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POLMACOXIB: A DRUG REVIEW
Full text linkPolmacoxib, a novel nonsteroidal anti-inflammatory drug (NSAID), has shown a promised therapeutic option for the management of osteoarthritis and other inflammatory conditions. This drug review mainly aims to provide a comprehensive overview of polmacoxib, focusing on its pharmacological properties, clinical efficacy, safety profile, and potential therapeutic applications. Polmacoxib is a notable drug due to its dual mechanism of action, combining selective COX-2 inhibition with inhibition of carbonic anhydrase, which may contribute to its enhanced anti-inflammatory and analgesic effects. Being a selective COX-2 inhibitor, it helps minimize gastrointestinal side effects typically caused by conventional nonselective NSAIDs. Data from clinical studies suggest that polmacoxib provides statistically and clinically significant analgesic and remarkable benefits. Clinical trials have demonstrated that polmacoxib provides substantial pain relief and functional improvement in patients with osteoarthritis.This review also explores the molecular basis of polmacoxib’s action, its pharmacokinetics, and emerging evidence from post-marketing surveillance
Advances in Drug and Gene Delivery Strategies: Revolutionizing Breast Cancer Therapy
Full text linkBreast cancer is a global health challenge, demanding innovative therapeutic approaches to improve patient outcomes. Nanotechnology has emerged as a promising avenue, facilitating targeted drug delivery to breast cancer cells while minimizing off-target effects. Nanoparticle-based formulations, including liposomes, polymeric nanoparticles and lipid-based nanoparticles offer precise control over drug release kinetics and enhanced bioavailability. Furthermore, gene delivery platforms have garnered attention for their potential to modulate gene expression and overcome drug resistance mechanisms in breast cancer. Moreover, the integration of innovative technologies, like CRISPR-Cas9 gene editing and RNAi, holds promise for targeted gene manipulation and personalized treatment approaches in cancer therapy
Nanomaterials to Transform Infection Control with Antimicrobial Solutions
Full text linkAntimicrobial resistance (AMR) is a major global health problem. The growing number of antibiotic-resistant microbes needs the development of novel antibiotics. Nanotechnology shows potential for overcoming bacterial resistance. Nanoparticles, particularly those around 100 nm, display higher antibacterial activity by using methods that differ from traditional antibiotics. When particle size reduces, materials such as zinc and silver improve their antibacterial action. There are several techniques to evaluate nanoparticle antibacterial activity, each having merits and downsides. This study critically evaluates selected literature, identifies bactericidal mechanisms, and discusses assessment procedures, emphasizing the importance of innovative approaches to bacterial infections
Semaglutide and the Evolving Landscape of Metabolic Dysfunction–Associated Steatotic Liver Disease
No full textThe FDA approved Semaglutide (Wegovy™) on August 15, 2025, for adults with MASLD and moderate to advanced fibrosis (F2–F3), making it the second approved therapy after Resmetirom. MASLD affects up to 38% of adults and is now the leading cause of liver disease. In the phase 3 ESSENCE trial, Semaglutide achieved resolution of steatohepatitis without worsening fibrosis in 62.9% versus 34.3% with placebo, with additional benefits in weight loss and glycemic control. While long-term data remain pending and access barriers exist, this approval marks a significant advance in MASLD therapy with meaningful histologic and metabolic improvements
A cross-sectional study of the correlation between working models, work-life balance and psychological distress in IT professionals in an urban setting.
No full textBackground: India makes up more than 19% of the global Information Technology (IT) Market. The health and well-being of the population employed in this sector will affect their productivity at work and, in turn, the economic outcome. Changes in working models and altered work-life balance can lead to increased distress in IT Professionals, hence the current study.
Methodology: The current cross-sectional descriptive study assessed 247 IT professionals. A semi-structured questionnaire was used for socio-demographic details, working models and work-life balance. Kessler Psychological Distress Scale (K10) Plus was used to assess psychological distress. Statistics and correlations were done using SPSS 20.
Results: Majority of participants were young adult males from a nuclear family working in hybrid mode. Moderate-severe psychological distress was noted in 87.1% and it was significantly high in young adults from nuclear families with less work experience and higher income. Individuals working in hybrid/onsite models with longer commutes and those prone to motion sickness also reported increased distress. Distress was higher in Individuals who prioritize physical activity despite their busy schedules.
Conclusion: An increase in psychological distress was observed in IT professionals more so in those who commute to work or work in hybrid models. Measures to decrease distress include- decrease in commute time, a gradual shift in mode of work and providing appropriate interventions to those experiencing higher levels of distress
A Study of Electrocardiogram and Echocardiography Parameters of Post Covid – 19 Patients
No full textBackground: Coronavirus Disease – 2019 [COVID-19] infection is multisystem disease not restricted to the lungs it has negative impact on Cardiovascular system by activation of ACE-2 receptors causing plaque stability, vascular inflammation and MI. ECG and 2D ECHO is a simple bed side diagnostic test can be used to assess cardiovascular disease involvement in such patients. We aimed to find out ECG and 2D ECHO abnormalities of Covid – 19 patients. To Study relation of SARS-COV-2 infection and Prevalence of Cardiovascular disease.
Methods: We perform Cross Sectional study among 500 Post Covid – 19 patients [\u3e20 and
Results: Out of Total 500 population Tachycardia abnormalities seen in 113 patients (22.6%), Rhythm abnormalities in 52 patients (10.4%), and QRS Complex in 36(9.2%), ST Segment Depression in 54(10.8%), Prolonged QT Interval in 22(4.4%), Poor R Wave in 36(7.2%), Chamber Morphology in 67(13.4%), Left Ventricular Systolic Function 159(31.8%), Left Ventricular Hypertrophy 104(20.8%), Aortic Jet Velocity 69(13.8%), Right Ventricular Systolic Pressure 102(26%).
Conclusion: In our study 302 (60.4%) of Post Covid – 19 patients have ECG and 2D ECHO changes. Patients with Severe Covid – 19 are at risk of Cardiac involvement in future. Periodic cardiac assessment of these patients is essential. ECG and 2D ECHO cardiography investigations are prerequisite in evaluation of cardiovascular disease. Our study has shown significant findings of ECG and 2D ECHO cardiogram hence our study concludes that ECG and 2D ECHO Cardiography must consider as an important diagnostic tools for evaluation of cardiovascular disease in Covid – 19 patients
Awareness on Environmental Air Pollution among Adults in Rural Mysuru
No full textIntroduction
Air pollution is a major environmental threat and one of the main cases of death among all risk factors known so far. Health effects also include preterm and low-birthweight, asthma as well as cognitive and neurological impairment basically having the potential to impact our whole body, way beyond our lungs. The proposed study focusses on to assess the awareness on air pollution and factors associated with it among adults in South Mysuru which can put a light on the preventive measures and policies to be taken by the individuals as well as the authorities.
Methodology
A Community-based cross-sectional study was conducted among adults more than 18 years in the rural field practice area of Suttur PHC. By systematic random sampling method 400 individuals were chosen from 2283 household. Every 5th house was selected and one member from the 5th house was selected by convenient sampling. Data was collected by pre validated semi structured questionnaire containing socio demographic profile, awareness on air pollution and awareness on factors associated with it. Analysis was done using SPSS 28.
Results
In the current study, 47 participants (11.8%) were unaware, whereas 353 (88.3%) were aware of environmental air pollution. The majority had an average awareness score of 48.5% regarding air pollution whereas 41% had poor awareness and 10.5% had excellent awareness.
Conclusion
The study concludes that although the majority of participants were aware of air pollution, a significant portion had poor awareness, highlighting the need for enhanced educational and preventive measures
Weight Gain Among Tuberculosis Patients and Its Association With Socio-demographic Profile and Disease-related Characteristics In Urban and Rural Areas of Mysuru.
No full textBackground: Tuberculosis remains a major public health burden in India, accounting for 25% of the global tuberculosis cases. Weight gain during tuberculosis treatment is a key recovery indicator influenced by sociodemographic and clinical factors. Addressing these challenges is crucial for achieving India’s Tuberculosis elimination goal by 2025.
Objectives: To assess weight gain across different phases of anti tubercular therapy among tuberculosis patients in urban and rural Mysuru, and to determine its association with sociodemographic and disease-related characteristics.
Methodology: A retrospective cross-sectional study was done using secondary data of tuberculosis patients who attended primary health care centers in urban and rural areas of Mysuru. Weight measurements were recorded at baseline, post-intensive phase and post-continuation phase of antitubercular-therapy. Sociodemographic and disease-related characteristics were collected. Statistical analysis included Friedman test to compare weight gain during different phases of antitubercular treatment, chi square test to find association of weight changes with socio-demographic and disease-related characteristics and ordinal logistic regression analysis performed to predict factors affecting weight changes.
Results: Overall, patients experienced a significant change in weight during treatment, with 85.8% showing weight gain, among whom 48% gained more than 3 kg. The prevalence of weight gain was slightly higher among the rural population compared to urban, though the difference was not significant. Sociodemographic and disease characteristics, such as gender and drug sensitivity, significantly influenced the outcomes.
Conclusion: Weight gain during antitubercular therapy is a significant indicator of recovery influenced by socio-demographic and disease related factors. Addressing them through targeted nutritional interventions and regular monitoring is crucial
Practices of Food Taboo and Food Faddism During Antenatal and Postnatal Period in Rural and Urban Areas
Full text linkIntroduction: Food faddism and taboos greatly influence pregnancy, childbirth, breastfeeding, etc. Hence, this study was undertaken to assess food taboos and food faddism practiced in the urban and rural field areas of Mysuru.
Methodology: It is a cross-sectional study conducted among antenatal and postnatal women in the Mysuru district, with a sample size of 200 participants. The data was collected using a standardized validated, pre-structured questionnaire. The data obtained was analyzed using SPSS V.22. Descriptive statistics like mean, Standard deviation, proportion, etc were used and inferential statistics like chi-square analysis/Fischer exact test were used to know the association of socio-demographic variables with dietary practices of study participants in urban and rural areas.
Results: During the antenatal period in the urban area, 79.3% of study participants followed food taboo and during postnatal period, 82.4% followed taboo. In the rural area, 80.5% of study participants followed food taboo and during postnatal period, 89.3% followed food taboo. During PNC, the association between occupation, number of pregnancies with food taboo were statistically significant. During antenatal period in the urban area, 92.7% of study participants followed food faddism and during postnatal period, 85% followed food faddism. In the rural area, 89.3% of study participants followed food faddism and during postnatal period, 86.4% followed food faddism. In both antenatal and postnatal period, the association between religion, number of pregnancies with food faddism were statistically significant.
Conclusion: More than 3/4th of the study participants practiced food faddism and food taboos during antenatal and post-natal perio
Adult Attention Deficit Hyperactivity Disorder: A Case Report
Full text linkAttention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that manifests in both childhood and adulthood. It is characterized by core symptoms such as inattention, hyperactivity and impulsiveness and impairment persisting into adulthood. Adult ADHD often coexists with other disorders including mood disorders, anxiety disorders, and substance use disorders, which complicate its diagnosis. Adults with ADHD may struggle with difficulties in focusing, organization, planning and impulsivity making it hard to sit still during exams or complete tasks efficiently. Restlessness, verbal outbursts and intrusiveness can strain relationships. These challenges impact academics, interpersonal relationships and daily functioning. Thus, there is a need for more documentation of adult ADHD