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The New Real Pavilions and Salons: Creating Spaces for AI Futures
Full text linkThe New Real Pavilions and Salons explore how to share transformative ideas through art and AI to equip future generations to flourish on a thriving planet in the midst of surprising, joyful and inclusive forms of intelligent life. These new models of technology-arts-society interaction broke new ground in how we facilitate a joint investigation of these pressing issues of concern
Artificial Intelligence, No Longer Sci-Fi
Full text linkNow that AI is no longer science fiction, how might embracing it, whilst recognising its limitations and ethical implications, enable new kinds of creative expression by artists and designers concerned with ethics, justice and sustainability? Futurist artist/designer/ engineer Sophia Brueckner shares her thoughts on why artists and designers are necessary to critique and shape the future of AI, and why the reasons to question its use are the very same reasons why artists and designers should engage with it
Friends on Purpose: The Queer in Friendship
Full text linkFriendship, when approached as an inherently queer relational form, challenges normative assumptions that hierarchise intimacy through the naturalisation and institutionalisation of the heteronormative family. Drawing on a personal narrative of a long-standing friendship, this article examines how such bonds can question and dismantle dominant intimacy hierarchies. It contributes to ongoing critiques of family as a normative institution by positioning friendship as a chosen, intentional and radical practice of intimacy: friends on purpose. To this end, autotheory is employed in order to represent the search for an adequate language for the intimate, non-institutionalised nature of relationships as well as to highlight its modes of radical subjectivity. The analysis further engages with historical concepts of intimate closeness such as the Boston Marriage, romantic friendship, the split-attraction model, and queerplatonic relationships, alongside the works of Michel Foucault, Didier Eribon, Angela Chen, and Geoffroy de Lagasnerie. Instead of integrating friendship into the institutional logic of family, it is conceptualised as a practice that disrupts conventional notions of kinship. At the same time, it is shown that non-institutionalised forms of relationships can still remain intertwined with amatonormativity and normative life scripts. By resisting the temporalities and prescribed values of romance, marriage, and reproduction, and by questioning their naturalisation, friendship opens up a powerful mode of relating beyond institutional recognition
The Concept of Family Across Cultures: Examining Differences Between the UK and China Through Museum Translations
Full text linkThis study explores the concept of family across cultures within the context of translation studies. It focuses on how the Chinese translation of the British Museum website presents the family by using the Cultural-Conceptual translation (CCT) model and Chinese perspectives on the family. This paper finds that the English version of the British Museum website primarily promotes a nuclear family model, whereas the Chinese version emphasises a broader family structure, which highlights intergenerational bonds and a collective orientation. Comparisons with the National Museum of China reveal how family-oriented activities differ: the English website of the British Museum encourages interactive engagement among family members, while the National Museum of China focuses on educational experiences where parents are more observers than active participants. Notably, the Chinese website of the British Museum removes family activities altogether, further highlighting the educational function of museums. The study follows a top-down approach, first analysing cultural aspects before moving to translation analysis
Bradykinin receptors in GtoPdb v.2025.3
Full text linkBradykinin (or kinin) receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Bradykinin (kinin) Receptors [94]) are activated by the endogenous peptides bradykinin (BK), [des-Arg9]bradykinin, Lys-BK (kallidin), [des-Arg10]kallidin, [Phospho-Ser6]-Bradykinin, T-kinin (Ile-Ser-BK), [Hyp3]bradykinin and Lys-[Hyp3]-bradykinin. Variation in pharmacology and activity of B1 and B2 receptor antagonists at species orthologs has been documented. icatibant (Hoe140, Firazir) is approved in North America and Europe for the treatment of acute attacks of hereditary angioedema. Inhibition of bradykinin with icatibant in COVID-19 infection is under clinical evaluation, with trial NCT05407597
Class A Orphans in GtoPdb v.2025.3
Full text linkTable 1 lists a number of putative GPCRs identified by NC-IUPHAR [206], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have recently been reviewed in detail [156]. The GPCRs in Table 1 are all Class A, rhodopsin-like GPCRs. Class A orphan GPCRs not listed in Table 1 are putative GPCRs with as-yet unidentified endogenous ligands.Table 1: Class A orphan GPCRs with putative endogenous ligands GPR3GPR4GPR6GPR12GPR15GPR17GPR20 GPR22GPR26GPR31GPR34GPR35GPR37GPR39 GPR50GPR63GPR65GPR68GPR75GPR84GPR87 GPR88GPR132GPR149GPR161GPR183LGR4LGR5 LGR6MAS1MRGPRDMRGPRX1MRGPRX2P2RY10TAAR2 In addition the orphan receptors GPR18, GPR55 and GPR119 which are reported to respond to endogenous agents analogous to the endogenous cannabinoid ligands have been grouped together (GPR18, GPR55 and GPR119)
Dopamine receptors in GtoPdb v.2025.3
Full text linkDopamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Dopamine Receptors [375]) are commonly divided into D1-like (D1 and D5) and D2-like (D2, D3 and D4) families, where the endogenous agonist is dopamine
Endothelin receptors in GtoPdb v.2025.3
Full text linkEndothelin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Endothelin Receptors [25]) are activated by the endogenous 21 amino-acid peptides endothelins 1-3 (endothelin-1, endothelin-2 and endothelin-3)
Formylpeptide receptors in GtoPdb v.2025.3
Full text linkThe human formylpeptide receptor subfamily of GPCRs (FPR: nomenclature described in [169, 227] [1, 2]) comprises three members (FPR1, FPR2, and FPR3). Two of these, FPR1 and FPR2, recognize peptides bearing N-terminal formyl-Met from invading bacteria [104] or mitochondria. These peptides function as danger signals in innate immunity. FPR1 and FPR2 are promiscuous and also recognize several non-formylated peptides, proteins, lipids and small molecules [169, 227, 104] of which some are able to initiate signals (balanced or biased) that mediate pro-inflammatory and/or inflammation resolving effects [136, 161]. In contrast, FPR3 remains less well-characterized in part due to the absence of selective ligands which has significantly impeded progress in its functional characterization [46, 173]
Free fatty acid receptors in GtoPdb v.2025.3
Full text linkFree fatty acid receptors (FFA, nomenclature as agreed by the NC-IUPHAR Subcommittee on free fatty acid receptors [118, 27]) are activated by free fatty acids. Long-chain saturated and unsaturated fatty acids (including C14.0 (myristic acid), C16:0 (palmitic acid), C18:1 (oleic acid), C18:2 (linoleic acid), C18:3, (α-linolenic acid), C20:4 (arachidonic acid), C20:5,n-3 (EPA) and C22:6,n-3 (docosahexaenoic acid)) activate FFA1 [9, 54, 65] and FFA4 receptors [45, 52, 96], while short chain fatty acids (C2 (acetic acid), C3 (propanoic acid), C4 (butyric acid) and C5 (pentanoic acid)) activate FFA2 [10, 67, 92] and FFA3 [10, 67] receptors. The crystal structure for agonist bound FFA1 has been described [115]