Akademicka Platforma Czasopism
Not a member yet
37874 research outputs found
Sort by
Alpha 1 Antitrypsin Deficiency Pathophysiology, Symptoms, Diagnosis, Treatment
Full text linkIntroduction: This review paper aims to emphasize how Alpha-1-antitrypsin deficiency is how can lead to serious disease states, indicating the pathophysiology, symptoms, diagnostic possibilities, therapeutic methods and proving that early diagnostics for this deficiency can protect the patient from its serious consequences
Materials and methods: A review of chosen literature in the PubMed database was conducted, using the following keywords: „Alpha-1-antitrypsin deficiency”, „Alpha-1-antitrypsin”
Summary: Alpha-1-antitrypsin deficiency is a relatively common condition that is often overlooked in diagnostic evaluations. It can lead to serious health complications, substantially reduce quality of life, and even shorten a patient's lifespan. Early diagnosis is essential because it allows for the adoption of healthier lifestyle habits and more consistent health monitoring, which can help mitigate the condition’s long-term consequences.
Conclusions: Symptoms of alpha-1 antitrypsin deficiency are quite prevalent and can affect individuals across all age groups—from infants and children to adults and the elderly. This deficiency may lead to serious complications, including COPD, emphysema, asthma, liver cirrhosis, hepatocellular carcinoma (HCC). A deep understanding of its pathophysiology has enabled the development of improved diagnostic techniques and novel treatment strategies. For instance, in young adults with COPD and children exhibiting signs of liver disease, it is advisable to measure alpha-1 antitrypsin levels or perform genotyping. In cases where a significant deficiency is detected, initiating replacement therapy and closely monitoring the patient's health is crucial
Effectiveness of Open, High and Low Prices in Stock Market Price Prediction
No full textStock market price prediction is vital for investment decision amid difficulties with effective price predictions. The paper aims to analyse the rate of effectiveness in actual stock market price prediction using the open, high and low prices. The paper draws insight from diverse prior research with assorted models such as Markov Chain, time series and computer aided stock price prediction. The paper’s approach is quantitative with forty-three days stock market price data from S&P500 and Shanghai Composite Index. Data was analysed with the regression statistics. Results show that the open, high and low prices can significantly predict the actual market price at probability level of P<0.0001 for both the S&P500 Index and the Shanghai Composite Index. Prediction rates exceed 70% for S&P500 and over 80% for Shanghai Composite Index. The model was verified by using data other observation periods (during the COVID-19 and during the financial crisis). The implication therefore is that in the absence of other expensive market information, an average investor may use the open, high and low prices to make a useful prediction of actual stock market price. The findings present a useful case reading for academics in business schools and offer an agender for future research to apply this model in other stock markets. The paper offers a novel value from the finding by demonstrating that the showing that application of open, high and low prices with regression may give a prediction accuracy rate of over eighty percent, which is higher than reported seventy percent prediction rate in prior work that used other models
Modular Cleaning Program w praktyce : Przykłady zastosowania na Wydziale Konserwacji i Restauracji Dzieł Sztuki krakowskiej ASP
Full text linkThe article discusses the Modular Cleaning Program, an aqueous system for cleaning painted surfaces. The first part presents basic theoretical concepts, the method’s workflow, and its potential applications. The second part describes the current practice of using MCP at the Faculty of Conservation and Restoration of Works of Art at the Academy of Fine Arts in Kraków, showing six conservation projects conducted as part of master’s theses in the years 2022/2023. These projects focused on the conservation and restoration of oil and tempera paintings on wood and canvas, wooden and stone sculptures, and contemporary art. Each case study describes the cleaned paint layer and types of removed materials, presents a series of cleaning tests, and presents the results. In the summary, conclusions regarding the application of the system were gathered.Artykuł omawia metodę oczyszczania warstwy malarskiej i usuwania nawarstwień za pomocą środków wodnych według systemu Modular Cleaning Program. W pierwszej części przedstawiono podstawowe zagadnienia teoretyczne, sposób pracy z programem i jego możliwe zastosowania. Druga część opisuje dotychczasową praktykę stosowania MCP na Wydziale Konserwacji i Restauracji Dzieł Sztuki ASP w Krakowie na przykładzie sześciu realizacji konserwatorskich prowadzonych w ramach dyplomów magisterskich w latach 2022/2023: z zakresu malarstwa sztalugowego na drewnie i płótnie, rzeźby drewnianej i kamiennej oraz sztuki współczesnej. W każdym z nich określono rodzaje oczyszczanej warstwy malarskiej i usuwanych nawarstwień, zaprezentowano szereg wykonanych prób i rezultaty oczyszczania. W podsumowaniu zebrano wnioski dotyczące stosowania roztworów wodnych i emulsji z MCP
Pelophylax ridibundus complex as bioindicator of the level of anthropogenic pollution of the environment
Full text linkThe work presents the relationship between the degree of pollution of water bodies and changes in the structure of internal organs of the marsh frogs, Pelophylax ridibundus complex, inhabiting these bodies of water. To determine this relationship, two natural lakes and one artificial water reservoir located in an industrialised area near the city of Astana in Kazakhstan were investigated and conclusions were drawn regarding the gradient of anthropogenic pollution. In addition, histological examinations of the gastrointestinal tract of frogs caught from these water bodies differing significantly in the gradient of heavy metal concentration were carried out. It was found that of the analyzed organs, the stomach and liver were the most sensitive to pollution. The concordance of the intensity of damage to these organs with the degree of pollution of the lakes and the reservoir, as determined by physicochemical analysis of the water, indicate that the studied species can be considered a bioindicator of early pollution of aquatic biotopes
O pewnych punktach stycznych w filozofii języka Ingardena i Fregego
Full text linkSelf-Report of a Lecture Delivered at the Second Ingarden Symposium (Polish Philosophical Society, Kraków Branch, June 27, 1975). First edition: Ruch Filozoficzny 34(3) (1976): 203–206.Autoreferat odczytu wygłoszonego podczas II Sympozjum Ingardenowskiego (Polskie Towarzystwo Filozoficzne, Oddział w Krakowie, 27 czerwca 1975 r.). Pierwodruk: Ruch Filozoficzny 34(3) (1976): 203–206
Multiplicity of solutions to critical p-Laplace equations involving a Hardy potential
No full textIn this paper, we prove the existence of at least pairs of nontrivial solutions to the doubly critical quasilinear elliptic problem
in , as well as in smooth bounded domains, where , and is strictly positive in a small ball.
Our results hold under the assumption that and
and are small enough.
To circumvent difficulties due to the lack of compactness of the problem, we combine Krasnosel'ski{\u\i}'s genus with a recent classification result by Oliva,
Sciunzi, Vaira (J. Math. Pures Appl. {\bf 140} (2020), 89-109) and global compactness results by Li, Guo, Niu (Nonlinear Anal. {\bf 74} (2011), no.\ 4,
1445-1464)
LS-category and topological complexity of Milnor manifolds and corresponding generalized projective product spaces
No full textMilnor manifolds are a class of certain codimension- submanifolds of the product of projective spaces. In this paper, we study the LS-category and topological complexity of these manifolds. We determine the exact value of the LS-category and, in many cases, the topological complexity of these manifolds. We also obtain tight bounds on the topological complexity of these manifolds.
It is known that Milnor manifolds admit and circle actions.
We compute bounds on the equivariant LS-category and equivariant topological complexity of these manifolds.
Finally, we describe the mod- cohomology rings of some generalized projective product spaces corresponding
to Milnor manifolds and use this information to compute the bound on LS-category and topological complexity of these spaces
Vitamin D and Selenium: Review of Clinical Trials of Synergistic Effects on Thyroid Antibody Levels and Disease Progression in Hashimoto’s Thyroiditis
Full text linkIntroduction:Hashimoto's Thyroiditis (HT) is a common autoimmune thyroid disorder caused by genetic predispositions and environmental factors, such as iodine imbalance, selenium deficiency, and stress. It is characterized by chronic lymphocytic infiltration of the thyroid gland, leading to hypothyroidism and the production of thyroid-specific autoantibodies, particularly anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) antibodies.
Materials and Methods:This study combined a literature review with clinical trial analysis to evaluate the role of selenium and vitamin D in HT. A systematic approach was used to identify and assess high-quality, relevant evidence.
Results:Selenium supplementation reduced TSH levels in patients without thyroid hormone replacement therapy (THRT) and significantly decreased TPOAb and MDA levels, with no impact on fT4, T3, or TGAb. Adverse events were rare and comparable to placebo. Vitamin D deficiency correlated with elevated TSH, anti-TPO, and anti-TG levels, with HT patients showing significantly lower vitamin D levels than healthy controls or hypothyroid patients. Both selenium and vitamin D demonstrated potential immunomodulatory benefits.
Conclusions:Selenium and vitamin D supplementation may aid in managing HT by reducing TSH and thyroid antibody levels, emphasizing the importance of addressing micronutrient deficiencies in autoimmune thyroid disorders
Ecocultural Perspectives On Mental Well-being and Self-harmony Among Sports Science Students
Full text linkDrawing on Rogers' humanistic psychology framework, this study explores the interplay between self-harmony and mental health among sports majors. For college students majoring in physical education, this theory serves as a significant reference for maintaining their mental well-being. This research delves into the relationship between the mental health status and self - harmony of physical education majors. By doing so, it aims to offer novel perspectives for the psychological health education and counseling tailored to this specific group of students. A random sampling approach was adopted to recruit physical education majors. Participants completed two validated instruments: the Symptom Checklist 90 (SCL-90) for assessing mental health symptoms, and the Self-Harmony Scale (SCL-HA) to measure congruence between self-concept and experiences. Data collection followed a double-blind protocol to minimize bias. The findings indicate that the disharmony between self and experience has the most profound impact on the mental health of these students, closely followed by communication - related issues. There exists a notable negative correlation between the mental health of physical education majors and the self - experience disharmony, while a significant positive correlation is observed between mental health and self - flexibility. Students with better mental health conditions exhibit remarkably higher levels of self - harmony and self - flexibility compared to those with poorer mental health. Drawing on Rogers' humanistic psychology framework, this study explores the interplay between self-harmony and mental health among sports majors. By employing mixed-method analyses (SCL-90 and SCL-HA scales), we identify key predictors of psychological well-being and propose actionable strategies for enhancing mental health interventions tailored to this cohort
An Overview of the Impact of Statin Therapy on Cardiac Incident Risk
Full text linkStatin therapy is a cornerstone in preventing and managing cardiovascular diseases, particularly in reducing the risk of cardiac incidents. This review presents a comprehensive overview of the impact of statin therapy on cardiac incident risk, examining its efficacy in primary and secondary prevention, the underlying mechanisms of action, associated adverse effects, and considerations for patient adherence. Evidence from large-scale randomized controlled trials and meta-analyses consistently demonstrates that statins significantly reduce the incidence of major cardiovascular events by lowering low-density lipoprotein (LDL) cholesterol levels and exerting pleiotropic effects like improving endothelial function and stabilizing atherosclerotic plaques. Although generally well-tolerated, statins may cause side effects, including muscle-related symptoms and a modest increase in the risk of type 2 diabetes. Patient adherence remains a critical factor in maximizing the therapeutic benefits of statin therapy.