38978 research outputs found
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Böhnke_EurSocioRev_2017_xGGO - Boeschoten & van den Goorbergh/Moya - Secondary Data Replication - y11
No full textDenson_AmEduResJourn_2009_zb3Y - Sisco/Méndez-Chacón - Secondary Data Replication - 41k2
No full text
Order-of-Magnitude Consistency Note: Information-Imprinting Geometry and Galactic Dynamics
No full textOrder-of-magnitude numerical consistency verification for the information-imprinting framework in galactic dynamics
Autonomic nervous system modulation by G protein-biased mu-opioid receptor agonists: a translational scoping review protocol
No full textBackground: G protein-biased mu-opioid receptor (MOR) agonists such as oliceridine and tegileridine were developed to reduce opioid-related side effects while keeping analgesic efficacy. The US FDA approved oliceridine in 2020 and China NMPA approved tegileridine in January 2024. Clinical development mainly focused on respiratory depression and gastrointestinal problems, but little attention has been paid to the autonomic nervous system (ANS) effects of these drugs. Traditional opioids change heart rate variability (HRV) and sympathovagal balance mainly through central mechanisms. It is not clear whether biased agonists show different autonomic profiles compared with traditional opioids. There is an ongoing scientific debate about whether the benefits of these drugs come from true signaling bias or from low intrinsic efficacy.
Methods: We will conduct a scoping review following JBI methodology and report according to PRISMA-ScR guidelines. We will search PubMed, Embase, Web of Science and Cochrane Library from database start to March 2026. FDA and NMPA regulatory documents will also be searched. Two reviewers will screen studies and extract data independently. We will include preclinical and clinical studies examining oliceridine, tegileridine or other biased MOR agonists that report cardiovascular or autonomic outcomes. Results will be organized in an Evidence Matrix by drug, evidence level and measurement timepoint. Animal studies will be stratified by anesthetic state (conscious versus anesthetized).
Discussion: We will evaluate evidence relevant to three competing hypotheses: that biased agonism preserves autonomic homeostasis; that observed benefits come from partial agonism rather than signaling bias; or that no meaningful autonomic differences exist between biased and traditional agonists. This review will map evidence gaps and inform future clinical trial design with autonomic endpoints. We note that tegileridine has much less published data than oliceridine, and this gap analysis will help set research priorities
Graskheenics: A Conceptual Framework for Signal-Based Internal Navigation and Post-Survival Orientation in Decision Alignment Under High-Pressure Conditions
No full textGraskheenics is a conceptual framework and evolving research program exploring internal navigation, decision orientation, and post-survival integration under high-pressure conditions.
This open-ended registration documents the theoretical development of the Graskheenics discipline, including signal-based navigation models, structural analysis of decision processes, and lived-experience-derived architectural mapping. The project examines how individuals recalibrate internal orientation after prolonged stress, crisis, or responsibility-intensive environments.
Rather than presenting a single experimental hypothesis, this registration establishes the foundational architecture of the framework, vocabulary, and applied logic derived from longitudinal real-world observation and reflective analysis.
Current outputs include:
Development of the Survival Architecture model
Signal Navigation protocols
GRASCODE™ operational logic: an 8-stage navigation sequence (Pattern > Mechanism > Choice > Idling > Activation > Responsibility > Decision > Transmission)
Tafheena — formalization of a pre-cognitive survival state within the Graskheenics framework
Applied conceptual analysis across leadership, crisis navigation, and high-stakes professional environments
Future directions may include:
Qualitative phenomenological studies
Applied training models and certification programs
Interdisciplinary collaboration with psychology, systems theory, decision science, and phenomenology
Empirical validation studies in high-consequence domains
This registration serves as a timestamped conceptual foundation and evolving research archive rather than a finalized empirical study.
Related work:
Grasman, Y. (2025). Tafheena: Survival Architecture — Book One.
Grasman, Y. (2026). Tafheena: Survival Architecture — Book Two.
LICENSING & PERMISSIONS:
This framework is released under CC-BY-NC-ND 4.0 during its
foundational development phase.
Commercial use, derivatives, and adaptations require prior
written permission from the author.
Licensing inquiries: [email protected]
License terms may be updated as the framework and community mature.
TRADEMARKS: Graskheenics®, GRASCODE™, Tafheena™ are protected
trademarks. Unauthorized use prohibited
ATB_Clostridum;Sarcina_perfringens_toxinotyping
No full textClostridium;Sarcina perfringes toxinotyping performed using PerfringeTyper (https://github.com/JA-Lacey/PerfringeTyper)
Summary output is in a 2 column .tsv format
sample perfrigens_toxinotype
SAMEA5694145,Type A
SAMEA47389918,Type A
SAMEA5694154,Type A
SAMEA111327977,Type C
SAMN25867891,Type A
SAMN10724005,Type F
SAMEA111327971,Type