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4th Switzerland-Japan Biomolecular Chemistry Symposium SJBCS2024: A Bridge of Biomolecular Chemistry
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Interdisciplinary Projects in Biology and Chemistry
Full text linkSince 1998, Thun High School has developed and implemented interdisciplinary, problem-based learning projects with the aim of preparing students for the successful completion of their Matura thesis. These projects have been integrated into the specialised subjects biology-chemistry course. To date, 11 large-scale projects and a number of smaller projects have been created. As well as teaching subject-specific content, these projects also develop interdisciplinary skills such as: self-organised learning; using scientific publication formats; conducting literature research; organised collaboration; and the preparation for the oral Matura examination. Each class completes at least three of these projects in the core biology-chemistry course. As teachers, we increasingly withdraw from instruction and guidance, thereby giving students more responsibility for the success of the project. This article presents the didactic concept using a concrete example and provides links to further information and insights into our various projects. Additionally, student feedback is presented, as well as the challenges and opportunities of interdisciplinary teaching
Raman Microspectroscopy for the Characterisation of Inorganic Additives in Plastic Consumer Products: Highlights of Analytical Sciences in Switzerland
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Understanding Photoinduced Symmetry- Breaking Charge Separation
Full text linkSymmetry-breaking charge separation (SB-CS) is a photoinduced electron transfer reaction in which the chromophore acts as both the acceptor and the donor. This reaction which is still poorly understood may enable long-lived charge separation interesting for many applications. Here we show that SB-CS can be realised bimolecularly with perylene and discuss the factors favouring it. Furthermore, using a pyrene bichromophoric system, we discuss the influence of interchromophore coupling and how the photophysics can be fine-tuned to yield SB-CS over other processes such as excimer formation
Structural and Mechanistic Insights into the Metalation of Fluoroarenes Mediated by a Superbasic Co(II) Bis(amide) Complex
Full text linkOver the past decades, s-block metal amides including LiTMP and TMPMgCl.LiCl (TMP = 2,2,6,6-tetramethylpiperidide) have found widespread applications in the deprotonative metalation of aromatic compounds. In contrast, transition metal amides usually exhibit diminished basicity to metalate these substrates. Here we present an overview of the synthesis of a highly reactive TMP-based cobalt(II) bis(amide) complex Co(TMP)2 and its relevance in the direct Co–H exchange processes with fluoroarenes. This deprotonative metalation reactivity can be further extended to cyclopentadiene to generate cobaltocene. Exhibiting an unusual reactivity, Co(TMP)2 has also been found to be highly nucleophilic, as evidenced by the insertion of CO2 molecules into both of its Co–NTMP bonds
Determination of the Absolute Configuration by 3D ED to Elucidate the Atroposelectivity in Aromatic Ring-Opening Metathesis
Full text linkThe determination of the absolute configuration of molecules bearing different stereogenic elements represents a fundamental and indispensable task in the field of stereochemistry. Whereas X-ray crystallographic analysis has been established as a broadly utilized and reliable technique to achieve this goal, limitations remain arising from the demanding requirements for the size and diffraction quality of the analyzed crystals. As an emerging technique, 3D microcrystal electron diffraction (3D ED) has increasingly been recognized to complement single crystal X-ray diffraction (SC-XRD). Having encountered challenges in determining the absolute configuration for the products obtained during the development of atroposelective aromatic ring-opening metathesis (AArROM), we herein describe in detail, how 3D ED allowed an assignment, which proved unfeasible using the conventional approach with X-ray crystallography