Asian Pacific Journal of Nursing and Health Sciences
Not a member yet
54 research outputs found
Sort by
Development and Evaluation of Interpenetrating Polymer Network Hydrogel for Controlled Release of Cefadroxil
Get PDFOral drug delivery is the most widely utilized route of administration among all the routes that have been explored for systemic delivery of drugs via pharmaceutical products of different dosage form. By increasing the concentration of cross linking agent drug entrapment efficiency increase but in case of percentage yield firstly it increases (A9- A10) after that in it decrease. Out of all the twelve formulation A-10 formulation is optimized and taken for further characterization
FDA-Approved Natural Disintrgrant for Fast Dissolving Tablets
Get PDFOrally disintegrating tablets (ODTs) are an emerging trend in novel drug delivery system and have received ever-increasing demand during the last few decades. ODTs are solid unit dosage forms, which disintegrates or dissolves rapidly in the mouth without chewing and water. This type of property in dosage form can be attained by addition of different excipients, in which disintegrants are the key adjuvant. In recent years, several newer agents have been developed known as super-disintegrants. Super-disintegrants are used to improve the efficacy of solid dosage form and influence the release rate of dosage form. Diverse categories of super-disintegrants are such as synthetic, semi-synthetic, natural and co-processed blends etc. These have been employed to develop effectual ODTs and to overcome the limitations of conventional tablet dosage forms. The plant derived natural super disintegrants comply with many requirements of pharmaceutical excipients as they are non-toxic, stable, easily available, associated with less regulatory issues as compared to their synthetic counterpart and inexpensive; also these can be easily modified into more polar form. This review discuss about the development of various kind of natural super-disintegrating agents, along with their role in the tablet disintegration and as potent candidate to be used in ODTs, which are being used in the formulation to provide the safer, effective drug delivery with patient compliance
Advancements in Protein based Nano Particulate system for treatment of Pulmonary Infections- A Review
Get PDFIn addition to the so-called small molecule drugs, proteins and peptides are of increasing interest forpharmacotherapy, due to several advantageous properties. In general, those compounds are administered parenterally. However, non-invasive routes of administration represent a great part of research. Amongst others is the pulmonary application of proteins and peptides for local delivery in the case of pulmonary diseases, such as idiopathic pulmonary fibrosis, where the alveolar epithelium is affected. To ensure an intracellular delivery, nano particles in a size range of 150 nm will be prepared via charge-mediated coacervation, characterized for their physicochemical properties and loaded with several model-proteins. The material used for nano particle preparation was chosen to be positively and negatively charged starch derivatives, which were synthesized from potato starch. Although nano particles in that size range are known to show an increased cell uptake, they do not show a high deposition in the deep lung. Thus, an advanced carrier system consisting of a fast dissolving micro particle matrix with embedded starch nano particles will be developed and characterized. Due to its aerodynamic properties, that carrier system must be able to deposit a high fraction of the applied dose in the deep lung (~50%), while at the same time demonstrating (in in vitro models) the ability to facilitate uptake of starch nano particles into cells of the alveolar epithelium after fast dissolution of the micro particle matrix
A Quasi-Experiment on the Effectiveness of Cardiac Rehabilitation in Quality of Life of Cardiac Patients with the Caregivers’ Involvement
Get PDFIntroduction: Coronary Heart Disease can result in impaired quality of life which can inhibit an early recovery with successful outcomes for cardiac patients. Objective: To investigate the effect of a structured cardiac education and early intervention cardiac rehabilitation program on quality of life in cardiac patients involving caregivers. Method: A quasi experimental study with a purposive sampling was carried out where 132 acute coronary syndrome patients hospitalized for treatment were recruited and allocated to the experiment and control group with and without caregivers. A structured educational intervention and cardiac rehabilitation was initiated for the experimental group with and without caregivers. The outcome was measured using the World Health Organization Quality Of Life-BREF (WHOQOL-BREF) instrument.Results: Data was measured with repeated measures ANOVA between baseline, discharge and follow-up between the intervention and control group with p<0.05 There was a statistically significant difference in QOL in both the groups with and without caregivers in the following domains: psychological health (F=3.784, p=0.002); social relationship (F=4.267, p=0.000) and environment (F=3.578, p=0.004). There was not a statistically significant difference between both the groups in the physical health domain (F=1.316, p=0.266).Conclusion: The results indicated that a structured cardiac educational intervention and cardiac rehabilitation with the involvement of the caregivers have significant effects on the quality of life of cardiac patients. The findings provide useful evidence to improve health outcomes of acute coronary syndrome patients involving the caregivers
Mucocele: A case report with brief review
Get PDFMucocele is a clinical term that basically includes two phenomenon i.e. mucus extravasation and mucus retention. Cysts arising in connection with minor salivary glands are common and about 90 per cent of cases are of the mucous extravasation type. These lesions are typically painless, dome-shaped, and fluctuant; they appear blue in colour secondary to the presence of mucin under the mucosa. The vesicular appearance created by the superficial nature of the mucin spillage, causes a separation of the epithelium from the connective tissue. The pathologist must be aware of this lesion and should not mistake it microscopically for a vesiculo-bullous lesion, especially mucous membrane pemphigoid. Here, we present a case report on mucocele with a brief review
Impact of Mobile Phone Use on Various Dimensions of Health among Students During COVID-19
Get PDFAlthough, all the countries have used various measures to reduce the transmission of the COVID-19 like complete or partial lockdown, travel restrictions, social restrictions etc but the effectiveness of these measures completely depend on the cooperation of the society members. The knowledge, attitudes and practices of people toward any disease play a vital role in determining a community’s readiness to accept behavioural change measures from government authorities. The aim of this study was to determine the Impact of Mobile Phone Use on Various Dimensions among students during COVID-19 of India. A cross-sectional online survey was conducted between 20th May and 05thJune 2020. 670 completed survey were received. The data was collected by following questionnaires: demographic characteristics questionnaire, knowledge questionnaire. Descriptive & inferential statistics were used to analyse the data. The study result revealed that the students have more negative impacts (52.22%) than positive impacts (47.78%) & significance association was found with education of students (p>0.05)
Phytoconstituents and Formulations For Wound Healing: A Review
Get PDFUse of herbal drugs to treat disease is almost universal and more affordable as there is widespread availability of herbs in the Himalayas. Number of aspects are associated with applications of herbal medicines in wound healing. With proper identification, phytochemical screening and performing toxicological studies, herbal medicine possesses various advantages like reduced side effects, effective with chronic conditions, cost effective, widespread availability. Besides these, it can be made a promising novel medicine with the use of Targeted drug delivery system.In view of this a detailed review of literature was carried out on different formulations and phytoconstituents responsible for wound healing activity, with special emphasis on different stages of wound healing, which could be of prodigious help in managing and treating various types of wounds
A review on nephrotic syndrome with their causes, complications and epidemiology
Get PDFNephrotic syndrome is a collection of symptoms due to kidney damage. This includes protein in the urine, low blood albumin levels, high blood lipids, and significant swelling. Other symptoms may include weight gain, feeling tired, and foamy urine. Complications may include blood clots, infections, and high blood pressure. Causes include a number of kidney diseases such as focal segmental glomerulosclerosis, membranous nephropathy, and minimal change disease. It may also occur as a complication of diabetes or lupus. The underlying mechanism typically involves damage to the glomeruli of the kidney. Diagnosis is typically based on urine testing and sometimes a kidney biopsy. It differs from nephritic syndrome in that there are no red blood cells in the urine. Treatment is directed at the underlying cause. Other efforts include managing high blood pressure, high blood cholesterol, and infection risk. A low salt diet and limiting fluids is often recommended. About 5 per 100,000 people are affected per year. The usual underlying cause varies between children and adults
Formulation and Optimization of Biodegradable Periodontal Chips Containing Metronidazole and Levofloxacin
Get PDFThis research aimed to developintrapocket,biodegradablechips ofpoly(d,l-lactide-co-glycolide) (PLGA) loaded with Metronidazole (MZ) and levofloxacin (LF),for sustained release local drug delivery in periodontal pocket to treat periodontitis. Metronidazole and levofloxacin are widely employed for the treatment of periodontitis,but high oral dose and resistance development after long-term oral administration limit their use, hence local delivery is a good approach. The chips were prepared by solvent casting technique using diethyl phthalate as plasticizer. Their physical characteristics, such as drug content,surface pH, swelling index, and folding endurance, exhibited results within limit. Further, FTIR and DSCstudies revealed stability of chips and compatibility between drugs and excipients.In vitro release in McIlvainebuffer pH 7.8 was of sustained nature assisted by the burst effect. Design-Expert® (11.0.4) software was used to study the effect of polymer & plasticizer on release of drugs Polymer concentrationsnegatively affected drug release and positively affected T90 (time for releasing 90% of the drug) due toaltered matrix density. In contrast, the plasticizer concentration increases membrane permeability andhence increased drug release, lowering T90. Forvarious response variables,polynomial mathematical models were generated usingmultiple regression analysis, and found to be statistically significant (????<0.05).The antibacterial efficacy of films was tested on Pseudomonas spp. Bacteroides spp., indicatinggood antibacterial activity. Optimized formulations were further used for preparing optimized biodegradable, Metronidazole-Levofloxacin sustained release chip. Conclusively, the films of MZ and LF were successful tools for the management ofperiodontitis
Hydrogel: Preparation, Characterization and Applications
Get PDFThis review article is intended to provide an overview of hydrogel as novel vesicular drug delivery system.For the treatment of many diseases large molecular weight proteins are required. These can be available with the availability of Hydrogels. Hydrogels are hydrophilic, three-dimensional networks, which are able to imbibe large amounts of water or biological fluids, and thus resemble, to a large extent, a biological tissue. They are insoluble due to the presence of chemical (tie-points, junctions) and/or physical crosslinks such as entanglements and crystallites. It has focused on to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel properties, method of preparation of hydrogel, advantages and disadvantages of hydrogel, characterization of hydrogel