CHIMIA
Not a member yet
8905 research outputs found
Sort by
From Lab to Production: Event Series on Insights into Process Chemistry: Chemical Education
No full textAs process chemistry is rarely included in university curricula, experts from Swiss companies pass on their experience to students at various levels.
A New Era for Peptide Therapeutics: Innovations, Challenges, and Future Directions: Medicinal Chemistry and Chemical Biology Highlights
No full textPeptide drugs are experiencing a renaissance driven by technological breakthroughs and the success of recent blockbuster drugs. A versatile peptide chemistry toolbox, modern synthesis techniques, and powerful discovery platforms are addressing many inherent roadblocks in peptide drug discovery and development allowing complex diseases to be targeted with high specificity and efficacy. As we enter a new era, peptide drugs are well suited to pursue inherently challenging, underrepresented targets and provide innovative treatment options
The 2024 Meet & Greet Event with Alfred Werner Scholars at the Merck Switzerland Biotechnology Development Center in Corsier-sur-Vevey
Get PDFDo we really need ligands in Ir-catalyzed C–H borylation?
Get PDFDirect borylation of C–H bonds is a privileged strategy to access versatile building blocks and valuable derivatives of complex molecules (late-stage functionalization, metabolite synthesis). This perspective aims to provide an overview and classification of the catalytic systems developed in this fast-growing area of research. Unexpected selectivity differences between two established directed-borylation systems have been discovered using high-throughput experimentation highlighting the importance of classical control experiments in catalysis research
Sustainable (–)-Ambrox Production: Chemistry Meets Biocatalysis
Get PDF(–)-Ambrox, the most prominent olfactive component of ambergris, is one of the most widely used biodegradable fragrance ingredients. It is traditionally produced from the diterpene sclareol chemically modified and cyclized into (–)-ambrox. The availability of the new feedstock (E)-β-farnesene produced by fermentation opened new routes to (E,E)-homofarnesol as a precursor to (–)-ambrox. Combining the chemical transformation of (E)-β-farnesene to (E,E)-homofarnesol and its enzymatic cyclization with an engineered Squalene Hopene Cyclase provided a new sustainable route for the production of (–)-ambrox at industrial scale. Compared to the traditional synthesis from sclareol, the new and innovative route from (E)-β-farnesene improves atom and step economy, reduces waste production, solvent and energy consumption
Exploring Zebrafish Embryonic Cell Line PAC2 by Proteomics Profiling: Highlights of Analytical Sciences in Switzerland
No full text
Operando Spectroscopy of Catalysts Exploiting Multi-technique and Modulated Excitation Approaches
Get PDFOperando spectroscopy combines the in situ determination of material structure by spectroscopy/diffraction techniques with the measurement of material performance, which is conversion/selectivity in the field of heterogeneous catalysis. A central question in operando spectroscopy is whether the signatures visible by the characterization methods are responsible for catalyst performance. Individual analytical methods can provide useful information, but their combination (multi-technique approach) is essential to obtain a complete perspective on molecular reaction mechanisms. This approach must be coupled to experimental protocols and mathematical algorithms enabling the ability to disentangle the contribution of the active structure from the unresponsive one. Here, we report an account with examples from our own research activities in catalysis science
Contribution of the Swiss Chemistry Community to SDGs – Perspective of the SCNAT Platform Chemistry
Get PDFSustainability has become indispensable – and so has the role chemistry plays in reaching the Sustainable Development Goals (SDGs). The Swiss Academy of Sciences (SCNAT) and its Platform Chemistry (PFC) can be a partner of the Swiss chemistry community in reaching (some of) these goals through their umbrella network. Next to all existing initiatives, SCNAT PFC recommends the chemistry community to support increasing scientific literacy such that for example students who want to contribute to a better environment in their future career become aware of the impact that chemistry has on sustainability and every day lives. The SDGs are a formalism that can be used to help communicating the impact of chemistry. It is important to keep on advertising also fundamental research, as this is the essential basis for any sustainable development