Journal Of Advanced Zoology
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Revolutionizing Drug Delivery: The Role of Nanofibers - A Review
Get PDFThe field of drug delivery has experienced a paradigm shift with the emergence of nanofibers as an innovative carrier system. This comprehensive review aims to delve into the multifaceted role of nanofibers in drug delivery, highlighting their unique properties and diverse applications in therapeutic interventions. Nanofibers, characterized by their high surface area-to-volume ratio and tunable properties, offer an exceptional platform for targeted and controlled drug release. Their versatile nature allows for precise engineering of size, morphology, and surface functionalities, enabling tailored drug delivery systems catering to specific therapeutic needs. This review encompasses a detailed analysis of the various fabrication techniques employed in producing nanofibers, encompassing electrospinning, self-assembly, and other advanced methodologies. Furthermore, the review presents an extensive survey of the diverse range of materials utilized in nanofiber production, such as polymers, proteins, and inorganic compounds, emphasizing their distinct advantages in drug encapsulation, protection, and release kinetics.The application spectrum of nanofibers in drug delivery is explored, spanning across various medical domains including cancer therapy, tissue engineering, wound healing, and infectious disease treatment. The review delves into recent advancements, challenges, and future prospects in this burgeoning field, underscoring the potential for nanofibers to revolutionize drug delivery strategies and improve therapeutic outcomes.In conclusion, this review underscores the pivotal role of nanofibers as a novel and promising carrier system in drug delivery, presenting a compelling case for their continued exploration and utilization in advancing medical treatments
Study On Financial Education Programs For Entrepreneurs
Get PDFThis study investigates how financial education initiatives significantly impact individuals\u27 intentions to pursue entrepreneurship. Through an analysis of these programs\u27 effects on risk management, strategic thinking, and financial literacy, the research demonstrates the variety of ways in which these initiatives influence people\u27s willingness to pursue entrepreneurial endeavors. In order to increase efficacy, the study highlights the significance of program design, delivery excellence, and continuing support systems. Positive effects are further enhanced by real-world case studies and applicability to a variety of entrepreneurial scenarios. Tailored program design, interactive learning strategies, all-inclusive support systems, flexibility in response to technology advancements, association with professionals in the field, and long-term effect evaluations are among the suggestions. By putting these recommendations into practice, financial education programs may become even more successful, producing a resilient and driven generation of company owners ready for the challenges of the competitive business environment
Quality Assessment Of Andrographis Paniculata (Burm. F.) Wall. Ex Nees W.S.R To Geographical Region.
Get PDFKalmegh Andrographispaniculata (Burm. F.) Wall. Ex Nees is one of the main ingredients used in many formulations like Mahavishgarbhataila etc, India`s various part having favourable for Kalamegh plant, but geographical environmental influences the physico-chemical properties like Ash, extractives values and phytoconstituents. All samples passes ayurvedic Pharmacopeial standards but strength showed variations and Belgaum region showed best for Kalamegh . Thus, study revels that medicinal plants collection habitat must be considered
A Comprehensive Review: Inflammatory Bowel Disease And Its Global Perspective
Get PDFInflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn’s disease (CD), represents a persistent gastrointestinal inflammatory condition. Initially labeled as a "Western disease," IBD was predominantly associated with Western lifestyles, but a shift in dietary and lifestyle patterns has led to a noticeable rise in Asian populations. The global prevalence of IBD reached 6.8 million cases in 2017, with a subsequent decrease to 4.9 million cases in 2019, showcasing a dynamic occurrence. The multifactorial pathogenesis involves genetic susceptibility, environmental factors, and an aberrant immune response to the gut microbiota. IBD is classified into CD, affecting any part of the gastrointestinal tract, and UC, limited to the colon and rectum. A third category, IBD-unspecified (IBD-U), is utilized when the inflammation\u27s origin is unclear. Complications, including strictures, fistulas, and colorectal cancer, emphasize the disease\u27s severity. Treatment options range from aminosalicylates to biologics, with emerging therapies and a focus on the mucosal antibacterial barrier offering potential advancements. Global healthcare organizations, recognizing IBD as a global ailment, aim to summarize epidemiological patterns to guide interventions. In study on global burden of disease 40 million cases were reported, prevalence of more than 1 percent of total global incidence has been seen worldwide, 41.00 thousand deaths, and 1622.50 thousand DALYs globally in 2019. While advancements have been made, further research is crucial to improve prevention and treatment strategies. The shift in the pathogenic focus towards mucosal antibacterial barriers presents a potential avenue for future developments, offering hope for enhanced outcomes and improved quality of life for individuals affected by IB
Role of Nitrogen Source for L-Glutaminase Production from Fungal Strain using through Submerged Fermentation
Get PDFL-glutaminase has attracted much attention due its wide range of applications in several fields. The L-glutaminase widely used in pharmaceutical and food industries. L-glutaminase is generally regarded as a key enzyme that controls the delicious taste of fermented foods such as soy sauce. L-glutaminase production was carried out by using supplementation of organic and inorganic nitrogen sources such as yeast extract, malt extract, peptone and urea at concentration ranging from 0.25% to 1.25% with increments of 0.25% and also different inorganic nitrogen sources like ammonium sulphate and ammonium chloride at concentration ranging from 0.025% to 0.125% with increments of 0.025%. The malt extract (1%) produced 399.9 IU, were best organic nitrogen source and ammonium sulphate (0.1%) appear to be good inorganic nitrogen source under submerged fermentation process and showed 546 IU. Current study is an exploring step to industrial sector to upscale their L-glutaminase production and it will useful strategy to commercial sector and alternative to old method
Chronotype patterns of medical shift workers at Government District Hospital of Bilaspur, Chhattisgarh, India
Get PDFThis study investigated the influence of chronotype behaviour on body mass index (BMI) and associated demographic factors among two distinct groups; a control group of daytime workers and a shift worker group. The control group, comprising fixed daytime workers, showed significant gender differences in BMI and chronotype scores, with females exhibiting higher BMI and more pronounced chronotype effects than males. Marital status significantly influenced BMI and chronotype in married and unmarried subjects differently, with unmarried individuals displaying stronger chronotype associations. A positive correlation between BMI and chronotype scores was observed, suggesting interdependence between circadian preferences and body composition. Among shift workers, females demonstrated significant effects of gender on both BMI and chronotype, whereas males did not. Marital status impacted BMI significantly only in married shift workers. The correlation between BMI and chronotype was also significant in shift workers, reinforcing the relationship between circadian rhythm and metabolic factors. Mann-Whitney analyses revealed that BMI significantly affected shift workers, while chronotype significantly influenced control subjects. These findings underscore the complex interactions between chronobiological factors, work patterns, and metabolic health, highlighting the importance of chronotype in understanding health outcomes in both shift and daytime workers
Biology Of Macrognathus Sp. With Special Reference To Macrognathus Pancalus (Hamilton) And Macrognathus Aral (Bloch And Schneider)
Get PDFMacrognathus is a genus of eel-like fish of the family Mastacembelidae of the order Synbranchiformes. The majority of South and Southeast Asia is home to these fish. The major food category of this genus is crustaceans (such as prawns) and aquatic insects (Chaoborus spp.), while juveniles mostly consume annelids (such as earthworms). According to various studies, it was found that the male: female ratio of Macrognathus sp is roughly 1:1. Macrognathus exhibit a wide range of fecundity, and the number of ova or eggs laid by a single female depends on a number of variables, including size, age, species, and the ecological habitats of the fish, including the availability of food. The fecundity of these fishes are found to be high when the fish were breeding, which occurred from May through August. The average ovarian diameter of M. pancalus has been found to increase on a monthly basis. In some studies, lentic habitats showed higher ova diameter than lotic habitats for Macrognathus sp. For Macrognathus sp. the males matured at lengths of 10 to 11 cm and females at lengths of 11 to 12 cm on the other hand M. aral was found to be matured at an average of 12.05 cm for males and 16.05 cm for females
Artificial Selection Of Elite Okra Accessions (Abelmoschus Esculentus (L.) Moench)Via Cluster Analysis
Get PDFForty-eight okra accessions were subjected to a replicated field trial arranged in a Randomized Complete Block Design (RCBD) to examine the genetic dissimilarity and distances pertaining to quantitative traits. Mahanalobis D2 analysis portioned the genotypes into ten separate clusters. Cluster II constituted the largest group followed by cluster III. Also three solitary clusters (VII, IX, and X) were reported. In compliance with genetic distances, cluster IV, VIII and VI had broad divergent genotypes within them along with wide genetic dissimilarity was between the clusters VII and X, following I and X, I and IX. Cluster IX had genotypes with high cluster means for fruit yield than others. Among various morphological characters, fruit yield per plant alone contribute nearly 36 per cent toward divergence preceded by days to first flower, and plant height at 80 per cent maturity. Therefore, top priority in artificial selection of diverse parents might be given to the genotypes in clusters I, II, VII and IX for attempting improvement of complex traits in okra
Evaluation Of Novel Iontophoretic Gel Containing Symphytum Officinale On Knee Osteoarthritic Patients
Get PDFIntroduction: One of the most prevalent disorders causing pain in the musculoskeletal system and eventual disability is osteoarthritis (OA). The concurrent use of pharmaceutical and non-pharmacological therapies is an essential component of the therapy. The purpose of this study was to assess the efficacy of iontophoresis therapy in patients with osteoarthritis (OA) of the knee joints using a newly formulated Gel containing symphytum officinale.
Material and Methods: The study included 126 patients with Knee osteoarthritis treated at the Outpatient department at Delhi Pharmaceutical Sciences & Research University, New Delhi. Three groups were randomly selected: group I (n = 42), received iontophoresis with newly developed Gel containing symphytum officinale treatment was applied followed by exercise protocol, group II (n = 42) received iontophoresis with Indomethacin gel was applied followed by exercise protocol , and group III (n = 42) received placebo treatment with knee exercise protocol only. The Visual analog scale (VAS), Western Ontario and McMaster Universities Arthritis Index (WOMAC), Pittsburg sleep quality index (PSQI) & Walking cadence were used for the clinical evaluation of the patients.
Results: Patients treated with a new gel containing symphytum officinale showed significant improvement in all assessed parameters compared to those treated with Indomethacin gel and placebo.
Conclusions: The most favorable iontophoresis resulted from the introduction of a new gel containing symphytum officinale, followed by an exercise protoco
Comprehensive Multivariate Analysis Of Rice (Oryza Sativa L.) Genotypes Of Tamil Nadu For Yield And Yield Attributed Traits
Get PDFAn experiment was performed to assess the variability parameters for biometrical traits in 104 rice genotypes. Higher estimates of GCV and PCV were found for single plant yield and filled grains per panicle along with high heritability and genetic advance. Single plant yield exhibited significant positive genotypic correlation for most of the yield contributing characters like number of productive tillers, number of filled grains per panicle, number of tillers, panicle length and thousand grain weight. The highest positive direct effects on yield were exhibited by number of filled grains per panicle followed by number of productive tillers at genotypic level for the improvement of rice yield. Estimates of genetic variability analysis exhibited, single plant yield and number of filled grains per panicle are positive for practically all variability factors tested. The study revealed high genetic variability, indicating that the genotypes could be utilized for further rice breeding