Multidisciplinary Digital Publishing Institute (Switzerland)
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Drug-Induced Acute Generalized Exanthematous Pustulosis: Mechanisms, Diagnosis, and Clinical Differentiation from Other Pustular Eruptions
No full textBackground/Objectives: Acute generalized exanthematous pustulosis (AGEP) is a severe drug-induced cutaneous reaction characterized by the abrupt onset of sterile pustules, fever, neutrophilia, and a T cell-mediated type IVd hypersensitivity response. This narrative review synthesizes current evidence on pharmacological triggers, immunopathogenic mechanisms, diagnostic criteria, and differential diagnosis to provide a clinically oriented framework. Methods: A comprehensive literature search was conducted in PubMed/MEDLINE, Scopus, ScienceDirect, and SpringerLink for studies published between 2000 and 2025, complemented by selected clinical reference sources. Studies addressing clinical features, immunological pathways, pharmacovigilance signals, and diagnostic tools for AGEP were included. Synthesis of Evidence: β-lactam antibiotics remain the most frequent triggers, while increasing associations have been reported with hydroxychloroquine, targeted therapies, immune checkpoint inhibitors, psychotropic agents, and vaccines. Immunopathogenesis is driven by IL-36 activation, CXCL8/IL-8–mediated neutrophil recruitment, and IL36RN mutations, explaining overlap with pustular psoriasis. Diagnostic accuracy improves through integration of drug latency, clinical morphology, histopathology, biomarkers, and standardized tools such as the EuroSCAR score. Conclusions: AGEP is a complex pustular reaction induced by diverse drugs and amplified by IL-36-mediated inflammation. Accurate diagnosis requires a multidimensional approach supported by structured algorithms and robust pharmacovigilance to identify evolving drug-associated patterns
Partially Observed Two-Phase Point Processes
No full textIn this paper, a two-phase spatio-temporal point process (STPP) defined on a countable metric space and characterized by a conditional intensity function is introduced. In the first phase, the process is memoryless, generating completely random point patterns. In the second phase, the location and occurrence time of each event depend on the spatial configuration of previous events, thereby inducing spatio-temporal correlation. Theoretical results that characterize the distributional properties of the process are established, enabling both efficient numerical simulation and Bayesian inference. A statistical inference framework is developed, for the setting in which the STPP is observed at discrete calendar dates while the spatial locations of events are recorded, their exact occurrence times are unobserved, i.e., interval-censored. This partial observation scheme commonly arises in ecological and epidemiological applications, such as the monitoring of plant disease or insect pest spread across a spatial grid over time. The methodology is illustrated through an analysis of the spatio-temporal spread of sugarcane yellow leaf virus (SCYLV) in an initially disease-free sugarcane plot in Guadeloupe, FrenchWest Indies
Precision Localization of Autonomous Vehicles in Urban Environments: An Experimental Study with RFID Markers
No full textThis paper presents an experimental study validating the feasibility of Radio Frequency Identification (RFID) marker systems as a complementary solution for autonomous vehicle (AV) localization in Global Navigation Satellite System (GNSS)-degraded urban environments. A novel synchronized dynamic testbed featuring hardware-level integration with wheel revolution tracking enables precise correlation of RFID marker reads with vehicle angular position. Experimental results demonstrate that multi-antenna configurations achieve consistently high read success rates (up to 99.6% at 0.5 m distance), sub-meter localization accuracy (~55 cm marker spacing), and reliable performance at average urban speeds (36 km/h simulated velocity). Spatial diversity from four strategically positioned antennas overcomes multipath interference and orientation challenges inherent to high-speed RFID reading. Processing latency remains well within the 58 ms time budget critical for autonomous navigation. These findings validate RFID’s potential for smart road infrastructure integration and demonstrate a scalable, cost-effective solution for enhancing AV safety and decision-making capabilities through contextual information transmission
Using Co-Design to Adapt a Digital Parenting Program for Parents Seeking Mental Health Support
No full textBackground/Objectives: Parental mental health challenges are associated with parenting difficulties and child mental health issues. Parenting interventions can support families; however, parents with mental health challenges face barriers to accessing parenting support, which is not consistently offered within adult mental health settings. Embedding technology-assisted parenting programs into these settings could provide accessible, holistic support. Partners in Parenting Kids (PiP Kids) is a digital parenting program designed to prevent child anxiety and depression, yet its suitability for parents with mental health challenges and fit within mental health services remains unclear. This study aimed to co-design and adapt PiP Kids for future implementation in an Australian adult mental health service. Methods: Parents who recently sought mental health support (n = 8) and service providers (n = 7) participated in co-design workshops to explore needs and preferences for a technology-assisted parenting program and iteratively develop a prototype. Parents (n = 3) trialled the online component of the prototype and participated in qualitative interviews to assess acceptability. Results: The adapted clinician-supported program was designed to facilitate (1) parent and clinician readiness for parenting support; (2) emotional and social support for parents and clinicians; (3) practical, personalised parenting knowledge; (4) parent-led empowerment; and (5) accessible, integrated support. Prototype clinician training was developed to strengthen the clinician-support component. Parents indicated initial acceptability of the online prototype while reiterating the value of including face-to-face support. Conclusions: This study co-designed an online, clinician-supported parenting program for future embedding within adult mental health settings. The findings highlight key considerations for developing and implementing technology-assisted interventions that promote family-focused care for parents seeking mental health support
Energy Management in Microgrids: Commercial, Industrial, and Residential Perspectives
No full textThis study aims to review the energy management of microgrids with a structured focus on residential, commercial, and industrial applications. Building on early optimization and control strategies, this study synthesizes advances in forecasting, uncertainty management, computational intelligence, and digital twin integration. Particular attention is given to multi-energy coupling through storage technologies, including hydrogen and thermal pathways, along with life cycle, trilemma, and sustainability considerations. Sector-specific energy management system (EMS) strategies are compared in terms of objectives, methods, and implementation challenges, highlighting both converging and unique requirements across application domains. Cross-sectoral challenges, such as interoperability, cyber-security, resilience valuation, and policy gaps, are analyzed, and emerging research directions, including artificial intelligence (AI)-driven optimization, hierarchical and multi-agent frameworks, and hydrogen-enabled autonomy, are outlined. This review aims to equip researchers, practitioners, and policymakers with a consolidated reference on microgrid EMS, bridging technical innovation with sustainable and resilient energy transitions
Barriers to Employment Among People with Disabilities in Trinidad and Tobago
No full textTrinidad and Tobago (T&T) has regional influence in the Caribbean, with a diversified economy focused on energy, manufacturing, and finance compared to the tourism-related economies of most of the other Caribbean islands. Notwithstanding, this has not translated into equitable opportunities for all, specifically for people with disabilities. A lack of disaggregated employment data thwarts effective policy planning for people with disabilities. This research sought to examine the barriers to their employment in T&T. Underpinned by the social model of disability, a concurrent mixed-methods approach was employed. Emanating from interviews with people with disabilities and key informants, challenges to employment access, employer perceptions, and apathy emerged as key themes, together with the underlying issues of a lack of legislation and inequitable access to mainstream education. The survey findings indicated that 64% of employers had never employed people with disabilities, 57% expressed neutrality regarding future employment of such individuals, and 69% had not introduced workplace accommodations. A key recommendation of the study is the establishment of an employer resource centre that assists employers in creating and maintaining inclusive workplace accommodations for people with disabilities. This study is the first in Trinidad and Tobago to examine these research objectives from multiple perspectives
Optical and Mechanical Characterization of Lignocaine-Impregnated Maltose-Based Dissolvable Microneedles
No full textDissolvable microneedles (DMNs) represent an innovative approach to patient-friendly drug delivery, eliminating the need for conventional hypodermic injections. This study reports on the fabrication, Confocal Laser Scanning Microscopy (CLSM)-based optical visualization of drug distribution, and mechanical characterization of maltose-based DMNs impregnated with lignocaine, a local anesthetic. Microneedles were fabricated using a micro-molding technique and dried for nine hours. Structural integrity was evaluated using Field Emission Scanning Electron Microscopy (FESEM); drug distribution was examined via CLSM; and mechanical strength was assessed using nanoindentation. The FESEM results showed uniform microneedle formation with sharp tips and smooth surfaces, averaging 435 µm in height and 116 µm in width, with no significant dimensional variability (p > 0.5). CLSM analysis indicated even distribution of lignocaine throughout the matrix. Mechanical testing showed that each microneedle withstood 0.6 N, surpassing the 0.1 N threshold required for skin insertion. These results support the viability of maltose-based DMNs for local anesthetic delivery, with implications for outpatient, pediatric, and self-administered care settings. Future investigations will include Franz diffusion and in vitro dissolution studies to examine release kinetics
Computation of Conduction and Displacement Current Densities in Modelled Human Organs near an Overhead Transmission Line
No full textThis study employs numerical simulations to analyse current densities in modelled human organs originating from extremely low frequency (ELF) electromagnetic fields emanating from a 110 kV single-circuit high-voltage transmission line. Exposure to these ELF fields gives rise to both conduction and displacement currents within the human body, potentially perturbing endogenous bioelectric currents and raising concerns of health risks. Using CST Studio Suite 2018 software, a three-dimensional multipart ellipsoidal anatomical model is developed to analyse these phenomena. Although displacement currents have lower magnitudes than conduction currents, they contribute significantly to the total current density and must therefore be included in rigorous safety assessments. Simulation results indicate that the current density values remain below the basic restrictions of the International Commission on Non-Ionizing Radiation Protection
Study on Thermophysical Properties and Electrical Conductivity Characteristics of Combustion Products from Propellants with Ionization Seeds
No full textDetailed knowledge regarding the thermophysical properties and electrical conductivity of the combustion products derived from solid propellants is essential for the optimized design and operation of solid-fuel rocket engines employing magnetohydrodynamic drive technology. However, the high-temperature and high-pressure environment prevailing during rocket operation makes the experimental measurement of these characteristics extremely difficult, while the ionization reactions obtained by adding ionization seeds containing cesium to solid propellants for increasing the electrical conductivity of gaseous combustion products makes the theoretical calculation of these characteristics extremely problematic as well. The present work addresses these issues by constructing a minimum Gibbs free energy constraint function in conjunction with the Debye–Hückel correction under the condition of ionization to calculate the equilibrium components of combustion products. The obtained equilibrium components are then applied in conjunction with Lennard–Jones potential energy theory and the Champan–Enskog framework to approximately calculate the specific heat, viscosity coefficient, and thermal conductivity of propellant gases over a wide range of temperatures and pressures. The Kantrowitz model is proposed to solve the electrical conductivity of combustion products. Finally, the accuracy of the numerical calculations is validated through the Langmuir probe experiment. The discrepancy between calculated and measured electron density decreases with increasing temperature and remains within 5% when the combustion product temperature exceeds approximately 1800 K. The validity of the proposed framework is demonstrated by examining the effects of temperature, pressure, and ionization seed content on the thermophysical properties and electrical conductivity of the combustion products derived from tri-base solid propellant with cesium atoms employed as ionization seeds
Suidae Coronaviruses: Epidemiology, Transmission, and Molecular Diagnosis
No full textThe emergence and spread of swine coronaviruses represent a growing challenge for both veterinary medicine and public health. These viruses exhibit high mutation rates, recombination potential, and the capacity for cross-species transmission. Among the most relevant pathogens are PEDV, TGEV, PRCV, PHEV, PDCoV, and SADS-CoV, which have caused significant outbreaks in swine production systems worldwide, with severe economic consequences. Recent evidence demonstrates coronavirus circulation in wild boar populations across Europe, including Italy, Spain, and Germany. Although wild boars are not confirmed as primary reservoirs, their ecological behavior and increasing overlap with domestic pigs raise concern over their potential role in maintaining viral circulation. Future research priorities should focus on developing a more integrated and coordinated system for the control of swine coronaviruses, including strengthened surveillance in both domestic pigs and wild boar populations, the use of molecular epidemiology techniques to identify emerging variants, and structured collaboration among veterinary, ecological, health, and regulatory sectors. Finally, investment is needed in the development of next-generation vaccines and diagnostic tools to address the considerable genetic variability of swine coronaviruses and to improve the prevention and early detection of and response to future epidemic threats