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Orchestrating Relevance – Critique of a Questionable Trait of Modern Science Communication
Get PDFThis essay critically analyzes the widespread phenomenon of claiming relevance when reporting original research. Specific examples from an area of method development in organofluorine chemistry demonstrate that the pursuit of worthiness of the corresponding research is mainly justified by putting forward a broad general industrial context that could potentially benefit in form of applications. However, it is deliberately ignored that such applications are in the vast majority of cases highly improbable or objectively unrealistic. Notwithstanding that scientists are nowadays often explicitly forced to orchestrate relevance, be it by researchfinancing institutions and/or journals’ reviewers, it is argued that this is, from the point of view of research ethics at least, problematic
Critical Materials: A Changing Horizon: Chemical Education
No full textNew and emerging technologies impact on the global demand for raw materials, and 30–40 minerals/materials are classed as ‘critical’. This article examines what this means and how it affects the futur
Practical Approaches to Genetic Code Expansion with Aminoacyl-tRNA Synthetase/tRNA Pairs
Get PDFGenetic code expansion (GCE) can enable the site-selective incorporation of non-canonical amino acids (ncAAs) into proteins. GCE has advanced tremendously in the last decade and can be used to create biorthogonal handles, monitor and control proteins inside cells, study post-translational modifications, and engineer new protein functions. Since establishing our laboratory, our research has focused on applications of GCE in protein and enzyme engineering using aminoacyl-tRNA synthetase/tRNA (aaRS/tRNA) pairs. This topic has been reviewed extensively, leaving little doubt that GCE is a powerful tool for engineering proteins and enzymes. Therefore, for this young faculty issue, we wanted to provide a more technical look into the methods we use and the challenges we think about in our laboratory. Since starting the laboratory, we have successfully engineered over a dozen novel aaRS/tRNA pairs tailored for various GCE applications. However, we acknowledge that the field can pose challenges even for experts. Thus, herein, we provide a review of methodologies in ncAA incorporation with some practical commentary and a focus on challenges, emerging solutions, and exciting developments
Finding Joy in Science
Get PDFThis piece discusses the importance of sustainable education within the framework of the UN’s 2030 Agenda for Sustainable Development. We emphasize the need to foster a lifelong love for learning by instilling curiosity, emotional bonds, and joy in students. We suggest simplifying teaching methods to maximize depth of understanding, integrating wonder and emotion into scientific education, promoting vertical exploration rather than just covering knowledge horizontally, and fostering resilience and independence through experiential learning. We also advocate for collaborative learning environments and incorporating real-world projects into education. Ultimately, the goal is to create spaces where students can explore, experience joy, and develop a lasting passion for learning
From Water Under Confinement to Understanding Life at Subzero Temperatures
Get PDFWater in confined geometries is highly relevant to biology, geology, and other fields where the function and properties of materials are significantly influenced by the presence and behavior of water in these environments. The structure and dynamics of confined water are strongly dependent on the confining geometry and its interaction with the interfaces. This review provides a brief overview of water under nano-sized hard and soft confinement, as well as water in living cells and in the hydration shells around biomolecules. Confined water exhibits distinct characteristics compared to bulk water, particularly in terms of nucleation, crystallization, molecular dynamics, and hydrogen bond network. In nano-sized confinements, water can remain in liquid state at extremely low temperatures (from –45 °C to –120 °C, at atmospheric pressure), offering insights into the fundamental physics of water and potentially enhancing our understanding of life in subzero temperature environments
