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ストール制御風車の出力特性と広帯域騒音に関する研究
Get PDFTo maximize the output of the stall-controlled wind turbine, the shape of the blades was optimized based on the adaptive design of experiment. The output of the blade elements that composed the impeller was analyzed using the blade momentum theory, and the setting angle that maximized the output of the wind turbine was determined based on Bayesian optimization. The output of the stall-controlled wind turbine generated by the optimization improved by 31.5% over that of the base model wind turbine at the main flow velocity of the design point. The optimized three-dimensional blade geometry maximized the lift-to-drag ratio near the blade tips. The spectral distribution of the predicted values indicated that the decrease in aerodynamic noise of the optimized wind turbine was due to a reduction in broadband noise distributed in the audible range.長崎大学大学院工学研究科研究報告, 55(105), pp.7-13; 2025departmental bulletin pape
Effects of primer components of silane and 10-methacryloyloxydecyl dihydrogen phosphate on resin bonding to tribochemical silica-coated highly translucent zirconia
Get PDFNagasaki University (長崎大学)博士(歯学)Objectives: To assess the influence of different primer compositions—silane (S), 10-methacryloyloxydecyl dihydrogen phosphate (MDP), and the combination of silane and MDP (S + MDP)—on the bonding performance of MDP-free and MDP-containing resin cements to highly translucent zirconia. Materials and methods: Tribochemical silica-coated zirconia plates were pretreated with one of three experimental primers, S, MDP, or S + MDP, with untreated specimens serving as controls. Subsequently, these plates were bonded to stainless-steel rods using either two MDP-free or two MDP-containing resin cements. Tensile bond strength was measured after 24 h (TC0) and following thermal cycling (4–60 °C for 10,000 cycles; TC10,000). Data were analyzed using a three-way analysis of variance (ANOVA), followed by one-way ANOVA and Tukey-Kramer post hoc tests (α = 0.05). X-ray photoelectron spectroscopy (XPS) assessed the elemental mass concentrations on the zirconia surfaces. Results: For MDP-free resin cements, MDP-treated specimens exhibited significantly greater bond strengths than controls, regardless of the aging conditions. However, a significant reduction in bond strength was observed between TC0 and TC10,000 in most of the MDP-free resin cement groups, except for one S + MDP group. Conversely, for MDP-containing resin cements, the S + MDP group exhibited no statistically significant differences between aging conditions. Notably, XPS analysis detected silicon, zirconium, and aluminum on the zirconia surfaces. Conclusions: No significant difference in tensile bond strength was observed between aging conditions for MDP-containing resin cements bonded to tribochemical silica-coated zirconia primed with S + MDP.
Clinical relevance: The combination of MDP-containing primers and resin cements demonstrated superior bonding performance to tribochemical silica-coated zirconia.長崎大学学位論文 学位記番号:博(医歯薬)甲第1711号 学位授与年月日:令和7年6月4日Author: Fumika Tsuda, Keiichi Yoshida, Takashi SawaseCitation: Clinical Oral Investigations, 28, art. no. 638; 2024Nagasaki University (長崎大学), 博士(歯学) (2025-06-04)doctoral thesi
Effects of tafamidis on the left ventricular and left atrial strain in patients with wild-type transthyretin cardiac amyloidosis
No full textNagasaki University (長崎大学)博士(医学)Aims: Although tafamidis is used in patients with wild-type transthyretin cardiac amyloidosis (ATTRwt-CA), its specific effect on cardiac function is unclear. Thus, this study aimed to investigate the effect of tafamidis on left atrial (LA) and left ventricular function using speckle-tracking echocardiography for 1 year of treatment in patients with ATTRwt-CA. Methods and results: We included 23 patients (mean age, 76 years) with ATTRwt-CA confirmed via biopsy. We analysed the left ventricular and LA strain using 2D speckle-tracking echocardiography and compared these parameters before and 1 year after starting treatment with tafamidis between 16 patients with sinus rhythm (SR) and 7 patients with atrial fibrillation (AF). In ATTRwt-CA patients with SR, LA reservoir strain significantly improved by 1-year tafamidis treatment (10.5 ± 5.0% to 11.9 ± 5.3%, P = 0.0307) although global longitudinal strain (GLS) did not (−10.6 ± 3.1% to −11.3 ± 3.0%, P = 0.0608). In contrast, LA reservoir strain was not significantly changed (5.4 ± 2.9% to 4.9 ± 1.7%, P = 0.4571), and GLS deteriorated (−8.4 ± 2.3% to −6.8 ± 1.4%, P = 0.0267) in ATTRwt-CA patients with AF. Conclusion: LA function improved with tafamidis treatment in ATTRwt-CA patients with SR but not left ventricular function. However, these cardiac functions did not improve with tafamidis treatment in ATTRwt-CA patients with AF.長崎大学学位論文 学位記番号:博(医歯薬)甲第1715号 学位授与年月日:令和7年9月19日Author: Rosy Haruna Nishizawa, Hiroaki Kawano, Tsuyoshi Yoshimuta, Chisa Eguchi, Sanae Kojima, Takako Minami, Daisuke Sato, Masamichi Eguchi, Shinji Okano, Satoshi Ikeda, Mitsuharu Ueda, Koji MaemuraCitation: European Heart Journal - Cardiovascular Imaging, 25(5), pp.678-686; 2023Nagasaki University (長崎大学), 博士(医学)doctoral thesi
Enhancing systemic lupus erythematosus treatment outcomes with an early initiation of belimumab: insights from a multicenter retrospective study within the first five years
No full textNagasaki University (長崎大学)博士(医学)Background: The human monoclonal antibody belimumab (BEL) has emerged as a promising treatment for systemic lupus erythematosus (SLE), particularly for reducing the need for glucocorticoids and minimizing organ damage. The optimal timing of BEL initiation has been unclear; emerging evidence suggests that early intervention with BEL, particularly within the first 5 years of diagnosis, may yield better outcomes by modulating disease progression and reducing flare frequency. Understanding the relationship between disease duration and BEL efficacy is essential for the development of tailored strategies. Patients and methods: We analyzed patients with SLE treated at our hospital and associated facilities who were diagnosed according to the 1997 ACR or 2012 SLICC criteria and who began BEL treatment between December 2017 and August 2021. Patients who were followed for ≥ 12 months after BEL initiation were included. We investigated the changes in the patients' Safety of Estrogens in Lupus National Assessment–Systemic Lupus Erythematosus Disease Activity Index (SELENA-SLEDAI) scores at 3, 6, 9, and 12 months after the introduction of BEL, comparing patients with disease durations ≤ 5 years to those with > 5 years. A mixed-effects model was adjusted for the patients' ages, prednisolone dosages, initial SELENA-SLEDAI scores, Systemic Lupus International Collaborating Clinics (SLICC) damage index (SDI), hydroxychloroquine use, and lupus nephritis. Clinical manifestations including arthritis, skin lesions, and hematological abnormalities were monitored to assess the broader impacts of BEL. Results: One hundred eleven patients were initially registered; among them, 97 patients were included in the final analysis. The study population (mean age, 41 years; mean SELENA-SLEDAI, 7 points; 51% using hydroxychloroquine) included 19 patients with a ≤ 5-year SLE duration and 78 with SLE durations > 5 years. The baseline SELENA-SLEDAI scores were higher in the ≤ 5-year group (p = 0.047), indicating more active disease. Patients with ≤ 5 years of disease had significantly greater improvements in SELENA-SLEDAI scores at 6, 9, and 12 months (p < 0.05). Conclusions: These results highlight the importance of early BEL initiation in SLE, demonstrating that patients with shorter disease durations achieve more substantial improvements in disease activity with early BEL treatment. Our findings also reveal the potential benefits of early BEL intervention and suggest that incorporating the disease duration into treatment decisions may optimize patient outcomes.長崎大学学位論文 学位記番号:共博(医歯薬)甲第53号 学位授与年月日:令和7年9月3日Author: Kanako Kojima, Kunihiro Ichinose, Masataka Umeda, Toshimasa Shimizu, Shuntaro Sato, Takahisa Suzuki, Yoshikazu Nakashima, Akitomo Okada, Yoshiro Horai, Keita Fujikawa, Toshiyuki Aramaki, Taiichiro Miyashita, Masako Furuyama, Naoki Matsuoka and Atsushi KawakamiCitation: Arthritis Research & Therapy, 27, art. no. 116; 2025Nagasaki University (長崎大学), 博士(医学) (2025-09-03)doctoral thesi
Altered expression of autophagy-related molecules and β-catenin in different subtypes of thyroid cancer: co-localization in intranuclear cytoplasmic inclusions
No full textNagasaki University (長崎大学)博士(医学)This study aimed to clarify the expression levels of autophagy-related molecules, such as β-catenin, LC3B, and p62, in thyroid carcinoma (TC) cases of different histological types and clinicopathological characteristics. A total of 70 surgically resected thyroid nodules, including 43 papillary thyroid carcinoma (PTC), and other control groups such as five follicular adenoma (FA), five hyalinizing trabecular tumor (HTT), five follicular TC (FTC), six poorly differentiated TC (PDTC), and six anaplastic follicular cell-derived thyroid carcinoma (ATC), were analyzed by dual-color immunofluorescence for β-catenin, LC3B, and p62. Statistical analyses were used to determine the association of autophagy-related molecules with BRAFV600E/TERT promoter mutations, Ki-67 labeling index, and clinicopathological characteristics. p62 immunoreactivity was most frequently observed in PTC, particularly in classical and tall cell subtypes. This protein appeared to co-localize with LC3B and β-catenin in intranuclear cytoplasmic inclusions (INIs) of PTC. Conversely, p62 expression was rarely observed in either FTC or PDTC. The expression levels of p62 and its co-localization with β-catenin and LC3B correlated significantly with the presence of the BRAFV600E mutation. Frequent co-localization of dot-shaped perinuclear β-catenin signals with a component of the trans-Golgi apparatus in tall cell PTC subtype was also observed. This study revealed differences in the expression patterns of β-catenin, LC3B, and p62 among different TC types. Abnormal β-catenin expression may be linked to autophagy dysfunction, which triggers genomic instability and promotes tumor aggressiveness. These autophagy-related molecules may be cooperatively associated with INI formation during PTC carcinogenesis.長崎大学学位論文 学位記番号:共博(医歯薬)甲第57号 学位授与年月日:令和7年9月19日Author: Yerkezhan Sailaubekova, Katsuya Matsuda, Yuko Akazawa, Hirokazu Kurohama, Yuki Matsuoka, Keiji Suzuki, Adiya Kerimbayeva, Hisayoshi Kondo, Van Phu Thang Nguyen, Thi Ngoc Anh Nguyen, Thi Nhung Nguyen, Shinya Satoh, Hisakazu Shindo, Hiroyuki Yamashita, Masahiro NakashimaCitation: Endocrine Journal, 72(11), pp.1205-1215; 2025Nagasaki University (長崎大学), 博士(医学) (2025-09-19)doctoral thesi
Analysis of adaptation mechanisms to climate change in Japan's food security framework
No full textNagasaki University (長崎大学)博士(環境科学)長崎大学学位論文 学位記番号:博(水・環)乙第19号 学位授与年月日:令和7年8月29日Nagasaki University (長崎大学), 博士(環境科学) (2025-08-29)doctoral thesi
Classical Chinese gardens and well-being: restoration through spatial design and interpretive engagement
No full textNagasaki University (長崎大学)博士(環境科学)長崎大学学位論文 学位記番号:博(水・環)甲第115号 学位授与年月日:令和7年8月29日Nagasaki University (長崎大学), 博士(環境科学) (2025-08-29)doctoral thesi
Projected temperature-related mortality attributable to the urban heat island effect in the Tokyo Metropolitan Area stratified by age and geographical location
No full textThe urban heat island (UHI) effect, intensified by climate change, is reshaping the distribution of temperature-related health risks by amplifying heat exposure while offsetting cold-related impacts. However, current assessments of the UHI's future health impacts remain incomplete. Therefore, we estimated future UHI-attributable mortality in the Tokyo Metropolitan Area (TMA) considering the combined effects of climate change and different demographic scenarios through the end of the 21st century. Age-specific temperature–mortality relationships were examined for populations aged <65 and ≥65 years, and UHI impacts were quantified by contrasting urban temperatures with non-urban counterfactuals. Under a high-emission pathway (SSP5–RCP8.5), the UHI effect is projected to increase heat-related mortality from 4,100 (2010) to 11,270 (2090s), while decreasing cold-related deaths from 17,454 (2010) to 12,655 by the 2090s. Population aging also significantly amplified heat-related mortality among older adults (≥65 years), even though younger populations (<65 years) also showed a notable heat-attributable mortality risk. Spatial analyses further revealed stronger declines in avoided cold-related mortality and sharper increases in heat-related mortality owing to the UHI effect in densely populated urban cores. These findings underscore the growing health burden of UHIs under climate change and highlight the need for targeted, age- and location-specific adaptation strategies to protect vulnerable populations.Environment International, 205, art. no. 109921; 2025journal articl
Monte Carlo simulation to optimize measurement geometry of continuous air monitor with Si semiconductor detector
No full textOne of the challenges in real-time monitoring of airborne alpha-emitting radionuclides using Continuous Air Monitors (CAMs) is to discriminate alpha particles emitted by artificial radionuclides from those emitted by natural radionuclides, as the alpha energy spectrum is easily degraded due to its high stopping power. Although the measurement geometry significantly affects the alpha energy spectrum, there are no reports that have investigated the optimized geometry. This study conducted a Monte Carlo simulation to optimize the measurement geometry of the CAMs. The CAM was modelled using a radiation transport simulation code, and the counting efficiencies for 218Po and 239Pu and the overlapping ratio were simulated. The Minimum Detectable Concentration (MDC) of 239Pu was then estimated as an indicator to optimize the geometry. Although a constant counting efficiency is generally used for the same geometry regardless of the alpha energy, the counting efficiency differed up to ∼0.04 by the alpha energy depending on the measurement geometry. The overlapping ratio for a 50-mm diameter detector ranged from 0.22 to 0.35, while those for a 25-mm diameter detector was below 0.25. This discrepancy is because of the incident angle distribution biased towards large angles. The lowest MDC was estimated to be ∼3 Bq m−3 at 20 L min−1 under 25 Bq m−3 of 218Po. The MDC was low for small filter diameters and Filter-to-Detector Distances (FDDs) under most of the simulated conditions. The results indicate that a shorter filter diameter and FDD would be preferable for alpha spectrometry under normal air pressure.Radiation Physics and Chemistry, 241, art. no. 113507; 2025journal articl