International Journal of Nutrology
Not a member yet
467 research outputs found
Sort by
Major scientific evidence of the increase in women's quality of life with the use of phytoestrogens: a systematic review
Full text linkIntroduction: In the context of women's health, climacteric and menopause are intrinsically linked and can bring about several psychological and physiological changes. The use of herbal medicines is an important tool in the attempt to alleviate symptoms, improving physical and mental disposition, as well as libido. Objective: This systematic review aims to present the main considerations and scientific evidence on the use of phytotherapeutics in climacteric and menopause to reduce symptoms and improve women's quality of life. Methods: The systematic review rules (PRISMA) were followed. The research was carried out from September to October 2024 in the Scopus, Embase, PubMed, Science Direct, Scielo, and Google Scholar databases, covering scientific articles from various eras to the present day. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 121 articles were found. A total of 32 articles were fully evaluated and 23 were included in this systematic review. Most studies showed homogeneity in their results, with X2=97.7%>50%. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 30 studies with a high risk of bias and 37 studies that did not meet GRADE. An asymmetrical funnel plot does not suggest a risk of bias among small sample-size studies. In search of symptom relief and based on knowledge of the side effects of hormone replacement therapy, many women resort to alternative therapy with herbal medicines. The main results support that supplementation with soy isoflavones as a natural source of phytohormones is associated with a reduction in the frequency and intensity of hot flashes, a recurrent symptom in the climacteric. The formulated blend of four herbal extracts (Glycine max, Cimicifuga racemosa, Vitex agnus-castus, and Oenothera biennis) supports skin health and antioxidant status in women of menopausal age. Furthermore, purified pollen cytoplasm can be considered an effective non-hormonal treatment alternative for the treatment of vasomotor symptoms, as well as mood and sleep disturbances in peri and post-menopause. Three clinical trials using the Danggui Buxue Tang herbal formula have been shown to alleviate menopausal syndrome, providing solid scientific evidence of its effectiveness
Metabolomic regulation of exosomes, microRNAs, and mesenchymal stem cells by melatonin and nutrients in the bone regeneration process: a systematic review
Full text linkIntroduction: The incidence and mortality of bone diseases are still gradually increasing, creating a significant financial burden for societies worldwide. The prevalence of osteopenia is projected to increase to 64.3 million Americans, and that of osteoporosis to 11.9 million by 2030. Melatonin, microRNAs, exosomes, and mesenchymal stem cells exert numerous physiological effects, including inducing anti-inflammatory and antioxidant functions, resetting circadian rhythms, and promoting wound healing and tissue regeneration, participating in the maintenance and regenerative processes of bones and cartilage. Objective: A systematic review was carried out to present the state of the art of melatonin regulation, mesenchymal stem cells, exosomes, microRNAs, and nutrients in the bone regeneration process. Methods: The systematic review rules (PRISMA) were followed. The search was carried out from March to May 2025 in the Scopus, PubMed, Science Direct, Scielo, databases, using scientific articles from 2016 to 2025. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and discussion: A total of 126 studies were selected that were submitted to eligibility analysis, and then 80 that did not meet the criteria were excluded. The final sample consisted of 46 studies eligible for the present systematic review. Most studies showed homogeneity in their results, with X2=79.5%>50%. The symmetrical funnel plot does not suggest a risk of bias between small sample-size studies. Conclusion: Melatonin has important functions in regulating the regenerative activities of mesenchymal stem cells that modulate, together with nutrients, the activities of exosomes and microRNAs in the bone regeneration process
Analysis of blood pressure of patients with obesity and its relationship with sodium intake and cardiovascular risk markers: a prospective observational cross-sectional study
Full text linkObesity is currently a serious clinical problem, and it is estimated that by 2035, approximately 1.77 billion adults will be overweight 1.53 billion will be obese, and arterial hypertension is one of the most prevalent comorbidities. One of the challenges associated with the correct approach to blood pressure among patients with obesity concerns its correct measurement. An alternative that has been used is measurement using automatic equipment, in addition to the usual positioning on the arm, also the wrist as the measurement site. Cardiovascular risk markers have been evaluated for sodium consumption, and it is considered that there is a strong relationship between excessive consumption and greater risk, including increased arterial stiffness. Objective: It was to evaluate whether blood pressure measurements obtained using automatic equipment on the arm and wrist are equivalent in patients with obesity, to analyze sodium consumption through urinary excretion, to evaluate the correlation between sodium consumption and blood pressure, to evaluate the correlation between sodium consumption and cardiovascular risk markers, and to observe markers related to lifestyle and health habits such as alcohol consumption, physical activity, smoking, sleep, work, lipid profile, glycemic profile, and renal function. Methods: A total of 47 patients treated at the Nutrology Outpatient Clinic of HCRP-USP in 2022 and 2023 were included. The inclusion criteria were patients aged between 20 and 60 years; both genders; Body mass index greater than 30 kg/m2. The exclusion criteria were the presence of body deformities that prevented anthropometry and/or blood pressure measurement; the presence of arm circumference greater than that allowed for cuff use; previous bariatric surgery; pregnancy; and Failure to perform the requested laboratory tests. Personal, anthropometric, and laboratory data were collected from each patient. Results and Conclusion: Systolic blood pressure did not show any difference between measurements on the arm and wrist. Diastolic pressure was different, being lower on the wrist. 93.6% of patients had a daily consumption greater than 2 g/day, the limit recommended by the WHO. No correlation was found between sodium intake and blood pressure measurements taken on the arm and wrist, as well as correlations between sodium intake and glycemic profile, lipid profile, and renal function. The prevalence of diabetes was similar to that observed in other studies involving patients with BMI > 30 kg/m2 but was higher than the overall prevalence. The presence of dyslipidemia was higher than the overall prevalence and also higher than other studies involving only patients with obesity. Renal function was preserved in most patients and the few who showed signs of impairment were all diabetic and/or hypertensive.
Graphical Abstrac
Anais XXIX Congresso Brasileiro de Nutrologia
Full text linkO Congresso Brasileiro de Nutrologia, o maior evento de Nutrologia do mundo, está na sua 29ª edição.
O CBN 2025 tem como propósito fundamental promover a integração entre destacados palestrantes nacionais e internacionais e os profissionais da área da saúde, com o propósito de estimular o intercâmbio de conhecimento, a atualização científica e a difusão de avanços relevantes no âmbito da Nutrologia.
Nesse sentido, é de extrema importância que os novos conhecimentos produzidos pela comunidade acadêmica, vinculados à Nutrologia em todo o país, sejam amplamente compartilhados e debatidos.
Dessa forma, além das conferências e palestras, foram selecionados 348 trabalhos, que estão publicados nesses Anais, e 10 foram escolhidos para serem apresentados oralmente durante o evento. Toda esta difusão de conhecimento enriquecerá ainda mais o CBN 2025
Clinical outcome of off-label drugs for weight loss: a systematic review
Full text linkIntroduction: Obesity occurs when calorie intake and energy expenditure occur, causing serious comorbidities. According to the Ministry of Health, 52.5% of Brazilians are overweight. A variety of drug classes approved for other indications have been used off-label in attempts to promote weight loss. Objective: It was to carry out a systematic review to list the main drugs used off-label to treat obesity and its comorbidities, as well as present the results of clinical studies. Methods: The PRISMA Platform systematic review rules were followed. The search was carried out from March to April 2025 in the Web of Science, Scopus, Embase, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 110 articles were found, and 29 articles were evaluated in full, and 18 were included and developed in the present systematic review study, out of a total of 20 (2 references are on the website and were not included) Considering the Cochrane tool for risk of bias, the overall evaluation resulted in 21 studies with high risk of bias and 31 studies that did not meet GRADE and AMSTAR-2. Most studies showed homogeneity in their results, with X2=78.8%>50%. Off-label prescribing is very common among doctors who treat obesity. However, randomized controlled studies must be increasingly encouraged and increased to present scientific evidence and, thus, propose a scientific formalism for the safe and effective use of off-label anti-obesity drugs. Naltrexonebupropion was associated with significant improvements in binge eating disorder, with a consistent pattern of weight loss. In people without diabetes, tirzepatide resulted in substantial reductions in body weight (16.5% to 22.4%) over 72 weeks
Validation of protocol for the treatment of obesity by the ketogenic diet, vitamin D and metabolic activators: a systematic umbrella review
Full text linkIntroduction: Obesity remains a major health risk worldwide, with a burden of comorbidities and mortality of up to 2.8 million people per year. However, implementing appropriate dietary regimens for weight reduction can potentially mitigate the epidemic of obesity and its comorbidities. Among these regimens, vitamin D, ketogenic diet, L-carnitine, morosil®, inositol, taurine, and coenzyme Q10 stand out. Objective: To present the main clinical studies, meta-analyses, consensuses, and guidelines to support the efficacy and safety of the treatment protocol for obesity and its comorbidities. Methods: The PRISMA Platform systematic review rules were followed. The search was conducted from January to February 2025 in the Web of Science, Scopus, Embase, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument, and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 153 articles were found, and 54 articles were evaluated in full, and 34 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 16 studies with a high risk of bias and 26 studies that did not meet GRADE and AMSTAR-2. Most studies showed homogeneity in their results, with X2=87.8% >50%. It was concluded that the main clinical studies, meta-analyses, consensuses, and guidelines published to date indicate promising results to support the efficacy and safety of the treatment protocol for obesity and its comorbidities, with the most solid results being presented by studies of vitamin D, ketogenic diet, and L-carnitine. The studies revealed that morosyl, inositol, taurine, coenzyme Q10, and chromium picolinate present better results in treating obesity when associated with other metabolic activators. Therefore, the proposal of the present treatment protocol can be validated by the associated use of these compounds in the treatment of patients with obesity
Current scientific perspectives on probiotics and gut health
Full text linkProbiotics are live microorganisms that have gained significant attention due to their potential to improve human health. Nowadays, probiotics are widely used to prevent and treat gastrointestinal disorders, such as irritable bowel syndrome, diarrhea, and inflammatory bowel disease. In the past few years, probiotics have been explored for their role in immune modulation, mental health, and skin conditions. Probiotic strains from the bacterial genus Lactobacillus, Bifidobacterium, and yeast Saccharomyces boulardii have demonstrated positive effects on gut microbiota composition as well as overall health. Advances in machine learning models based on next-generation genomic sequencing information and microbiome research are unveiling new probiotic strains and supporting further development of personalized probiotic therapies tailored to individual microbiomes. In spite of their promising health benefits, many challenges still remain, including strain-specific variability, regulatory hurdles, and long-term safety and efficacy concerns. This review article covers the overall current market scenario, probiotic research and development, and new bioinformatics approaches in the discovery of new probiotic strain identification for health benefits
Evidence from clinical studies on prevention and treatment of cervical cancer through nutrological management: a systematic review
Full text linkIntroduction: Cervical cancer is the second leading cause of death among women of childbearing age worldwide. In 2020, an incidence of 604,000 and 342,000 deaths were estimated. Possible primary preventive strategies include diet and dietary supplements. Objective: This was to conduct a systematic review to clarify the main scientific evidence from clinical studies on the prevention and treatment of cervical cancer through nutritional triggers and nutrology. Methods: The systematic review rules of the PRISMA Platform were followed. The search was conducted from February to May 2025 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 81 articles were found. A total of 20 articles were evaluated in full and 15 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 31 studies with a high risk of bias and 24 studies that did not meet GRADE and AMSTAR-2. Most studies showed homogeneity in their results, with X2=89.8%>50%. It was concluded that a diet rich in plant-based nutrients may be important in reducing the risk of cervical cancer. Adherence to the Mediterranean diet reduces the risk of cervical cancer by 60%. Changes in dietary habits may contribute to preventing the onset of cervical cancer by 30% to 40%. The consumption of sugary drinks is associated with type II endometrial cancer. The consumption of fruits and vegetables reduces the risk of cervical cancer. Vitamin D may exert beneficial actions in the early stages of cervical cancer, preventing its onset and progression. Lactobacillus strains isolated from human breast milk may be considered a topical drug with a potential therapeutic index due to their efficacy against cervical cancer cells
Treatment and prevention of metabolic syndrome through the mediterranean diet: a systematic review
No full textIntroduction: Diets are useful according to the nutritional deficiencies or needs of each individual in terms of health and aesthetics in general. In this sense, the search for weight loss is one of the constants that impact the population to solve the problem of obesity. It is important to highlight the association of MetS (metabolic syndrome) with cardiovascular diseases, increasing overall mortality by approximately 1.5 times and cardiovascular mortality by approximately 2.5 times the Mediterranean diet is the main therapeutic proposal for the treatment of MetS. Objective: This study presented the Mediterranean diet as a therapeutic proposal for the treatment and prevention of metabolic syndrome and evaluated its effectiveness as a nutritional benefit in quality of life. Methods: The model followed for the systematic review was PRISMA. The search strategy was carried out in the databases PubMed, Embase, Ovid and Cochrane Library, Web of Science, Science Direct Journals (Elsevier), Scopus (Elsevier), and OneFile (Gale), from February to March 2025. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: 142 articles were found. A total of 32 articles were assessed in full and 25 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 18 studies with a high risk of bias and 21 studies that did not meet GRADE and AMSTAR-2. Most studies presented homogeneity in their results, with X2=92.3%>50%. It was concluded that the beneficial effects of the Mediterranean diet in reducing the prevalence of metabolic syndrome, therefore, the dietary pattern described in the Mediterranean diet combined with physical activities can be used as a useful clinical tool in the treatment of metabolic syndrome. In addition, the suggested menu, with foods rich in fiber, is associated with a reduction in cardiovascular risk and, therefore, the Mediterranean diet is recognized as an agent for promoting health and preventing obesity. In this sense, it is clear that dietary factors can play a fundamental role both in the individual components and in the prevention and control of metabolic syndrome. Recent data associate the presence of metabolic syndrome with a lower consumption of whole grains, fruits, and vegetables. Therefore, there is a close relationship between these foods and dietary fiber, and soluble fiber is probably more directly related to these effects
Clinical results of the functions of melatonin in the mitigation of comorbidities of obesity and type 2 diabetes mellitus: a systematic review
Full text linkIntroduction: In the scenario of chronic non-communicable diseases, there are more than 2.2 billion overweight and obese people in the world. Brazil has an estimated population of more than 20.0 million people in 2025. Studies show that a reduction of around 10.0% in weight also favors the reduction of type 2 diabetes mellitus (T2DM). The imbalance in sleep patterns and the consequent decrease of melatonin (MEL) concentrations in the human body have a major impact on health with the development, mainly of obesity and T2DM. Objective: It was to present the main clinical results of the functions of melatonin in mitigating the comorbidities of obesity and type 2 diabetes mellitus. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from May to June 2024 in the Web of Science, Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: 182 articles were found. A total of 35 articles were evaluated in full and 28 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 35 studies with a high risk of bias and 32 studies that did not meet GRADE and AMSTAR-2. Most studies showed homogeneity in their results, with X2=77.8%>50%. It was concluded that melatonin is an important participant in the regulation of energy metabolism, including body weight, insulin sensitivity, and glucose tolerance. Randomized placebo-controlled clinical studies have shown that daily melatonin consumption can be effective in controlling blood pressure, including systemic blood pressure, mean arterial pressure and pulse pressure, and reduces anthropometric indices of obesity in patients, as it increases mass and activity of brown adipose tissue, functioning as an antiobesogenic hormone. Melatonin can regulate adipose tissue and adipokines, such as adipocyte lipolysis, and fat deposition. Furthermore, melatonin can interact with intracellular molecules, acting as an effective antioxidant. Several studies have pointed to a greater risk of developing obesity in people who sleep less than six hours a day. The hormonal changes that occur during sleep deprivation may explain the increase in caloric intake and decrease in leptin, increase in ghrelin and peptide YY. Melatonin also regulates food intake by regulating the production and secretion of insulin, glucagon, and cortisol. Epidemiological studies have shown a link between sleep deprivation, insulin resistance, and T2DM