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Tracing Aerosol Sources via Measurements and Data Mining: Highlights of Analytical Sciences in Switzerland
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Green Synthesis of Stereodefined Tri- and Tetrasubstituted Alkenes via 100% Atomeconomic and Regio-, and Stereoselective Halo-chalcogenation and Sulfonylation of Alkynes
Full text linkAchieving 100% atom economy in an organic transformation is a challenging task but it is always desirable in the context of green chemistry. Difunctionalization of alkynes using a bifunctional reagent is a useful strategy to achieve 100% atom economy, however, the challenge is to control the regio- and stereoselectivity of the reaction. In this article, we discuss the recent advances in developing 100% atom economic, highly regio- and stereoselective halo-chalcogenation and chlorosulfonylation strategies with alkynes for the green and sustainable synthesis of stereodefined tri- or tetrasubstituted alkenes, and its application in accessing valuable molecules including a marketed drug in a green and sustainable manner. The green chemistry metrics are presented to highlight the greenness of some of these protocols
Driving Sustainable Chemistry: Insights from the Swiss Green Economy Symposium (SGES): Highlights scienceindustries
No full textThe Swiss chemical, pharmaceutical and life sciences industries are facing a pivotal moment in their transformation towards sustainability. The Swiss Green Economy Symposium (SGES), held annually in Winterthur, has become a key platform for stakeholders across industry, academia, and government to discuss and advance strategies related to defossilization, circularity, and biodiversity protection
Bio-Based Approaches for Selective Cyclization
Full text linkCyclic natural products offer important, unique scaffolds and functionalities for the pharmaceutical industry. They are produced by enzymes catalyzing a wide range of cyclization reactions. This large family of enzymes creates distinctive cyclic structures via a variety of mechanisms naturally evolved for selectivity. In this review, we aim to present an overview of these natural catalysts, the therapeutic compounds for which they are involved in the production, as well as engineering efforts to tune them for anthropogenic needs in human medicine. Biochemical methodologies commonly used for the discovery and engineering of enzymes will also be highlighted, with an emphasis on enzymatic terpene cyclization and Pictet-Spengler-type cyclization
Chemigenetic Approaches for the Development of Fluorescent Biosensors for Biological Imaging
Full text linkFluorescent biosensors are essential for probing analyte dynamics and enzyme activities with high spatial and temporal resolution in living cells by functional microscopy. Recently hybrid, or so called chemigenetic, biosensors have emerged, that integrate the strengths of synthetic fluorophores – such as spectral diversity, high brightness and photostability – with the specificity and sensitivity of genetically encoded sensing units. Beyond enhancing optical performance, synthetic chemistry can also expand the repertoire of sensing units themselves, creating opportunities for novel biosensor designs sensing previously inaccessible analytes. In this review, we summarize the protein-labeling strategies used in chemigenetic biosensor design with particular emphasis on self-labeling protein tags. We further discuss biosensor design principles, representative applications, and emerging advances that highlight the growing impact of chemigenetic biosensors in functional microscopy
