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Vitaport: A Learning and Artistic Path for Public Outreach on Transporter Biology, Health and Drug Discovery
Get PDFIn occasion of its conclusion, the National Center of Competence in Research (NCCR) TransCure launched a temporary learning and artistic path in the city of Bern named \u27Vitaport - Was unser Körper transportiert\u27. The path explained how nutrients are transported through our body and how molecules find their way to the right organ to achieve their effect there. NCCR TransCure researchers, together with students of the Bern School of Design, developed ceramic objects, texts and information graphics that took the public on a multidisciplinary journey of discovery through the human body. In this article, we report about aims, development, challenges and outcome of this ambitious science outreach project in which we could experience a rewarding and successful collaboration between scientists and artists
Photochemistry of Rhenium(I) Diimine Tricarbonyl Complexes in Biological Applications
Get PDFLuminescent rhenium complexes continue to be the focus of growing scientific interest for catalytic, diagnostic and therapeutic applications, with emphasis on the development of their photophysical and photochemical properties. In this short review, we explore such properties with a focus on the biological applications of the molecules. We discuss the importance of the ligand choice to the contribution and their involvement towards the most significant electronic transitions of the metal species and what strategies are used to exploit the potential of the molecules in medicinal applications. We begin by detailing the photophysics of the molecules; we then describe the three most common photoreactions of rhenium complexes as photosensitizers in H2 production, photocatalysts in CO2 reduction and photochemical ligand substitution. In the last part, we describe their applications as luminescent cellular probes and how the photochemical ligand substitution is utilized in the development of photoactive carbon monoxide releasing molecules as anticancer and antimicrobial agents
Fiat lux!
Get PDFPhotochemistry made the transition from a natural observable to a scientific discipline in the latter half of the 19th Century CE. This short article looks at the development of the discipline in its first 100 years with a particular emphasis on the participation of Swiss scientists
Fostering Research Synergies between Chemists in Swiss Academia and at Novartis
Get PDFWe present a short overview of the way Novartis chemists interact and collaborate with the academic chemistry community in Switzerland. This article exemplifies a number of collaborations, and illustrates opportunities to foster research synergies between academic and industrial researchers. It also describes established programs available to academic groups, providing them access to Novartis resources and expertise
Photophysics and Charge Generation in Low Energy-offset Blends for Organic Solar Cells
Get PDFThe power conversion efficiency of organic solar cells has seen a huge improvement in recent years with state-of-the-art solar cells showcasing efficiencies of ~18.5 %, which is approaching the performance of inorganic and hybrid-perovskite solar cell technologies. This improvement can be mainly attributed to the discovery of highly efficient donor:acceptor blends with a near-zero energetic offset between the molecular orbital levels of the donor and the acceptor component. A distinctive feature of the high efficiency, low energy-offset blends is that they exhibit a concomitant increase in the short-circuit density and the open-circuit voltage of the solar cell. High open-circuit voltage results from the reduced photon energy loss in the exciton dissociation step, while a high short-circuit current density can be attributed to an efficient charge generation process. The reasons for the efficient exciton dissociation and subsequent separation of Coulomb bound electron-hole pair at negligible driving force is not well understood and, in this short review, we highlight recent results which shed light on the mechanism of charge generation in low energy-offset blends
From Academia to the Market – Air-stable Ni(II)/Josiphos Catalysts
Get PDFThe design, synthesis, commercialization and application of air stable Ni(II)/Josiphos complexes has been realized in a collaboration between Solvias and ICBMS (University Lyon 1). The Ni-complexes are utilized as versatile precatalysts for diverse cross coupling reactions. Apart from being active in established C–C and C–N couplings at low catalyst loadings, the novel Ni-precatalysts enabled the development of the challenging monoarylation of ammonia, ammonia surrogates and even alkylammonium chlorides with aryl carbamates. Finally, the alpha-arylation of acetone with aryl chlorides, carbamates and pivalates was demonstrated using the Ni(II)/Josiphos precatalysts
Heterogeneous Metal-Organic Framework Catalysts for Suzuki-Miyaura Cross Coupling in the Pharma Industry
Get PDFThe synthesis of drug substances (DS) requires the continuous effort of the pharma industry to ensure high sustainability standards. Suzuki Miyaura cross coupling is a fundamental C-C bond-forming reaction to produce complex DS intermediates. The present contribution points out the way, in which the synthesis of DS intermediates by C-C cross coupling can be economically competitive, while minimizing waste by selecting the appropriate heterogeneous catalyst. By comparing homogeneous, immobilized heterogeneous catalysts on silica and metal-organic framework (MOF) catalysts, while considering the perspectives of academia and industry, the critical parameters for a successful industrial application of heterogeneous catalytic Suzuki Miyaura cross coupling reactions were identified. Heterogeneous catalysts, such as MOFs, may provide the complementary platform for reducing waste and the costs of production related to such transformations
