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Prevalence, antibiotic resistance, and biofilm formation of coagulase-positive staphylococci in Izmir Tulum Cheese
Get PDFKoagülaz-pozitif stafilokoklar (CPS), stafilokokal gıda zehirlenmelerinde başlıca bakteriyel etkenler olup, insanlarda ve hayvanlarda enfeksiyonlara neden olarak önemli bir halk sağlığı riski oluştururlar. Bu çalışmada, İzmir ilindeki çeşitli perakende satış noktalarından toplam 100 İzmir Tulum Peyniri örneği toplanmıştır. Peynir örneklerinden standart kültürel yöntemler kullanılarak CPS izolatları elde edilmiştir. CPS izolatlarının fenotipik antibiyotik dirençleri agar disk difüzyon testi ile, biyofilm oluşturma kapasiteleri ise kolorimetrik yöntemle belirlenmiştir. Çalışmada, analiz edilen 100 İzmir Tulum Peyniri örneğinin 30'unda (%30) CPS izole edilmiş ve bu örneklerin 27’sinde (%27), Türk Gıda Kodeksi Mikrobiyolojik Kriterler Yönetmeliği'nde belirtilen maksimum CPS sınırı olan 10³ CFU/g’nin üzerinde CPS düzeyleri tespit edilmiştir. Antimikrobiyal direnç testi sonucunda, 30 CPS izolatının %90’ının penisiline dirençli olduğu belirlenmiştir; diğer yaygın antibiyotiklere direnç oranları ise %83,3 klindamisin, %56,7 siprofloksasin ve %53,3 tetrasiklin olarak tespit edilmiştir. Ayrıca, izolatların %76,7’sinin çoklu ilaç direncine sahip olduğu, yani farklı antibiyotiklerle kolayca öldürülemediği ve bu durumun tedavi seçeneklerini sınırladığı belirlenmiştir. Bunun yanı sıra, CPS izolatlarının %83,3’ünün biyofilm oluşturma kapasitesine sahip olduğu tespit edilerek, bunun gıda güvenliği üzerindeki olumsuz etkisi vurgulanmıştır. Elde edilen bulgular, süt ürünlerinde biyofilm oluşumuna karşı yenilikçi stratejilerin yanı sıra daha sıkı hijyen protokolleri ve kontrollü antibiyotik kullanımının gerekliliğini ortaya koymaktadır.Coagulase-positive staphylococci (CPS) are the main causative bacterial agents of staphylococcal food intoxication, posing a significant public health risk and causing infections in humans and animals. In this study, a hundred Izmir Tulum Cheese samples were collected from various retail outlets in the Izmir province. CPS isolates from cheese samples were identified using standard cultural methods. The phenotypic antibiotic resistance of CPS isolates was determined using the agar disk diffusion test method, while their biofilm formation capacity was assessed using the colorimetric method. In the study, CPS was isolated from 30 out of 100 analyzed Izmir Tulum Cheese samples (30%), and it was determined that 27 of these samples (27%) had CPS levels exceeding the maximum acceptable limit of 10³ CFU/g set by the Turkish Food Codex Microbiological Criteria Regulation. Antimicrobial resistance analysis revealed that among the 30 CPS isolates, 90% were resistant to penicillin, while resistance rates to other commonly used antibiotics were 83.3% for clindamycin, 56.7% for ciprofloxacin, and 53.3% for tetracycline. Additionally, 76.7% of the isolates were multidrug-resistant, meaning they were not easily killed by different antibiotics, which limits treatment options. Furthermore, 83.3% of the CPS isolates had the capacity for biofilm formation, highlighting its impact on food safety. These findings emphasize the need for stricter hygiene protocols, controlled antibiotic use, and innovative strategies to combat biofilms in dairy production
Investigation of the relation between primary-aged children's screen addiction and their skills to regulate emotions
Get PDFBu araştırmada ilkokul dönemindeki çocuklarda gözlenen ekran bağımlılığı, problemli görsel medya kullanımı ile çocukların duygu yoğunluğu ve duygu düzenleme becerileri arasındaki ilişkilerin incelenmesi amaçlanmaktadır. Çocuğun yaşı, cinsiyeti, yaklaşık günlük ekran süresi, sahip olduğu görsel medya aracı, ailenin ekonomik durumu gibi değişkenlerden yararlanılmıştır. Çalışmanın ayrıca okullarda sağlık, eğitim ve aile iş birliği çalışmaları için farkındalık oluşturması, destekleyici çalışmalara yol gösterici olması amaçlanmaktadır. Araştırma ilişkisel tarama modeline göre tasarlanmıştır. Betimsel bir desende yürütülmüş, veriler tek seferde öğretmenler aracılığıyla elden toplanmıştır. Veri toplama araçları olarak demografik bilgi formu, problemli medya kullanım ölçeği ve çocuklar için duygu düzenleme ölçeği kullanılmıştır. Duygu yoğunluğu ve duygu düzenleme becerilerinin problemli medya kullanımı üzerindeki yordayıcılığını incelemek için gerçekleştirilen analiz sonuçlarına göre, çocuklarda öfke duygu yoğunluğu ve heyecan duygu yoğunluğu problemli medya kullanımını anlamlı şekilde yordamaktadır.The objective of this study is to examine the relationships between screen addiction, problematic visual media use, and children's emotional intensity and emotion regulation skills observed in primary school children. Variables such as the child's age, gender, approximate daily screen time, the visual media tool owned by the child, and the economic status of the family were utilised. Additionally, the study aims to raise awareness for health-education and family cooperation studies in schools and to guide supportive studies. The research was designed in accordance with the relational survey model. It was conducted in a descriptive design, and the data were collected manually by teachers at one time. The demographic information form, problematic media use scale and emotion regulation scale for children were used as data collection tools. According to the results of the analyses conducted to examine the predictive power of emotion intensity and emotion regulation skills on problematic media use, the model was found significant. In the model, anger emotional intensity and excitement emotional intensity significantly predicted problematic media use in children
Comparison of the overall fit of three-unit posterior fixed dental prostheses fabricated with laser sintering and conventional casting methods
Get PDFObjectives The aim of this study was to investigate the marginal, internal, and occlusal discrepancies of three-unit posterior cobalt-chromium (Co-Cr) fixed dental prostheses (FDPs) produced using five different fabrication techniques. Materials and methods Segmental maxillary models were prepared from polyamide material using a laser sintering method. The maxillary first premolar and first molar teeth were prepared to receive posterior FDPs. Direct metal laser sintering (DMLS) and selective laser melting (SLM) were used as two metal laser Co-Cr framework production systems. FDP specimen patterns were prepared by manual wax carving (Cast), 3D-printed polymer (3DP), and CAD/CAM wax and cast using the lost-wax technique as conventional methods. In total, 100 Co-Cr metal framework specimens were prepared for posterior FDPs (n = 20). The silicone replica technique was used to measure marginal, internal, and occlusal discrepancies of all frameworks. A stereomicroscope was employed to detect discrepancies at 100x magnification. The data were analyzed using two-way ANOVA (alpha = 0.05) and post hoc Bonferroni adjustment (alpha = 0.005) for pairwise comparisons. Results There were no significant differences between the occlusal discrepancy values of premolar abutments of FDPs when compared with different fabrication methods (P > 0.05). The highest marginal discrepancy value was detected as 116.22 mu m for molar abutment when the Cast method was used (P < 0.05). The highest occlusal discrepancy values were detected as 135.60 mu m and 141.49 mu m for molar abutments of posterior FDPs when the 3DP and Cast methods were used. The lowest marginal discrepancy value was detected as 38.94 mu m for molar abutments when the DMLS method was used (P < 0.05). Conclusions The DMLS method was more successful than other fabrication methods when fit values of abutment teeth for posterior frameworks were compared. Clinical relevance The morphology of the abutment teeth and the fabrication techniques of FDPs migth affect the discrepancy values of FDPs planned. It was seen that the discrepancy values were lowest with the DMLS and SLM methods. Considering the results of this in-vitro study, DMLS and SLM techniques may be more appropriate option than the 3DP method, which starts with digital design and ends conventionally casting technique for posterior three-unit FDPs.Scientific and Technological Research Council of Turkiye (TUBITAK); Kutahya Dumlupinar University Scientific Research Projects Coordination Office [2016-88]Open access funding provided by the Scientific and Technological Research Council of Turkiye (TUBITAK).This research was partially supported by Kutahya Dumlupinar University Scientific Research Projects Coordination Office under grant number 2016-88
Identification of lactic acid bacteria isolated from the protected geographical indication Edirne white cheese using MALDI-TOF MS: Impact of ripening time and type of milk on microbial diversity
No full textIn this study, the diversity of lactic acid bacteria (LAB) in three different Edirne white cheeses produced using sheep, cow, and goat milk was investigated using MALDI-TOF/MS over a 180-day ripening period. In total, 201 LAB belonging to 15 different species were detected. Enterococcus faecium, which constituted 43.28% of the LAB, was the dominant species in all three types of cheese. However, its abundance decreased throughout storage in goat and cow cheeses, followed by Lactococcus lactis in sheep cheese, Streptococcus macedonicus, Lactiplantibacillus plantarum, Leuconostoc mesenteroides in cow cheese, and L. plantarum and Latilactobacillus curvatus in goat cheese. The type of milk and the ripening time affect the microbial diversity in cheese
The effect of neoadjuvant chemotherapy on survival outcomes in patients with variant histologies who underwent radical cystectomy with precystectomy diagnostic accuracy: A multicenter study of the Turkish Urooncology Association
No full textObjectives To evaluate the role of neoadjuvant chemotherapy in the final treatment plan and its impact on survival in bladder cancer patients who were diagnosed with variant histology in the radical cystectomy specimen and whose diagnostic accuracy was achieved with the previous transurethral resection of the bladder specimen. Methods In this retrospective multicenter study, data from 221 patients across 9 centers were analyzed between January 2012 and January 2022. The primary endpoint was overall, cancer-specific, recurrence-free, and metastasis-free survival rates among patients with and without neoadjuvant chemotherapy, and the secondary endpoint was to identify independent predictors of survival. The Kaplan-Meier method was used to estimate overall survival, cancer-specific survival, recurrence-free survival, and metastasis-free survival, and multivariate analyses were performed using the Cox-regression model. Results Kaplan-Meier estimates of overall, cancer-specific, recurrence-free, and metastasis-free survival demonstrated no significant difference between two groups. Cox multifactorial analysis revealed that the age (HR 1.030, 95% CI 1.003-1.057, p = 0.027), presence of pT4 tumor stage (HR 3.861, 95% CI 1.303-11.494, p = 0.015), and pN+ (HR 2.288, 95% CI 1.475-3.550, p < 0.001) at radical cystectomy histopathology were independent predictors of overall survival; presence of pT4 tumor stage and pN+ at radical cystectomy histopathology were independent predictors of cancer-specific survival (HR 8.245, 95% CI 1.873-36.292, p = 0.005 and HR 1.792, 95% CI 1.049-3.061, p = 0.033) and metastasis-free survival (HR 9.957, 95% CI 1.286-77.073, p = 0.028 and HR 2.949, 95% CI 1.674-5.197, p < 0.001); and the age (HR 1.047, 95% CI 1.006-1.090, p = 0.025) and pN+ at radical cystectomy histopathology (HR 4.150, 95% CI 1.917-8.981, p < 0.001) were independent predictors of recurrence-free survival. Conclusion Neoadjuvant chemotherapy does not provide any survival advantage in variant histology; therefore, considering the disadvantages, such as delaying radical cystectomy, which can lead to inadvertent disease progression and chemotherapy-related toxicities, cautious should be exercised when administering neoadjuvant chemotherapy.Turkish Urooncology Association: Levent Turkeri and Burak Argun; Urooncology, TurkeyMembers of Bladder Cancer study group of Turkish Urooncology Association: Levent Turkeri and Burak Argun have contributed to this study, but due to the authorship regulations of the Association of Urooncology, Turkey, their names are mentioned only in the acknowledgment section
Preparation of PVA-Cotton Fiber-Carbonyl Iron Composite Film for the Removal of Tetracycline from Water
No full textAs the use of antibiotics such as tetracyclines has increased, their presence in water has also risen, making their removal from water sources increasingly important. In this study, a film containing polyvinyl alcohol (PVA), cotton fiber, and carbonyl iron (PVA-CF/CI) was prepared, and its use as an adsorbent material for removing tetracycline from water was investigated. The characterization of the PVA-CF/CI film was carried out using SEM-EDAX and FTIR analyses. It was observed that the addition of carbonyl iron to the PVA film significantly increased tetracycline removal. The adsorption kinetic of tetracycline was found to follow pseudo-second-order model, and the adsorption isotherm model was best described by the Langmuir isotherm model. Tetracycline removal reached 90.8% at pH 3 and 1 g film dose. The qmax obtained with the PVA-CF/CI film containing carbonyl iron was 3.8 times higher than that obtained with the PVA film alone. As a result, while the addition of cotton to the films was not significantly effective, the addition of carbonyl iron was found to significantly enhance tetracycline removal. Additionally, it is possible to produce a more economical and less toxic film polymer by using PVA, cotton, and carbonyl iron.Tekirdag Namimath;k Kemal University BAP [NKUBAP.06.YL.22.445]This study was supported by Tekirdag Nam & imath;k Kemal University BAP with the project number NKUBAP.06.YL.22.445
Evidence-based care for nipple problems while breastfeeding
No full textBreast milk is the most suitable and nutritious food for babies and contains all the nutrients needed for healthy growth and development. It is recommended that breast milk is given within the first hour after birth and that exclusive breastfeeding is continued for the first 6 months. Breastfeeding is the easiest way to give breast milk to the baby. Breastfeeding is defined as feeding the baby with breast milk directly from the breast. However, breastfeeding can be interrupted by problems caused by the mother or the baby. Common nipple problems that interfere with breastfeeding are painful, fissure/wound, and flat/inverted nipples. While flat/inverted nipples are usually congenital, painful, fissure, or wound nipples can occur later. As a result, the baby may be prevented from receiving breast milk. To ensure babies' uninterrupted access to breast milk, nipple problems must be eliminated through planned and effective breastfeeding management. Mothers should be encouraged to breastfeed, and breastfeeding should be initiated and maintained in a healthy way. Appropriate and individualized nursing approaches should be planned. In this section, evidence-based practices for nipple problems which prevent breast milk intake and cause breastfeeding problems will be discussed in the light of the literature. © 2025 by Nova Science Publishers, Inc. All rights reserved
Kentsel Kimliğin Güçlendirilmesinde Yeşil Altyapının Rolü: Cumhuriyet Dönemi Ankara Örneği
Get PDFBu çalışma, Cumhuriyet Dönemi Ankara sınırında kent kimliği ve yeşil ağ planı etkileşimini ele alarak kimlik temelli bir yeşil ağ plan modeli geliştirmeyi amaçlamaktadır. Bu doğrultuda, yeşil ağ planının tarihi ve kültürel ögeler ile açık ve yeşil alanları entegre etmesi hedeflenmiştir. Ulus Tarihi Kent Merkezi'nde açık ve yeşil alanların azalması ve parçalanması nedeniyle, ekolojik ve rekreasyonel açıdan sürdürülebilir bir yeşil ağ oluşturulması önerilmektedir. Önerilen modelde, Atatürk Bulvarı ve Ankaray Metro Hattı iki ana bağlantı koridoru olarak belirlenmiştir. Çalışma alanında tanımlanan potansiyel yeşil ağ ögelerinin yakın çevredeki açık ve yeşil alanlarla ilişkilendirilmesi, bütüncül ve işlevsel bir yeşil ağ oluşturulması açısından kritik öneme sahiptir. Bu kapsamda, Ankara Yeşil Kuşak Projesi, Atatürk Orman Çiftliği, Kazan ve Mogan Gölü gibi önemli doğal alanların kentsel ekosistemle entegrasyonu sağlanarak sürdürülebilir bir yeşil altyapı oluşturulması hedeflenmiştir. Yeşil ağ planının akarsu koridorları ve diğer doğal alanlarla bağlantılı hale getirilmesi, ekolojik sürekliliğin sağlanması ve rekreasyonel faydaların artırılması açısından önem taşımaktadır. Sonuç olarak, önerilen model, Ankara kent ekosistemine entegre, kimlik temelli ve sürdürülebilir bir yeşil ağ planı sunmaktadır
The Effect of the Quadriceps Angle on the Gait Pattern in Young Adults Aged 18-25 Years
No full textAim: The Quadriceps angle (Q angle) is used for the prediction, diagnosis, and follow-up of pathologies of knee joint. It gives information about the direction and size of forces applied to the patella. It is described as the angle formed by lines drawn from anterior superior iliac spine to the midpoint of the patella, and from the midpoint of the patella to tibial tuberosity. It gives information about the alignment of anatomical structures of the knee joint. We aimed to investigate the effects of Q angle upon gait and static balance. Materials and Methods: A sample of 106 female and 105 male healthy subjects at age 18-25 years participated in our study. After notting their height and weight, bilateral Q angles were measured with goniometer in standing and supine positions. The force platform Zebris (c) FDM System Type FDM 1.5 and the WinFDM computer program were used for the gait and stance analysis. SPSS 20 program was used for statistical analysis of the obtained data. Statistical significance limit was determined as p<0.05. Results: We assessed that there was no significant relationship between Q angle and gait analysis parameters. We observed that some of ground reaction force parameters and the butterfly diagram parameters obtained through the gait analysis as well as some of the stance analysis parameters were weak or moderately related to the Q angle. Parameters related to the Q angle did not show a pattern that would be classified by the Q angle measurement method or by the side or by the gender. Conclusion: We think that it is necessary to conduct more extensive research in order to clarify the relationship between Q angle and walking pattern. We suggest that our research will contribute to the literature as a pioneering study in terms of the relationship between the Q angle and gait analysis as well as the stance analysis
Enhancing the Functionality and shelf life of poppy sherbet by optimizing ultrasound and propolis using response surface methodology: Impact on phenolic compounds, organic acids, sugar components, and sensory characteristics
No full textPoppy plant, scientifically known as Papaver rhoeas L., is an annual herbaceous wild plant. Propolis boasts numerous health advantages. This study aimed to optimize a novel functional beverage enriched with propolis and enhanced with ultrasound technology using Response Surface Methodology (RSM). Optimization focused on total bioactivities and general acceptability, determining optimal amounts of propolis extract (53.33 mg/100 mL), ultrasound time (7.56 min), and ultrasound amplitude (75.76%) to create the optimized ultrasound-treated propolis poppy sherbet (UTP). The optimized UTP had a high total phenolic content (552.25 mg GAE/L), a DPPH value of 9.26 mu mol trolox/g, a total antioxidant capacity of 42.16 mg Cy-3-gly/mL (Cyanidine-3-glycoside/mL), and a general acceptability score of 7.87. The consistency between experimental results and RSM predictions confirmed the approach's accuracy. After 21 days, bioactive components, phenolic compounds, organic acids, sugars, and sensory properties were assessed. UTP showed enhanced bioactive components and sensory properties compared to standard poppy sherbet, with higher glucose and turanose among 17 phenolic compounds. However, sensory attributes like color, aroma, and taste significantly declined over storage. As a result, these findings contribute to the development of functional beverages and the further enhancement of poppy-related foods using RSM optimization.University of Castilla-La Mancha (UCLM); Junta de Comunidades de Castilla-La Mancha (JCCM); European Funds from the European Social Fund Regional Operational Program (FSE +); JCCM; UCLM; King Saud University, Riyadh, Saudi Arabia [RSPD2025R641]; [SBPLY/21/180501/000283]The authors would like to thank the University of Castilla-La Mancha (UCLM) , and Junta de Comunidades de Castilla-La Mancha (JCCM) for their financial support via the project Ref. SBPLY/21/180501/000283 Recovery, revalorization of agri-food waste and its environmental impact. Also, we are thankful to the Postdoctoral Contract Financed by European Funds from the European Social Fund Regional Operational Program (FSE +) 2021-2027, JCCM and UCLM. The authors thank Re-searchers Supporting Project number (RSPD2025R641) , King Saud University, Riyadh, Saudi Arabia for funding this research