Journal Of Advanced Zoology
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Sustainable Skylines: A Study Of Green Building Initiatives In PCMC
Full text link“The greatest threat to our planet is the belief that someone else will save it.” Well said by Robert Swa. This research paper focuses on this belief that we need to pay attention towards green initiative for environment conservation and energy efficiency as it is very essential for earth for long term sustainability. PCMC (Pimpri Chinchwad Municipal Co-orporation) has planned to spend Rs. 5000 crores on Green projects. One of Greenest and first in India Corporate Campus in World is Suzlon One earth situated in Magarpatta road, Hadapsar, Pune. This Campus is completely relying on renewable energy sources, utilizing a combination of hybrid wind turbines, solar panels, and photovoltaic cells for power generation. This studies depicts importance of green building initiative and by 2025, the majority of residential areas in PCMC are expected to transition into self-sustaining real estate developments. The PCNTDA (Pimpri Chinchwad New Town Development Authority) has outlined a structured, forward-thinking, and eco-conscious approach to real estate development in PCMC
Tourists’ Satisfaction Towards Service Quality Of Hotels In Goa, India
Full text linkHotel business is one of the main activities of the hospitality industry. Hotel service gives home feeling to the tourists at destination. Hospitality industry will not survive if they don’t provide quality services to the tourists. The present paper investigates influence of service quality dimensions of hotel services on the tourists’ satisfaction. Total 600 tourists including both domestic and foreign were interviewed and collected data was analysed using SPSS software. Exploratory factor analysis was conducted for the purpose of dimension reduction and the influence of identified dimensions of service quality of hotels on tourists’ was tested using multiple regression analysis. The study revealed positive influence of identified dimensions of service quality of hotels on the tourists’ satisfaction, with coefficient of determination R2 of 74.5%. The study will prove beneficial to the stakeholders in improving their service quality and maintain tourists’ satisfaction and tourists’ loyalty.
 
Fingerprint Recognition System: A Systematic Literature Review
Full text linkThe biometrics system is mainly focuses on fingerprint recognition and how this system would be implemented. If it is implemented in research area, this system would authenticate or contradict the uniqueness of each individual endeavouring to gain access to the research region with a given sum of precision.The method of authenticating a person\u27s identity through a comparison of their fingerprints with previously captured samples is known as fingerprint recognition. Human finger impressions in the form of ridges and grooves are called fingerprints. The minutiae points, or the places where scars start or end, are used to locate fingerprints stored in the system. To create a minutiae template, these are further mapped with lines connecting them.An additional key challenge of this will understand the methods used to analysed the information from the scan. There are several different methods has been implemented by different researchers for the fingerprint recognition system. In this paper the literature of the different approaches are discussed
Bio- Method Development And Validation Of Ketotifen Fumarate In Rabbit Plasma Using RP-HPLC
Full text linkA simple, Accurate, precise method was developed for the simultaneous estimation of Ketotifen Fumarate in human plasma was developed and validated. By using Protein Precipitation, the sample preparation was prepared. Chromatogram was run through Discovery C18 (150x 4.6 mm, 5m) Mobile phase containing Buffer Na2HPO4: Methanol taken in the ratio 55:45 was pumped through column at a flow rate of 1.0ml/min. Buffer used Sodium Phosphate Buffer in this method was buffer. For the separation of Ketotifen Fumarate Internal Standard [IS] used is Remogliflozin. The Temperature was maintained at 30°C. Optimized wavelength selected was 222.0nm. Retention time of Ketotifen Fumarate and Internal Standard were found to be 2.980 min and 2.344 min. The standard curve was linear (R2 >0.995) over the concentration range of 9-360 ng/ml. According to ICH guidelines, each analytical validation parameter was determined. As accuracy, precision, recovery, and other validation parameters were all within the guidelines\u27 constraints, the bioanalytical technique created approach was selective, robust, and reliable. Without any interference from plasma, the peaks generated for the target substance and the internal standard were adequately separated from one another and had a sufficient tailing factor. Therapeutic drug monitoring (TDM), bioequivalence research, pharmacokinetics studies, toxicology, and biological investigations might all greatly benefit from the technique.
 
Therapeutic Potential Of Bacopa Monnieri Against Alcohol Induced Cardiac Toxicity In Rats
Full text linkA study was conducted to investigate the potential protective effects of Bacopa monnieri extract on alcohol-induced toxicity in rats, focusing on its hypolipidemic and cardioprotective properties. For a period of 30 days, the experimental rats were orally intoxicated with alcohol (2 g/kg body weight) daily. Simultaneously, Bacopa monnieri extract was administered at a dose of 200 mg/kg body weight. The results of the study revealed that the rats subjected to alcohol-induced toxicity experienced a significant reduction in antioxidant defense systems, such as reduced glutathione (GSH) and ascorbic acid, while the activity of glutathione-S-transferase was enhanced compared to the control group. Additionally, the alcohol-induced group exhibited increased levels of triglycerides (TG) and total cholesterol (TC), as well as a significant decrease in phospholipids (PL). However, when Bacopa monnieri was supplemented along with alcohol, it significantly improved the antioxidant status and normalized the lipid profiles. These findings suggest that Bacopa monnieri possesses cardioprotective and hypolipidemic activities, which provide protection against alcohol-induced toxicity
Preliminary Descriptions And Analysis Of Physical Development, Movement Readiness And Health Level Of Girls Students ( Handball
Full text linkIn this paper, the physical training and health conditions of female students playing handball sports were analyzed using innovative methods.  
Exploring Intestinal Barrier Function And Drug Delivery
Full text linkIn recent years, significant efforts have been made to understand oral drug absorption mechanisms and to develop new research models. These studies have been conducted using both in vitro and in vivo models and play a crucial role in determining the rate and extent of drug absorption in the intestines. Specifically, the permeability value (Peff value) is a common measure used to assess drug intestinal passage. Today, there is an increasing need for reliable gastrointestinal absorption models that can be used in preclinical studies to develop new drugs and appropriate dosages. However, collaboration and integration across different disciplines are important for further advancements in this field. Strengthening connections between pharmaceutical, biopharmaceutical, biochemical, and physiological research areas can contribute to a better understanding of drug absorption mechanisms and biopharmaceutical progress. Particularly, the use of animal models that mimic human intestinal drug permeability and the role of human cell culture models in investigating drug absorption in the intestine are highlighted as significant steps in this regard. Such research enables a more detailed examination of intestinal drug diffusion processes, which are crucial for the biopharmaceutical advancement of pharmaceutical compounds. Understanding factors such as the interactions between drug molecules and membrane transport molecules that affect the intestinal Peff value can further advance the assessment and improvement of drug absorption processes
Use Of Machine Learning For Intelligence Detection For Pharmaceutical Drug-Drug Interactions
Full text linkArtificial neural networks (ANNs) have been developed to predict the clinical significance of drug-drug interactions (DDIs) for a set of 35 pharmaceutical drugs using data compiled from the Web-based resources, Lexi- comp and Vidal, with inputs furnished by various drug pharmacokinetic (PK) and/or pharmacodynamic (PD) properties, and/or drug-enzyme interaction data. Success in prediction of DDI significance was found to vary according to the drug properties used as ANN input, and also varied with the DDI dataset used in training. The Lexicomp® dataset is found to give predictions marginally better than those obtained using the Vidal® dataset, with the best prediction of minor DDIs achieved using a multi-layer perceptron (MLP) model trained using enzyme variables alone (F1 82%) and the best prediction of major DDIs achieved using a MLP model trained on PK/PD properties alone (F1 54%). Given a more comprehensive and more consistent dataset of DDI data, we conclude that machine learning tools could be used to acquire new knowledge on DDIs, and could thus facilitate the regulatory agencies, and pharmacovigilance of newly licensed drugs
Comparative analysis of Hematological changes in Type 2 DM and Hypertensive Patients Post-Covid 19 Vaccination.
Full text linkBackground: The global response to COVID-19 emphasizes vaccination\u27s crucial role, raising concerns about potential hematological changes in individuals with Type 2 diabetes mellitus (DM) and hypertension. Type 2 DM, linked to elevated blood glucose and organ dysfunction, and hypertension, impacting cardiovascular and kidney health, pose challenges. This research aims to analyze post-COVID-19 vaccination hematological changes in these populations, offering insights for tailored vaccination strategies.
Material and Method: The study, involving 100 patients (50 each with Type 2 DM and hypertension), obtained ethical clearance and analyzed hematological parameters using Sysmex XN-330. Inclusion criteria covered clinically diagnosed adults who completed the COVID-19 vaccination series within six months, ensuring accessible medical records and informed consent.
Result: Post-COVID-19 vaccination, T2DM patients demonstrated significantly higher Hemoglobin levels (T2DM: 13.37 ± 2.05 gm/dl; Hypertensive: 11.95 ± 1.87 gm/dl, P < 0.001) and elevated Total Red Blood Cell count (T2DM: 4.73 ± 0.57 million/microliter; Hypertensive: 4.2 ± 0.6 million/microliter, P < 0.001). Absolute leukocyte counts in T2DM were notably increased for Neutrophils, Lymphocytes, Monocytes, and Eosinophils compared to Hypertensive patients. Haematocrit was higher in T2DM (41.33 ± 5.37%) than in Hypertensive patients (37.44 ± 5.5%, P = 0.00028). Platelet Count, Total Leukocyte Count, and differential leukocyte counts showed no significant differences.
Conclusion: The study emphasizes the nuanced hematological responses post-COVID-19 vaccination in Type 2 Diabetes Mellitus and Hypertensive patients. Recognizing these variations underscores the significance of considering underlying health conditions when assessing post-vaccination hematological profiles
Quantification of bone marrow fat fraction in type 2 Diabetes Mellitus using Dixon MRI
Full text linkBackground: Due its chronic nature, diabetes mellitus (DM) can damage several body systems. In the skeletal system it can cause bone loss, increased bone marrow fat content and even osteoporosis. Recently, skeletal fragility is a known complication of type2 DM (T2DM) with increased fracture risk.
Aim of study: to evaluate the utility of Dixon magnetic resonance imaging (MRI) to quantify bone marrow fat (BMF) and assess the fat fraction (FF). As evidence that non mineralized component may be important in the evaluation of bone strength.
Patients and methods: This case control study included 50 participants classified into 2 groups: group A (control group) included 30 normal healthy age, sex and body mass index (BMI) matched population, group B included 20 T2DM patients without microvascular complications, Dixon MRI of lumbosacral spine and both hips was performed for all participants with quantification of bone marrow FF.
Results: The study showed a statistically significant difference in FF measured by Dixon MRI in lumbar vertebrae but not femoral neck between T2DM cases and control. This may be explained by higher FF normally in femur more than the vertebrae. Pairwise comparisons with Bonferroni correction for multiple tests revealed that FF in lumbar vertebrae was statistically significantly higher in the non-complicated diabetic group vs. the control group (p-value =.001)
Conclusion: T2DM is associated with changes in the bone quality with increased bone marrow FF that can be reliably assessed using Dixon MRI. This can be used as potential therapeutic target for drugs to restore proper BMF content, early prevention and treatment of fractures