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Identification of shared pathophysiological molecules of major psychiatric disorders: A comprehensive analysis of serum immune complex antigens before and after electroconvulsive therapy
No full textRecent studies indicate common inflammatory findings have been identified in peripheral blood in patients with major psychiatric disorders, including schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). Electroconvulsive therapy (ECT) frequently improves both severe symptoms and inflammatory markers in these conditions. However, the shared inflammatory mechanisms underlying these disorders, and thus, reliable biomarkers remain unclear. We hypothesized that the activation of immune complexes (ICs) contributes to inflammatory pathogenesis of these disorders. Using immune complexome analysis, we examined antigens forming ICs (IC-antigens) in the serum of patients with SCZ, BD, and MDD (n = 60) before and after ECT. Our analysis showed that although the overall quantity of ICs did not change before and after ECT, four proteins significantly decreased following ECT. These proteins were DENN domain-containing protein 1C (DENND1C), double-stranded RNA-specific editase 1 (ADARB1), perilipin-4, and coagulation factor XI, which were all consistently detected as IC-antigens across patient groups. Notably, DENND1C, ADARB1, and perilipin-4 were specific to psychiatric patients and absent in healthy controls. The abundance of these IC-antigens significantly correlated with psychiatric symptom scores, with DENND1C showing a particularly strong correlation with total symptom scores across all three disorders. These findings suggest that DENND1C may contribute to the shared pathophysiology of SCZ, BD, and MDD through antigenization or IC formation. This highlights its potential as a biomarker for ECT treatment availability and diagnostic/treatment efficacy monitoring.Journal of Neuroimmunology, 405, art. no. 578623; 2025journal articl
Exploring Unmet care needs among the elderly people with the impairment of Activity of Daily Living (ADL) in Kwale county Kenya - A mixed-methods study -
Get PDF長崎大学学位論文 [学位記番号]博（Global Health）甲第17号 [学位授与年月日]令和7年3月6日(2025-03-06)thesi
Integrated approach to investigate groundwater nitrate nitrogen pollution and remediation simulation in Shimabara Peninsula, Nagasaki, Japan
No full textGroundwater is the general source of drinking water in the Shimabara Peninsula, Nagasaki, Japan, and consequently, occurring nitrate nitrogen (NO3-N) pollution in the groundwater is a significant problem. Although various countermeasures have been implemented, nitrate nitrogen concentrations remain serious. Therefore, it is necessary to evaluate effects of different potentially effective countermeasures by simulating various remediation processes using numerical calculations. First, to determine the status of nitrate nitrogen pollution and groundwater quality, we sampled and analyzed 179 groundwater and spring water samples from 2011 to 2021. Principal component analysis (PCA) and hierarchical cluster analysis (HCA) were used to characterize the water quality. A trilinear diagram classified most groundwater samples into Ca-HCO3 and Ca–(SO4 + NO3) types. A small number of samples were classified as Na-HCO3 type. PCA extracted three principal components, accounting for 82% of the total variance. The extracted principal components indicated that mineral dissolution with water–rock interaction, nitrate nitrogen pollution, denitrification, and seawater pollution control the water chemistry in the study area. HCA classified 179 samples into five clusters. The combination of PCA and HCA results revealed that each cluster had markedly different ion concentrations depending on the degree of influence of each principal component. The nitrate nitrogen concentration ranged from 0.1 to 42.8 mg/L, and the average was 4.5 mg/L. Compared with the Japanese drinking water standard of 10 mg/L, 23 sites (13%) exceeded the standard. The spatial distribution of nitrate nitrogen concentration showed that nitrate nitrogen pollution is particularly severe in the northeastern region. Therefore, a numerical model of groundwater flow and nitrate nitrogen transport was developed to simulate nitrate nitrogen behavior in the northeastern region. To simulate the remediation process from nitrate nitrogen pollution, the reduction in nitrate nitrogen supply from agricultural land (fertilizer) and livestock facilities was assumed to be between 0 and 80% in 20 cases. The simulation results showed that the current pollution situation is a result achieved over the past 44 years. To reduce pollution in the most effective way, a 40% reduction in fertilizer applied to agricultural land is necessary. This is likely to reduce the nitrate nitrogen level in groundwater to permissible levels after approximately 50 years. These simulations of the remediation process are important for the determination of reduction target of the pollutants and necessary administrative decision-making.Environmental Earth Sciences, 84(10), art. no. 256; 2025journal articl
Microarchitectural analysis of the metacarpophalangeal joint using HR-pQCT in patients with rheumatoid arthritis: A comparison with healthy controls
Get PDF長崎大学学位論文 [学位記番号]博（医歯薬）甲第1666号 [学位授与年月日]令和7年3月5日(2025-03-05)thesi
Potential effect of topical antibiotics administration in the oral cavity on the reduced number of bacteria entering the lower respiratory tract after oral cancer surgery
Get PDF長崎大学学位論文 [学位記番号]博（医歯薬）甲第1679号 [学位授与年月日]令和7年3月19日(2025-03-19)thesi
(Epi)genetic and clinical characteristics in 84 patients with pseudohypoparathyroidism type 1B
Get PDF長崎大学学位論文 [学位記番号]博（医歯薬）甲第1685号 [学位授与年月日]令和7年3月19日(2025-03-19)thesi
Broadened substrate specificity of bacterial dipeptidyl-peptidase 7 enables release of half of all dipeptide combinations from peptide N-termini
Get PDF長崎大学学位論文 [学位記番号]博（医歯薬）甲第1688号 [学位授与年月日]令和7年3月19日(2025-03-19)thesi
Ex vivo expansion of primary cells from limb tissue of Pleurodeles waltl
Get PDF長崎大学学位論文 [学位記番号]博（医歯薬）甲第1702号 [学位授与年月日]令和7年3月19日(2025-03-19)thesi
Urolithin A Modulates PER2 Degradation via SIRT1 and Enhances the Amplitude of Circadian Clocks in Human Senescent Cells
Get PDF長崎大学学位論文 [学位記番号]共博（医歯薬）甲第45号 [学位授与年月日]令和7年3月5日(2025-03-05)thesi
Association between gross features and coexistence of BRAFV600E and TERT promoter mutations in papillary thyroid carcinomas: a combined analysis incorporating clinicopathologic features
Get PDF長崎大学学位論文 [学位記番号]共博（医歯薬）甲第49号 [学位授与年月日]令和7年3月19日(2025-03-19)thesi