Journal Of Advanced Zoology
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A Study On Potential Drug Target For SARS-CoV-2-And Combinatorial Therapeutic Approach To Combat COVID-19
Get PDFThe COVID-19 pandemic caused by (SARS-CoV-2) a threat, leading to numerous deaths and socioeconomic disruptions. Spurred intense research efforts effective treatment. Our study provides a brief overview COVID-19. Urgent need for effective treatments has prompted extensive research to identify potential drug targets against disease. Review shows most promising drug and their associated therapeutic approaches for combating COVID-19. Key targets include the spike protein, which facilitates viral entry into host cells, and proteases essential for viral replication. Additionally, RNA-dependent RNA polymerase (RdRp) inhibitors have been explored to inhibit viral RNA replication, highlighting their mechanisms of action, potential therapeutic benefits, and challenges in drug development. Host factors, such as the ACE2 receptor and immune response modulators, are also targeted. Combination therapies and overcoming challenges in the drug development are crucial for successful COVID-19 treatment. In this review the molecular docking study is discussed here. The future perspective of drug targets for COVID-19 encompasses a range of innovative approaches aimed at combating the virus and preparing for future outbreaks. The review also discusses the challenges faced and future directions in the field of drug target research for COVID-19. This review will provide an overview of the anticipated advancements in drug target discovery and development for COVID-19, highlighting key areas of focus and potential strategies
Isolation And Characterization Of Lactobacillus Sp. From Different Dairy Products And Fermented Foods For Their Application On Gastrointestinal Disorder
Get PDFProbiotics are live, nonpathogenic bacteria that promote the health of their hosts. Probiotics and fermented foods are the two most significant and often-used functional food components. Functional foods have a variety of nutritive advantages. Idli, dhokla, pickles, and other traditional Indian dishes that benefit the host include dairy products with probiotics. They increase the live microbial supplements\u27 capacity for survival and implantation. In our study, the detection was done of probiotics that were isolated from fermented sources such as fermented rice water, Whey water, Cow milk, and Idli batter collected from different places in Rangamati, West Midnapore, West Bengal.
The isolation of probiotics was carried out by the standard serial dilution methods in Nutrient media. The confirmatory test was done on De Man, Rogosa and Sharpe broth. Suspected lactic acid bacteria were further purified. Morphological and biochemical characterization of isolated organisms was also done. The isolated bacteria were identified by comparing the investigated characters of the isolates to Bergey’s manual of determinative bacteriology. The isolated Lactobacillus sp. satisfy the criteria required for a probiotic, such as pH (tolerance to harsh conditions low), and optimum temperature can produce bacteriocin extra-cellularly which may inhibit gastrointestinal malfunctions such as Colitis. These isolates may have the potential to be used as probiotics
Assistive Intelligence Sensing Device With Python Intergration
Get PDFAn assistive intelligence sensor device is a comprehensive solution aimed at improving the mobility and independence of people with visual or hearing impairments. It integrates an array of advanced hardware components including Node MCU and Arduino board for data processing, GPS module with antenna for accurate location tracking, emergency key switch for instant warning activation, and time of flight sensor for accurate obstacle detection. A vibrator for haptic feedback, a Wi-Fi module for seamless connectivity and a display for visual feedback. Additionally, the device includes a laptop with a Python-coded program for real-time object detection using a camera, which helps identify and classify objects in the user\u27s environment. Leveraging the Blynk IoT app, the device facilitates instant communication with caregivers or emergency responders, ensuring peace of mind and timely assistance when needed. Also, apart from detecting nearby obstacles and providing haptic feedback, the device uses a GPS module to live track the user\u27s location, ensuring safety and security during outdoor navigation. The integration of intelligent software algorithms further enhances the functionality of the device, enabling it to adapt to various environments and user needs. This manuscript provides a comprehensive overview of the device\u27s design, functionality, and potential applications to improve the quality of life of individuals with disabilities. By integrating state-of-the-art hardware components with intelligent software solutions, the Assistive Intelligence sensor device represents a significant advance in assistive technology, empowering users to navigate their surroundings with confidence an
Iot-Based Patient Health Monitoring System
Get PDFThe emergence of the Internet of Things (IoT) has revolutionized healthcare by enabling remote patient monitoring systems. This system utilizes wearable sensors to collect vital signs such as heart rate, blood glucose level and body temperature. If the patient\u27s temperature increases above 100 degrees Celsius then the alarm will be generated. The collected data is transmitted wirelessly to a secure cloud platform for real-time analysis and visualization. This allows Doctors to remotely monitor patients\u27 health conditions, intervene promptly in case of emergencies, and improve overall care quality
Efficacy Of Surge Faradic Eletrical Muscle Stimulator With S.E.R.F (Stabilisation Through External Rotation Of The Femur) Strap On Piriformis Syndrome
Get PDFBackground: Piriformis syndrome is a neuromuscular disorder characterized by compression of the sciatic nerve by the piriformis muscle, resulting in pain and dysfunction. This manuscript investigates the efficacy of combining Surge Faradic Electrical Muscle Stimulation (EMS) with stabilization using an external rotation femur strap for the management of piriformis syndrome
Methodology: The study involved 40 participants (18 males, 22 females) aged 30 years and above. Three conditions were evaluated: 1) Piriformis Muscle Spasm measured using NPRS scale, 2) Hip Joint Range of Motion (particularly internal and external rotation), and 3) FAIR TEST to confirm positive piriformis syndrome.
Results: Post-intervention, participants reported no pain during activities. SERF STRAP significantly improved hip joint range, shifting from maximum internal rotation to absolute external rotation. Graphical representation of NPRS scale showcased reduced muscle spasm.
Conclusion: Preliminary results suggest that the combination of Surge Faradic EMS with femur strap stabilization significantly reduces pain intensity, improves functional disability, and enhances muscle strength compared to traditional EMS therapy alone
Prevalence And Observed Patterns Of Radiculopathy In Low Back Pain
Get PDFBackground: Low back pain (LBP) is a prevalent condition that affects a significant portion of the population, often leading to disability and decreased quality of life. Among the various etiologies of LBP, radiculopathy—nerve root compression or irritation—emerges as a notable cause. This study aims to assess the prevalence of radiculopathy in patients presenting with low back pain and to delineate the common patterns observed in clinical practice.
Methods: A observational study was conducted involving 500 patients who presented with low back pain to outpatient clinics over a one-year period. Patients were evaluated using a combination of clinical assessments, imaging studies (MRI and CT scans), and electrodiagnostic tests to confirm the presence of radiculopathy. Data on demographics, symptomatology, and clinical findings were collected and analyzed.
Results: Among the 200 patients, 140 (36%) were diagnosed with radiculopathy. The most commonly affected nerve roots were L5 (45%) and S1 (35%). The typical presentation included radiating leg pain, numbness, and muscle weakness corresponding to the affected nerve root distribution. MRI findings revealed that disc herniation (70%) was the most frequent cause of radiculopathy, followed by spinal stenosis (20%) and spondylolisthesis (10%). The prevalence was higher in males (60%) compared to females (40%), and the average age of patients with radiculopathy was 45 years.
Conclusion: Radiculopathy is a significant contributor to low back pain, affecting over one-third of patients in this study. L5 and S1 nerve roots are most frequently involved, with disc herniation being the predominant cause. Understanding these patterns is crucial for the accurate diagnosis and effective management of radiculopathy in LBP patients
Effect Of Magnetic Treatment On Seed Germination Of Mung Bean (Vigna Radiata)
Get PDFThe effect of stationary magnetic field on seed germination of Mung bean (Vigna radiata) seeds was examined under Normal Laboratory Conditions (NLC). Mung (Vigna radiata) seeds were exposed to magnetic field of strength 1.5 mT for time duration of 15 minute, 20 minute and 25 minute. Under normal laboratory conditions, seed germination rate, root length and stem length were monitored and measured. The results revealed that Mung Bean (Vigna radiata) seed with magnetic treatment shows noticeable change for germination rate, root length, and stem length compared to NLC. The magnetic field exposure of 1.5 mT for 25 minute resulted in a greater germination rate than the NLC. It was observed that the root and stem lengths were increased. Remarkable changes were observed in protein analysis for magnetically treated seeds compared to NLC seed
Dragon Fruits And Strawberries In The Same Field, A New Paradigm In The Farming Of Sundarban, West Bengal, India
Get PDFThis study focuses on the successful mixed cultivation of exotic strawberries (Fragaria × ananassa) from the Rosaceae family and dragon fruits (Hylocereus lemairei) in the southern regions of the Sundarbans, West Bengal, India. By leveraging the available agricultural land in the challenging Sundarbans ecosystem, this innovative approach optimizes production through a harmonious mixed cropping system. A decade ago, strawberry farming was predominantly confined to the hill areas of India (Awasthi, 2010)[1]. The agricultural landscape in South 24 Parganas, Sundarbans, is undergoing a transformative shift with the simultaneous cultivation of dragon fruits and strawberries in the same field. This paper explores the evolving trend of this mixed cultivation system, with a specific focus on determining the optimal soil mixture through experimentation in various pots. The identified optimal soil mixture is then implemented in the field after successful trials in different parts of Sundarbans. Additionally, the paper discusses the benefits, challenges, and opportunities associated with this innovative farming model. By showcasing the advantages of integrating these two commercially viable crops and highlighting the refined soil mixture, the study aims to inspire farmers and stakeholders to adopt similar approaches. This collective effort contributes to the sustainability and economic prosperity of the Sundarbans regio
Seasonal Dynamics Of Ant Communities In Forest Ecosystems: Statistical Analysis And Ecological Insights
Get PDFA seasonal diversity was conducted in the forest of Bagepalli range of Chikkaballapur forest of Karnataka, India from August 2022 to August 2023. 21 species of ants were observed in this range belonging to 15 genera by following three methods such as pitfall traps, handpicking and bush beating. The abundant subfamily was Formicinae with 5 genera and under Myrmicinae, two genera were observed under the subfamily Ponerinae and one genus each from Subfamilies Pseudomyrmicinae and Dolichoderinae. The most abundant species were found to be Camponotus compressus followed by Oecophylla smaragdina. From the collection of ants few invasive species were also observed such as Anoplolepis gracilipes and Plagiolepis sp.. Two mathematical indices were followed and those were Shannon-Weaver Index and Simpson Index to study the diversity and compare the species richness from the three seasons – summer, monsoon and winter, and a statistical data was formed, the abundance in species were also observed to study which species were dominant and during which season. The maximum diversity was observed during the monsoon season followed by the summer and the least diversity was during the winter. The ants usually prefer a moist environment. The study assumes that the ant diversity can predict the environment
In-silico approaches of Abrus precatorius compounds as potential drug inhibitors against alpha-amylase protein (4gqr).
Get PDFT2DM is characterized by high blood glucose levels and can result in significant consequences such as nephropathy, neuropathy, retinopathy, and cardiovascular disease. Inhibiting the digestion of dietary carbohydrates is one of the treatment options for managing postprandial hyperglycemia in T2DM. 95% patient have type II diabetes mellitus. Although many synthetic drugs have been identified against pancreatic a-amylase. These medications have side effects, and new medications are being developed to address these issues. Managing diabetes without side effects is a significant challenge. This study tested 83 active constituent derived from the plant Abrus precatorius against the human pancreatic a-amylase using in-silico computational approaches such as molecular docking and molecular dynamics simulation approaches. Schr€odinger, a drug discovery package with modules applicable for molecular docking, protein-ligand interaction analysis, molecular dynamics studies. Six active constituent, namely, the Vitexin (-10.6kcal/mol), delphinidin-3-5,diglucoside(-10.5kcal/mol,), abrusin(-9.18kcal/mol), taxifolin-3-glucoside (-8.83 kcal/mol) , pelargonidin3-glucoside (-8.72 kcal/mol), and Quercetin (-8.22 kcal/mol ). All the docking score more negative than the control ligand, i.e. Myricetin (–7.3kcal/mol). The molecular dynamics analysis suggested that top two docked compounds, it showed considerable stability within the protein’s active site. As a result, Both compounds found in this work are proposed as promising antidiabetic possibilities and should be evaluated further in vitro and in viv