CHIMIA
Not a member yet
8905 research outputs found
Sort by
Per- and Polyfluoroalkyl Substances in Swiss Fish – a Health Problem? Highlights of Analytical Sciences in Switzerland
No full textSolvent Selection for Circular Designs – Bridging Process Needs and Sustainability Goals
Full text linkPharmaceutical industries play a crucial role in enhancing global health outcomes; however, like many other sectors, they also encounter significant environmental challenges. The extraction of raw materials and the manufacture of active pharmaceutical ingredients (APIs) result in considerable waste production, substantial resource consumption, and environmental pollution. Transitioning from traditional linear economic models to circular processes presents an opportunity for more sustainable pharmaceutical operations that benefit both communities and the environment. The circular economy framework – grounded in resource efficiency, waste minimization, and material regeneration – offers a path towards comprehensive sustainability in pharmaceutical practices. This is particularly relevant in the area of solvent usage, which accounts for over half the input mass and associated waste in most processes. This article examines the application of circular economy principles to solvent selection within process design, highlighting its significance as a central component of sustainable pharmaceutical development
Chiral Bifunctional Photocatalysts with Aromatic Ketones as Photosensitizers
Full text linkBecause the biological activity of a molecule is directly linked to its three-dimensional configuration, the preparation of chiral compounds is a central discipline in synthetic organic chemistry. With the exploitation of photoredox catalysis that gives access to open-shell (radical) intermediates under mild and sustainable conditions, unprecedented molecular architectures can now be synthesized. However, the parent enantioselective transformations have been developed at a slower pace because suppressing non-catalyzed background reactivities has presented a major hurdle. Designer bifunctional photocatalysts containing a H-bonding motif for substrate recognition and a diaryl ketone as the photosensitizer embedded in a chiral scaffold are useful catalysts in asymmetric radical transformations. Herein, an overview of enantioselective transformations in which this class of catalysts has been successful and future directions are discussed
Continuous Flow Singlet Oxygen Photooxygenation Reactions: Recent Advances and Applications
Full text linkPhotooxygenation reactions are sustainable alternatives to standard oxidation methods for the synthesis of crucial building blocks, natural products and drugs. This review is intended to provide readers with the latest advances on the development of singlet oxygen (1O2) mediated photooxygenations using continuous flow technology
Metallocene Hydrides: Their Didactic Value for Teaching Organometallic Chemistry: Chemical Education
No full textMetallocene hydrides, Cp2MHn (n=1-3), are complexes known for elements of Groups 3 to 8. Their properties can be understood by the use of a common qualitative MO diagram
The Chemical History of a Paint Box: Chemical Education
No full textThe history of mankind is the history of colour. The colours of objects, fabrics, manuscripts and illustrations from the past betray their cultural origins. A look into the modern paint box reveals some of the chemical history associated with colour