International Journal of Nutrology
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Major evidence of the GLP-1 analog (liraglutide) in the treatment of obesity: a systematic review
Get PDFIntroduction: Obesity is a chronic disease that affects a significant portion of the population. In Brazil, in the surveillance survey of risk and protective factors for diseases, more than half of the Brazilian population, 55.7% are overweight. Objective: A systematic review of the literature was carried out with the primary objective of verifying the effectiveness of weight loss of liraglutide in obesity, the secondary objective is the evaluation and clinical benefits secondary to the medication. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from September to October 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results: A total of 84 articles were found, 52 articles were evaluated and 20 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 8 studies with a high risk of bias and 19 studies that did not meet GRADE. Most studies showed homogeneity in their results, with X2 =96.9% >50%. In this context of a serious disease with a high prevalence in the population, a literature review was carried out to verify the effectiveness of weight loss of liraglutide 3.0mg in obesity. A total of 781 works were found, of which all titles and abstracts were individually evaluated and sixteen related to the clinical question and PICOS were selected. Primary studies show the superiority of liraglutide over placebo and orlistat in weight loss and improvements in clinical outcomes. Conclusion: Liraglutide 3.0mg proved to be a safe and effective option in the treatment of obesity
Gut-Skin axis and healthy skin: a systematic review
Get PDFIntroduction: The skin has a multifactorial aging process, both by intrinsic and extrinsic predictors. Skin diseases contributed almost 2.0% to the global burden of 308 diseases and injuries in recent years. The role of the gut microbiota (GM) in human aging is important. GM directly affects aging through the gastrointestinal system. The microbial impact on the skin is still not fully understood. Objective: The present study analyzed the major scientific evidence on the relationship between gut microbiota and the skin, emphasizing the importance of intestinal health for aesthetically healthy skin. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from February to May 2023 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 137 articles were found. A total of 47 articles were fully evaluated and 27 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 30 studies at high risk of bias and 13 studies that did not meet the GRADE. It was concluded that current scientific evidence reveals the existence of an important Skin-GM axis, highlighting the management of dermatoses through probiotics and prebiotics, as well as lifestyle changes. To establish aesthetically healthy skin, it is imperative to manipulate the gut microbiota to achieve balance. Thus, treatments that elevate or repair a bowel are essential as adjunctive therapy in the management of inflammatory skin diseases and may contribute to the effectiveness of standard dermal therapy
Tissue regeneration and gut microbiota-skeletal muscle axis via microRNAs and nutrition: a systematic review
Get PDFIntroduction: In the scenario of muscle regeneration in athletes, maintenance of skeletal muscle function is the prerequisite for tissue homeostasis and increased performance. MicroRNAs play a positive role in expanding our understanding of the controlling factors for skeletal muscle function. Recent progress has been made regarding gut microbiota, regenerative nutrition, and skeletal muscle metabolism. Objective: It was to carry out a systematic review of the main relations of regeneration of skeletal muscle-gut microbiota through nutrological functions, cells, and microRNAs. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from February to April 2023 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 217 articles were found. A total of 97 articles were fully evaluated and 49 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 54 studies at high risk of bias and 34 studies that did not meet the GRADE. It was concluded that miRNAs are widely present in skeletal muscle and play an irreplaceable tuning role in the proliferation, differentiation, apoptosis, development, and other physiological processes of skeletal muscle cells. The proposal that miRNAs are primarily involved in the cell's stress response makes miRNAs ideal for mediating the skeletal muscle response to changes in contractile activity. Research has accumulated evidence that confirms that miRNAs have played an important regulatory role in cell proliferation and differentiation, thus regulating skeletal muscle growth as highlighted in the small intestine by intestinal stem cells (LGR5+). The ketogenic or high-glucose diet regulates the self-renewal balance of LGR5+. Self-renewal and HSC differentiation can be regulated by manipulating vitamin C, A, or D levels and valine restriction. The composition of each athlete's microbiome influences sports performance
Pmma body injection and hypercalcemia correlation: a cross-sectional observational study on the comprehensive analysis of variables
Get PDFIntroduction: Hypercalcemia related to aesthetic intramuscular implants exclusively made of PMMA (polymethylmethacrylate) is a very rare condition. Late complications of these implants are related to poorly understood inflammatory triggers, which may reactivate stabilized implants, increase calcitriol production, and lead to hypercalcemia. Methods: Records of patients seen between 2022 and 2023 with a PMMA microsphere body implant and a subsequent diagnosis of hypercalcemia were searched. Medical history, medication use, data on PMMA implantation, and laboratory tests related to calcium metabolism were described and subjected to variable correlation analysis. The instituted treatments were described. Results: A total of 17 female patients with exclusive body PMMA implants confirmed by ultrasonography or MRI (Magnetic Resonance Image) developed hypercalcemia between 2017 and 2022. Prior renal disease, COVID-19 infection, vitamin D use, and anabolic steroid use correlated with laboratory changes in hypercalcemia. Larger PMMA implant volumes led to parathyroid hormone suppression. Conclusion: Patients with PMMA body implants may rarely present with hypercalcemia when variables such as renal disease before implantation, high doses of vitamin D or anabolic steroids are present. Based on the data presented and the available scientific literature, recommendations for patient investigation, implant volume limit, and patient follow-up after the procedure were made
Anais XXVII Congresso Brasileiro de Nutrologia - n. 27, v. 1, 2023
No full textO Congresso Nacional de Nutrologia, maior evento da área na América Latina, está na sua 27ª edição.O CBN 2023 tem como missão prover articulação entre os mais renomados palestrantes nacionais e internacionais, juntamente com os profissionais da saúde - acadêmicos, médicos, nutricionistas, psicólogos - com o objetivo de transmitir conhecimento e atualização sobre os mais variados temas que envolvem nossa especialidade.Nesse contexto, é de grande valia que os novos conhecimentos científicos que estão sendo gerados pela comunidade acadêmica, envolvidos pela Nutrologia em todo o país, sejam compartilhados.Dessa forma, além das conferências e palestras, foram selecionados 381 trabalhos, que estão publicados nesses Anais, e 13 foram escolhidos para serem apresentados oralmente durante o evento. Toda esta difusão de conhecimento enriquecerá ainda mais o CBN 2023
State of the art and major clinical outcomes of the use of essential oils in the performance of athletes: a systematic review
Get PDFIntroduction: Essential oils (EOs) has been around for years and studies show that they are useful in treating various diseases and improving health. According to the United States OEs Handbook, OEs are a vital part of complementary and alternative medicine and the positive findings of OEs are now becoming a trend in sports performance research for athletes. Objective: It was to list the main scientific findings of clinical studies on the effectiveness of essential oils in improving the health and sports performance of athletes. Methods: A total of 195 articles were found involving clinical studies of the influence of essential oils on human health. After this process, 42 articles were included and 32 were discussed in this study. The present study was prepared following the systematic review guidelines – PRISMA. Results and Conclusion: Essential oils have been used in medicine for decades and have been proven to eliminate toxins from the body. They are also shown to improve the body's ability to absorb essential vitamins and nutrients. In this sense, the application of these oils not only helps to prevent and heal sports injuries but also to stimulate and relax the mind and body, leading to higher levels of fitness. Because of these inherent properties of EOs, there is growing interest in using them to tone the body and mind in a variety of ways, such as musculoskeletal preparation, injury prevention, and improving mood and performance to achieve a higher success rate in sports. sports and fitness, as well as post-exertion recovery. They can be used as an aid to make recovery faster, reducing the effect of fatigue and raising the energy level of the mind and body
NutrUgraft - preoperative supplementation in ultra HD liposuction with ultrasound-guided rectus abdominis fat transfer: a prospective longitudinal cohort clinical study
Get PDFLiposuction triggers an inflammatory response as a result of surgical trauma. Preoperative dietary supplementation has been implemented to enhance recovery. The purpose of this study was to evaluate patients’ perceptions of the use of preoperative dietary supplementation through a questionnaire. We conducted a prospective study of 80 healthy patients, 2 men, and 78 women, with a mean age of 34.8 years. Thirty days before surgery, all patients have prescribed the NutrUgraft protocol: CoQ10 200 mg, Dimpless 40 mg, Biointestil 300 mg, and IBS Care 100 mg. The Impact® dietary supplement was also prescribed, 1 unit daily for 7 days. On postoperative day 30, patients answered 5 objective questions: (1) How do you rate your healing? Good, fair, or poor; (2) Did you feel safer by receiving preoperative supplementation? Yes, no, or indifferent; (3) Postoperatively, your bowel: functioned normally, constipated, or had diarrhea; (4) Postoperatively, did you develop fibrosis? Yes, no, or I don’t know; and (5) If undergoing another surgery in the future, would you like to receive preoperative supplementation again? Yes, no, or indifferent. Of 80 patients evaluated, 80% classified their healing as good, 90% reported feeling safer by receiving preoperative supplementation, 85% reported that their bowel functioned normally postoperatively, 80% reported not developing fibrosis, and 91.25% would like to receive supplementation again if undergoing another surgery. Based on the results, patients had a positive perception of all topics evaluated, thus highlighting the importance of dietary supplementation in the preoperative period of plastic surgery
Family hypercholesterolemia and LDLR mutations in communities of european origin in southern Brazil: a prospective observational cohort study
Get PDFFamilial hypercholesterolemia (FH) is an autosomal dominant disease characterized by high levels of circulating low-density lipoprotein (LDL) and premature coronary heart events. A quarter of the population of Southern Brazil is affected by hypercholesterolemia and the region has the highest mortality rates due to cardiovascular disease in the country. The aim of this study was to describe LDLR mutations in European descendants with FH living in Southern Brazil. Ten mL of venous blood were taken from 40 patients and used for DNA extraction and subsequent Polymerase Chain Reaction (PCR). The DNA fragments were sequenced and analyzed and the data obtained were compared to reference values from the University of California Santa Cruz (UCSC) Genome Browser. A total of 15 mutations were identified in 38 patients (95% of the total samples). These mutations were located in exons 11 (P518L) and 15 (D727G) in Italian, Portuguese and Spanish descendants and the *105T>G mutation, still undescribed, should be critically evaluated by means of mRNA alteration studies. The present study demonstrated for the first time the presence of the P518L mutation located in exon 11 of the LDLR gene in European descendants living in southern Brazil. This mutation has a high potential to be pathogenic since it is located in a domain responsible for LDLR release from the endoplasmic reticulum (ER)
Influences of mindset and lifestyle on sports performance: a systematic review
Get PDFIntroduction: In the scenario of the mindset and performance of athletes, the athlete's lifestyle becomes an integral part of this development. e need to focus on the mindset of athletes, exploring the perspectives of elite athletes through a qualitative approach, in order to understand the lifestyle and other factors to which they attribute their success. Objective: It was to carry out a systematic review to present the main studies on the influence of mindset (mindset) on the performance of athletes, as well as the entire lifestyle scenario for this development. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from January to March 2023 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 118 articles were found, and 32 articles were evaluated in full and 29 were included and developed in this systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 52 studies with a high risk of bias and 14 studies that did not meet GRADE. It was concluded that mindsets such as believing in yourself after failure (called the constructive mental code) are very beneficial for athletes' perseverance, motivation, and performance improvement. Still, a positive mindset can positively influence the performance of athletes, showing that mental skills training can lead to better performance in competition. Thus, champion athletes attribute their good mindset as the main predictor of competitive success. However, it is necessary to inform and encourage these practices in coaches and support staff in the area of the psychological skills of athletes. Mindfulness can benefit athletes' mindsets and performance. Cognitive variables, such as coping with stress, are significantly correlated with performance. Highperformance strategies include using honed mental rehearsal skills and practicing recovery
A review of the role of vitamin d in autoimmunity
Get PDFIntroduction: The main function of vitamin D is to increase the intestinal absorption of calcium, participating in the stimulation of active transport of this ion in enterocytes. Extra-renal hydroxylation of vitamin D also occurs, originating the vitamin that would act in an autocrine and paracrine manner, with functions of inhibiting cell proliferation, promoting cell differentiation, and immune regulation. Objective: It was to review the scientific literature on the role of vitamin D in autoimmunity. Methods: A search was carried out on scientific articles centered on the proposed theme: “Role of vitamin D in autoimmunity”. Several search engines that carried scientific information in the health area were used to carry out this study, such as Google Scholar and the Medical Publications database (PubMed), and Scientific Electronic Library Online (SCIELO). In collecting the information, the descriptors used to carry out this research were: vitamin D; vitamin D in preventing diseases; vitamin D and autoimmune diseases; vitamin D; autoimmune diseases. The inclusion criteria used in this study were publications of scientific articles available in full and with free electronic access, limited to a period between 2011 and 2022, and selected articles in Portuguese and English. Results and Conclusion: Based on this methodology, it was possible to analyze a population of 58 articles that were selected for the study and constituted the sample used in this review. Several studies point to the effects of vitamin D not related to calcium metabolism, such as antineoplastic activity (particularly concerning breast, colon, and prostate cancers, and lymphoproliferative diseases), antihypertensive and immunomodulatory. Vitamin D deficiency and its use for treatment have been described in various autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, lupus, inflammatory bowel disease, myasthenia gravis, scleroderma, alopecia areata, psoriasis, vitiligo, autoimmune hepatitis, type 1 diabetes mellitus, autoimmune thyroiditis, etc. The effects of vitamin D on the immune system are related to the tolerance of self-antigens, exerting an inhibitory effect on the Th1 and Th17 type lymphocyte pattern, and a promoting effect on the expression of the Th2 and Treg pattern through the action of vitamin D in all cells of the system through the vitamin D receptor. More studies are needed to establish safe and effective doses in the management of these properties of vitamin D