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KİRA BEDELİNİN TARAF ANLAŞMASIYLA ARTTIRILMASINA İLİŞKİN SINIRLAMALAR VE SINIRLARI AŞAN ANLAŞMALARDA BEDELİN İADESİ
No full textTürk Borçlar Kanunu’nda konut ve çatılı işyerlerini konu alan kira sözleşmelerine özel önem atfedilmiş ve bu tarz sözleşmelere genel kira sözleşmesi hükümlerine nazaran ayrıksı düzenlemeler öngörülmüştür. Yıllar boyunca devam edebilen bu sözleşmelerde, kira bedelinin başlangıçta taraflarca öngörülen miktarda devam etmesi, zamanla paranın gücünün azalması ve edimler arasındaki dengenin bozulması sebebiyle hakkaniyetli olmayacaktır. Bu nedenle kira bedelinin tarafların anlaşmasıyla arttırılmasına kanun koyucu imkân tanımaktadır. Ancak konut ve çatılı işyeri kiralarında kira bedelinin arttırılmasına ilişkin özel düzenlemeler yapılarak, tarafların kararlaştırdıkları artış oranı/miktarı kiracıyı korumak gayesiyle sınırlandırılmaktadır. Tarafların bu sınırları aşan anlaşma yapmaları halinde kısmi hükümsüzlük yaptırımı uygulanarak fazla ödenen tutarın iadesi söz konusu olabilecektir. İadenin hukuki dayanağı konusunda doktrinde sebepsiz zenginleşmeye göre iade ile sözleşmeye dayalı iade şeklinde farklı görüşler bulunmaktadır. Çalışmamızda konut ve çatılı işyeri kiralarında yenilenen dönemde kira bedelinin artışına ilişkin anlaşmalardaki mevzuat sınırları belirtilerek, tarafların bedel artışına ilişkin anlaşmalarının geçerliliği ve geçersizlik hallerinde kiracının fazla ödediği tutarı isteyip isteyemeyeceği mevzuat, doktrin görüşleri ve yargı kararları ekseninde incelenmeye çalışılacaktır
Clinical and functional outcomes of hand surgery for recessive dystrophic epidermolysis bullosa
No full textRecessive dystrophic epidermolysis bullosa causes blistering and scarring of the hands, resulting in contractures fused web spaces and altered function. The aim of this study was to present the short- and mid-term clinical and functional results of a large case series of patients who underwent surgery for recessive dystrophic epidermolysis bullosa-related pseudosyndactyly. The study included 75 hands in 39 children (21 boys, 18 girls) with a mean age of 8 years (range, 4-15) and minimum follow-up of 1 year. Children were assessed with the Birmingham Epidermolysis Bullosa Severity Score Sheet and the ABILHAND-Kids questionnaire before operation and at final follow-up. There were varying degrees of recurrent scarring in all the hands by 24 months after operation. The ABILHAND-Kids questionnaire showed a significant improvement in ability to perform 17 of 21 tasks. In conclusion, despite recurrence that may develop in the short and mid term, surgical release can provide significant improvements in hand function.Level of Evidence: I
Duygu Odaklı Psikoterapi Ekolünün Bulimia Nervoza Olgularında Etkililiğine Dair Sistematik Bir Gözden Geçirme
No full textAbstract Bulimia nervosa is an eating disorder characterized by binge eating episodes and compensatory behaviors. Emotional regulation difficulties play a significant role in cases of bulimia nervosa. Individuals diagnosed with bulimia nervosa are known to experience challenges in regulating their emotions, particularly during negative emotional states, leading to loss of control, binge eating, and compensatory behaviors. In this context, Emotion-Focused Therapy (EFT) offers an effective approach by targeting emotional regulation in the treatment of bulimia. This review aims to examine the findings of studies investigating the effectiveness of Emotion-Focused interventions in the treatment of bulimia nervosa. For this purpose, 928 potential articles were identified, with four studies meeting the eligibility criteria included in this review. The selected studies involved participants with bulimia nervosa and were based on various research methodologies, such as randomized controlled trials, case studies, and time series designs. Emotion-Focused interventions have been found to improve emotional regulation skills in individuals diagnosed with bulimia nervosa, thereby reducing binge eating behaviors and bulimia symptoms. However, follow-up studies have yielded inconsistent findings regarding symptom relapse. While Emotion-Focused Therapies appear to be effective in the treatment of bulimia nervosa, there is a need for further research to expand the current knowledge in this area.Özet Bulimia nervoza, tıkınırcasına yeme atakları ve telafi edici davranışlarla karakterize bir yeme bozukluğudur. Bulimia olgularında duygusal düzenleme güçlükleri önemli bir rol oynar. Bulimia nervoza tanılı bireylerin duygu düzenleme zorluğu yaşadığı, özellikle olumsuz duygulanım durumlarında kontrol kaybı yaşayarak tıkınırcasına yeme ve telafi edici davranışlar sergilediği bilinmektedir. Bu bağlamda Duygu Odaklı Psikoterapi, bulimia tedavisinde duygusal düzenlemeyi hedef alarak etkili bir yaklaşım sunmaktadır. Bu derleme, bulimia tedavisinde Duygu Odaklı müdahalelerin etkililiğini inceleyen çalışmaların bulgularını gözden geçirerek meyi amaçlamıştır. İlgili amaç doğrultusunda potansiyel olarak 928 makale tespit edilmiş, uygunluk kriterlerini karşılayan 4 çalışma bu gözden geçirmeye dahil edilmiştir. Çalışmalar bulimia nervoza bozukluğuna sahip katılımcılarda yapılan, randomize kontrollü çalışmalar, vaka çalışmaları ve zaman serisi desenleri gibi farklı araştırma metodolojilerine dayanarak seçilmiştir. Duygu Odaklı Müdahalelerin bulimia nervoza tanılı bireylerde duygu düzenleme becerilerini geliştirdiği ve bu sayede tıkanırcasına yeme davranışlarını ve bulimia belirtilerini azalttığı görülmektedir. Bununla birlikte takip çalışmaları semptom nüksü konusunda tutarsız bulgular elde etmiştir. Duygu Odaklı Terapilerin bulimia nervoza tedavisinde etkili olduğu görülmekle birlikte mevcut alanın genişletilmesine ve daha fazla araştırmaya ihtiyaç duyulmaktadır
Artificial Intelligence Technologies in Rehabilitation
No full textVirtual reality (VR) has experienced significant growth in the healthcare industry in recent years. Its utilization in the feld of physiotherapy has also gained momentum, particularly in the realm of rehabilitation. © 2025 Elsevier B.V., All rights reserved
Evaluation of systemic immune and inflammatory biomarkers in pediatric idiopathic intracranial hypertension patients
No full textBackground & Objective: Idiopathic intracranial hypertension (IIH) is characterized by increased intracranial pressure with normal cerebrospinal fluid analysis and neuroimaging findings. The aim of this study is to evaluate the relationship between systemic immune-inflammation index (SII) (neutrophil*platelet/lymphocyte count) and systemic inflammation response index (SIRI) (monocyte*neutrophil/lymphocyte count) as inflammatory markers with IIH in pediatric patients. Methods: A total of 42 eyes from 21 pediatric patients diagnosed with IIH and 42 eyes from 21 control subjects were included in the study. Macular and peripapillary measurements, neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio (PLR), SII, and SIRI were recorded. Results: The study included groups matched for age and gender. When comparing inflammatory parameters, significantly higher values were observed in individuals with IIH for NLR (P < 0.001), PLR (P = 0.005), SII (P < 0.001), and SIRI (P < 0.016). In the univariate analysis of inflammatory parameters, NLR, PLR, MLR, SII, and SIRI values were identified as potential markers for IIH (P = 0.001, P < 0.001, P = 0.004, P = 0.004, P = 0.001, respectively). In the multivariate logistic regression analysis, NLR and PLR values were significantly higher (NLR: OR=3.8, 95% differences were found in mean retinal nerve fiber layer thickness (RNFLT) values between the two groups on OCT (p<0.001). Significant differences were also detected in ganglion cell layer thickness values between the two groups (p=0.003). Conclusion: Multivariate logistic regression analysis suggests that NLR and PLR values could be effectively used in the diagnosis and treatment of the disease. No statistically significant differences were found between groups in SII and SIRI values
Interaction Activity of Metal-Free Phthalocyanine Compound Bearing Tetra -(2-(N-2-Cyanoethyl)aminoethylsulfanyl) Units with DNA
No full textThe phthalocyanine having 4-(2-(N-2-cyanoethyl)aminoethylsulfanyl) group had been reported earlier in the literature. In this current studying, DNA binding activity of 1Pc phthalocyanine bearing 4-(2-(N-2-cyanoethyl)aminoethylsulfanyl units was examined spectroscopically via elctronic absoption, A fluorescence titration, melting point profile, A electrophoresis and viscosity methods. The interaction activity of 1Pc compound was examined at differing concentrations. UV/Vis spectrometer, viscosity, Afluorescence spectroscopy and thermal melting temperature confirmed that 1Pc binds to the DNA. The K-b of 1PcAis also estimated via UV/Vis titration and K-b of 1Pc was computed as 2.1394 x 10(6) M-1. The K(b)value demonstrated that 1Pc reacts with DNA by an intercalative mechanism. Alongside this research, the mechanism by which the compound binds to DNA was investigated by determining Tm. The Tm of DNA + 1Pc complex was identified as 74.31. This data confirmed that 1Pc binds to DNA intercalatively. All the results obtained from the used methods demonstrated that 1Pc phthalocyanine compound has an efficient DNA interaction activity and 1Pc phthalocyanine compound interacts with DNA via an intercalative mechanism. As a result, the compound mayAbe a therapeutic agent due to its DNA interaction property
Evaluating the Accessibility, Usability, and Security of Corporate Investor Relations Web Pages: A Case Study of the Turkish Stock Market
No full textThis study investigates the accessibility, usability, and security of investor relations (IR) web pages of 53 companies listed on the Istanbul Stock Exchange (BIST), focusing on both BIST-30, representing the most liquid and highly capitalized companies, and BIST-2022, companies that had their initial public offerings (IPOs) in 2022. Using automated testing tools, the analysis examines adherence to the WCAG 2.1 guidelines, mobile responsiveness, and security measures. The findings reveal that accessibility issues, particularly related to the robust and perceivable principles, are prevalent across the assessed web pages, with BIST-30 companies showing a higher rate of errors. While BIST-2022 companies generally performed better in usability, with faster loading times and fewer broken links, security assessments indicated low to medium risks across both categories. This study contributes to the limited literature on the quality assessment of corporate IR web pages and highlights the necessity for enhancements in accessibility, usability and security, providing valuable insights for web administrators and developers to improve the quality of IR web pages
Challenges in Interpreting Cerebrospinal Fluid Viral Polymerase Chain Reaction Results: Understanding the Results Related to HHV-6, HHV-7, and Enterovirus
No full textObjective: We have aimed to evaluate our experience in interpreting polymerase chain reaction (PCR) test results of cerebrospinal fluid (CSF) samples for human herpesvirus (HHV)-6, HHV-7, and enterovirus in children with suspected viral meningoencephalitis. Method: Children aged 1 month to 5 years underwent PCR analyses. Samples were collected via lumbar puncture and assessed using real-time PCR for the identification of enterovirus, HHV-6, and HHV-7. Results: Most (79. 8%) of 109 CSF samples analyzed did not show the presence of any viral particles. Among the positive samples, 8.3% were positive only for HHV-6, 6.4% for HHV-7, and 1.9% for enterovirus. Two samples showed positivity for both HHV-6 and HHV-7; one sample for HHV-7 and enterovirus; and another sample for HHV-6, HHV-7, and enterovirus. Among the PCR-positive patients, fever (77%) and seizures (59%) were the most prevalent presenting symptoms. A statistically significantly higher incidence of seizures was observed in patients with HHV-7 positivity compared to those in whom no virus was detected (p=0.003). At discharge, three patients received alternative diagnoses. Conclusion: The most frequently detected virus was HHV-6, followed by HHV-7. Enterovirus was detected at a lower frequency than expected, most probably due to the rapid clearance of enterovirus from the CSF and coronavirus disease 2019 mitigation. Considering the possible latency or chromosomal integration (for HHV-6), clinical presentations, CSF findings, and patient-specific additional diagnostic work-up were influential on the decision-making process for diagnosis. In the absence of advanced molecular techniques, it is crucial to recognize that HHV-6 and HHV-7 may be bystanders, and other potential pathogens and diagnoses should be considered.Scientific Research Projects Unit of the University of Health SciencesFinancial Disclosure: This work was supported by the Scientific Research Projects Unit of the University of Health Sciences
Design and Simulation of a High-Order Memristor Emulator Based on Cascaded OTA Integrators
No full textThis paper proposes a novel nth-order memristor emulator circuit that employs operational transconductance amplifiers (OTAs), grounded capacitors and a single NMOS transistor. Unlike traditional emulators, which are limited to first-order behavior, the presented design realizes higher-order memristive characteristics electronically by cascading integrator stages. This approach offers a practical way to investigate the complex memory effects that are crucial for advanced computational models and difficult to achieve with physical devices or first-order emulators. The emulator is fully resistorless and offers electronic tunability via OTA bias currents, providing memductance control. The circuit was implemented using 0.18 mu m CMOS technology and validated through PSPICE simulations. The results demonstrate characteristic pinched hysteresis loops (PHLs) that vary with frequency, confirming the circuit's memristive nature. The emulator supports both incremental and decremental configurations, exhibiting robust performance under Monte Carlo and temperature variation analyses
Diagnostic Success of Non-contrast Computed Tomography Findings in Central Acute Pulmonary Thromboembolism: A Case Control Study
No full textOBJECTIVE: Computed tomography pulmonary angiography (CTPA) is the gold standard in the diagnosis of pulmonary thromboembolism (PTE) but it cannot be used safely in conditions such as renal failure and contrast allergy. Therefore, recognition of emboli with noncontrast thoracic CT can be useful in the management of PTE. The aim of our study was to determine the diagnostic success of noncontrast thoracic CT findings in the diagnosis of PTE. MATERIAL AND METHODS: Patients who had both non-contrast thorax CT and CTPA imaging within 24 hours and were diagnosed with PTE were analyzed. A control group was formed by randomization in a 1:1 ratio (n = 55). CTPA images of the patients in both groups were evaluated blindly by two expert radiologists and demographic and clinical characteristics were recorded. RESULTS: Fifty-five patients had embolism. The mean age was 68.5 +/- 15.2. Mortality rates were 36.4% in the embolism group and 40.0% in the control group. The main pulmonary artery diameter was significantly higher in the PTE group (32.0 mm vs. 29.4 mm, P = 0.007). The mean attenuation of the pulmonary blood pool in the PTE group was higher than that of the control group [46.2 Hounsfield CONCLUSION: Direct and indirect findings obtained from non-contrast thoracic CT can help the diagnosis, in patients in whom CTPA cannot be performed. Diagnostic utility may increase when the presence of these findings is evaluated together with clinical and laboratory findings. Validation studies should be performed in larger populations