332 research outputs found
Sort by
Treatment burden, not health risk attitude associated with adherence in patients with mental illness in South India
Get PDFBackground: Attitude towards health risks and treatment burden may mediate treatment adherence in therapeutic care. There is a paucity of study examining the levels and relationships of these variables in patients with mental illness. Objective: This study was conducted to know the relationships of health risk attitude & treatment burden and medication adherence in patients with mental illness. Settings and design: Cross-sectional, Hospital-based study. Methods and material: One hundred seventy consecutive participants in remission of mental illness were recruited. The patient\u27s details were assessed with Sociodemographic proforma while attitude towards health risk was assessed with Health-Risk Attitude Scale (HRAS). To evaluate the burden of treatment, the Treatment Burden Questionnaire (TBQ) was used while medication adherence was rated with the Medication Adherence Rating Scale (MARS). Statistical analysis used: Descriptive statistics, KruskaleWallis H, Linear regression analysis. Results: Mean score on MARS was 4.9 (SD ± 1.7) while HRAS and TBQ were 62.2 (SD ± 8.6) and 44.2 (SD ± 23). On linear regression analysis scores of TBQ were statistically significant positively linked to HRAS score (R2 ¼ .35, df ¼ 1, F ¼ 94.2, p ¼ 0.001), While Scores on MARS were statistically significant negatively linked TBQ and HRAS score (R2 ¼ .53, df ¼ 2, F ¼ 97.1, p ¼ 001). Conclusions: Health risk aversion and treatment burden may upraise in mentally ill, and linked to poor medication adherence
Understanding the Status of Important Criteria Air Pollutants and Its Health Effects – A Review
Get PDFIn India, airborne pollutant is serious, and a growing illness cause of concern, adding considerably to the country\u27s disease burden. Atmospheric effects are generally known to have several harmful health implications. India\u27s air pollution has risen significantly because of population expansion, rising vehicle numbers, fuel usage, inefficient transit networks, poor land use patterns, industrialisation, and most importantly, insufficient environmental legislation. Because air pollution is a major factor, this has an impact on human health. People gradually understood that contaminated outdoor air had detrimental consequences on human health. Hypercholesterolemia, breathing problems, chronic obstructive pulmonary disease (COPD), and asthma are all connected to ambient air pollution on a global scale. The purpose of this research is to review the literature on air quality and how it impacts population livelihoods
A brief review of the impact of silver nanoparticles on agriculture and certain biological properties: A case study
Get PDFNanotechnology is progressively becoming a popular field of research because it has been successful in changing our agricultural and food systems. According to research published by the UNFAO, agriculture as well as its derivatives would be in high demand sooner or later, owing to nutritional changes. Nanoparticles have been reported to be used in an agricultural sector, because of its capacity to encourage crop growth and yield. Among metal nanoparticles, Silver Nanoparticles (AgNPs) are attracting a lot of attention. We have highlighted some of the agricultural uses of AgNPs, which include pest management, plant disease detection, crop enhancement, and crop production
Comparison of Conventional PAP smear and Manual Liquid Based Cytology with P16 marker in screening for cervical cancer in Indian tertiary healthcare setups in Mysuru
Get PDFIn India, there are 20.2 per 100000 new cases of Cervical Cancer diagnosed and 11.1 per 100000 deaths annually accounting for more than one fifths of global cervical cancer deaths. [1] Thus, due to an absence of a national immunization program to cover human papillomavirus (HPV) vaccination and lack of accessible cervical cancer screening, the disease is characterized by late detection, lack of access to affordable and quality health care, and high mortality rates. [2]
Papanicolaou Smear Test was a novel invention by Dr George Papanicolaou in the year 1927 which gained maximum popularity in 1950 as a screening test for Cervical Cancer. Liquid based cytological technique has been recently developed and has gained popularity because in preliminary studies the use of such techniques was associated with a reduction in incidence of inadequate cervical smears. [3, 4]
Manual Liquid Based Cytology (MLBC) is a technique that enables cells to be suspended in a monolayer and thus improves detection of precursor lesions and improvement of specimen adequacy. MLBC has been reported to improve the effectiveness of cervical cancer screening in a population by increasing the detection of histologically confirmed neoplastic and preneoplastic disease while simultaneously decreasing over diagnosis of benign processes. [1]
Liquid-based cytology (LBC), although claimed to provide clearer background and better preservation of nuclear and cytoplasmic details, have yet to be proven to have better sensitivity and specificity for identification of high-grade cervical intraepithelial lesions compared to the conventional smears.[5]
P16 expression, which can be detected immunohistochemically, is directly related to the presence of HPV [8]. Thus, this protein can be used as a biomarker that can add significant diagnostic precision in the assessment of CIN lesions [7, 9].
Add about ancillary technique like use of immunomarker p16 on mlbc.
The aim of this study is establishing that MLBC with p16 immunomarker is very effective in screening for cervical cancer as it overcomes the major setbacks like inadequate sampling, drying artefacts and obscuring blood which are seen in conventional PAP smear technique
TYPE 2 AUTOIMMUNE PANCREATITIS
Get PDFA 23-year-old female patient with no previous co-morbidities came to our hospital with a history of back pain for 4 days. No history of nausea/ vomiting/ loose stools/ fever/ melena/ hematemesis/ jaundice/ethanol abuse. The patient was not on any alternative medication. Physical examination was within normal limits. Serum amylase and lipase were elevated , measured 152U/L and 780 U/L respectively. AST/ ALT/ ALP were elevated , measured 88/139/308 respectively. Rest of the liver parameters and blood investigations were within normal limits
Determining Vitamin D Status: A Comparison Between Diabetic And Non-diabetic Women With Breast Cancer By RP-HPLC
Get PDFBackground:
Suboptimal levels of Vitamin D, remains a common problem worldwide and its prevalence is high in India, ranging from 70-100%. Several molecular mechanisms have been found about the effects of Vitamin D in modulating glycemic levels and its protective nature in the development of breast cancer. Breast cancer in India is a common problem and studies regarding its association with Vitamin D levels among diabetics remain inconclusive. This study aims to find the association between Vitamin D status and breast cancer in diabetic and non-diabetic women.
Materials and methods:
25 hydroxy vitamin D levels were estimated by RP-HPLC. A total of 25 serum samples were analysed (20 Breast cancer patients+5 normal).
Results:
Serum sample analysis report of breast cancer patients (irrespective of diabetic status) showed 50% low Vitamin D compared to normal individuals.
Conclusions:
Vitamin D deficiency is very common among women suffering from breast cancer. Although diabetic breast cancer women have lower Vitamin D levels when compared to non-diabetic women, the results in this study are not statistically significant
Multi-modality Typical Imaging features in Superior Pulmonary Sulcus (Pancoast) tumour: A case report
Get PDFA 53 years old male patient came with complaints of pain and tingling sensation of left shoulder joint & left upper limb since 3 months. Patient is a chronic smoker with past history pulmonary tuberculosis. The patient had completed ATT 15 years bac
In silico Screening of Violacein as an epidermal growth factor receptor inhibitor
Get PDFEGFR is a key player in the signalling cascades of various kinds of cancers and tyrosine kinase inhibitors block EGFR signalling. Natural products have long been used as candidates for therapy in the management of cancer. Violacein, a bacterial pigment, has been known for its numerous biological applications such as antimicrobial, antileishmanial, antiviral, as well as antitumoral. Computational studies have concluded that it may have activity against cancers like pancreatic cancer, thyroid cancer, colorectal cancer, and endometrial cancer indicating its potential application as a broad range of anti-cancerous drug. This study aimed to perform the molecular docking of violacein with the EGFR protein to ascertain its EGFR inhibitor property, which could lead to the development of a novel anti-cancer drug