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Fascinating Ambimobile Aryldiones in Crop Protection: Managing Grass Weeds and Harmful Sucking Insects
Full text linkThis review examines the innovation journeys, developments, and properties of two ambimobile crop protection compounds containing a 2-aryl-1,3-dione pharmacophoric motif: pinoxaden for post-emergence broad-spectrum grass weed control in cereals, and spiropidion for protecting multiple crops against damaging and difficult to control piercing and sucking pests. Both active ingredients function as propesticides, hydrolyzing in planta to release their bioactive aryldione forms, which inhibit acetyl-CoA carboxylase and disrupt fatty acid metabolism. As weak acids with specific physicochemical properties, these aryl cyclic diones demonstrate ambimobility in plants, enabling them to access both long-distance translocation pathways in plant vasculature, xylem, and phloem. This systemic translocation is crucial for both herbicidal and insecticidal applications
Iron-Based Deep Eutectic Solvents: Versatile and Powerful Tools in Sustainable Organic Synthesis
Full text linkDeep Eutectic Solvents (DESs) based on abundant and non-toxic first-row metals have emerged as versatile and sustainable alternatives to conventional solvents/promoters in a variety of synthetic organic protocols under greener and milder reaction conditions. In particular, Fe(III)-based Lewis Acidic DESs (LADESs) have recently shown great potential as dual solvent/promoter systems enabling efficient transformations under air and recyclable conditions without requiring toxic volatile organic compound (VOC) solvents at any stage in the protocol (synthesis, isolation or purification). Specifically, in this short review, we summarize our recent progress in the application of FeCl3-based DESs as sustainable and efficient promoters/solvents in organic synthesis by presenting two representative examples: i) the hydration and hydration/oxidation of terminal or internal alkynes to yield methyl ketones or 1,2-diketones, respectively; and ii) the Friedel-Crafts benzylation reaction. The performance, recyclability, mechanistic features and green metrics for these processes are discussed, highlighting the promise of this approach for sustainable synthesis
DMCCB Basel Symposium 2025: Strategies for Addressing Challenging Targets: Medicinal Chemistry and Chemical Biology Highlights
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Inkjet Printing: The Future of Disposable Electrochemical Sensors? Highlights of Analytical Sciences in Switzerland
No full textOxazinoazaarenes as Versatile Intermediates for Regioselective Late-Stage C–H-Functionalization and Skeletal Editing of Pyridines, Isoquinolines and Quinolines
Full text linkAzaarenes, particularly pyridines, represent some of the most important structural and functional motifs across various fields. Consequently, late-stage C–H bond functionalization and skeletal editing of azaarenes hold significant value, particularly for accelerating structure–activity relationship studies. Dearomatized intermediates derived from such azaarenes offer an innovative strategy for selectively modifying these valuable cores. Among them, oxazinoazaarenes are a practical and scalable platform for regioselective meta- and para-C–H functionalization and skeletal editing of the azaarene moiety. This short review highlights the advancements in oxazinoazaarene-based pyridine modification methods achieved by our group and others
Adding New Dimensions to Protein Structures with Room-Temperature Serial Crystallography: Medicinal Chemistry and Chemical Biology Highlights
No full textStructure-based drug design (SBDD) uses experimentally determined structures of proteins to aid in the identification of hits and development of leads for protein targets. Improving the physiological relevance of protein structures that are routinely determined at cryogenic temperature will undoubtedly help to improve this design process. One way that this can be achieved is through serial crystallography; a method that can be used to determine the high-resolution structure of proteins at room temperature. Additionally, through the application of time-resolved serial crystallography, protein dynamics can be investigated – providing another dimension to protein structure determination. How this information can be used to guide SBDD is yet to be seen. This article gives a brief overview into serial crystallography, including the experimental challenges faced by researchers in the field and some recently published pharmacologically relevant proteins studied using this technique