomography (CT), ultrasonography, and metabolic evaluation, have improved early detection and classification of urinary stones.
Treatment options range from conservative medical management to surgical interventions, including extracorporeal shock wave lithotripsy (ESWL), ureteroscopy (URS), and percutaneous nephrolithotomy (PCNL), with evolving techniques enhancing stone clearance and minimizing recurrence. Furthermore, lifestyle modifications, adequate hydration, and pharmacological interventions play crucial roles in the prevention of recurrent stone formation.
The growing prevalence of urolithiasis underscores the need for continuous advancements in both preventive and therapeutic strategies. Further research into stone pathophysiology, metabolic risk assessment, and novel treatment modalities is essential to reduce morbidity and healthcare costs associated with this condition
Research on the cultivation system of college campus football reserve talents from the perspective of integration of sports and education
Full text linkWith the rapid development of football in our country and the country's increasing emphasis on the training of football talents, establishing an effective environment for the development of talents has become the key to improve the level of campus football. Under this background, the training of college campus football reserve personnel is faced with many challenges, such as the single training mode, the insufficient integration of resources and so on. Starting from the aspects of training concept renewal, curriculum system construction, teacher team construction, site facility guarantee, this study focuses on the construction path of college campus football reserve talent cultivation system from the perspective of sports and education integration. Through the research, it is found that constructing a scientific and reasonable training system is of great significance to improve the quality of college football reserve talents, which not only provides strong support for the development of college football, but also helps to promote the students' physical and mental health and all-round development, and lays a solid foundation for the long-term development of football cause in our country
COVID-19 Sequelae: Long-Term Impairments in Physical Performance
Full text linkIntroduction: Five years ago, the world faced the COVID-19 pandemic. The rapidly spreading disease necessitated extensive research by scientists and physicians on symptom progression, therapeutic options, and, most importantly, complications associated with the infection. Some of the most common post-COVID-19 complications affect the ability to return to physical activity and subsequent physical performance. Although the acute phase of infection tends to present with mild symptoms in physically active individuals, the resulting complications can be far more disruptive, significantly impairing the recovery process and the ability to resume training.
Aim of the study: The aim of this study is to review the available literature to analyze potential COVID-19 complications and their impact on physical performance and return to play (RTP).
Materials and methods: A comprehensive review of the literature available across reputable databases including PubMed, Scopus, Google Scholar, Embase and Cochrane Library. The study was conducted using a systematic search of keywords, including "COVID-19", “post- COVID”, “return to play”, "myocarditis", "athletes," "long COVID-19", "physical performance", “Fatigue” and “exercise tolerance”.
Results and conclusion: Physically active individuals tend to experience a milder acute phase of infection; however, they are also affected by complications resulting from the disease. Cardiovascular and respiratory complications, along with chronic long-COVID syndrome, reduce physical performance and delay the return to peak fitness. It is crucial to reintroduce training gradually and conduct thorough monitoring of the patient's condition, despite the desire for a rapid return to exercise
Use of amitriptyline, bupropion and agomelatine in the treatment of non-depressive disorders: a review of mechanisms and therapeutic indications
Full text linkIntroduction
Antidepressants such as amitriptyline, bupropion and agomelatine are widely used not only in the treatment of depression, but also in other conditions. Their mechanisms of action affect different neurotransmitter systems, allowing their use in the treatment of pain, addiction or sleep disorders. Amitriptyline, which is a tricyclic antidepressant, has strong analgesic effects. Bupropion, a dopamine and norepinephrine reuptake inhibitor, helps in the treatment of addiction and ADHD. Agomelatine, a melatonin receptor agonist, has been shown to regulate diurnal rhythms, making it useful in the treatment of insomnia and other sleep disorders.
Aim of the Study
The aim of this study is to analyse the use of amitriptyline, bupropion and agomelatine in the treatment of conditions other than depression, with a focus on their mechanisms of action and clinical efficacy.
Materials and Methods
An analysis of PubMed papers was conducted using keywords: antidepressants, tricyclic antidepressants, SSRI, amitriptyline, bupropion, agomelatine.
Basic Results
Amitriptyline is highly effective in the treatment of neuropathic pain, migraines and insomnia due to its potent action on serotonin and histamine receptors. Bupropion is used in the treatment of nicotine addiction and ADHD, as it acts on the dopaminergic and noradrenergic systems to improve concentration and impulse control. Agomelatine, as a melatonin receptor agonist, is used to regulate diurnal rhythms, making it helpful in the treatment of sleep disorders and adaptation to time zone changes. Each of these drugs has unique properties that go beyond their primary use in depression
Acute appendicitis in children - review focused on diagnostics and treatment
Full text linkIntroduction and ObjectiveAppendicitis is one of the most common surgical conditions in both children and adults.There are numerous diagnostic tools available, as well as a variety of treatment options,including both pharmacological and surgical methods. This summary focuses on the currentknowledge regarding the disease, its diagnosis and treatment.Review MethodsA literature review was conducted using the PubMed database to gather information onappendicitis. The main search term used was "appendicitis," with the review specificallyconcentrating on the diagnosis and treatment of the condition.Description of the State of KnowledgeDiagnosing appendicitis involves taking a medical history, performing a physicalexamination, conducting laboratory tests, and using imaging, which also help assess theseverity of the condition. Treatment options range from antibiotic therapy to open surgery andlaparoscopic appendectomy.ConclusionsThe analysis of the review suggests that both diagnosis and treatment depend on variousfactors, with the patient's clinical presentation and the surgeon's experience being among themost important. Treatment approaches are continually evolving, such as with thedevelopment of different laparoscopic techniques, including one-incision laparoscopicappendectomy in addition to the conventional three-incision method. However, moretraditional treatments, like antibiotic therapy and open appendectomy, remain in use.Key words: appendicitis; children; diagnostics; treatment; appendectom
Health from the roots - benefits of ginseng supplementation
Full text linkBackground: Ginseng has been used in traditional Chinese medicine for thousands of years as a cure for various diseases. The term “ginseng” is a popular name for herbal drugs that are based on the roots of several distinct species of plants, mainly Korean or Asian ginseng (Panax ginseng C.A. Meyer) and American ginseng (Panax quinquefolius). In this study, we aimed to analyze the health benefits of ginseng.
Materials and methods: We analyzed publications found in PubMed and Google Scholar. Articles were selected on the basis of keywords such as “ginseng’’, “Panax ginseng”, “ginsenosides”, and “health benefits”. For the final analysis, the eligible articles were published from 2010--2024.
Results: All of the research findings regarding the benefits of ginseng on cognitive function are consistent with their results. Ginseng supplementation has a positive effect on cognition in humans. Seniors are the group of patients who benefit the most from ginseng. Additionally, studies have suggested positive effects on obesity, coronary disease and diabetes.
Conclusions: Panax ginseng supplementation can be recommended for patients, as it seems to be relatively safe for them and has several positive effects on health. Further studies are needed to investigate the influence on human health better
Studying the impact of professional constraints and challenges on job well-being and employee motivation in sports clubs during the COVID-19 pandemic
Full text linkToday, the world is facing the Corona crisis and the changes it has created. The aim of this study was to investigate the stress and job satisfaction of Iranian sports clubs during the Covid 19 pandemic. This research is applied in terms of purpose and survey type in terms of data collection method. The statistical population of this study is all employees of sports clubs who were selected using Morgan table and available sampling method (due to limitations and compliance with health protocols). Finally, 304 questionnaires were used in statistical analysis. In order to analyze the data obtained from the implementation of the research tool, the structural equation model, PLS software was used. Findings showed that job stress has a positive and significant effect on job satisfaction and also the results indicate the need for proper management to reduce the risk and reduce job stress of employees and also increase employee satisfaction. In the era of Corona and with the current economic and health problems, as well as the inability to predict the disappearance of this disease, you should think of more appropriate measures as soon as possible with regard to the activity of reopening sports venues
Autism spectrum disorder: definition, global epidemiology, prevalence in Poland and worldwide, and heredity
Full text linkIntroduction: The understanding of autism spectrum disorder (ASD) has evolved significantly. First mentioned in 1911, autism was described as "early childhood autism" by Leo Kanner in 1943, and a milder form, Asperger syndrome, was outlined by Hans Asperger in 1944. Expanding diagnostic criteria have led to increased recognition, with prevalence rising from 1 in 2,000 children in the 1980s to about 1 in 100 today. This growth is attributed to improved diagnostics, awareness, and healthcare access. While its exact causes remain unknown, ASD risk is influenced by genetic, environmental, prenatal, and perinatal factors, with genes like SHANK3, CHD8, and FMR1 playing key roles.
The aim of the study: This study aims to provide a comprehensive overview of autism spectrum disorder by examining its definition, historical context, epidemiology, and heredity. Special attention is given to global prevalence rates, with a focus on comparative trends in Poland, as well as genetic advancements shaping our understanding of this condition.
Material and method: In our article we used English databases such as PubMed and Google Scholar. We selected the articles according to keywords such as “ASD”, “autism”, “history of autism”, “epidemiology”, “inheritance”, “genetic”. The articles we used were published from 1943, mainly 2019-2024.
Conclusions: ASD is a complex condition influenced by genetic and environmental factors. Advances in diagnostics and awareness have led to increased prevalence rates globally. Genetic studies highlight key hereditary components, offering insights for early intervention. Ongoing research and culturally tailored strategies are essential to improve diagnosis, support, and quality of life for individuals struggling with this condition
PARP Inhibitors in the Treatment of Ovarian Cancer: a review of the latest research
Full text linkIntroduction
Ovarian cancer is a leading cause of cancer mortality globally due to late-stage diagnosis and limited treatment options. PARP inhibitors have shown promise as effective treatments for recurrent and various stages of ovarian cancer.
Aim of the Study
This study reviews the efficacy and application of PARP inhibitors in ovarian cancer treatment over the past 15 years, focusing on literature from the PubMed database post-2009 and considering FDA and EMA guidelines.
Review methods
A literature review was conducted using the PubMed database, focusing on studies published after 2009. The review also incorporated recommendations from the FDA and the European Medicines Agency regarding the use of PARP inhibitors in ovarian cancer treatment.
Results
The findings highlight the substantial impact of PARP inhibitors on ovarian cancer treatment, improving PFS and overall outcomes. Olaparib, niraparib, and rucaparib have become integral to ovarian cancer management, offering effective options for patients with BRCA mutations or homologous recombination deficiencies. These inhibitors have been validated in multiple clinical trials, underscoring their robustness and effectiveness. Combination therapies, such as olaparib with bevacizumab, further enhance therapeutic outcomes, showcasing the potential for synergistic effects.
Summary
PARP inhibitors represent a significant advancement in ovarian cancer treatment, offering improved survival outcomes for patients with specific genetic profiles. Their integration into standard care protocols underscores their importance and efficacy, providing valuable therapeutic options in the fight against ovarian cancer