Journal Of Advanced Zoology
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“Design, Synthesis, And Characterization Of Novel Benzimidazole Derivatives And Their Biological Evaluation”
Get PDFBecause of their various biological functions and possible therapeutic uses, benzimidazole derivatives have drawn a lot of interest in medicinal chemistry. Our goal was to create, manufacture, and assess a number of new benzimidazole derivatives with improved pharmacological properties in this work. In order to maximize target interactions with particular biological targets, the benzimidazole scaffold was logically modified during the design process. A multistep synthetic process was used to create the novel derivatives, allowing for the integration of various functional groups. The effective synthesis of the intended chemicals was confirmed by characterizing techniques such nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, and infrared spectroscopy. The produced compounds were then evaluated using an in vitro techniques. Human cell lines were used in preliminary cytotoxicity tests to get knowledge about the derivatives\u27 possible safety characteristics. This study\u27s findings identified a number of benzimidazole compounds with significant biological properties and possible medicinal uses. In conclusion, a number of substances with remarkable therapeutic potential have been produced as a result of the design, synthesis, and assessment of novel benzimidazole derivatives
Recent Advances Of Biotechnology In Medicine And Pharmacology
Get PDFThe term Biotechnology in the field of the medicines and pharmacology are very useful for the development and growth in production of medicines and drugs. Its applications in the fields of industries related to the medicine and agriculture are very wide. The development, enhancement, and the usage of modern and innovative techniques, procedures including the production of the personalized medicines and technologies related to CRISPR. The main aim of the present study is to show the role and usage of the innovative and modern approaches that are used by the biotechnology in the fields of the medicine and pharmacology. The collection, gathering, assembling of information and knowledge that are done by using the secondary sources, explaining the importance and benefits of the biotechnology including interpretivism philosophy. Explanation of various analysis that includes the development of various antibiotics, medicines and drugs that are made by the modern biotechnological processes
The Potential Of Stem Cell Therapy
Get PDFThe study of stem cell therapy has led to the development of a very advanced, promising, and effective method for conducting scientific research. This success has ushered in a new era of treatment through various paths of dividing patterns. After the regeneration of stem cells, different lab procedures are used to cultivate distinct cell types. Quality control and teratoma development assays are among the methods used to evaluate the growth kinetic characteristics of the stem cells. To determine the best natural-type environmental conditions for a certain differentiation, various culture mediums are tested. Extracellular vesicle-based therapies and graphene scaffolds, which have enormous therapeutic potential due to their adaptability, are some of the structures used. This review focuses on the discovery of many stem cells and their potential for therapeutic use in modern medicine. The wide range of stem cell functions creates a very effective technique that offers an alternative for disorders that cannot be cured. The objective of the review is to draw attention to the stem cell treatment system among researchers
The Significance Of Effective Corporate Governance And Transformational Big Data Analysis In Enhancing Firm Financial Performance
Get PDFThe financial performance of a firm is an indication of its competence in effectively operating and managing its activities while carefully following sound financial management standards. The financial success of a corporation is frequently a reflection of the effective application of Good Corporate Governance (GCG) principles. The implementation of Good Corporate Governance (GCG) establishes a strong basis for a firm to carry out its activities in a transparent, ethical, and accountable manner. The aim of this study is to assess the application of corporate governance practices (GCG) and the effectiveness of big data analysis in influencing financial performance. Additionally, it seeks to investigate the intermediary function of big data analysis in the connection between GCG and financial performance. The study used a quantitative methodology, whereby data was collected via a survey questionnaire administered using a Likert Scale ranging from 1 to 5. A random sampling method was used to choose 188 samples from State-Owned Enterprises listed on the Amman Stock Exchange. The data gathering period spanned from August 2023 to September 2023. The participants in the study consisted of employees and supervisors from these firms. The data gathered underwent analysis by Structural Equation Modeling (SEM) utilizing the SmartPLS program. The study results suggest that GCG has a favorable and substantial impact on big data analysis, serving as a basis for digital transformation. In addition, GCG plays a beneficial and substantial role in enhancing the company\u27s financial performance. The use of big data analysis has shown a favorable influence on financial performance, underscoring the significance of technology in enhancing financial outcomes. Furthermore, it has been shown that the analysis of large amounts of data serves as an intermediary in the connection between GCG (good corporate governance) and financial performance. This emphasizes the vital role of technology in linking effective corporate governance practices with the most favorable financial results
Comparative Studies And Performance Of Cu And Cd Removal Using Industrial Effluents And Synthetic Samples In Continuous Column Reactor
Get PDFThe experimental data obtained proved that the effect of bed weight, flow rate and initial metal ion concentration plays a significant role on the removal of Cu (II) and Cd (II).The column performance calculation involves various parameters such as breakthrough time, saturation time, Volume treated at breakthrough point (ml), Volume treated at saturation point (ml), mads, mtotal, % removal have been calculated for both the metals using synthetic and industrial effluents. The detailed comparison studies have been reported in this paper along with explanation for both copper and cadmium. The cadmium metal % removal for synthetic solutions is better than industrial effluents at different bed heights and volumetric flow rates. The inverse trend for copper % removal is observed which shows that industrial effluent is better than the synthetic sample which may be due to more adsorbent dosage and influence of synergistic effect in the column. This trend is due to presence of Phenols, cresols, other heavy metals, sludge, major concentrations of adsorbates and impurities in industrial effluent. Overall in comparison with industrial effluents for cadmium, the synthetic solutions have proved to be more superior in terms of column total % removal and better performance was observed with synthetic solutions than industrial effluents. The adsorbent can be used for longer time before it needs replacement or regeneratio
Different Strategies of Asymmetric Synthesis
Get PDFAsymmetric synthesis is one of the significant subjects of research in recent times. It incorporates regulating stereochemistry of compounds to produce enantiomerically pure chemical substances. Chiral auxiliaries/substrates and enantioselective reagents and organocatalysis are used for the synthesis of enantiomerically pure molecules in organic synthesis. Significance of chiral compounds results in the generation of new bonds in a stereo and enantio-controlled method. Separation of enantiomers from enantiomerically impure sources is a difficult process. Asymmetric synthesis finds its challenging applications in medicinal chemistry, pharmacology, life sciences, chromatography, and extraterrestrial chemistry. This article features the eco- friendly approach and cost-effectiveness of different strategies of asymmetric synthesi
Sugarcane Fermentation: Probiotics and Gut Benefits
Get PDFSugarcane is rich in dietary fibers and is known for its positive effects on the gastrointestinal tract. It offers a wide array of health benefits for mammals. The sugar industry generates substantial residue amounts. Fermenting sugarcane with probiotic strains positively impacted gut flora in all instances. Maintaining the viability of these probiotic microorganisms is crucial when creating functional food products. Several factors can reduce their effectiveness in the gut. Sugarcane juice contains high levels of nutrients, minerals, and polyphenolic compounds, devoid of allergens and easily accessible. Fruit juices serve as excellent carriers for probiotics. Creating probiotic beverages while preserving taste and appearance is an innovative approach. The combination of probiotics and other dietary substances is gaining interest in promoting gastrointestinal health. Sugarcane juice, rich in nutrients and beneficial properties, is an optimal vehicle for probiotic organisms, contributing to overall health. Consequently, selecting appropriate probiotics and ensuring their effective delivery poses a technological challenge. This paper offers an overview of research articles summarizing procedures and techniques for enhancing probiotic viability. It also discusses ongoing research and challenges while outlining future opportunities for researchers based on existing literature
Revisiting The Role Of Sbi In Digitization Mapping: A CSR Initiative
Get PDFDigitalization has inaugurated a new approach to publicize socialization in all types of organizations, generally, and businesses specifically. Stakeholders now favour companies that adhere to social standards and virtues. The companies comprehend that it is essential for the advertising of their CSR activities so that the viewing public can fully comprehend that they are engaged with a business that delivers facilities that benefit society. With the advancement of technology, cyberspace provides several portals upon which content can be posted. Once the viewers are engaged with the organization, the word is dispersed in such a way that the company garners prominence. Using such an added benefit, the company uses this framework to endorse the business to its full extent too. This is accomplished with the assistance of digital marketing. This paper emphasizes the marketing potential of CSR efforts for businesses and the necessity of social media advertising of such programs in the current technology era. This essay also discusses how using digital channels like social media, websites, blogs, and emails to promote CSR initiatives can be advantageous to the business in the long run. As a result, this article aims to connect the CSR principle to marketing by categorizing various theoreticalviewpoints that suggest a connection between the two concepts. The present paper is an attempt to capture the extent of digitalisation of services and the subsequent impact on the CSR performances of the largest bank in the Indian sub-continent- State Bank of India. The paper tries to analyse the growth of CSR activities vis a vis the rate of digital services provided by the bank
Assessment Of The Knowledge And Awareness Towards The Aetiology And Diagnosis For Gingival Recession And Attitude Towards Its Management
Get PDFAim– The Aim of the study is to assess of the Knowledge and Awareness towards the aetiology and Diagnosis for Gingival Recession and attitude towards its management among interns and post-graduates.
Materials and Methods: 250 dental professionals including interns and postgraduates from diverse specialties participated in an online survey. This self-prepared questionnaire-based survey consisting of 14 questions was carried out at Rama dental college Kanpur for a period of 2 months.
Statistical analysis used:
Descriptive statistics have been used to summarize and describe the distributions of responses for each question. These statistics include measures like counts, percentages, means, and standard deviation. The Chi-square test and ANOVA test were used to analyze and compare the variables.
Results:54.8% of interns and postgraduates had good knowledge and attitude towards aetiology and management of gingival recession, 44.4% had intermediate knowledge whereas 0.8% had poor knowledge.
Conclusion: The study concluded that the Knowledge and Awareness towards the aetiology and Diagnosis for Gingival Recession and attitude towards its management among interns and postgraduates was good
The Impact Of Metformin, Magnesium, And Vitamin - D On Mitigating Lipid Metabolism In Streptozotocin (Stz)-Induced Diabetes In An Albino Rat Model
Get PDFThis research investigates the impact of metformin, magnesium, and vitamin D on lipid metabolism in streptozotocin-induced diabetes using an albino rat model. Metformin, known for its glucose-lowering effects, is explored for potential influences on lipid metabolism, while magnesium and vitamin D, essential nutrients, are examined for their roles in modulating lipid abnormalities in diabetes. The study, employing six groups of male Wistar rats with distinct interventions, including metformin alone and in combination with vitamin D and/or magnesium, aims to unveil synergistic or additive effects on lipid regulation. Ethical approval was obtained, and diabetes induction, treatment administration, euthanasia, and lipid profile estimation were conducted following established protocols. Untreated diabetic rats exhibited significant lipid parameter deviations compared to the control group. Metformin alone demonstrated positive effects, further enhanced by combinations with vitamin D and/or magnesium. The metformin + vitamin D + magnesium combination yielded the most favorable outcomes in liver and kidney lipid profiles, suggesting a potential synergistic effect in mitigating diabetes-induced lipid changes. The study emphasizes the importance of multifaceted approaches for managing diabetes-associated complications. Validation of these findings and assessing translational potential in human diabetes management warrant further research and clinical studies