Journal Of Advanced Zoology
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An Assessment Of Opioid Poisoning
Full text linkOpioids are commonly used for management of pain. The term opioids include compounds that are extracted from the poppy seed as well as semi synthetic and synthetic compounds. Their regular non-medical use, Prolonged use, misuse and the use without medical supervision can lead to opioid dependence and other health related problems. Opiate dependence is the disorder of regulation of opioid use arising from repeated or continuous use of opioids. In worldwide, about 275 million people or {5.5 percentage of global population aged 15 to 64 yrs.} Used drugs At least once in 2019. Among them about 62 million people used opioids. Opioid use can lead to death due to effects of opioids on the part of the brain which regulates breathing. The number of opioid overdoses has increased in recent years in several countries in part due to the increased use of opioids in the management of chronic pain. Males, People of older age and people with low social economic status are at higher risk of opioid overdose than women. In this article we highlighted about various types of opioids, how it causes effects and symptoms for acute poisoning and chronic poisoning and suggested some of the safety measures and treatment guidelines regarding the opioid overdose condition
Pharmacogenetic Variation Of CYP2C19 Affecting The Efficacy Of Anti-Platelet Therapy
Full text linkAntiplatelet drugs used to treat and prevent platelet aggregation in conditions like stroke and cardiovascular events. Pharmacogenetics plays a vital role in affecting the treatment outcome due to its variation. Cytochrome P450 (CYP450) enzymes especially, CYP2C19 play in the metabolism of a variety of medications, including clopidogrel and genetic variation of CYP2C19 may affect clopidogrel metabolism which is a prodrug. Through encouraging a shift in antiplatelet therapy toward customized medicine, it improves the science of pharmacogenetics. More precise and effective patient care in the area of cardiovascular health is possible if doctors are encouraged to consider hereditary traits while prescribing antiplatelet medications.
Keywords: Anti-platelet, pharmacogenetics, CYP450, genetic variation in CYP2C19, clopidogrel, prasugrel and ticagrelo
Wild Ethnomedicinal Plants At Rhimona National Park Of Kokrajhar District Of Bodoland Territorial Region In Assam: A Survey-Based Study And Review
Full text linkThe research endeavor delved into the exploration of wild ethnomedicinal plants situated within Rhimona National Park, nestled in the Kokrajhar district of the Bodoland Territorial Region (BTR) in Assam, North East India. These plants, endowed with ethnomedicinal qualities, hold significant importance for the bodo tribal communities residing in the district, serving as invaluable sources of herbal medicines. To comprehensively document the ethnomedicinal knowledge embedded within these biodiverse landscapes, the study employed a methodical approach. Through interviews and detailed questioning, information was meticulously gathered to unveil the traditional uses of various plants as medicinal resources within the expansive expanse of Rhimona National Park. The findings of the investigation revealed a rich tapestry of biodiversity, identifying a total of 51 plant species belonging to 36 families. These botanical entities play a dual role, not only serving as sources of local vegetables but also contributing to the traditional pharmacopeia for the treatment of a myriad of ailments. The survey brought to light a diverse array of plant forms, encompassing herbs, shrubs, climbers, and a few towering trees, collectively underscoring the dynamic relationship between the indigenous communities and the wealth of ethnomedicinal flora flourishing in this unique natural habitat. This research contributes valuable insights into the intertwined dynamics of cultural practices, traditional knowledge, and the rich botanical heritage existing within the confines of Rhimona National Park
Design And Fabrication Of Emergency Braking System InFour-Wheeler
Full text linkMostly people prefer using cars and four wheelers for efficient transportation. Vehicle Technology is increasing to a wide extent especially in braking systems and sensing systems. Vehicles equipped with modern braking technology is designed with simple collision avoidance system, which will help to detect a collision which is likely to occur and applying emergency brake to avoid it. Such technologies will reduce the number of accidents which causes worst damages, serious injury, and even death. In this automatic braking system, there is a four- wheel cart in which rare wheels are being motorized for drive wheel. FRONT wheels have been pivoted for staring mechanisms. New friction brakes are designed for emergency braking. The brakes are operated by motorized mechanism, which is spring-loaded. The drive of the car is remote operated. Two sensors are used for front and rare for avoiding damage to the car at the time of parking. The sensors used are a capacitive type which can sense both Metal and non-metal obstacles. Also, two relays are used after the sensors which activate the braking motor when obstacles are sensed either in forward or reverse direction
Pancreas Transplant: Brief Review Of The Journey, Current Evidence And Future Prospects.
Full text linkPancreas transplantation has emerged as a ground breaking medical intervention for individuals suffering from diabetes mellitus, offering a potential resolution to the root cause of the disease. This review seeks to explore the realm of pancreas transplantation in greater depth. It encompasses the historical progression, nuanced surgical methodologies, intricate immune suppression protocols, resultant clinical effects, and the encouraging trajectories that offer promise in propelling this field forward. This article also entails the current scenario of pancreas transplant in India as well as the latest upgradation in techniques and modalities of pancreas transplant
Isolation Of Bacillus Thuringiensis From Soil Sample, Identified By 16s Rrna Analysis And Identify Its Larvicidal Activity On Jasmine Plant
Full text linkBacillus thuringiensis (Bt) is having a most important role in the field of agriculture and genetic engineering because of its uniqueness in protein production. It supports to control various pest in plants such as green fly, white fly, beetles and few types of larvae by its toxic nature. It works well as insect and pest controller in the genetically modified crops. The Bt toxic genes were used in some crops for the pest control. In this work, we had to isolate the target bacterial strains from agricultural soil. The isolated bacterial strains were identified by macroscopic and microscopic observations. Later the isolated bacterial strains forwarded to 16s rRNA analysis for the bacterial confirmation. The isolated bacterial strain used to control pest in the jasmine plants and positive level of results were collecte
Role Of Biomarkers In Enhancing Accuracy Of Human Disease Diagnosis
Full text linkIn modern medicine, the role that biomarkers play in improving the precision of human illness diagnosis has grown crucial. Biomarkers are measurable indicators of natural cycles or circumstances that provide valuable insights into the early identification, prediction, and response to therapy of many diseases. The significance of biomarkers in improving the accuracy of symptoms by elucidating their ability to represent cellular and subatomic changes associated with specific illnesses. Their potential in the screening, diagnosis, and observation of diseases such as neurological problems, cardiovascular ailments, and malignant growths has been unparalleled. The coordination of state-of-the-art revelations like proteomics, metabolomics, and genomes consider an intensive assessment of biomarkers, empowering medical experts to tweak meds in light of the novel qualities of every patient. In the appraisal of disease risk, the utilization of biomarkers as early advance notice systems has filled fundamentally in the new past. Biomarkers are signs of disease cycles, regular normal cycles, or pharmacological responses to treatment. Society is enormously affected by the utilization and irrefutable proof of biomarkers in the clinical and medical areas. We take a gander at the scope of encounters, different definitions, portrayals, qualities, and exposures of biomarkers in this review. Moreover, an evaluation is made on the likely uses of biomarkers all through the past 10 years in the recognizable proof, representation, and the board of different sicknesses
Therapeutic Potential Of Benincasa Hispida For The Treatment Of Alzheimer Disease
Full text linkThis article provides details on the annual climbing plant Benincasa hispida, a natural herb from the cucurbitaceae family.. The fruit is also called as winter gourd, ash gourd and kushmanda fruit. It is the most well-liked herb that is readily available to communities for medicinal and nutritional purposes. The phytochemical review indicates the presence of pentacyclic triterpene, flavonoids, volatile oils, bryonolic acid, alnusenol, multiflorenol, isomultiflorenol, lupeol, β-sitosterol etc. Benincasa hispida fruit is one of incredible fruit which can improve health, treat a variety of illnesses and prevent many more. Pharmacological studies have revealed that the Benincasa hispida plant is useful in the treatment of several nerve diseases, including peptic ulcer, diabetic mellitus, internal organ hemorrhages, jaundice, epilepsy, and Alzheimer\u27s disease.. The review mainly focuses on the effect of the fruit Benincasa hispida\u27s potential to treat alzheimer\u27s disease.This article covers all relevant information regarding Benincasa hispida with both historical and contemporary example
Glimpses Of Modern India In Gita Mehta’s ‘Snakes And Ladders
Full text linkGita Mehta, in her fiction and non-fiction, has dealt with the paradox of the old and the new as a significant component of Indian culture. Scholars tend to believe that the twin factors of tradition and modernity are not antithetical to each other, as some earlier thinkers used to consider. They always co- exist, drawing regularly from each other and work together for the progression of society. Taking into consideration the observations of the scholars on the aspects of tradition, modernity, modernization and westernization, the present article is an effort to study Gita Mehta’s attempt to explore the dual strands of the Indian ritualistic past and its modern rationalistic present, their interaction and their impact on the Indian culture. For this study, Mehta’s non-fiction Snakes and Ladders: Glimpses of Modern India is being taken into consideration
Adulticidal, Ovicidal And Repellent Properties Of Parthenium Hysterophorus Extract Against Dysdercus Cingulatus (FAB.) (Hemiptera: Pyrrhocoridae)
Full text linkThe advent of synthetic pesticide resistance poses a challenge to insect control and can have hazardous effects on the environment. In the future, botanical insecticides could make good substitute biocontrol methods.This study was designed to assess the adulticidal, ovicidal, and repellent potential of the crude methanol solvent extracts from Parthenium hysterophorus. In adulticidal activity, methanol extracts of Parthenium hysterophorus leaves were prepared and used at different concentrations ranging from 100 to 1000 ppm. Methanol extracts of Parthenium hysterophorus were allowed to continuously feed on adult Dysdercus cingulatus for 96 hours. Taken extracts were tested for their ovicidal activity by spraying them on freshly laid down Dysdercus cingulatus eggs. One hundred newly laid eggs were given a total of six treatments with varying concentrations of methanol extract, i.e., 25, 50, 75, 100, and 125 ppm. In study of repellent, half of a filter paper disc was evenly coated with methanol extract of Parthenium hysterophorus at various concentrations, i.e., 25, 50, 75, and 100 ppm. Each filter paper\u27s other halves were left untreated. After air-drying, the modified half discs were assembled again as full discs in a Petri dish. Five insects were placed in the centre of each filter paper, then placed in a Petri dish. The ovicidal and repulsive activity data were expressed as mean ± S.D. and One-way ANOVA with a significant (p<0.05). The adult D. cingulatus mortality rate notably increased with the increase in the concentration of plant extract of the P.hysterophorus egg hatchability was significantly declined by methanol extract of P. hysterophorus exposure and was found to be concentration dependent .The repellent activity also was found to be concentration dependent .This result show methanol extract of P. hysterophorus leaves can may kill the red cotton bug adult, egg and show repellent activity against D. cingulatus in dose dependan