Journal of Ideas in Health
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Assessment of anxiolytic-like effects of acute and chronic treatment of flurbiprofen in murine
Get PDFBackground: Non-steroidal anti-inflammatory drugs are commonly used medications with atypical pharmacological effects. This aims to evaluate the anxiolytic-like effects of flurbiprofen in rodent models.
Methods: In vivo experimental try was conducted from October 2022 to January 2023 at the college of veterinary medicine, university of Mosul, Iraq. The effect of flurbiprofen was assessed in mice exposed to the elevated plus maze (EPM), light-dark box test (LDT), and open-field test (OFT). Fifty male mice were divided into two groups of twenty-five, weighing 30–35 g, for acute and chronic treatment. Each group was subdivided into five subgroups: distilled water was administered to the control group; the positive control was injected with 10 mg/kg diazepam; and the flurbiprofen groups were administered orally at 10, 20, and 40 mg/kg. Each subgroup was subjected to EPM, LDT, and OFT one hour after administration. The second group was also subdivided like the first group. It was treated for 15 days constantly and subjected to anxiety tests on the 16th day.
Results: Acute treatment with 20 mg/kg flurbiprofen revealed an anxiolytic effect, with increased time spent in the open arm of the EPM test, increased time spent in the LDB test, and increased time spent in the central area in the OFT compared to the control group. Chronic administration of flurbiprofen was ineffective in producing an anxiolytic effect.
Conclusion: The low doses of flurbiprofen may eliminate the anxiety effect in experimental mice; however, the anti-anxiety effect does not appear significantly after repeated or chronic administration of flurbiprofen
The prevalence of depression and anxiety in nurses caring for covid-19 patients in Saudi Arabia: a single center experience
Get PDFBackground: Healthcare workers in direct contact with confirmed COVID-19 patients often face a negative impact on psychological health. This study aims to examine the prevalence of anxiety and depression among nurses caring for COVID-19 patients.
Methods: A cross-sectional survey was conducted during the COVID-19 pandemic from January 2022 to April 2022 at King Faisal Specialist Hospital and Research Center in Riyadh, Saudi Arabia. The prevalence of depression and anxiety was assessed using the Patient Health Questionnaire (PHQ-9), and the Generalized Anxiety Disorder-7 (GAD-7) questionnaire. Kruskal–Wallis’s test was used to compare the total scores of the PHQ-9 and GAD-7 with respect to demographic characteristics. P<0.05 was considered statistically significant.
Results: A total of 123 nurses were included in the study. Most of them were females (69.92%), aged 30–39 years (45.53%), had a bachelor\u27s degree in nursing (75.61%), and had more than ten years of experience (3830.89%). The depression and anxiety prevalence in the study was 78.1% and 72.4%, respectively. Nurses aged 30–39 years were significantly associated with depressive symptoms. Female nurses showed significantly higher scores for depression and anxiety than males 74.42% and 67.45%, respectively.
Conclusion: The findings suggest that nurses are at risk for developing depression and anxiety. Therefore, regular mental health screening is necessary for nurses, particularly during a pandemic
Knowledge and practice regarding prevention of osteoporosis among Iraqi women
Get PDFBackground: Osteoporosis is known to cause long-acting disability. This study aimed to explore the knowledge, and preventive practice among women attending the primary health centers (PHC) in Al Ramadi City, west of Iraq.
Methods: A cross-sectional study was conducted between January and March 2022. A simple random sampling technique was recruited to collect samples using face-to-face interviews of women during the routine visit to PHCs. Univariate and bivariate were used to analyze the data. The statistical package for the social sciences was used for data analysis.
Results: Two hundred and fifty women were interviewed with a mean age of 37.9 ±11.3 years. The majority of them were married (87.0%), and unemployed or housewives (66.0%). Although, most of the participants heard about osteoporosis (238, 95.2%), and the possibility to cause pain before the occurrence of fracture (67.6%), the average knowledge score on osteoporosis was 55.75 ± 18.87. Furthermore, the surveyed women reported that practices of sunlight exposure (p=0.000), calcium-rich foods (p=0.003), and Vitamin D supplementation (p=0.022) are significantly related to reducing the risk of Osteoporosis. Healthcare providers played a significant role to support women with osteoporosis-related knowledge.
Conclusion: Although most women heard about the disease, their level of knowledge was modest, which might affect the measures necessary to prevent the disease
Evaluation of oncology-related healthcare professionals\u27 knowledge and practices on sustainable nutrition, Ankara, Turkey
Get PDFBackground: Increasing population, limited resources, and climate change require adopting more sustainable diets. This study aims to evaluate health professionals\u27 knowledge levels and practices on sustainable nutrition.
Methods: A cross-sectional study was conducted between January 2022 and May 2022 at Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital in Ankara. The research was performed by using the "Stretched Sampling Method". A semi-structured and self-reported online survey was recruited to collect data from healthcare professionals. Data from 298 participants were subjected to descriptive and univariate analyses to evaluate differences in knowledge mean scores and SCOFI scores. The data analysis results with the SPSS 26.0 program were accepted as a 95% confidence interval, with significance p≤0.05.
Result: A total of 298 people participated in the study. The mean age of respondents was 36 years (13±10.8). More than two-thirds (79.2%) were females, more than half (52%) were nurses, 20.5% were doctors, 60.4% had a bachelor\u27s degree, % and 12.8 had a master\u27s degree. Sustainable nutrition knowledge and SCOFI mean scores were 10.71±5.3 (0-24) and 54.09±13.2, respectively. 37.9% of the participants stated that they had heard of the concept of sustainable nutrition before. The sustainable nutrition knowledge of females was lower, and the SCOFI score was higher (P>0.05). The SCOFI score of the 18-25 age group was lower than the other age groups (P<0.05). Sustainable nutrition knowledge means scores increased as the education level increased (P<0.05). Dieticians had the highest sustainable nutrition knowledge and SCOFI score (P<0.05). The SCOFI score of those working in the surgery room and intensive care unit was lower than the other units (P<0.05).
Conclusion: Training for healthcare professionals might increase sustainable nutrition knowledge and awareness
Experimental inoculation of the Botox perineurally of facial nerve and followed by histological assessment for its effect on the zygomatic bone of rabbits
Get PDFBackground: Botox, derived from the toxin produced by Clostridium botulinum, is an attenuated toxin employed as a treatment for cervical dystonia, overactive bladder, strabismus, cerebral palsy, and non-surgical cosmetic procedures. This study aimed to explore the impact of injecting Botox around the facial nerve on the left side of rabbits, specifically focusing on the histological changes in the zygomatic bone.
Methods: Twenty-five adult rabbits of a local breed, weighing 1500-1800 gm and of both sexes, underwent a 15-day acclimation period prior to the experiment. The rabbits were randomly assigned to four groups (1st, 2nd, 3rd, and 4th). A singular intramuscular injection of Botox at a dose of 3.5 U/kg was administered to the left facial muscles. The rabbits in each group were then sacrificed at distinct time points after injection: day 10, day 15, day 30, and day 45. All rabbits survived until the end of the experiment, at which point they were euthanized with chloroform. Post-euthanasia, the rabbits\u27 facial zygomatic bones were dissected and subjected to histological assessment.
Results: The results indicated notable changes in the zygomatic bone, including prominent vacuoles within the bony matrix, cracks with cellular debris, limited osteocytes, and collagen bundles resembling woven bone. Additionally, in the day 30 group (T3), irregular bone borders and atrophied osteogenic cells were observed, while the day 45 group (T4) exhibited necrotic areas and bone fragments within the bone matrix.
Conclusion: In conclusion, Botox, derived from Clostridium botulinum, serves various medical purposes. The study focused on injecting Botox around rabbits\u27 facial nerves to assess its impact on zygomatic bones histologically. Following a controlled injection and specific time intervals, the examined bone samples exhibited distinct changes, providing insights into Botox\u27s effects on bone morphology
Detection of SARS-CoV-2 variants among travelers crossing the northern international border checkpoint in Duhok province, Iraq
Get PDFBackground: Variants of SARS-CoV-2 have been detected along with the worldwide COVID-19 transmission. Insufficient data exists regarding SARS-CoV-2 variants in Iraq, particularly concerning travelers at Iraqi border crossings. This study aimed to screen SARS-CoV-2 variants among individuals entering Iraq from Turkey through the Ibrahim Khalil international border checkpoint.
Methods: A total of 116 (52 females, 64 males) COVID-19-positive cases from June 6, 2021, to July 30, 2021, were randomly selected from the Ibrahim Al-Khalil border crossing point between Turkey and Iraq. The patients were Iraqis tested positive for COVID-19 through nasopharyngeal and oropharyngeal swab collections. The confirmation of SARS-CoV-2 cases involved RNA extraction and real-time reverse transcription polymerase chain reaction (RT-PCR), following the World Health Organization guidelines. All samples were subjected to variant detection using the reverse transcription RT-PCR method. The RNA was extracted using a Zybio nucleic acid extraction kit and the RT-PCR was conducted using SARS-CoV-2 S-gene mutation detection RT-PCR kit.
Results: In the 116 patients, we detected variants B.1.1.7, B.1.617.1.2, B.1.617.1.3, and Omicron sub-lineages (B.1.1.529, BA.1) at frequency rates of 13, 16, 45, and 36 cases, respectively. The highest prevalence rate was the delta variant among the tested subjects (38.8%) followed by the Omicron sub-lineages (B.1.1.529, BA.1) at 31%.
Conclusion: This finding, which is the first of its kind at the northern Iraqi border checkpoint, suggests that these two variants could be a source of COVID-19 circulating in the Duhok province in Iraq. Additional studies are warranted across the country’s border entry points
Perceived stress among Sri Lankans during the economic crisis: an online survey
Get PDFBackground: The Sri Lankan population\u27s mental health was undoubtedly significantly impacted by the county’s economic crisis. This study investigated the prevalence of perceived stress and its socio-demographic predictor.
Methods: A web-based cross-sectional survey was undertaken in July-August 2022, using google forms. The respondents were assessed for socio-demographics, and the level of stress experienced over the previous month. Ten-item self-reported perceived stress scale (PSS) was used to assess stress levels analysis. Descriptive statistics and logistic regression analysis were used.
Results: A total of 1214 respondents, aged ≥18 years were included in the survey. The majority were females (60%). The mean PSS score of this population was 21.95 ±6.09. More than half of the respondents reported moderate levels of stress (68.5%), while 23% registered high levels. A significant association was demonstrated between stress levels and variables age, gender, and residential area. Respondents below the age of 40 years (OR 1.936, 95% CI, 1.365-2.748, P<0.001) were more likely to report higher odds of having increased PSS scores, while men (OR 0.640, 95% CI, 0.491-0.835, P=0.001), and those without children (OR 0.556, 95% CI, 0.409-0.756, P<0.001) had significantly lower odds of reporting PSS.
Conclusion: Respondents experienced moderate to high levels of stress during the financial crisis in Sri Lanka. Higher stress was predicted by younger age, female gender, and having children. The results highlight the urgent need for stress management interventions to boost resilience and improve psychological well-being in this situation.
Zoonoses awareness and health perception in livestock farmers: Example of a city in Western Türkiye
Get PDFBackground: Zoonotic diseases are on the increase globally. Relevant disease awareness practices regarding public knowledge are useful for disease control. This study aimed to evaluate the relationship between individuals\u27 perception of health and awareness of zoonotic diseases.
Methods: A cross-sectional study was conducted among farmers in the villages of Kutahya province, located in the west of Türkiye, between February and March 2022. A questionnaire involving questions about the sociodemographic characteristics of the participants in the first part and information about the transmission route of zoonotic diseases and the Health Perception Scale (HPS) in the second part was used in this study. Mann Whitney U and Kruskal Wallis-H Test was performed to compare group medians. P<0.05 was considered statistically significant.
Results: The mean age of the participants was 44.10±10.73. The mean score of the individuals obtained from the HPS was 46.62±4.58. The health perception of the participants was found to be moderate. There was a negative correlation between the control center and precision sub-dimensions and age (respectively r: -0.260, p<0.001; r: -0.320, p<0.001). A positive correlation was found between the importance of health and self-awareness and age (respectively r:0.248, p<0.001; r:0.279, p<0.001). Those who knew that zoonoses could be transmitted from sheep, cattle, and humans had higher HPS scores than those who did not know (respectively p:0.003; p:0.001; p:0.007).
Conclusion: Increasing health perception in livestock farmers may effectively prevent zoonotic diseases
The community knowledge, awareness, and practices influencing transmission of toxoplasmosis in Mbeya District, Tanzania
Get PDFBackground: Toxoplasmosis caused by Toxoplasma gondii is an important but neglected zoonotic disease of global distribution. The study aimed at evaluating community knowledge, awareness, and practices linked to transmission and control of the disease among the residents of urban and peri-urban areas of Mbeya District, Tanzania.
Methods: A cross-section study was conducted from January 2022 to March 2022 in the Mbeya district. A semi-structured questionnaire was self-administered to gather information on social demographic characteristics, knowledge, and risk behaviors related to toxoplasma infection, chi squire was employed to test the difference where p-value < 0.05 was considered statistically significant.
Results: A total of 100 respondents were recruited. The majority (38.0%) of the respondents were aged 26 - 35 years and (49.0%) had attained primary education. The average mean age was 35.6 (+ 11.5 SD), 57% were male while 43.0% were female. Only 22 percent of the respondents were aware of toxoplasmosis and among them, 10 percent were aware of the clinical manifestations of the disease and 20 percent knew the mode of the disease transmission. Identified risk practices include lack of deworming in cats (81.0%), outdoor cats management (60.0%), disposal of cats\u27 faces in gardens (36.0%), use of cats in controlling rodents (41.0%), and not wearing gloves during gardening (77.0%). Children are noted to be at the highest risk of contracting the disease as they are greatly involved in caring for cats. (49.0%). The knowledge of the disease was found to be associated with sex (males) p value= of 0.041, occupation (medical employees) p-value =0.002, and high level of education of the respondents\u27 p value =0.000.\.
Conclusion: The study revealed a low level of knowledge of the participants and practiced risky behaviors for disease transmission. Thus, we recommend to relevant authorities to offer education to the community concerning Toxoplasmosis
Omenn syndrome: the drama of a family, congenital ichthyosis is not always mundane!
Get PDFBackground: The case we are reporting is about one of the rare manifestations of severe combined immunodeficiency, Omenn syndrome (OS).
Case presentation: A 43-days-old female presented with thick diffuse erythrodermic scaly ichthyosiform lesions on the scalp, face, and trunk since birth. lymphadenopathy, splenomegaly, and growth retardation as well as eosinophilia and increased serum IgE levels. A pregnancy was planned for an allograft of bone marrow, but the procedure was not carried out due to a persistent post-covid pneumopathy with bilateral parenchymal condensation that resulted in death.
Conclusion: This case report intends to incite clinicians to be alert to this possible diagnosis and not to underrate an immune deficiency in the case of neonatal erythroderma