Shiga University of Medical Science Hospital
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イチ チイキ ザイジュウ コウレイシャ ニ オケル シンタイテキ セイシンテキ シャカイテキ ケンコウ ノ イジ ト ペット シイク トノ カンレン ノ ケントウ Kチョウ シッカイ チョウサ
No full text学位授与機関： 滋賀医科大学 修士（看護学）第185号 平成27年3月10
セイシン ショウガイ ノ コドモ オ モツ チチオヤ ノ カゾク シンリ キョウイク ニ ヨル ヤクワリ サイコウチク
No full text学位授与機関： 滋賀医科大学 修士（看護学）第190号 平成27年3月10
ガン カンレン センイガ サイボウ ノ キノウ ソガイ ニ ヨリ ジュジョウ サイボウ ワクチン リョウホウ ニ ヨッテ ユウドウサレル コウシュヨウ メンエキ オウトウ ワ ゾウキョウスル
No full text学位授与機関： 滋賀医科大学 博士（医学）甲第728号 平成27年3月10日Cancer Science. 2015, 106(2), p.134-4
Sleep, mental health status, and medical errors among hospital nurses in Japan.
No full text博士（医学）滋賀医科大
ジョセイ イシ ガ シュウギョウ ヲ ケイゾク シテイクタメノ テイゲン ： ジョセイ イシ ノ シュウギョウ ト キャリア ノタメノ アンケート シュウケイ ケッカ カラ ミエテキタ ゲンジョウ ト シュウギョウ ケイゾク ノタメニ イマカラ ヒツヨウナ コト
No full textShortages of physicians commonly seen outside urban areas are partially due to disproportional concentration of physicians tocities. However, some claim that it is also caused by a declining number of physicians in actual practice resulting from an increase in thenumber of female physicians. In collaboration with the Shiga University of Medical Science Alumni Association “Koikai,” the Network ofShiga Prefecture Female Physicians distributed a questionnaire to 826 female graduates of Shiga University of Medical Science toinvestigate their current situations and obtain their opinions about work life balance. The number of respondents completing thequestionnaire was 213, which consisted of 162 full-time physicians, 39 part-time physicians, 3 medical professionals other than physicians, 2graduate school students, and 7 non-workers. Based on the results of the questionnaire, we propose the following issues to Shiga Prefectureand the national government: 1) exemption from night-shift and after-hours on-call duty during pregnancy and child-rearing; 2) jobassistance through a short working hour system, etc.; 3) continued employment by reducing excessive workload among full-time physicians;and 4) improvement of in-hospital childcare centers/care facilities for sick children, including the increase in the number of such facilities
シガ イカ ダイガク イガクブ フゾク ビョウイン シカ コウクウ ゲカ ニ オケル シュウジュツキ コウクウ キノウ カンリ ノ ゲンジョウ ト テンボウ
No full textThe implementation of perioperative oral health management reduces the risk of intraoperative and postoperative complications. For example, it prevents postopera tive infectious endocarditis and aspiration pneumonia to remove the source of infection in the oral cavity and reduce the number of bacterial infectious endocarditis postoperative. In addition, adequate perioperative oral health management can prevent secondary infection caused by oral ulcers in patients undergoing radiation therapy or chemotherapy. Improving oral hygiene leads to improvement in postoperative the quality of life of patients. In our department, we established a dental support system. It was implemented for the management of oral hygiene in patients in all departments, particularly those with difficulty in oral self-cleansing and a high risk of infection. Since 2012, oral care of perioperative patients has been introduced as perioperative oral management. We have performed this in cooperation with doctors belonging to other departments. Here we report the future prospects in light of findings obtained to date
Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients
No full text博士（医学）滋賀医科大
The impact of altered O-GlcNAcylation on fructose-derived metabolic derangements due to deletion of O-GlcNAc transferase in the hepatocytes.
No full text科学研究費補助金研究成果報告書研究種目: 基盤研究(C)研究期間: 2012～2014課題番号: 24591350研究代表者: 関根 理（滋賀医科大学・医学部・助教）細胞内代謝経路のヘキソサミン経路を介したO-結合型糖修飾（O-GlcNAc）は栄養素により活性化される。 本研究では、果糖過剰摂取による肝臓における細胞内蛋白のO-GlcNAc修飾の調節異常を介した代謝異常への影響に着目した。①マウス系統間での果糖摂取による肝臓でのO-GlcNAc修飾核内蛋白の発現量が、脂肪肝や代謝異常と関連していた。②転移酵素O-GlcNAc transferase(OGT)遺伝子の肝臓特異的ノックアウトモデルマウスは、O-GlcNAc修飾蛋白の発現が減少し、組織学的に肝細胞障害や偽胆管の形成、線維化を著明に認めており、OGTが細胞の恒常性を保つのに重要であると考えられた。O-GlcNAcylation is characterized by the addition of O-linked β-N-acetylglucosamine to proteins and serves as an intracellular nutrient sensor for modulating cell functions. O-GlcNAc transferase (OGT) is a critical enzyme for O-GlcNAcylation. We found out that protein O-GlcNAcylation and expression of OGT was increased in the liver fed a high-fructose diet compared to a control diet related to elevation of the lipogenesis and metabolic disorders, associating to the susceptibility to high-fructose diet. To examine the physiological role of O-GlcNAcylation in hepatocyte biology, hepatocyte-specific OGT-deleted mice (Ogt-KO) were generated by crossbreeding Ogt-flox mice with Albumin-Cre mice. Ogt-KO showed severe hepatocellular damage, proliferation of bile ducts and fibrosis. Our results suggest that protein O-GlcNAcylation is a key modulator for nutrient-derived metabolism in the liver, and tuning of OGT-mediated protein O-GlcNAcylation is essential to maintain hepatocyte homeostasis