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Comparative Analysis of Postoperative Inflammatory Response after Total Knee Arthroplasty (Unilateral and Bilateral) Between Indian and International Populations: A PRISMA 2020 Systematic Review and Meta-Analysis
No full textThis systematic review aims to quantify and compare postoperative inflammatory marker trajectories following total knee arthroplasty (TKA) in Indian versus international populations. The review will synthesize quantitative data on C-reactive protein (CRP), interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR), and tumor necrosis factor-alpha (TNF-α), focusing on peak values, timing of peaks, and normalization kinetics after unilateral and bilateral procedures.
The review further aims to examine the clinical implications of population-specific inflammatory kinetics for postoperative pain management, infection surveillance, and rehabilitation progression. A PRISMA 2020 compliant methodology will be followed, with meta-analysis conducted using random-effects models
Dual Stability Theorem in Relational Mechanics: The Four Fundamental Forces Mapping and Topological Boundary Conditions of "Sharing Glory" and "Enduring Adversity"
No full textThe Topological Singularity of Love: A GUTCM Perspective
This study aims to resolve the academic impasse within traditional sociology and evolutionary psychology regarding the ambiguous definition of "True Love," which has long been reductionistically categorized as a mere dopamine-driven biochemical illusion. Grounded in the Global Unified Theory of Cosmic Mind (GUTCM) and the framework of mental topology, this research—for the first time—rigorously maps the four fundamental forces of the universe (Gravity, Strong Interaction, Weak Interaction, and Electromagnetism) onto the dynamics of human relationships, proposing a mathematical model for the absolute stability of intimacy.
The Mapping of Fundamental Forces
The research indicates that initial attraction is merely a curvature in Phase Space, recognized as Gravity. Conversely, the worldly concepts of "sharing prosperity" and "enduring adversity" correspond essentially to the Strong Interaction and Weak Interaction found in micro-physics.
This paper introduces two core variables:
Non-zero-sum Glory Superposition (Self-consistency coefficient, α)
Negentropy Carrying Capacity (Infinite potential well mechanism, ∫L B dt)
The Anti-Efficiency of Topological Deadlock
Through these variables, it is rigorously demonstrated that true love is not a random fluctuation of emotion. Instead, it is a highly energy-intensive "Topological Deadlock Structure" that defies the biological principle of maximizing energy efficiency (Anti-Efficiency).
Only when both parties undergo the full tempering of the four fundamental forces—simultaneously satisfying the "Quark Confinement" (internalization) of the Strong Force and the "Decay Endurance" (resistance to heat death) of the Weak Force—can the system overcome the biological instincts of jealousy and harm avoidance.
The Singularity of Will: At the Singularity where classical mechanics collapse, a Nash Equilibrium is attained.
This proves that true love is a micro-singularity forcibly forged by free will within a high-entropy universe; it is the Möbius Strip closure completed by two consciousness particles within the absolute vacuum
New hypothesis: "Six-factor theory of erythropoiesis control" HIF-PH inhibitors correct TNF-α over-induction in ESA-resistant anemia.
No full textESAs have made significant contributions to the treatment of renal anemia over the years. Furthermore, many reports have been published on the tissue-protective and anti-inflammatory effects of ESAs. While the normal EPO receptor is an EPOR homodimer, their tissue-protective and anti-inflammatory effects are distinct from those of ESAs, as they are primarily mediated by a heteroreceptor consisting of EPOR and CD131. Conversely, the paradox exists that large doses of ESAs may be harmful to the human body, necessitating the construction of a new theory, along with the development of ESA-resistant anemia. Incorporating the pharmacological effects of recently introduced HIF-PH inhibitors, we propose a new hypothesis, the "six-factor theory of erythropoiesis control." Because a single experimental or observational study is not sufficient to prove the theory, we present it in a review format.The six factors are EPO, Tumor Necrosis Factor-α (TNF-α), Leptin, Hypoxia-Inducible Factor （HIF）, GATA transcription factor (GATA), and Nuclear Factor-kappa B (NF-κB). The underlying cause of erythropoiesis-stimulating agent (ESA)-resistant anemia is the over-induction of TNF-α by large amounts of ESA itself. This is corrected by HIF-PH inhibitors. Iron metabolism and hemoglobin synthesis control are downstream of the six factors that regulate the baseline balance between red blood cell production and infection defense. Iron metabolism is controlled from the upstream by TNF-α and Leptin, which inhibit iron utilization, and by HIF and EPO, which promote iron utilization. Important downstream factors are Transferrin Receptor (TfR) 2, Hepcidin, Erythroferrone, and Fibroblast Growth Factor 23 (FGF23). FGF23, TfR2, and Leptin are at the crossroads of erythropoiesis, iron metabolism, and bone metabolism. Endogenous EPO is reduced by ESA overdose and restored by HIF-PH inhibitors. The pharmacological action of HIF-PH inhibitors, which are highly effective in treating ESA-resistant anemia, is to produce physiological EPO and improve iron metabolism. Furthermore, HIF-PH inhibitors adjust the imbalance of the six-factor network, creating an environment for efficient red blood cell production. The basis for this is the suppression of TNF-α production by HIF-PH inhibitors. Clinically, if sufficient iron can be replenished to protect the body from the harmful effects of iron deficiency and side effects such as thrombosis can be controlled, HIF-PH inhibitors may become the first choice of standard treatment for renal anemia. The advent of HIF-PH inhibitors has shed light on previously unknown biological mechanisms, and discussions are likely to progress on fine-tuning the treatment of renal anemia and the combined use of ESAs and HIF-PH inhibitors in small doses
New hypothesis: "Six-factor theory of erythropoiesis control" HIF-PH inhibitors correct TNF-α over-induction in ESA-resistant anemia.
No full textESAs have made significant contributions to the treatment of renal anemia over the years. Furthermore, many reports have been published on the tissue-protective and anti-inflammatory effects of ESAs. While the normal EPO receptor is an EPOR homodimer, their tissue-protective and anti-inflammatory effects are distinct from those of ESAs, as they are primarily mediated by a heteroreceptor consisting of EPOR and CD131. Conversely, the paradox exists that large doses of ESAs may be harmful to the human body, necessitating the construction of a new theory, along with the development of ESA-resistant anemia. Incorporating the pharmacological effects of recently introduced HIF-PH inhibitors, we propose a new hypothesis, the "six-factor theory of erythropoiesis control." Because a single experimental or observational study is not sufficient to prove the theory, we present it in a review format.The six factors are EPO, Tumor Necrosis Factor-α (TNF-α), Leptin, Hypoxia-Inducible Factor （HIF）, GATA transcription factor (GATA), and Nuclear Factor-kappa B (NF-κB). The underlying cause of erythropoiesis-stimulating agent (ESA)-resistant anemia is the over-induction of TNF-α by large amounts of ESA itself. This is corrected by HIF-PH inhibitors. Iron metabolism and hemoglobin synthesis control are downstream of the six factors that regulate the baseline balance between red blood cell production and infection defense. Iron metabolism is controlled from the upstream by TNF-α and Leptin, which inhibit iron utilization, and by HIF and EPO, which promote iron utilization. Important downstream factors are Transferrin Receptor (TfR) 2, Hepcidin, Erythroferrone, and Fibroblast Growth Factor 23 (FGF23). FGF23, TfR2, and Leptin are at the crossroads of erythropoiesis, iron metabolism, and bone metabolism. Endogenous EPO is reduced by ESA overdose and restored by HIF-PH inhibitors. The pharmacological action of HIF-PH inhibitors, which are highly effective in treating ESA-resistant anemia, is to produce physiological EPO and improve iron metabolism. Furthermore, HIF-PH inhibitors adjust the imbalance of the six-factor network, creating an environment for efficient red blood cell production. The basis for this is the suppression of TNF-α production by HIF-PH inhibitors. Clinically, if sufficient iron can be replenished to protect the body from the harmful effects of iron deficiency and side effects such as thrombosis can be controlled, HIF-PH inhibitors may become the first choice of standard treatment for renal anemia. The advent of HIF-PH inhibitors has shed light on previously unknown biological mechanisms, and discussions are likely to progress on fine-tuning the treatment of renal anemia and the combined use of ESAs and HIF-PH inhibitors in small doses
Qualitative Research Meta-Integration of Hypertensive Patients' Experiences in Self-Management Using Mobile Health Technologies
No full textAbstract：Objective: To synthesize the experiences of hypertensive patients in self-management with mobile health (mHealth) technologies, and provide a reference for the future development of mobile medical tools that better align with patients' self-management needs.Methods: Databases including Web of Science, PubMed, CINAHL, Embase, the Cochrane Library, Scopus, China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP Database, and the Chinese Biomedical Literature Database (CBM) were retrieved for relevant literatures from their establishment to January 2026. After conducting quality assessment on the literatures, meta-aggregation was adopted to synthesize the research results.Results: A total of 10 literatures were included, from which 30 explicit research findings were extracted. Through repeated reading and in-depth analysis, these findings were categorized into 10 themes and further synthesized into 3 integrated results, namely: the positive effects of mHealth technologies on self-management in hypertensive patients; the practical problems encountered during the application of mHealth technologies; and the subsequent optimization demands for mHealth technologies in the process of self-management.Conclusion: Most hypertensive patients recognized the positive role of mHealth technologies in their self-management, yet certain problems still exist in clinical practice. In the subsequent development of mHealth tools, priority should be given to meeting patients' personalized needs, enhancing their self-management capabilities through the integration of online and offline interventions, and catering to their demands for home-based rehabilitation
Data and analytic code for "From suppression to expression: How loss of personal control facilitates hate speech among the internally unmotivated"
No full textIntegrating Multiplexing into Confineable Gene Drives Effectively Overrides Resistance in Anopheles stephensi
No full textRevisiting Nostalgia for Current and Ex-Romantic Partners: Affective Profiles and the Moderating Effect of Relationship Duration
No full textNostalgia is a self-relevant, socially grounded emotion marked by a sentimental longing for the past. Compared to the well-documented benefits known about general personal nostalgia, most nostalgia studies in both emotion and relationship science rely heavily on Western samples, and nostalgic effects of former partners are mixed. With an Asian sample, the present research had two main aims: (a) experimentally replicate the nostalgic effects of current and ex-partners on current relationship quality and (b) examine the moderating role of relationship duration. Results revealed both ex and romantic nostalgia increased relationship satisfaction, and more interestingly, romantic nostalgia decreased relationship commitment in shorter relationships. Furthermore, exploratory analyses highlighted distinct affective patterns within romantic nostalgia. Implications and contributions are further discussed
Resolving the Representation Crisis in Relativistic Quantum Mechanics_ The Relational Event-Coordination Framework
No full textThe Dirac and Foldy-Wouthuysen (FW) representations of relativistic quantum mechanics produce conflicting predictions for fundamental observables like location, spin, and probability density, creating a fundamental stalemate. This representation crisis undermines quantitative results across the field, yet researchers continue to work within restrictive methodologies—low-dimensional models, paraxial approximations, or classical circuit simulations—that mask rather than resolve the underlying mathematical tension. We propose the Relational Event-Coordination (REC) framework, which redefines position as a relational property emerging from a Hilbert space of spacetime events rather than an intrinsic particle operator. Within this framework, Lorentz symmetry acts as a geometric unitary, and observables arise from covariant clock POVMs conditioned against spacetime foliation. The REC framework recovers the Dirac density where covariance and continuity requirements dominate, while mapping to FW variables when classical alignment becomes necessary. Neither representation holds privileged status; both describe the same underlying events under different conditioning regimes. We identify testable predictions involving twisted electron beams in non-inertial frames and high-energy particles in intense laser fields, offering pathways toward empirical resolution of the representation paradox.
Keywords: Dirac representation, Foldy–Wouthuysen transformation, relational quantum mechanics, relativistic observables, Event-Hilbert Space, Newton–Wigner localization, POVM, representation crisi