Advances in BioScience
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Evaluation some Biochemical Levels in Patients undergoing Hemodialysis in Baghdad Governorate
Get PDFThe objective of investigating some biochemical parameters like urea, creatinine, Hb and other parameters as CRP and leptin in the serum of ESRD patients on hemodialysis pre-dialysis.
Method: Sample of 250 cases which consists of the patient with ESRD, their mean ages were 52.66 ± 12.55 years with ranged from 18-83. Moreover, under hemodialysis treatment not less than three months. Apparently, 20 healthy subjects were selected as (control) for comparison.
Results: The results showed that there was a significant increase (p<0.01) in the serum urea, creatinine, CRP, and leptin. While, revealed significant (p< 0.05) decrease in the levels of uric acid, serum glucose, albumin, inorganic phosphorus, potassium, Hb and platelet in patients before dialysis compared to the control group. Non-significant (p>0.05) is in total cholesterol, calcium and total protein in patients undergoing hemodialysis which was compared to the control group. It is concluded from the findings of the present study, it shows a highly significant increased serum concentration of leptin as well as, elevated serum values of CRP. Whereas a highly significant decrease in GFR and CrCl result from loss of the ability of the kidney to clearance. Also, abnormal mineral parameters and hematological parameters. According to the results of this study, serum total protein and cholesterol cannot be used, as a diagnostic marker of nutrition disorders in patients on regular hemodialysis requires further investigation and clarification
Change in Liver Histoarchitecture by Sulphur Dioxide Induced Toxicity and Its Vitalization by Emblica officinalis in Albino Rat
Get PDFAtmosphere is a dynamic entity, which absorbs different pollutants from nature and anthropogenic sources, hence act as sink for those pollutants. Different types of gaseous pollutants are absorbed by the atmosphere, SO2 is one of them. SO2 enters in the body through the inhalation and then makes its entry into the blood and affects different body systems. Liver is an important vital which control most of the body activities, any change in liver or liver cell architecture leads to its abnormal functioning, results in deleterious effects. Emblica officinalis is a nutrient rich supplement which contains tannins, alkaloids, phenolic compounds, amino acids, carbohydrates and a rich source of vitamin C. Emblica officinalis has a potential to cure the histopathological alterations induced by SO2 in albino rats
Molecular detection of virulence factors (adhesion genes) in some Staphylococcus epidermidis locally isolated from different clinical sources
Get PDFThe icaA and icaD genes are found in bacterial cells. The icaA and icaD genes allow a bacterium to produce biofilm. Biofilms are an important virulence determinant in bacteria because biofilm formation significantly increases resistance to antibiotics and promotes host defenses. The ability of biofilm production can be determined by two phenotypic methods and genotypic methods of some adhesion factors (icaA and icaD). The phenotypic methods included the Congo-red agar (CRA) and Microtiter plate (Mtp). The results showed that 58 (69%) from 84 isolates were positive for producing biofilm on (CRA) plates and the 55 (65%) from 84 isolates were positive for adhesion and biofilm formation by (Mtp) on the O.D. 490nm. The extraction of DNA is subjected to use for polymerase chain reaction (PCR) which is used to amplify specific genes. The production of viscous layer of Staphylococcus epidermidis was investigated by using Molecular analysis (PCR) monoplex to amplify the virulence factor (icaA, icaD) genes (adhesion factors) with the amplicon sizes 188 bp and 198 bp, respectively. The results of the genes icaA and icaD represented as sixty for (46) 54.8% and thirty (30) 35.7%, respectively. The conclusion to these study detection to icaA and icaD genesis important virulence factor
Identification and Description of Copulatory Complex in Tarsotrechus polhemi Anderson, 1980
Get PDFThe genus Tarsotrechus was described by Anderson. Belonging to the subfamily Eotrechinae Anderson, 1975 is represented by a single species, Tarsotrechus polhemi Anderson, 1980. The present contribution provides an account of copulatory complex of the species for the first time
Assessment of toxicity of lambda-cyhalothrin for Heteropneustes fossilis and Channa punctatus
Get PDFInsecticidal use in agriculture gained momentum around the mid-twentieth century. Fungicides are also used in agriculture for the prevention of fungal infection in seed grain. Later these compounds discharge in nearby water bodies and consumed by fishes and other aquatic life. These fat-soluble contaminants concentrate in the adipose tissue of fishes by bioaccumulation and biomagnification. The present study helps in assessment of toxicity of lambda-cyhalothrin, a pyrethroid to fishes Heteropneustes fossilis and Channa punctatus
Toxicity Assessment of Nickel Nitrate and Effect on Total Leucocyte Count in Albino Rat
Get PDFHeavy metals contribute a variety of adverse health effects. There are over 20 different heavy metal toxins that can impact health effects and each toxin produces different behavioural and physiological misconduct in an exposed individual. Heavy metals have bioimportance as trace element but the biotoxic effects of many of them in human biochemistry are of great concern. Hence, there is a need for understanding of the conditions such as concentration and oxidation states which make them harmful and how biotoxicity occurs. Nickel nitrate affects body physiology following its absorption through food, water and air. Predetermined doses of nickel nitrate (Ni(NO3)2] in acute (1d) and subacute (7, 14, 21, 28ds) treatments revealed significant increase in total leucocyte count (TLC). The results indicate extent of toxicity and enhancement in total leucocyte count under toxic stress of nickel nitrate in albino rat
Sugar Mill Effluent Induced Histological Changes in Kidney of Channa punctatus
Get PDFSugar is everyday need of every human being. Sugar is produced from sugar mills situated in various parts of our country. Sugar mills produced a large amount of sugar with many types of byproducts which finally went into water sources (mainly rivers) as effluents. This effluent contains high amount of toxic elements with wide range of chemicals. This will definitely affect life of aquatic organisms like fishes in rivers. The present study is designed to carefully observe the histological changes produced by toxic substances present in Chatta sugar mill effluent in kidney of Channa punctatus
First record of Neogerris assimilis Anderson, 1975 from India with Description of Copulatory Complex
Get PDFThe genus Neogerris is recorded for the first time from India. The copulatory complex, feature of a great taxonomic significance is studied and described for the first time
Increased level of miRNA 30b-3p in patients with prostatic hyperplasia and testosterone with high-level of prostate-specific antigen
Get PDFBackground: Prostate cancer (PCa) is the most common causing cancer-related in death in men and lack of reliable diagnostic tool. MicroRNAs are small molecules single-stranded RNA that affecting protein expression at the level of translation and dysregulation can dramatically affect cell metabolism. However, the using of circulating miRNAs as diagnostic biomarkers for diagnosis of PCa is still unknown.
Methods: Ten patients with prostatic hyperplasia with high-level of PSA and 10 healthy controls were conducted in this study. The reverse transcription of miRNA based on quantitative polymerase chain reaction (qPCR) were used for evaluating the dysregulation of miRNA 30b-3p and using of ELISA to evaluate the level of prostate-specific antigen (PSA) and testosterone hormone.
Results: Circulating miRNA 30b-3p level was increased in patients with prostatic hyperplasia with higher level of PSA as compared with healthy controls. Also, the testosterone hormone was increased in those patients as compared with normal level of testosterone in healthy individuals.
Conclusion: The serum miRNA 30b-3p level increased in patients with hyperplasia in prostate and may be one of potential biomarker for diagnosis of PCa
RETRACTED: Reduction mechanism of nanoparticle using leaf extract of Cassia fistula
No full textThis article has been retracted at the request of the Dr. Suvidya Ranade, Department of Chemistry, Savitribai Phule Pune University, Maharashtra State, India