Shiga University of Medical Science Hospital
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Protective effects of intercalated disk protein afadin on chronic pressure overload-induced myocardial damage.
No full textAdhesive intercellular connections at cardiomyocyte intercalated disks (IDs) support contractile force and maintain structural integrity of the heart muscle. Disturbances of the proteins at IDs deteriorate cardiac function and morphology. An adaptor protein afadin, one of the components of adherens junctions, is expressed ubiquitously including IDs. At present, the precise role of afadin in cardiac physiology or disease is unknown. To explore this, we generated conditional knockout (cKO) mice with cardiomyocyte-targeted deletion of afadin. Afadin cKO mice were born according to the expected Mendelian ratio and have no detectable changes in cardiac phenotype. On the other hand, chronic pressure overload induced by transverse aortic constriction (TAC) caused systolic dysfunction, enhanced fibrogenesis and apoptosis in afadin cKO mice. Afadin deletion increased macrophage infiltration and monocyte chemoattractant protein-1 expression, and suppressed transforming growth factor (TGF) β receptor signaling early after TAC procedure. Afadin also associated with TGFβ receptor I at IDs. Pharmacological antagonist of TGFβ receptor I (SB431542) augmented mononuclear infiltration and fibrosis in the hearts of TAC-operated control mice. In conclusion, afadin is a critical molecule for cardiac protection against chronic pressure overload. The beneficial effects are likely to be a result from modulation of TGFβ receptor signaling pathways by afadin
トヨサト ビョウイン ニ オケル フククウキョウカ ダイチョウガン シュジュツ ノ ゲンジョウ ト カダイ
No full textBetween April 2007 and September 2015, 95 patients received laparoscopic surgery for colorectal cancer resection. We compared age, clinical stage, operative time, and surgical complication in two groups (2007 to 2011 and 2012 to 2015). Though the operative time was longer in the latter group, the complication of anastomotic leakage and bladder disorder decreased. A qualified surgeon of endoscopic surgical skill qualification system began to participate in the operation from 2014 and operative time was shortened 60 minutes on average. We need to strengthen our clinical system to operate elder patients safe and influence our community to have an examination for colon cancer
バッシゴ ノ シケツ ニ クリョシタ ジュウショウ ケツユウビョウ B カンジャ ノ 1レイ
No full textHemophilia B is X-linked recessive heredity-related bleeding disorders by the factor Ⅸ lack. The number of patients of this country is approximately 1,000 and a rare disease. We report a case that had difficulty in hemostasis after the tooth extraction of the seriously ill hemophilia B patient with review of literature. A 4 years old boy came to our hospital for main complaint by majority tooth caries medical treatment under the general anesthesia. The past history included hemophilia B and he received two times a week of factor IX replacement therapy. We accepted caries as intraoral views in maxillary left B, mandibular right D, mandibular left D, E. We recognized two tooth-like non-transmitted images on a panoramic X ray and CT images in the maxillary both sides A apical area at the first medical examination. We judged that teeth extraction was necessary, because these disturb eruption of the maxillary both sides first. In cooperation with the pediatrics, we treated caries and extracted supernumerary teeth embedded in a maxillary midline under the general anesthesia. After surgery, he left the hospital without abnormal bleeding. But, he repeated bleeding for one and a half months and we had difficulty in hemostasis. Healing is good in acknowledgment of the epithelization of the wound now
ビクウ ナイ ケンタイ チュウ Aβ42 ソクテイ ホウホウ ノ カイハツ オヨビ ケンジョウ ヒト ボランティア エノ テキヨウ
No full text学位授与機関： 滋賀医科大学 博士（医学）甲第741号 平成28年3月10日Journal of Brain Science. 2014, 44, p.5-23
ニホンジン ダンセイ ニ オケル コウミツド リポ タンパク (HDL) リュウド ノウド ト ケイドウミャク ノ センザイセイ ドウミャク コウカ トノ カンレン
No full text学位授与機関： 滋賀医科大学 博士（医学）甲第742号 平成28年3月10日Atherosclerosis. 2015, 239, p.444-450
Dガタ アスパラギン サン ガ マウス セイソウ ニ オイテ セイシ ケイセイ ニ アタエル エイキョウ ノ ケントウ
No full text学位授与機関： 滋賀医科大学 博士（医学）甲第755号 平成28年3月10日Bioligy of Reproduction. 2016, 94(2) :30
ジョセイ カンゴショク ノ ショクギョウ ト カテイ ノ リョウリツ ニ オケル ヤクワリカン カットウ ニ カンスル ケンキュウ リショク シタ カンゴショク ト シゴト オ ケイゾク シテイル カンゴショク トノ ヒカク ケントウ
No full text学位授与機関： 滋賀医科大学 修士（看護学）第204号 平成28年3月10
ヒト シンキン Kv1.5 カリウム チャネル ニ オケル アラキドンサン ノ サヨウ ブイ
No full text学位授与機関： 滋賀医科大学 博士（医学）甲第760号 平成28年9月14日British Journal of Pharmacology. 2015, 172(22), p.5281-5292
