Journal Of Advanced Zoology
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Determining Carotid Pulse Wave Velocity in Dogs with Canine Cognitive Dysfunction by Doppler Ultrasonography
Get PDFA neurodegenerative condition affecting geriatric dogs is called “canine cognitive dysfunction”, (CCD) a disease that is similar to Alzheimer’s disease in many aspects. Vascular risk factors have been implicated in the development of all-cause dementia and Alzheimer’s disease in humans. The purpose of this study was to determine the carotid pulse wave velocity in CCD dogs by Doppler ultrasonography and compare with normal dogs. Carotid ultrasonography was done on 17 CCD dogs that were positive base on CCD rating scale. One way ANOVA (post-hoc Scheffe) was used to compare the velocities among the vessels.
Mean values of RI and PI in CDS(cognitive dysfunction syndrome) positive dogs were more than those of CDS negative dogs and the mean values of PSV, EnDV and MV in CDS positive dogs were less than those of CDS negative dogs. But there was no significant association between the values of carotid pulse wave velocity among CDS positive and negative doges. However, the results of this study may be useful as a baseline data for future investigations
Comparative Analysis Of Lung And Breast Cancer Complexity Using Single-Cell RNA Sequencing Data
Get PDFWe performed a thorough analysis of six single-cell RNA sequencing (scRNA-seq) datasets from the 10X Genomics Database in this work. We used Principal Component Analysis (PCA) to reduce dimensionality, clustering, quality control, normalization, identification of high variable features, data preprocessing, and Uniform Manifold Approximation and Projection (UMAP) for visualization. To better comprehend cellular heterogeneity, we also identified marker genes for each cluster and looked at gene correlation networks. In comparison to breast cancer datasets, our results showed that lung cancer datasets had more edges and marker genes in their gene correlation networks. This implies that the lung cancer samples have higher levels of molecular complexity and heterogeneity. Furthermore, a detailed depiction of the cellular environment that highlighted the complex interactions between cell groups was made possible by the UMAP visualization. The underlying biology of lung and breast cancers is better understood because to the discovery of marker genes and the examination of gene correlation networks. The found intricacy in datasets related to lung cancer could have consequences for comprehending disease subgroups, signaling pathways, and overall heterogeneity. This work lays the groundwork for future investigations into the molecular details of cancer and the development of tailored treatment plans
Ecofriendly Dyes: Extraction, Characterization and Potential Applications
Get PDFIndians were thought to be forerunners in the technique of natural dyeing. Although indigenous knowledge systems have been practiced for many years, the usage of natural dyes has declined over generations owing to a lack of documentation and accurate understanding of the extraction and dyeing processes. As a result, natural dyes aren\u27t commercially viable. Currently, all ecologically hazardous synthetic chemical dyes are utilized to colour textile fabrics. They are nonbiodegradable, carcinogenic, and cause water contamination and waste disposal issues. Natural colours provide a viable answer to these issues. Natural dyes are used to colour textiles, meals, medicines, and cosmetics. Dyes are also used in small amounts to colour paper, leather, shoe polish, wood, cane, candles, and other materials. Historically, dyes were obtained only from natural sources. Natural dyes, on the other hand, suffer from the inherent limitations of uniform application and dye standardization, since dyes obtained from comparable plants or natural sources are impacted and exposed to the vagaries of climate, soil, cultivation practices, and so on. As a result, standardization procedures play a critical and essential role for natural dyes to be properly commercialized and compete with synthetic dyes. This study is all about natural dyes, their extraction, characterization, applications, and their uses
A Novel Delivery Of Ketoprofen Loaded Gastroretentive Mucoadhesive Nanoparticles Fabricated By Gelatin/Pluronic F68 For The Management Of Rheumatoid Arthritis
Get PDFA promising medication delivery method that can target specific medications at the absorption site is the use of mucoadhesive nanoparticles. This experiment was conducted to develop mucoadhesive gastroretentive ketoprofen nanoparticles, a non-steroidal anti-inflammatory medicine used to treat rheumatoid arthritis (RA).
To carry out the research, a new experimental design was fabricated. This new design made use of a three-factor, two-level central composite. The desolvation procedure was applied to generate nanoparticles that are mucoadhesive and gastroretentive. The formulations were evaluated by various preliminary parameters and transmission electron microscopy(TEM), Fourier-transform infrared spectroscopy (FTIR), zeta potential, particle size, and entrapment efficiency.
To ascertain the adhesion characteristics and release kinetics of the improved batch, in vitro drug release and ex-vivo mucoadhesion tests evaluation were conducted. The idea was to develop a formulation that would enable the stomach to deliver drugs continuously. Keeping therapeutic drug levels in the stomach for a longer period may be used to treat RA symptoms effectively
Electronic Structure And Vibrational Analysis Of Norclozapine (8-Chloro-11-Piperazine-1-Yl-5H-Dibenzo[B,E] [1,4]Diazepine)
Get PDFIntroduction: N-desmethyl clozapine or norclozapine is a benzodiazepine substituted with chloro and piperazino groups which is a major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist. It has a role as a metabolite, a delta-opioid receptor agonist, and a serotonergic antagonist. It is a dibenzodiazepine, a member of piperazines, and an organochlorine compound.
Methods: The structure and the ground state energy of the molecules under investigation have been analyzed employing the DFT / B3LYP level. The optimized geometry and their properties such as equilibrium energy, frontier orbital energy, dipole moment, and vibrational frequencies have been used to understand the activity of Norclozapine.
Results: The calculated highest occupied molecule orbital or HOMO and the lowest unoccupied molecular orbital or LUMO energies show that charge transfer within the molecule. The vibrational spectra of IR and Raman have been interpreted with the help of the B3LYP level of theory with the 6-31G basis set from the Density function theory.
Conclusions: The optimized structural parameters such as bond lengths, and bond angle were determined at B3LYP level theory with a 6-31G basis set. Simulation work of Norclozapine is in process. Simulation report of Norclozapine we will report very soon.
 
Service Learning: A Need Of The Hour For Promoting Social Responsibility Among Students In Higher Educational Institutions Through The New Education Policy
Get PDFA type of experiential learning known as "service-learning" blends academic study with community involvement. The field of service-outcomes research suffers from an absence of critical evaluation. This study used an inductive approach to discover the causes and consequences of the issue and develop strategies for dealing with them. The research strategy was anchored on qualitative and inductive approaches. Semi-structured, in-depth, one-on-one interviews with six participants. Additionally, two focus groups were convened. The information acquired from diverse sources underwent a sequential and comparative analysis relevant to the study. The research reveals the connection between intellectual growth and personal transformation through service-learning. Although it also identifies potential drawbacks, it is suggested that service-learning is often beneficial and possibly favorable to students transformation. Furthermore, the study suggests incorporating service learning components as one of the mandatory subjects in the corresponding major course through the New Education Policy.
 
Machine Learning Enhance The Future Of Education
Get PDFEducation is a basic right of every human being, it helps us to overcome problems in our daily lives. It helps us to understand the workings of the world and deal with any problems in our day-to-day lives. Education has undergone many changes due to the occurrence of Covid-19 which led to numerous technological advancements, which have affected the way teachers educate and the way students learn. One of the important events in the technology sector has been the occurrence or surfacing of AI and machine learning.
It improves the prospect of education and improves the learning environment for the students. Machine learning has had an enormous influence on the education industry. Currently, Machine Learning has become one of the most lucrative fields in the IT sector. Machine learning is a revolutionizing technology that will transform the entire educational experience for teachers as well as students. Through machine learning, teachers can create a lesson plan based on the needs of individual students. It provides feedback based on individual students understanding of concepts and behavior. With the help of the feedback, the teacher will be able to recognize flagging students immediately and take appropriate actions by changing the lesson plan according to the needs of the students. Feedback is a vital part of every system. Here, the feedback is provided to both the students and teachers.
 
Comparative Evaluation Of Different Carbon Sources In The Biofloc System While Growing Out Common Carp (Cyprinus Carpio L.) Fry
Get PDFA 10 weeks feeding trial was carried out to evaluate the effects of different carbon sources (sugar beet molasses: SBM + BFT, sugar: S + WF (Wheat Flour) BFT, corn starch: CS + BFT) on water quality, growth performance, for common carp FRY. Results showed a significant difference in water quality parameters among different culture systems; CS + BFT had the lowest amount of total ammonia nitrogen (TAN) at the end of culture period. The fish weight was the highest in CS + BFT. Overall, this study suggests that microbial flocs formed in corn starch based biofloc can improve common carp growth performance and tanks water quality under zero water exchange and hence ensures sustainabilit
Diagnosis And Treatment In Children Of Gastrointestinal Diseases And 12- Finger Ulcer
Get PDFIn children - polyetiological diseases of the gastrointestinal tract and 12-finger ulcer, in children they are rare, in origin pylori Hilobacteri plays an important role. In children, diseases of the gastrointestinal tract by 9% and 12 fingers - by 91%, and in 600 children - by 1. Manifested by various clinical signs, which in some cases are characterized by bleeding, increasing lateral tissues, pyloric ring stenosis and require long-term treatment. To date, the incidence is more, in school-aged children - 60%, in children 5-7 years old - 40%, which is associated with pylori Hilobacteri infection
Formulation And Evaluation Of Karanj Silver Nanoparticle Gel
Get PDFPongamia pinnata Linn.( Aka Karanja in Ayurveda) is a rough tree and a traditionally used medicinal factory set up throughout the India. It\u27s generally used in Ayurveda and has an immense eventuality in treating colorful skin conditions like eczema, psoriasis, itchy skin, infections of skin. The end of present study was to prepare tableware nanoparticle herbal gel expression containing methanolic excerpt of Karanj on psoriasis. Topical gel expression was designed by using methanolic excerpt of seeds of pongamia pinnata in varied attention. The gel was prepared by using tableware nitrate, chitosan, carbopol 934, Pongamia Pinnata Extract( KARANJ), Methanol, propylene glycol, methyl paraben, propyl paraben,triethanolamine, glycerin and needed quantum of distilled water. The set gels were estimated for medicine content, pH, spread capability, physical appearance, density, swelling indicator, prolixity study, unity and grit. The results prove that gel phrasings were good in appearance and unity