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フリーランスにおけるバウンダリーレス・キャリアに関する理論的検討
No full textThe purpose of this study is to review previous research on boundaryless career and freelancers and to present remaining issues and future research. Although there is growing social interest in the working styles of freelancers, there are still issues remaining regarding their working styles. In this study, I will first discuss the impact of boundaryless careers on career success. Second, it reviews the theoretical perspectives that have been clarified in previous studies. This study contributes to the development of career theory by focusing on individuals who are not employed by organizations, and it also contributes to the management of freelancers.長崎大学経済学部創立120周年記念論文集経営と経済, 105(1-2), pp.249-272; 2025departmental bulletin pape
広告はメディア需要にどのような影響を与えるのか？―広告回避の支払意思額と有料利用の関係―
No full textThis paper quantifies the monetary value of advertising disutility by measuring consumers' willingness to pay to avoid ads. It also clarifies the impact of this disutility on demand for media services. First, through model analysis, it demonstrates how the disutility people feel toward advertising affects ad volume, paid service usage rates, and consumer surplus. The results show that the impact of advertising disutility on ad volume and paid usage rates varies depending on the structure of the media market. Subsequent empirical analysis uses results from our original survey to determine the monetary valuation of advertising disutility and then examines its relationship with the amount paid for paid services. The results show that increased disutility positively correlates with the amount paid for paid services, indicating that increased advertising disutility encourages the use of paid services.長崎大学経済学部創立120周年記念論文集経営と経済, 105(1-2), pp.303-330; 2025departmental bulletin pape
Clinicopathological and molecular characteristics of papillary thyroid carcinoma in adolescent and young adult patients
No full textNagasaki University (長崎大学)博士(医学)Adolescent and young adult (AYA, 15–39 years old) patients with papillary thyroid carcinoma (PTC) experience significant psychological distress and place great importance on obtaining information regarding the disease; however, their demands remain unmet. We aimed to investigate clinicopathological and molecular features of PTC in AYA patients and compare them to those of PTC in older patients (≥40 years). This retrospective study enrolled 1,677 patients diagnosed with PTC from January 2018 to December 2022, with 400 AYA patients and 1,277 older adults. At the time of diagnosis, AYA patients with PTC had higher rates of presentation in females, larger tumor size (>2.0 cm), lymphatic vessel invasion, chronic thyroiditis, clinical lymph node metastasis, and pathologic lymph node metastasis, but lower rates of multifocality and extrathyroidal extension compared with PTC in older adults. The two groups had no significant differences regarding surgical method and distant metastasis. The prevalences of BRAF p.V600E and TERT promoter mutations of PTC were significantly lower in AYA patients (69.1% vs. 82.6% and 1.3% vs. 18.8%, respectively; both p < 0.001). In conclusion, PTC in AYA patients differed from PTC in older patients. Particularly, BRAF p.V600E and TERT promoter mutations in AYA with PTC were less frequently observed than in older adults.長崎大学学位論文 学位記番号:共博(医歯薬)甲第51号 学位授与年月日:令和7年9月19日Author: Van Phu Thang Nguyen, Hirokazu Kurohama, Yuko Akazawa, Thi Ngoc Anh Nguyen, Katsuya Matsuda, Yuki Matsuoka, Zhanna Mussazhanova, Kenichi Yokota, Shinya Satoh, Hiroyuki Yamashita, Thi Nhung Nguyen, Yerkerzhan Sailaubekova and Masahiro NakashimaCitation: Endocrine Journal, 72(2), pp.221-227; 2025Nagasaki University (長崎大学), 博士(医学) (2025-09-19)doctoral thesi
Studies on the post-capture anti-predator tactics in juvenile Japanese eels
No full textNagasaki University (長崎大学)博士(水産学)長崎大学学位論文 学位記番号:博(水・環)甲第114号 学位授与年月日:令和7年8月29日Nagasaki University (長崎大学), 博士(水産学) (2025-08-29)doctoral thesi
Differential impact of graft-versus-host disease on post-transplant outcomes of chronic myelomonocytic leukemia according to transplant procedures
No full textAllogeneic hematopoietic stem cell transplantation (allo-HSCT) provides curative outcomes for chronic myelomonocytic leukemia (CMML). We conducted a retrospective study to clarify the protective impact of acute and chronic graft-versus-host disease (aGVHD and cGVHD) on relapse by transplant procedures in 314 CMML patients. Interaction effects of conditioning intensity were observed with aGVHD (Pinteraction=0.181) and cGVHD (Pinteraction=0.256) for the cumulative incidence of relapse (CIR), whereas interaction effects of donor type were not detected with GVHD. In patients with the myeloablative conditioning regimens, the multivariate analysis showed that the development of aGVHD was not associated with overall survival (OS). The development of limited cGVHD correlated with better OS (HR [95 % CI], 0.34 [0.14–0.81]; P = 0.015); and that of extensive cGVHD correlated with better OS (HR, 0.44 [0.21–0.91]; P = 0.026) and lower CIR (HR, 0.28 [0.08–0.94]; P = 0.040). In patients with the reduced-intensity conditioning regimens, the development of grade I-II aGVHD correlated with better OS (HR, 0.39 [0.20–0.76]; P = 0.005) and lower CIR (HR, 0.30 [0.13–0.70]; P = 0.006). The development of extensive cGVHD correlated with better OS (HR, 0.44 [0.20–0.96]; P = 0.039). The present results suggest that the type and severity of GVHD mediating graft-versus-leukemia effects against relapse were influenced by conditioning intensity in CMML patients.Leukemia Research, 159, art. no. 108134; 2025journal articl
Efficacy and Safety of Atezolizumab Plus Bevacizumab for Patients With Hepatocellular Carcinoma and Child–Pugh Class B
No full textBackground & Aims: Despite the advances in systemic therapy for unresectable hepatocellular carcinoma (HCC), patients with Child–Pugh class B (CP-B) liver function face a significant unmet need. This study evaluated the efficacy and safety of atezolizumab plus bevacizumab (Atez/Bev) in patients with unresectable HCC and CP-B. Methods: This retrospective study included 796 patients who received Atez/Bev between October 2020 and July 2024 from 10 institutions in Japan. The median observation period was 14.6 months. The liver function was assessed using the CP classification and modified ALBI (mALBI) grade. The progression-free survival (PFS), overall survival (OS) and median survival time (MST) were evaluated. Results: Patients with CP-B had significantly shorter PFS and OS than those with CP-A (median PFS, 4.6 months vs. 7.0 months; MST, 10.3 months vs. 23.2 months) (PFS, p = 0.009; OS, p < 0.001). Although CP-B was associated with a higher incidence of bleeding-related events, the discontinuation rate due to adverse events did not differ from that of CP-A. As a factor for stratifying CP-B outcomes, significant differences in the PFS, OS and response rate were observed between mALBI grades ≤ 2b and 3 (PFS, p = 0.004; OS, p = 0.024; response rate, p = 0.001). In multivariate analysis, the mALBI grade (hazard ratio [95% CI]: 2.388 [1.186–4.810]; p = 0.014) was extracted as a factor contributing to OS in patients with CP-B. Conclusion: Atez/Bev therapy demonstrated efficacy and safety in patients with CP-B, especially when hepatic reserve is maintained within mALBI grade 2b.Liver International, 46(1), art. no. e70466; 2025journal articl
Experimental Evaluation of a Line-Start Consequent-Pole Surface Permanent-Magnet Motor with Simple Rotor Design Strategies for Performance Improvement
No full textThe line-start permanent-magnet (LSPM) motor combines the direct-on-line starting of induction motors with the high efficiency of permanent-magnet (PM) synchronous motors, but conventional interior PM designs are difficult to manufacture and surface PM (SPM) designs often suffer from limited starting torque and reduced efficiency. This paper investigates consequent-pole SPM designs, in which the number of magnets is reduced by half while maintaining equal magnet volume, enabling simple rotor construction and improved starting performance. A prototype is manufactured and tested, confirming smooth synchronization under load. Efficiency is constrained by the non-sinusoidal flux distribution of the consequent-pole structure. Rotor design strategies enlarging the air gap near the iron poles are analyzed, and a finite element method analysis shows improved torque and efficiency without loss of starting capability.Machines, 13(11), art. no. 1003; 2025journal articl
Normalized Energy Dissipation Rate in Shear Turbulence
No full textIn shear turbulence, a relationship between the normalized mean energy dissipation rate and the spectral equation is established. Simulations show that, as the Reynolds number increases, a term from the nonlinear interactions becomes constant, supporting the zeroth law of turbulence which states that the dissipation rate remains finite at high Reynolds numbers. The study also finds that the integral of the low-pass filtered energy flux is a critical factor for the zeroth law, rather than the constant flux assumed in the classic energy cascade picture. Additionally, in turbulence driven by a mean velocity gradient, dissipation is related to the scale of turbulence production.Journal of the Physical Society of Japan, 95(1), art. no. 013401; 2025journal articl
Calculation method for axial load-carrying capacity of the tension-side brace in CFST K-joints with an external stiffener
No full textTo develop a calculation method for the axial load-carrying capacity of the tension side brace in CFST K-joints with an external stiffener, experimental studies on ten CFST K-joints and nonlinear finite element parametric analyses were conducted. The failure modes and stiffening effects of CFST K-joints with the external stiffener were revealed. The sensitivity of load-carrying capacity to stiffener plate and geometric parameters was systematically investigated. Existing formulas for CFST K-joints were verified to develop a new calculation method for the CFST K-joints with the external stiffener. The results demonstrate that the failure location of CFST K-joints shifts from the crown toe to the saddle and crown heel regions by the external stiffening. The external stiffener enhances the load-carrying capacity by 28.3–47.8 %. The load-carrying capacity shows positive correlations with the stiffener thickness factor (λ), stiffener height factor (η), wall thickness ratio (τ), and diameter-thickness ratio of the chord (γ) (with gradually decreasing slopes), a positive correlation with the angle between the chord and brace (θ) (with increasing slope), and a negative correlation with the diameter ratio (β). The existing calculation formulas for the load-carrying capacity of tensile brace in CFST K-joints demonstrated unacceptable accuracy for externally stiffened CFST K-joints, whereas the proposed formula for stiffened joints achieved a maximum deviation of 4.6 %, demonstrating superior computational accuracy.Structures, 82, art. no. 110568; 2025journal articl
損益計算構造試論
No full textThe aim of this essay is to present a tentative theory on simple income computational structure from the standpoint of the relation ship between the balance sheet and the income statement. Before clarifying the relationship, this essay places bookkeeping as the place of income computation. Then this essay examines simple income computational structure and positions capital account as an essential element which integrates business resources for commercial use to calculate income, because capital account is reference point which distinguishes return on capital from return of capital. Based on this capital account role, the difference of the income computation under the Asset-and-Liability view and the Revenue-and-Expense view is simply the difference in the pattern of the entity's total income allocation from the entity's founding to its demise. But in the value added accounting which may contribute to stakeholder capitalism, the total amount of value added will differ from the traditional total amount of income. This indicates that the simple income computational structure may need to be modified in stake holder capitalism.島田章准教授定年退職記念号In Honour of Associate Prof. Akira Shimada経営と経済, 105(3), pp.137-158; 2025departmental bulletin pape