8905 research outputs found

    Editorial

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    Session Inorganic Chemistry

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    Session Medicinal Chemistry & Chemical Biology

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    SCS Fall Meeting 2022

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    Microbes to the Rescue – Exploring the Chemistry of Microbial Communication and Using it to Protect Plant Health

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    Plants are densely colonized by diverse microbial communities. These microbes, which provide important benefit to their host supporting its growth and health, interact with each other and with their host plant by exchanging chemical signals, among which volatile organic compounds (VOCs). This review presents some of our current research lines in the field of microbial VOCs, including their bioactivities on both plants and plant pathogens, and the abiotic and biotic factors influencing their emission. Understanding how VOCs emission is regulated in plant-associated microbes is one of the major challenges for both fundamental and translational aspects of this research field

    Dragonflies that Change Colour: Nature\u27s Hidden Redox Chemistry: Chemical Education

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    The colour distinction between male and female, and between young and mature male dragonflies of the genera Crocothemis and Sympetrum arises from simple redox chemistry. This natural phenomenon has inspired the development of a class of electrochromic devic

    Block Copolymer-based Photonic Pigments: Towards Structural Non-iridescent Brilliant Coloration

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    Creating color through the self-assembly of specific building blocks to fabricate photonic morphologies is a promising and intriguing approach to reproducing the flamboyant visual effects and dynamic properties observed in the natural world. However, the complexity and lack of robustness in the manufacture of these nanostructured materials hinder their technical exploitation on a large scale. To overcome such limitations, here we present a novel methodology to create bioinspired photonic pigments as dispersed and micrometer-scale particles based on highly ordered concentric lamellar microspheres made of block copolymers. First, we introduce the fabrication protocol and the advantages of this approach compared to the traditional colloidal self-assembly. Then, we discuss some possible future research directions focused on developing hybrid organic-inorganic photonic pigments with enhanced dielectric contrast, reduced scattering, and specific functionalities. Finally, we speculate on possible applications for these structures that go beyond their use as simple photonic pigments

    Shimadzu lanciert ihr neues Kompaktes LCMS: Mit LCMS 2050 das grosse Ganze im Bild

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    Das Neue Produkt in der LCMS-Linie von Shimadzu Kompaktes System mit High-End-Ergebnissen Zuverlässig, langlebig und einfach zu bedienen

    Vesicular Glutamate Transporters in Astrocytes as Potential New Therapeutic Targets: Astrocyte-targeted Viral Vectors Expressing Inhibitory Nanobodies

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    Astrocytes, the main Central Nervous System (CNS) glial cell type, actively release transmitters, including glutamate, and thereby participate in physiological brain information processing. However, dysregulated transmitter release from astrocytes can contribute to CNS disease pathogenesis and progression. Therefore, targeting astrocyte glutamate release is a promising new therapeutic strategy in hyper-glutamatergic brain conditions, as it does not directly block glutamatergic neurotransmission. Basing on the evidence that astrocytes express Vesicular Glutamate Transporters (VGLUT), in collaboration with other NCCR TransCure partners, we developed an innovative approach for astrocyte-selective delivery of nanobodies inhibiting VGLUT. We inserted the anti-VGLUT nanobody constructs in astrocyte-directed viral vectors that were administered peripherally, crossed the blood-brain-barrier and led to successful cell-specific CNS-wide expression of the nanobodies

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