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Surface Organo-Iron Chemistry Towards Efficient Reverse Water-Gas Shift Catalysis
Full text linkThe low-temperature reverse water-gas shift (LT-RWGS) is a critical and energy effective technology for syngas production and the mitigation of anthropogenic carbon emissions. Developing efficient and well-defined catalysts for the LT-RWGS, from which structure-activity relationships can be drawn, is a significant challenge. Herein we describe how the identification of the grafting properties of tetramesityldiiron (Fe2Mes4) helps with designing tailored and highly efficient catalysts of PtFe@SiO2 composition. To that end, a molecular analogue, Fe2Mes3OSi(OtBu)3, was synthesized and characterized by X-ray diffraction, 57Fe-Mössbauer and 1H-NMR spectroscopy. The results confirmed that tetramesityldiiron grafts onto silica via selective displacement of a single mesityl ligand, forming Fe2Mes3@SiO2, while steric hindrance likely prevents secondary interactions with surface siloxide bridges. This work highlights the potential of tetramesityldiiron as a versatile precursor for synthesizing bimetallic MFe@SiO2 systems, enabling the rational development of highly efficient LT-RWGS and CO2 hydrogenation catalysts
Towards the Rational Design of Monovalent Degraders: Lessons Learnt from Cyclin K Degraders
Full text linkMonovalent degraders can enhance pre-existing surface complementarity between a target protein and a ligase to induce target degradation via the proteasome. For the most part, degraders have been discovered serendipitously and structure-activity relationship (SAR) studies have been limited, making it difficult to rationally design new compounds. Here we discuss how work on the SAR of cyclin K degraders demonstrates that a broad range of compounds can stabilise protein-protein interactions to induce degradation and how it lays the foundation for further monovalent degrader discovery
Challenges and Opportunities in DNA Encoded Library Screens
Full text linkIn our lab we have been developing techniques that attempt to capture or amplify signals in pooled compound mixtures for several years. DNA encoded libraries (DELs) are the most widely used pooled mixtures in early drug discovery. DELs are massive collections of small molecules, where each individual molecule is covalently linked to a unique DNA strand that can serve as an identification tag by sequencing. The industry standard for selecting DELs is affinity enrichment, which inherently can only search for direct binding. We outline here two of the ways that we are attempting to extend the potential of DEL screens into new areas
Nanopore Technology: When Proteins Analyse Proteins
Full text linkNanopore sensing is an emerging technology that can distinguish subtle differences in molecules and allows the observation of molecular processes. The technique has revolutionized DNA sequencing through long reads of single molecules. Following this success, nanopores are now increasingly applied to protein analysis. Proteins play central roles in cellular function and major diseases, however their analysis using established methods is complicated by the lack of protein-amplification methods. Here, two examples of nanopore-based protein analysis are described: the identification of biomarkers, and the analysis of protein function
Natural Products as Timeless Remedies – Unlocking Nature’s Treasure Trove
Full text linkNatural products are an essential source of medicines, accounting for a large proportion of approved drugs nowadays. However, the isolation of active natural products from complex extracts is challenging. To address this bottleneck, a drug discovery strategy was developed in our lab, that combines the screening of an in-house crude plant extract library of more than 2,500 samples with an HPLC-based activity profiling approach. This workflow is used routinely in our group and was successfully applied to numerous natural product drug discovery projects
Enhancing the Brightness of Red-emitting Fluorophores in Aqueous Solution by Molecular Encapsulation
Full text linkFluorescence spectroscopy and microscopy in biomolecular environments are usually performed in aqueous solution and preferably using red-emitting dyes. However, water quenches their fluorescence. We explore in this contribution how host-guest interactions between red-emitting fluorophores and macrocycles such as cyclodextrins and cucurbiturils can prevent quenching by shielding the dyes from water, thereby enhancing their brightness. We successfully apply this strategy in super-resolution imaging
Johann Jakob Balmer im Chemieunterricht heute
Full text linkThe background and fundamentals of Johann Jakob Balmer’s work on the spectral lines of hydrogen are presented. His interdisciplinary approach, scientific methodology, and current experiments on emission, absorption and diffraction can still contribute to fundamental concepts in chemistry education