Journal Hosting Service | The University of Edinburgh
Not a member yet
5244 research outputs found
Sort by
Open Science, Data, and Methodologies: Lessons learned from the NIHR-RESPIRE Network in Asia
Full text linkNIHR-RESPIRE, a Global Health Research Unit funded by NIHR, is committed to advancing respiratory health research in Asia. We prioritise Open Science, Data, and Methodologies to maximise research data utility securely, sharing the lessons encountered across seven LMIC partner countries (Bangladesh, Bhutan, India, Indonesia, Malaysia, Pakistan, and Sri Lanka). Our strategic shift from traditional data sharing to LMIC-tailored Open Science practices ensures data privacy and security. This includes refining Data Management Plans, metadata standards, and mandating FAIR Data sharing, providing methodological support, and developing Open Science Policy Guidelines. We advocate for the adoption of open science principles to maximise secure data use and value with a focus on FAIR data. We also provide aid to partners in enhancing their data-related skills, hosting regular meetings, and establishing internal data monitoring structures to bolster cross-cutting activities within RESPIRE.
Through capacity building, we have enabled high-quality respiratory health research using Open Science principles, enhancing data sharing efficiency, research visibility, and ultimately respiratory health outcomes in Asia and beyond. Our experience underscores the following lessons:
Flexibility in data sharing, tailored to LMIC researchers\u27 needs, is essential;
Training and support to enhance knowledge of methodologies and dispel misconceptions are key to successful data stewardship;
Appointing a focal person for structured anonymised data sharing and supporting the internal Data Monitoring Committee are critical.
We recognise Open Science\u27s potential to foster innovation, collaboration, and knowledge sharing in respiratory health research
How to Find the Soul of a Sailor (2024)
No full textIn a collection of weathered sailing diaries, artist Kasia Molga found more than just memories of her father – she discovered a baseline for measuring how profoundly our oceans are changing. Molga takes her late father\u27s maritime journals – precise records of waves, winds, and weather from 1984 –and uses artificial intelligence to imagine how he might describe those same seas in 2084. \u27How to Find the Soul of a Sailor\u27 emerges as both a memorial and a prophecy – a daughter\u27s attempt to hear her father\u27s voice echo acrossa century of environmental change
Community Health and Multi-directional integration in Cables Wynd House, Leith: Community Development Approaches
No full textIn this article, I reflect on my experience of working alongside community activists trying to support community health and multi-directional integration in Cables Wynd House (‘the Banana Flats’), Leith, and how its reputation in the city may have presented difficulties. I bring together insights from Community Development, Migration Studies and other disciplines, as well as reflections on my own practice, and suggest a model for working towards community health and multi-directional integration in neighbourhoods on the receiving end of area-based stigma
Hamish Henderson and Cultural Activism
No full textThis article is based on The Hamish Henderson Memorial Lecture given in the Scottish Storytelling Centre on 9th November 2024. I start with some general thoughts on what is culture, and cultural activism. Then I examine the cultural activism of Hamish Henderson (1919-2002) poet, songwriter, soldier and scholar. He was a world-renowned folklorist, a pioneering lecturer in the School of Scottish Studies, founded in Edinburgh University In 1951, and a leader in the folk song revival of the 1950s and 1960s. His activism was influenced by the ideas of Antonio Gramsci, Italian Marxist philosopher and writer (1891-1937) imprisoned and tortured by the fascist Italian state. Gramsci was also a very important influence on the Liberation movement in Latin American in the 1960s and 70s. I will discuss how the influence of Paolo Freire came to be embedded in the practice of the Adult Learning Project (ALP) in Edinburgh and share some examples of liberating cultural action which demonstrate the values and beliefs ALP shared with Henderson, Gramsci and Freire
Prospero’s Tri-Filial Family Unit: Queer Childhood as a Tool and Threat to Heteropatriarchal Maintenance and Restoration in William Shakespeare’s The Tempest
Full text linkThis paper explores the quasi-familial dynamic in William Shakespeare’s The Tempest, proposing that Prospero’s efforts to restore and secure patriarchal authority in Italy and on the island are contingent upon his abusive paternal control over three queer child figures: Ariel, Caliban, and Miranda. Drawing on early modern childhood studies and queer theory, this paper reads these figures as queer children: mutable, gender-unstable, arrested in development, and marked by naïveté. It is among the first studies to conceptualise these characters as a tri-filial unit whose queer identities are instrumentalised to construct a vision of heteropatriarchal stability. Prospero fosters his children’s queerness by maintaining them in queer states, manipulating these conditions to advance his heteropatriarchal agenda of securing his biological daughter’s marriage to the prince of Naples. However, as the play progresses, each child figure begins to resist or outgrow Prospero’s control, ultimately revealing the fragility and artificiality of the hetero-patriarchal structures he seeks to uphold. This paper argues that The Tempest exposes the inherent instability of patriarchal power, showing that the very queer identities Prospero manipulates become the agents of its potential undoing
Lashing out Against the Backlash: Constructing a Queer-Timed Narrative in the Affective Space of the Kitchen in Kim Ji-young, Born 1982
Full text linkRecognized as a key text in contemporary South Korean feminist activism, the novel Kim Ji-young, Born 1982 has been invoked in other feminist narratives as a means of “delivering both the revelation of collective trauma and the criteria for reinterpreting what had been experienced through new temporal alternatives to what had been the ‘official’ story’” (Lee 218). However, the novel’s potential “to magnetize a mass awakening” seems to be limited to an endemic context (Lee 218). Though stimulating debate in East Asian countries (Yang 1558), neither the novel nor the film has received enough critical attention internationally. I aim to bridge the gap in current scholarship by analyzing the feminist narrative of Kim Ji-young, Born 1982 in a broader theoretical context. Drawing upon Susan Faludi’s theory on anti-feminist backlash, I explore how the new temporal alternatives opened up by the novel further emerge through the spatial dynamics of the kitchen in the cinematic medium, thereby enabling Ji-young to lash out at the backlash against the film. I first examine, in the context of anti-feminist backlash, the mobilization of negative affect in feminist theory as a means of speaking out against patriarchal oppression. Then, engaging with queer feminist theory, I analyze how a means of openly expressing these negative affects is offered through Ji-young’s mental breakdown, which constructs a queer-timed narrative that transforms the kitchen into a space of female creativity. While exploring the liberating potential of this transformation, at the same time, I reflect upon whether the queer narrative of Kim Ji-young, Born 1982 is effective by questioning the validity of applying a Euro-centric theoretical framework to a film set in an East Asian country
Lithic industries and stylistic entities during the Early Neolithic (LBK) in the Rhine-Meuse-Seine basins
Full text linkThe study of the decorated ceramics of the Rubané or Linearbandkeramik (LBK) has long structured the construction of the chronological sequence of the Early Neolithic of northwestern Europe. Recent contributions make it possible to individualize regional stylistic groups. Examination of the different regional corpuses shows that, following the break-up of a common stylistic stage known as the Flomborn entity, the decorative elements of each region evolved differently giving rise to individualised entities that sometimes seem very homogeneous in terms of the style of decorations used (e.g., the Rhine-Meuse ensemble of the Middle Rubané).
This contribution aims to compare the results obtained from the ceramic corpus with those of the lithic industry. It shows that out of a common base, regional differences emerged that are also quite significant, whether from the point of view of the procurement of raw materials, reduction process or tool typology. For example, the geographical networks of raw material circulation reveal preferential axes between certain regions (such as the northern and southern parts of the Ardennes Massif) or, on the contrary, border effects that must be compared and contrasted with the entities previously defined on the basis of decorated ceramics. The theoretical significance of these initial observations and the contribution that the techno-economic analysis of lithic industries can drive to the understanding of the relations between communities in the Early Neolithic of the Rhine-Meuse-Seine basins will be examined through network analysis
Apelin receptor in GtoPdb v.2025.3
Full text linkThe apelin receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee on the apelin receptor [73] and subsequently updated [75]) responds to apelin, a 36 amino-acid peptide derived initially from bovine stomach. apelin-36, apelin-13 and [Pyr1]apelin-13 are the predominant endogenous ligands which are cleaved from a 77 amino-acid precursor peptide (APLN, Q9ULZ1) [88]. A second family of peptides discovered independently and named Elabela [13] or Toddler, that has little sequence similarity to apelin, is present, and functional at the apelin receptor in the adult cardiovascular system [98, 71]. The enzymatic pathways generating biologically active apelin and Elabela isoforms have not been determined but both propeptides include sites for potential proprotein convertase processing [81]. Structure-activity relationship Elabela analogues have been described [65, 90]. The stoichiometry of apelin receptor-heterotrimeric G protein complexes has been studied using cryogenic-electron microscopy [99]. A crystal structure for the apelin receptor in complex with a G protein-biased agonist has been reported [96]
Bombesin receptors in GtoPdb v.2025.3
Full text linkMammalian bombesin (Bn) receptors comprise 3 subtypes: BB1, BB2, BB3 (nomenclature recommended by the NC-IUPHAR Subcommittee on bombesin receptors, [118, 5]). BB1 and BB2 are activated by the endogenous ligands neuromedin B (NMB), gastrin-releasing peptide (GRP), and GRP-(18-27). bombesin is a tetra-decapeptide, originally derived from amphibians and structurally closely related to GRP. The three Bn receptor subtypes couple primarily to the Gq/11 and G12/13 family of G proteins [118]. Each of these receptors is widely distributed in the CNS and peripheral tissues [81, 118, 259, 288, 373, 115, 6, 375, 125, 204]. Activation of BB1 and BB2 receptors causes a wide range of physiological/pathophysiogical actions, including the stimulation of normal and neoplastic tissue growth, smooth-muscle contraction, respiration, gastrointestinal motility, feeding behavior, secretion and many central nervous system effects including regulation of circadian rhythm, body temperature control, sighing, behavioral disorders and mediation of pruritus [210, 118, 204, 259, 211, 37, 375, 211, 44, 4]. BB3 is an orphan receptor, although some propose it is constitutively active [328]. BB3 receptor knockout studies show it has important roles in glucose and insulin regulation, metabolic homeostasis, feeding, regulation of body temperature, obesity, diabetes mellitus and growth of normal/neoplastic tissues [154, 81, 223, 208, 4, 208]. Bn receptors are one of the most frequently overexpressed receptors in cancers and are receiving increased attention for their roles in tumor growth, as well as for tumour imaging and for receptor-targeted cytotoxicity especially for advanced prostate and breast cancer [210, 167, 13, 136, 377, 371]. Bn receptors are also receiving attention because they are one of the primary neurotransmitters for pruritus [37, 128, 240]
Ghrelin receptor in GtoPdb v.2025.3
Full text linkThe ghrelin receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee for the Ghrelin receptor [19]) is activated by a 28 amino-acid peptide originally isolated from rat stomach, where it is cleaved from a 117 amino-acid precursor (GHRL, Q9UBU3). A unique post-translational modification (octanoylation of Ser3, catalysed by ghrelin Ο-acyltransferase (MBOAT4, Q96T53) [138] is essential for binding and activation of ghrelin receptors in all tissues, including the hypothalamus and pituitary [61]. Structure activity studies showed the first five N-terminal amino acids to be the minimum required for binding [4], and receptor mutagenesis has indicated overlap of the ghrelin binding site with those for small molecule agonists and allosteric modulators of ghrelin function [47]. The authorities in Japan have in 2020 approved the orally active agonist anamorelin, for the treatment of anorexia in cancer patients [130]. PF-05190457 is a small-molecule inverse agonist targeting the ghrelin receptor that has been progressed to phase I clinical trial for the treatment of alcoholism and has been demonstrated to decrease appetite [32]. An endogenous antagonist and inverse agonist called Liver enriched antimicrobial peptide 2 (Leap2), expressed primarily in hepatocytes and in enterocytes of the proximal intestine [38, 71] inhibits ghrelin receptor-induced GH secretion and food intake [38]. The secretion of Leap2 and ghrelin is inversely regulated under various metabolic conditions [74]. In cell systems the ghrelin receptor is constitutively active [48], and this property is responsible for modulation of D2 receptor signalling [20], and is attenuated by a naturally occurring mutation (A204E) that is associated with familial short stature [96]